Few & Far Between: Conversations from the Front Lines of Drug Development

Few & Far Between: Conversations from the Front Lines of Drug Development

Welcome to Few & Far Between! Chris O'Brien, CEO of Biorasi, is your host for Conversations from the Front Lines of Drug Development - from clinical research and policymakers to biotech innovators and industry leaders.

Episodes

July 22, 2025 44 mins

Is the epigenome the "software" of the cell nucleus?

Find out in our latest episode of the Biorasi Few & Far Between podcast! Host Chris O'Brien welcomes Jim Brown, President and CEO of DURECT Corporation, for a conversation on the importance of a pharmacoeconomic strategy, developing new treatments for alcohol associated hepatitis, and moving beyond what a single individual can do i...

Mark as Played

How do experienced troubleshooters solve a difficult problem? By asking the right questions first!

Welcome back to part two of our conversation with Michael Tolentino, MD, Co-Founder and Head Scientific Consultant at Aviceda Therapeutics. Join host Chris O'Brien as he and Dr. Tolentino, explore the traits of top problem solvers, the power of communication, and how silos and "bad apples" ...

Mark as Played

How much do you know about clinical trials in Latin America? Take a deep dive with us as we explore the benefits and risks of running studies in this region.

In our latest episode of the Biorasi Few & Far Between podcast, host Chris O'Brien welcomes Julio G. Martinez-Clark, CEO and Co-Founder at bioaccess®. Tune in as we spotlight the advantages of running studies in #LATAM - from da...

Mark as Played

The challenge? Decoding the human immune system. Get ready to meet the top challenger on today's episode of the Biorasi Few & Far Between podcast.

Host Chris O'Brien welcomes Michael Tolentino, MD, Co-Founder and Head Scientific Consultant at Aviceda Therapeutics, to the podcast. Tune in to part one of this special two-part episode as we explore Michael's start in ophthalmology, grou...

Mark as Played

How do mission, vision, and data analysis fit into today's biotech goals?

Host Chris O'Brien welcomes Frank David, Founder and Managing Director of Pharmagellan to the podcast. Tune in as we explore R&D strategy, de-risking tactics, and how to think about valuation.

Listen in to the latest episode of the Biorasi Few & Far Between podcast today!

 

 

...
Mark as Played

How does a biotech balance great science with IP security to tell their story? Find out on today's episode of the Few & Far Between podcast!

Host Chris O'Brien welcomes Joshua Kresh, Emily Michiko Morris, and Mark Schultz from IPPI: The Intellectual Property Policy Institute. Tune in for a fascinating discussion on the dos and don'ts of IP protection.

Listen to the latest episode tod...

Mark as Played

How do you turn back the epigenetic clock for humans and their animal companions? 

Host Chris O'Brien welcomes Dan Oliver, CEO and Founder of Rejuvenate Bio, to the podcast. Tune in as we take a deep dive into parallel clinical trials designed to address chronic, age-related diseases in people and their pets. Plus, we'll zoom in on the right corporate structure for biotech products and t...

Mark as Played

Now on the Few & Far Between podcast:

Did you know that one in ten people with Type 1 Diabetes (TD1) die from hypoglycemia? Today's guest, who has TD1, explains how he turned his passion for helping others into innovative treatments for diabetes and other chronic diseases.

Host Chris O'Brien welcomes Jonathan Rigby, Chairman and CEO at Sernova, to the podcast. Listen in as we spotlig...

Mark as Played

Today on the Biorasi Few & Far Between podcast:

What if you could read a story before its official release? Competitive intelligence gives you early access to information on emerging trends in clinical trials.

 

On today's episode, host Chris O'Brien welcomes Eileen Faucher. Eileen is the Principal and Founder of Brass Tacks Health, a company that provides insights that biotechs need...

Mark as Played

"You have to have the right people, the right team, and good science." - John Celebi, President and CEO, Sensei Bio

Welcome back to Biorasi's Few & Far Between podcast. On today's episode, host Chris O'Brien welcomes John Celebi to the pocast.

Be sure to tune in for insights into assembling a core management team and how to build openness and inclusivity into biotech company culture.

