August 1, 2025 • 16 mins
George Noory and author Douglas Mulhall explore his research into total stress load and how it is hurting millions of people, if some stress is actually good for you, and the surprising health benefits of cholesterol.
See omnystudio.com/listener for privacy information.
Mark as Played
Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:00):
Now here's a highlight from Coast to Coast AM on iHeartRadio.
Speaker 2 (00:05):
And welcome back George nor you along with Douglas smallhall
as who are talking about your health as Lady's book
is called Discovering the Nature of Longevity. Doug tell us
a little bit about that book again. I know you're
on with me a couple of years ago when we
had you on talking about that but refreshing.
Speaker 3 (00:21):
Yeah, well, George, and you know it's been the number
one Amazon bestseller several times since then. But basically, you know,
the subtitle speaks about the book and this relationship to
total stress load. It's restoring the heart and body by
targeting hidden stress. And there are many things that are
(00:43):
actually covered in the book that are pretty unique because
it looks at some of the hidden stresses that often
don't show off in tests, like I spoke about just
before the break, and it looks at some of the
systems in the body that most people almost are never
told about. And I'll almost no doctors are treating right now.
Just one of the most important examples is the fiber
(01:04):
that drives every move you make and every breath you take.
That's the elastic fiber that's in your skin, your arteries,
all of your connective tissue, all of your organs. And
you know, for anyone who wants to know what this
stuff is all about you, you can do the pinch test.
And what you can do is you can take the
skin on the back of your hand, pinch it between
(01:26):
your thumb and your forefinger, hold it up for about
two or three seconds, and let it go. Now, if
you're younger, it'll snap right back, but if you're older,
it goes down more slowly, and if you're really old,
it doesn't go down at all. So that's the elastic
fiber in your body, and that's actually what drives every
single movement, what lets your body breathe and pump blood
(01:49):
is incredibly important and most people have never heard of it. Now,
there's a nasty side story to elastin George. After the
age of thirty, it starts to do grade because the
body stops assembling it and at that point, guess what,
it gets damaged by all kinds of total stress load,
(02:10):
including bad food, toxins, emotional overstressed, physical injury, and even
the friction of red blood cells bumping against the walls
of your argeries. As your body pumps blood. So the
problem there is that that provokes the constant inflammation, this
(02:30):
chronic inflammation that actually some of the ads we're talking
about during your break, and this constant inflammation is really
bad for you and triggers a lot of these diseases.
So the good news is that there are some new
therapies out there, some of them are in clinical trial,
(02:52):
one of them is on the market today already that
are actually restoring this elastin fiber. And they didn't just
come out of the blue, George. They came out of
twenty five years of hard research that led to several
discoveries in how to restore elastin fiber. And I'm the
(03:13):
co founder of a company called Elastrin Therapeutics, which is
actually focusing on restoring the elastic fiber and arteries and
reversing this calcification that I spoke about earlier where we're
all attorney to stone because degraded elastic and calcification are
(03:35):
closely linked. So that's the other focus of the book
is on these new technologies and therapies that are actually
repairing the damage done by this total stress load. So
the other thing is that the book also describes a
few well established nutraceutical therapies that are restoring vascular health,
and foremost among those is something called NANOBACTX. It's been
(03:58):
around for twenty five years and it seems to have
a pretty good track record. You can see more about
NANOBACTX on the book's website, and I've also written a
companion publication about this, called The Story of Nanobactx, which
is on Amazon. So the problem faced by all of
those solutions, George, is that it's ridiculously expensive to get
(04:21):
approved as a therapy because you have to do clinical
trials costing tens of millions or hundreds of millions of dollars.
So a lot of good solutions out there simply don't
have the financial firepower to go through that process and
aren't recognized in conventional billing reimbursement systems. Now that's beginning
(04:41):
to change, but it's slow. So all of those factors
are covered in quite some detail in the book.
Speaker 2 (04:48):
Is a little bit of stress good for you, Douglass
at all?
Speaker 1 (04:51):
Bad?
