The Flux by Epistemix

The Flux by Epistemix

Welcome to The Flux - where we talk data, decisions, and stories of people asking the what-if questions to create an intentional impact on the future.

Episodes

July 8, 2025 27 mins

Les Craig joins us to discuss how simulation and synthetic data are changing the way organizations prepare for infectious disease outbreaks. From helping public health leaders visualize complex scenarios to enabling pharmaceutical companies to explore new R&D pathways, Les explains how advanced modeling technology empowers faster, smarter decisions. This episode unpacks how simulation can move ideas from theory to action and wh...

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In this episode of The Flux, host John Cordier sits down with innovation pioneer Mickey McManus to explore what it means to design for uncertainty in a world where complexity is the norm. Mickey draws on decades of experience from leading Maya Design and shaping decision-support tools for DARPA, to helping build the Future of Learning team at Autodesk to share insights on how human-centered design, systems thinking, and simulation ...

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In this episode of The Flux, we explore how modeling trust, belief, and social sentiment can unlock deeper insights in public health. Our guest, Philippe Giabbanelli, shares how agent-based models are evolving to capture not just behaviors, but the opinions and social dynamics that drive them like vaccine hesitancy or trust in institutions. We discuss the challenges of representing complex human psychology in simulations, the impor...

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In a world full of linear thinking, Dan Eichelsdoerfer is building a company grounded in complexity. In this episode, Dan joins The Flux to discuss why agent-based models are finally ready for prime time and how Macrocosm is creating tools to simulate economic and energy systems with more nuance, flexibility, and realism than ever before.

Dan talks about the interdisciplinary “glory days” of modeling inside Macrocosm, wher...

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On this episode of The Flux, agent-based models (ABMs) have long lived on the fringes of mainstream economics but that’s changing. Doyne Farmer breaks down how advances in computing and data are fueling a new era of bottom-up modeling. He explains where ABMs outperform traditional models, why certain fields (like epidemiology and traffic systems) adopted them earlier, and how economics is finally catching up. We explore the structu...

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In this episode of The Flux, we talk with Laura Sheppard, a research fellow at University College London’s Centre for Longitudinal Studies, about how data mining can uncover powerful insights from unexpected sources. Laura shares her work using the British Library’s Ethos dataset, a comprehensive record of UK doctoral theses - to explore gender inequality in higher education. We discuss the process of inferring gender from names, t...

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In this episode of The Flux, host John Cordier sits down with Andrew Crooks at the Complex Social Systems Society Conference in Santa Fe. They dive into the world of agent-based modeling (ABM) - what it is, why it matters, and how it helps us simulate and better understand human behavior in complex systems. From simulating traffic jams to modeling social influence on vaccine uptake, Andrew shares how data, geography, and synthetic ...

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What if we could predict the impact of a pandemic, a policy change, or even a war before it happens? Hamdi Kavak joins The Flux to discuss how agent-based modeling enables researchers to explore "what if" scenarios and simulate real-world behaviors at both small and massive scales. We dive into the applications of ABM in government-funded projects, the difficulties of modeling millions of agents, and how better communicat...

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In this episode of The Flux, host John Cordier, CEO of Epistemix, sits down with Paul Amoruso to explore his unexpected journey into the world of agent-based modeling (ABM). What started as a course recommendation turned into a passion for understanding complex systems and using data to drive better decisions.

Paul shares insights from his academic path, the value of interdisciplinary collaboration, and why ABMs foster explainabilit...

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In this episode of The Flux, host John Cordier interviews Jim Malone at the Complex Social Systems Conference in Santa Fe. Jim, an experienced government acquisition professional, shares his fascinating journey from contracting to pursuing a PhD in Computational Social Science. He discusses the importance of understanding complexity in systems, particularly in government contracting and policy-making. Jim explores how modeling and ...

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Welcome to The Flux! In this episode, host John Cordier, CEO at Epistemix, explores the intricacies of agent-based modeling and its impact on decision-making with Aaron Frank. Recorded live at the Complex Social System Society of America's conference in Santa Fe, New Mexico, Aaron shares his journey from traditional national security research to computational models and agent-based simulations. The discussion covers the evolut...

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In this episode of The Flux, hosted by John Cordier, CEO at Epistemix, we delve into the fascinating world of agent-based modeling (ABM) with Tom Pike, co-lead for MESA. Recorded live at the Complex Systems Society conference in Santa Fe, New Mexico, Tom shares insights on democratizing ABM through Python, its significance in decision-making, and innovative applications such as COVID-19 policy modeling in Costa Rica. The discussion...

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This episode explores the economic development potential of technology developed in New Mexico, focusing on industry-based research and the collaboration between companies, universities, and government labs. It delves into the evolution of technology, highlighting key insights from Dr. Brown of the Santa Fe Institute, whose work integrates the concepts of evolutionary technology and complexity economics, particularly through agent-...

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In this episode of The Flux, hosted by John Cordier, CEO of Epistemix, we hear from Timothy Clancy, a researcher from the University of Maryland's START program. Recorded at the Complex Social Systems Society of the Americas Conference in Santa Fe, New Mexico, Clancy shares insights from his career, which spans government work and applied studies on national security. They discuss the evolution of modeling in policy-making, th...

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In this episode of The Flux, host John Cordier, CEO at Epistemix, interviews Sherwin Brown from MITRE. Sherwin shares his journey into agent-based modeling, starting from his background in health management and policy. He discusses the role of data science and analytics in solving complex problems, such as monitoring the impact of the Affordable Care Act and tackling issues like homelessness and opioid overdoses. Sherwin emphasizes...

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In this episode of 'The Flux,' we dive deep into data-driven decision making with Bill Rand from NC State University. Join us as Bill discusses his work in agent-based modeling, social media misinformation, and various innovative projects. Discover how agent-based modeling can provide insights into human behavior, business analytics, and even intergenerational trauma. Learn how different modeling approaches can help forec...

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In this episode of The Flux, join Dave Freed, Senior Director at Ansys, as he delves into the transformative world of computer simulations. With a rich history from Exa Corporation to OnScale and Ansys, Dave explores the evolution and future of simulations, highlighting their pivotal role in automotive, aerospace, and nuclear engineering. Discover how simulations have advanced to replace costly physical testing, improve accuracy, a...

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In this episode of The Flux, host John Cordier interviews Matt Madden, Director of the BYU Marketing Lab, about his work in making complex statistics and marketing analytics accessible. Madden discusses the lab's unique approach, which allows students to apply their skills in real-world consulting projects. They delve into key topics like market research techniques such as conjoint analysis, which helps students and clients un...

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In this episode of The Flux, host John Cordier sits down with Don Burke, co-founder of Epistemix and a trailblazing epidemiologist, to explore the fascinating intersection of infectious disease research, artificial intelligence, and agent-based modeling (ABM). Burke shares his journey from a traditional career in infectious disease research to becoming a passionate advocate for modeling and simulation, offering a behind-the-scenes ...

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In this episode of The Flux, John Cordier interviews Rob Axtell from
George Mason University, where he leads the largest graduate program
in agent-based modeling (ABM) globally. Axtell shares his journey into
complex systems modeling and how the field has evolved since the
1990s. He explains how George Mason’s Ph.D. program in
Computational Social Science is shaping the next generation of experts
who go on t...

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