...

Mark as Played

"There's that old saying, 'culture is how people behave when nobody's looking.' So, if you want to be effective, your [mission and value statements] have to be specific enough to actually guide behavior." - Ben Olds, Executive Coach and Managing Partner, Haven Human Asset Ventures

Read more

Mark as Played

"If you bring powerful technology to a problem that is well understood, then you can really make a difference." - Marc Lajoie, CEO at Outpace Bio

Read more

Mark as Played

"It's really a very important challenge we had from the very beginning, to see how to stabilize nanoparticles with the messenger RNA so they are not destroyed during nebulization." - Dr. Carsten Rudolph, CEO and Managing Director at Ethris

Welcome to the latest episode of Biorasi's Few & Far Between podcast. Join host Chris O'Brien and guest, Dr. Carsten Rudolph, as they discuss the ...

Mark as Played

"We don't endeavor Read more

Mark as Played

"I hope we're moving into the age of the generalist, where knowing how to learn and learning how to learn are more important than specialized knowledge." - Isaac Stoner, Co-founder and CEO at Octagon Therapeutics

Welcome to the latest episode of Biorasi's Few & Far Between podcast. Join host Chris O'Brien and guest, Isaac Stoner, as they discuss immunology, how to build a company, an...

Mark as Played

“Our studies are open for those that have exhausted standard of care, and we're showing improved responses, and the data is promising. So, I really hope that as we scale up and generate more data, we can actually move to newly diagnosed patients.” - Diana Azzam, PhD, Assistant Professor at Florida International University, Co-Founder at First Ascent Biomedical

Welcome to the latest episo...

Mark as Played

"It's amazing how many companies there are and how many opportunities for a kind of a match between a human that needs some help and a company that can help." - Craig Serra, Head of Clinical Research Scientif...

Mark as Played

"I learned very early on that the stupidest cancer cell was cleverer than the cleverest oncologist." - Justin Stebbing, Editor-in-Chief of Oncogene, previously the UK's first NIHR Research Translational Professor of Oncology, Professor of Biomedical Sciences, Anglia Ruskin University, Cambridge.

Welcome to the latest episode of Biorasi's Few & Far Between podcast. Join host Chris O'B...

Mark as Played

"Technologies have changed enormously in terms of how we can basically procure, preserve, and then interrogate a tumor specimen...like effectively in real time, like a living cancer specimen." - Dr. Keith Flaherty, Director of Clinical...

Mark as Played

"Artificial Intelligence is a tool that really levels up and creates almost like an equity for everybody to participate and, when used effectively, to really accelerate medicine's development." - Dr. Ole Isacson, Professor of Neurology and Neuroscience, Harvard Medical School.

Welcome to the February episode of Biorasi's Few & Far Between podcast. Join host Chris O'Brien and Dr. Ole ...

Mark as Played

Popular Podcasts

    If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.

    Dateline NBC

    Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Special Summer Offer: Exclusively on Apple Podcasts, try our Dateline Premium subscription completely free for one month! With Dateline Premium, you get every episode ad-free plus exclusive bonus content.

    On Purpose with Jay Shetty

    I’m Jay Shetty host of On Purpose the worlds #1 Mental Health podcast and I’m so grateful you found us. I started this podcast 5 years ago to invite you into conversations and workshops that are designed to help make you happier, healthier and more healed. I believe that when you (yes you) feel seen, heard and understood you’re able to deal with relationship struggles, work challenges and life’s ups and downs with more ease and grace. I interview experts, celebrities, thought leaders and athletes so that we can grow our mindset, build better habits and uncover a side of them we’ve never seen before. New episodes every Monday and Friday. Your support means the world to me and I don’t take it for granted — click the follow button and leave a review to help us spread the love with On Purpose. I can’t wait for you to listen to your first or 500th episode!

    24/7 News: The Latest

    The latest news in 4 minutes updated every hour, every day.

    The Bobby Bones Show

    Listen to 'The Bobby Bones Show' by downloading the daily full replay.

Advertise With Us
Music, radio and podcasts, all free. Listen online or download the iHeart App.

Connect

© 2025 iHeartMedia, Inc.