Speaker 3 (04:52):
Oh, George, You hit the nail on the head. Absolutely,
some stress is essential for good health. But he needs
some physical stress to keep in shape. Your brain needs
to be pushed to keep you alert and constantly learning.
In emergencies, a short burst of stress gets your adrenaline flowing,
(05:15):
keeps you really sharp, and can get you out of trouble.
Your emotions can also be from a bit of stress,
so you can learn how to deal with difficult situations.
So actually there's a lot of short term stresses that
are basically keeping us alive. Now, telling when it becomes
bad for you can be tricky business, because anyone who's
(05:37):
been overstressed for a long period knows that sometimes you
just don't notice until it's too late you get sick.
But there are all the normal warning signs like constant fatigue, irritability,
feeling run down, not sleeping well, and these can be
a result and a cause. But in a nutshell, George, yes,
(05:57):
stress is essential for our lives, but that's short term stress.
That's a different beast.
Speaker 1 (06:03):
That is amazing.
Speaker 2 (06:04):
What does some doctors say about this, Douglas, Well, that's
very interesting.
Speaker 3 (06:10):
You should mention that, George, because the healthcare system is
starting to change its attitude towards this, because it's being
overwhelmed by chronic conditions that are not responding well to
conventional approaches. Now, the good news is that there's a
new generation of doctors coming up who are much more
(06:31):
aware of these integrated factors. And there's a well established
cadre of thousands of holistic and integrative physicians out there
who are well aware of total stressload. The other thing, George,
is that total stressload is far more measurable than it
used to be. And that's because there's a wider range
(06:53):
of instruments and biomarkers. And I just want to give
you a few examples so people that there can see
what I'm talking about. Okay, So for example, there's some
technical names here, but there's something called Life Events and
Difficulties Scheduling or LEADS, and this is a structured interview
that assesses the major stressors across your lifetime. It's scored
(07:15):
on severity and the duration of stress. The Stress and
Adversity Inventory, the acronym HAHA is strained. It's a computer
assistant questionnaire that adds up lifetime and recent stressors acute
and chronic, and that produces a cumulative stress score. There's
the Homes and Ray Stress Scale, and this is a
(07:36):
checklist that assigns life change units to major life events,
and then scores reflect the total stress load and are
correlated with the risk of illness. There's a whole bunch
of others perceive stress stress scale physiological biomarkers of alostatic
load George. Now, allostatic load is the medical term for
(07:59):
total stress load, and it was actually developed in the
early nineteen nineties by scientists who actually did the science
and were able to quantify that. So some of the
composite scores that you see around this include a combination
of blood pressure, waste of hip ratio, fasting, glucose serum, cortisol,
(08:23):
and a whole bunch of other things. So you can
see that there are a lot of these methodologies out
there that conventional medicine is really starting to pay attention
to now because they're getting desperate. The whole system is
being overstressed by people who had stressed well.
Speaker 2 (08:44):
With Douglas small Hall, author of the Discovering the Nature
of Longevity, we'll take calls with Douglas next hour here
on Coast to Coast. Truly remarkable. How did you uncover this?
Speaker 3 (09:01):
I didn't uncover it, George. What I did was, I
have to say I made a discovery of the work
of a scientist. His name is doctor Neuren Vivahari, and
he is the guy who actually discovered that the impacts
(09:24):
of this total stress load on the elastic in our
body is what was triggering cardiovascular conditions. And the way
he did it, George, was absolutely fascinating. He was trying
to understand why in heart valves, one side of the
heart valve turns to stone it calcifies, and the other
(09:48):
side of the heart valve wasn't calcifying. And when he
did the microscopic examination, he found that the side that
was calcifying had much higher levels of elastin fiber to
keep it flexible, and that elastin fiber, as I described earlier,
(10:09):
was degrading. Now as it degraded, George, what was happening
was it was sending out, hey, help me, help me
fix me signal, and the cells in the body were
responding to that with guess what inflammation to clean up
the mess so that you know, the elastin could be repaired.
The only problem is that the body wasn't repairing it
(10:30):
anymore because it wasn't manufacturing or assembling this elastic fiber.
