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April 4, 2025 12 mins

Let’s talk PDAC—Join Dr. Katharine Caldwell for a discussion with expert biliary and pancreatic surgeon Dr. Dominic Sanford. This episode of the Washington Manual of Surgery Podcast will focus on pancreatic ductal adenocarcinoma and is a companion to Chapter 19 of the 9th edition of the bestselling Washington Manual of Surgery.  

Drs. Caldwell and Sanford discuss the management of pancreatic ductal adenocarcinoma (PDAC). They go into detail on the importance of distinguishing between benign and malignant biliary obstructions and the use of lab tests and imaging for diagnosis. They discuss treatment strategies based on disease staging and the standards of care, involving locally advanced or borderline resectable PDAC. The discussion covers the use of neoadjuvant chemotherapy and surgical options, including the Whipple procedure, as well as post-operative complications that may arise and the management of pancreatic leaks and fistulae. 

Guest Host: Katharine Caldwell, MD – general surgery resident at WashU Medicine and associate editor of the Washington Manual of Surgery

Guest: Dominic Sanford, MD, is an assistant professor in the Department of Surgery at WashU Medicine. Dr. Sanford’s specialty is in minimally invasive surgery of the pancreas, bile ducts, liver, spleen and adrenal glands and his research interests include improving pancreatic cancer patient outcomes.

Citations:

Modified fistula risk score: https://pubmed.ncbi.nlm.nih.gov/28408176/

The original fistula risk score paper: https://pubmed.ncbi.nlm.nih.gov/23122535/

The leak/pancreatic fistula classification scoring system (A/B/C) from 2017: https://pubmed.ncbi.nlm.nih.gov/28040257/

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The Washington Manual of Surgery Podcast is a companion to the Washington Manual of Surgery (9th Edition). For more comprehensive surgical education, pick up a copy of the Washington Manual of Surgery: https://bit.ly/41xJ0aQ

If you liked this episode, check out our recent episodes here: https://www.buzzsprout.com/2422197

For more information about the Department of Surgery at WashU Medicine, visit https://surgery.wustl.edu/ and follow us on social media.

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