Surgical Diseases of the Liver: Part 2 - Washington Manual of Surgery

Let’s talk surgical liver disease—Join general surgery resident Dr. Catherine Zivanov for a discussion with expert liver transplant surgeon, Dr. William Chapman. This episode of the Washington Manual of Surgery Podcast will be part 2 of 2 focusing on the surgical care of liver disease and serves as a companion to Chapter 17 of the 9th edition of the bestselling Washington Manual of Surgery. 

In this episode of the Washington Manual of Surgery podcast, Dr. William Chapman, a leading abdominal transplant and hepatobiliary surgeon, discusses malignant liver diseases with host Dr. Catherine Zivanov. 

Topics covered include the application of the MELD score for liver disease prognosis, criteria for liver transplantation such as Milan and UCSF criteria, and  treatment strategies for hepatocellular carcinoma and colorectal liver metastases. The episode also delves into the role of future liver remnant and the use of portal and hepatic vein embolization to enhance surgical outcomes. 

This topic is covered in more than one episode of the Washington Manual of Surgery Podcast, so please check out part 1 of this topic focused on the surgical treatment of benign liver diseases! 

Guest Host: 

Catherine Zivanov, MD, MPHS – General surgery resident at WashU Medicine. 

Guest: 

William Chapman, MD – Director of the Division of General Surgery and Chief of the Section of Transplant Surgery. He is a specialist in liver transplantation, transplantation surgery, hepatobiliary surgery, and liver diseases. 

Citations: 

Liver Imaging Reporting and Data System (LI-RADS): 

Fowler KJ, Potretzke TA, Hope TA, Costa EA, Wilson SR. LI-RADS M (LR-M): definite or probable malignancy, not specific for hepatocellular carcinoma. Abdominal Radiology (NY), 2018. 

Milan Criteria and Beyond: 

Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. The New England Journal of Medicine, 1996. 

Mazzaferro V, Citterio D, Bhoori S, et al. Liver transplantation in hepatocellular carcinoma after tumour downstaging (XXL): a randomised, controlled, phase 2b/3 trial. The Lancet Oncology, 2020. 

Model for End-Stage Liver Disease (MELD): 

https://optn.transplant.hrsa.gov/data/allocation-calculators/meld-calculator/ 

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The Washington Manual of Surgery Podcast is a companion to the Washington Manual of Surgery (9th Edition). For more comprehensive surgical education, pick up a copy of the Washington Manual of Surgery: https://bit.ly/41xJ0aQ

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For more information about the Department of Surgery at WashU Medicine, visit https://surgery.wustl.edu/ and follow us on social media.

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