So this, this is what this is a major cause
of aging, it turns out, and this is what's been
cutting into our longevity. So when doctor Vavahari expanded this
and he looked into the wall of the arteries, he
discovered that the wall of the artery has this degraded
(10:55):
elastin in it. And guess what that is exactly where
the calcification begins, dis hardening of the arteries. A lot
of people are told, oh, yes, you know, it's cholesterol
that causes arterial stiffening. Well it does, but most of
the time that comes along a lot later after this
(11:16):
damage to lastin has caused this chronic inflammation in the
wall of the artery or in the lining of the
artery that actually is where the blood flows through the arteries.
So then George he started looking, he started looking for
things that could could prevent this, and he came up
(11:39):
with two things. One was a well known chemical. It's
approved by the FDA. It's called DTA and it's known
to grab heavy metals out of tissue and you know,
take it out of your body. There's a process called
keelation that's been used, you know, for years and years
and years to get rid of these these these heavy
metals and when he used this is in very high amounts,
(12:03):
he found that it could actually decalcify this damaged elastin.
The problem, George, is that those high levels were toxic themselves.
So what he had to do was he had to
package the decalcifying stuff into nanoparticles that were targeted specifically
to this damaged elastin. And for that, he and doctor
(12:25):
Charles Rice together had to invent an antibody that was
specific for damaged elastin. And when they did that bingo,
they were able to deliver high concentrations of this decalcifying
material straight to the elastin without toxifying the rest of
the body. And now that therapy is going into clinical
(12:49):
trial testing, and actually there's one company that has used
another substance that actually restores the elastin that is in
phase three testing right now for preventing aneurysms from bursting,
because aneurysms are caused by the weakened the lastin in
your body. Yeah, it's really exciting stuff, George, And anyone
(13:13):
who has an aneurism, and there's ten million Americans out
there who have it, should go to the site of
Nectaro Medical. You can find it on my website because
they are still recruiting for their clinical trials on preventing
aneurysms from bursting, George, So that's becoming available in clinical
(13:34):
trials right now, Douglas.
Speaker 2 (13:37):
Can you have too much elastin in your system?
Speaker 3 (13:41):
Well, that's a good question, George, because actually too much
alastin is not the problem. Too much incompletely formed and
damaged elastin particles are what's causing the problem because guess what,
the body recognizes those as foreign objects and so it
triggers the immune system to have this chronic inflammatory response.
(14:05):
So these are known as elastin degradation particles or eedps,
and you will find there's a test for levels of
edps in the blood, and as we age, guess what,
the EDT levels start to accelerate, and in people with
(14:27):
severe heart disease, for example, they are highly elevated. So
the answer to your question is the stuff that's incompletely
formed because the body is no longer assembling it, and
the stuff that is the result of degradation is definitely
causing problems throughout the whole body. That is what you
can have too much of. But the good news is
that these new therapies are starting to solve that problem.
Speaker 2 (14:51):
Excellent. Now you mentioned cholesterol earlier. I'm told that too
low of cholesterol is worse than too high.
Speaker 3 (15:00):
Well, it's like everything else, ay, I mean you do
need to have a balance. I mean cholesterol is Yes,
it's essential for some of your cells to function, so
you know, it's not a nasty, that awful thing. But
here's the question, why do you get this cholesterol build
up in your arteries? That starts to make sense, George,
(15:25):
when you get into this injury inflammation cascade that is
a result of this damage to elasti Because here's what happens.
What happens is that when the cells detect this injury
to the elastic fiber, they respond with an inflammatory response.
(15:46):
That inflammatory response involves delivering certain proteins, so inflammatory proteins,
to the site of the damage to clean it up.
Those inflammatory proteins aren't just thrown out of the cell
willy nilly. They're packaged in little things called ECerS XXXI zomes,
(16:06):
which are little nanoparticles that are programmed with inflammatory and
guess what, calcifying nanoparticles and proteins that actually try to
wall off the problem.
Speaker 1 (16:21):
Listen, to more. Coast to Coast AM every weeknight at
one am Eastern and go to Coast to coastam dot
com for more
Now here's a highlight from Coast to Coast AM on iHeartRadio.
Speaker 2 (00:05):
And welcome back George nor you along with Douglas smallhall
as who are talking about your health as Lady's book
is called Discovering the Nature of Longevity. Doug tell us
a little bit about that book again. I know you're
on with me a couple of years ago when we
had you on talking about that but refreshing.
Speaker 3 (00:21):
Yeah, well, George, and you know it's been the number
one Amazon bestseller several times since then. But basically, you know,
the subtitle speaks about the book and this relationship to
total stress load. It's restoring the heart and body by
targeting hidden stress. And there are many things that are
(00:43):
actually covered in the book that are pretty unique because
it looks at some of the hidden stresses that often
don't show off in tests, like I spoke about just
before the break, and it looks at some of the
systems in the body that most people almost are never
told about. And I'll almost no doctors are treating right now.
Just one of the most important examples is the fiber
(01:04):
that drives every move you make and every breath you take.
That's the elastic fiber that's in your skin, your arteries,
all of your connective tissue, all of your organs. And
you know, for anyone who wants to know what this
stuff is all about you, you can do the pinch test.
And what you can do is you can take the
skin on the back of your hand, pinch it between
(01:26):
your thumb and your forefinger, hold it up for about
two or three seconds, and let it go. Now, if
you're younger, it'll snap right back, but if you're older,
it goes down more slowly, and if you're really old,
it doesn't go down at all. So that's the elastic
fiber in your body, and that's actually what drives every
single movement, what lets your body breathe and pump blood
(01:49):
is incredibly important and most people have never heard of it. Now,
there's a nasty side story to elastin George. After the
age of thirty, it starts to do grade because the
body stops assembling it and at that point, guess what,
it gets damaged by all kinds of total stress load,
(02:10):
including bad food, toxins, emotional overstressed, physical injury, and even
the friction of red blood cells bumping against the walls
of your argeries. As your body pumps blood. So the
problem there is that that provokes the constant inflammation, this
(02:30):
chronic inflammation that actually some of the ads we're talking
about during your break, and this constant inflammation is really
bad for you and triggers a lot of these diseases.
So the good news is that there are some new
therapies out there, some of them are in clinical trial,
(02:52):
one of them is on the market today already that
are actually restoring this elastin fiber. And they didn't just
come out of the blue, George. They came out of
twenty five years of hard research that led to several
discoveries in how to restore elastin fiber. And I'm the
(03:13):
co founder of a company called Elastrin Therapeutics, which is
actually focusing on restoring the elastic fiber and arteries and
reversing this calcification that I spoke about earlier where we're
all attorney to stone because degraded elastic and calcification are
(03:35):
closely linked. So that's the other focus of the book
is on these new technologies and therapies that are actually
repairing the damage done by this total stress load. So
the other thing is that the book also describes a
few well established nutraceutical therapies that are restoring vascular health,
and foremost among those is something called NANOBACTX. It's been
(03:58):
around for twenty five years and it seems to have
a pretty good track record. You can see more about
NANOBACTX on the book's website, and I've also written a
companion publication about this, called The Story of Nanobactx, which
is on Amazon. So the problem faced by all of
those solutions, George, is that it's ridiculously expensive to get
(04:21):
approved as a therapy because you have to do clinical
trials costing tens of millions or hundreds of millions of dollars.
So a lot of good solutions out there simply don't
have the financial firepower to go through that process and
aren't recognized in conventional billing reimbursement systems. Now that's beginning
(04:41):
to change, but it's slow. So all of those factors
are covered in quite some detail in the book.
Speaker 2 (04:48):
Is a little bit of stress good for you, Douglass
at all?
Speaker 1 (04:51):
Bad?
Speaker 3 (04:52):
Oh, George, You hit the nail on the head. Absolutely,
some stress is essential for good health. But he needs
some physical stress to keep in shape. Your brain needs
to be pushed to keep you alert and constantly learning.
In emergencies, a short burst of stress gets your adrenaline flowing,
(05:15):
keeps you really sharp, and can get you out of trouble.
Your emotions can also be from a bit of stress,
so you can learn how to deal with difficult situations.
So actually there's a lot of short term stresses that
are basically keeping us alive. Now, telling when it becomes
bad for you can be tricky business, because anyone who's
(05:37):
been overstressed for a long period knows that sometimes you
just don't notice until it's too late you get sick.
But there are all the normal warning signs like constant fatigue, irritability,
feeling run down, not sleeping well, and these can be
a result and a cause. But in a nutshell, George, yes,
(05:57):
stress is essential for our lives, but that's short term stress.
That's a different beast.
Speaker 1 (06:03):
That is amazing.
Speaker 2 (06:04):
What does some doctors say about this, Douglas, Well, that's
very interesting.
Speaker 3 (06:10):
You should mention that, George, because the healthcare system is
starting to change its attitude towards this, because it's being
overwhelmed by chronic conditions that are not responding well to
conventional approaches. Now, the good news is that there's a
new generation of doctors coming up who are much more
(06:31):
aware of these integrated factors. And there's a well established
cadre of thousands of holistic and integrative physicians out there
who are well aware of total stressload. The other thing, George,
is that total stressload is far more measurable than it
used to be. And that's because there's a wider range
(06:53):
of instruments and biomarkers. And I just want to give
you a few examples so people that there can see
what I'm talking about. Okay, So for example, there's some
technical names here, but there's something called Life Events and
Difficulties Scheduling or LEADS, and this is a structured interview
that assesses the major stressors across your lifetime. It's scored
(07:15):
on severity and the duration of stress. The Stress and
Adversity Inventory, the acronym HAHA is strained. It's a computer
assistant questionnaire that adds up lifetime and recent stressors acute
and chronic, and that produces a cumulative stress score. There's
the Homes and Ray Stress Scale, and this is a
(07:36):
checklist that assigns life change units to major life events,
and then scores reflect the total stress load and are
correlated with the risk of illness. There's a whole bunch
of others perceive stress stress scale physiological biomarkers of alostatic
load George. Now, allostatic load is the medical term for
(07:59):
total stress load, and it was actually developed in the
early nineteen nineties by scientists who actually did the science
and were able to quantify that. So some of the
composite scores that you see around this include a combination
of blood pressure, waste of hip ratio, fasting, glucose serum, cortisol,
(08:23):
and a whole bunch of other things. So you can
see that there are a lot of these methodologies out
there that conventional medicine is really starting to pay attention
to now because they're getting desperate. The whole system is
being overstressed by people who had stressed well.
Speaker 2 (08:44):
With Douglas small Hall, author of the Discovering the Nature
of Longevity, we'll take calls with Douglas next hour here
on Coast to Coast. Truly remarkable. How did you uncover this?
Speaker 3 (09:01):
I didn't uncover it, George. What I did was, I
have to say I made a discovery of the work
of a scientist. His name is doctor Neuren Vivahari, and
he is the guy who actually discovered that the impacts
(09:24):
of this total stress load on the elastic in our
body is what was triggering cardiovascular conditions. And the way
he did it, George, was absolutely fascinating. He was trying
to understand why in heart valves, one side of the
heart valve turns to stone it calcifies, and the other
(09:48):
side of the heart valve wasn't calcifying. And when he
did the microscopic examination, he found that the side that
was calcifying had much higher levels of elastin fiber to
keep it flexible, and that elastin fiber, as I described earlier,
(10:09):
was degrading. Now as it degraded, George, what was happening
was it was sending out, hey, help me, help me
fix me signal, and the cells in the body were
responding to that with guess what inflammation to clean up
the mess so that you know, the elastin could be repaired.
The only problem is that the body wasn't repairing it
(10:30):
anymore because it wasn't manufacturing or assembling this elastic fiber.
So this, this is what this is a major cause
of aging, it turns out, and this is what's been
cutting into our longevity. So when doctor Vavahari expanded this
and he looked into the wall of the arteries, he
discovered that the wall of the artery has this degraded
(10:55):
elastin in it. And guess what that is exactly where
the calcification begins, dis hardening of the arteries. A lot
of people are told, oh, yes, you know, it's cholesterol
that causes arterial stiffening. Well it does, but most of
the time that comes along a lot later after this
(11:16):
damage to lastin has caused this chronic inflammation in the
wall of the artery or in the lining of the
artery that actually is where the blood flows through the arteries.
So then George he started looking, he started looking for
things that could could prevent this, and he came up
(11:39):
with two things. One was a well known chemical. It's
approved by the FDA. It's called DTA and it's known
to grab heavy metals out of tissue and you know,
take it out of your body. There's a process called
keelation that's been used, you know, for years and years
and years to get rid of these these these heavy
metals and when he used this is in very high amounts,
(12:03):
he found that it could actually decalcify this damaged elastin.
The problem, George, is that those high levels were toxic themselves.
So what he had to do was he had to
package the decalcifying stuff into nanoparticles that were targeted specifically
to this damaged elastin. And for that, he and doctor
(12:25):
Charles Rice together had to invent an antibody that was
specific for damaged elastin. And when they did that bingo,
they were able to deliver high concentrations of this decalcifying
material straight to the elastin without toxifying the rest of
the body. And now that therapy is going into clinical
(12:49):
trial testing, and actually there's one company that has used
another substance that actually restores the elastin that is in
phase three testing right now for preventing aneurysms from bursting,
because aneurysms are caused by the weakened the lastin in
your body. Yeah, it's really exciting stuff, George, And anyone
(13:13):
who has an aneurism, and there's ten million Americans out
there who have it, should go to the site of
Nectaro Medical. You can find it on my website because
they are still recruiting for their clinical trials on preventing
aneurysms from bursting, George, So that's becoming available in clinical
(13:34):
trials right now, Douglas.
Speaker 2 (13:37):
Can you have too much elastin in your system?
Speaker 3 (13:41):
Well, that's a good question, George, because actually too much
alastin is not the problem. Too much incompletely formed and
damaged elastin particles are what's causing the problem because guess what,
the body recognizes those as foreign objects and so it
triggers the immune system to have this chronic inflammatory response.
(14:05):
So these are known as elastin degradation particles or eedps,
and you will find there's a test for levels of
edps in the blood, and as we age, guess what,
the EDT levels start to accelerate, and in people with
(14:27):
severe heart disease, for example, they are highly elevated. So
the answer to your question is the stuff that's incompletely
formed because the body is no longer assembling it, and
the stuff that is the result of degradation is definitely
causing problems throughout the whole body. That is what you
can have too much of. But the good news is
that these new therapies are starting to solve that problem.
Speaker 2 (14:51):
Excellent. Now you mentioned cholesterol earlier. I'm told that too
low of cholesterol is worse than too high.
Speaker 3 (15:00):
Well, it's like everything else, ay, I mean you do
need to have a balance. I mean cholesterol is Yes,
it's essential for some of your cells to function, so
you know, it's not a nasty, that awful thing. But
here's the question, why do you get this cholesterol build
up in your arteries? That starts to make sense, George,
(15:25):
when you get into this injury inflammation cascade that is
a result of this damage to elasti Because here's what happens.
What happens is that when the cells detect this injury
to the elastic fiber, they respond with an inflammatory response.
(15:46):
That inflammatory response involves delivering certain proteins, so inflammatory proteins,
to the site of the damage to clean it up.
Those inflammatory proteins aren't just thrown out of the cell
willy nilly. They're packaged in little things called ECerS XXXI zomes,
(16:06):
which are little nanoparticles that are programmed with inflammatory and
guess what, calcifying nanoparticles and proteins that actually try to
wall off the problem.
Speaker 1 (16:21):
Listen, to more. Coast to Coast AM every weeknight at
one am Eastern and go to Coast to coastam dot
com for more
The Best of Coast to Coast AM News
Host
George Noory
Popular Podcasts
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.
The Joe Rogan Experience
The official podcast of comedian Joe Rogan.
Dateline NBC
Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Special Summer Offer: Exclusively on Apple Podcasts, try our Dateline Premium subscription completely free for one month! With Dateline Premium, you get every episode ad-free plus exclusive bonus content.