The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understand how stress, travel, toxins, and metabolic overload reprogram cells, shut down energy, and accelerate aging, and how restoring mitochondrial function can reverse that trajectory from the inside out.
Watc...
One freezing sip on a Tibetan mountain rewired his hunger, silenced cravings, and unlocked a kind of fat-burning “switch” no doctor ever mentioned. What happened next—Silicon Valley obsession, a global butter shortage, and a new theory of weight loss—might change how you see food forever.
The only coffee I drink: Danger Coffee: https://dangercoffee.com/DAVE15
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This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this episode, you’ll learn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way.
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Most people are struggling in modern relationships, and it is not because they are broken. It is because the systems around them are. In this episode, you’ll learn why roughly 65 percent of people operate from insecure attachment, why that quietly destroys energy, trust, and intimacy, and how secure attachment becomes a critical biohacking upgrade for human performance, longevity, and emotional resilien...
Mood, motivation, and emotional resilience are not personality traits. They are biological systems. In this episode, you’ll get the 12 greatest mood boosters on Earth, not as a clickbait supplement list, but as the real biological levers that control dopamine sensitivity, hormones, neuroplasticity, and energy production.
Watch this episode on YouTube for the full video experience:
Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?
In this video, Dave Asprey breaks down what really happens when you fast for 3 days—and why short fasts don’t reach the deep repair zone your body is built for.
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Back in 2024 with Calley Means at South by Southwest, we sat down and talked about his mission to flip the old American food pyramid upside down for the greater good. Well guess what, the pressure is finally working! This rerun is the ultimate receipt that focus, repetition, and smart lobbying for human health can still move the needle!
Host Dave Asprey sits down with Calley Mean...
Creatine is a hot subject right now, but I’m guessing you might not know as much about it as you could. Well step into a new creatine masterclass with our friends from Qualia. This episode shows you why it is not just for muscle, but one of the most powerful and well studied upgrades for brain energy, metabolism, sleep resilience, and long term human performance. You will l...
You’re about to hear one of the most honest longevity conversations ever recorded. This co hosted episode brings together two longevity leaders with opposing views on how long humans can live, yet enormous respect for each other and the science. Recorded live at Eudemonia, this discussion gives you clear frameworks for longevity, biohacking, human performance, and anti aging without all the tr...
Most men think ED is just a performance issue. It’s not. It’s one of the earliest warning signs of cardiovascular decline and it often appears years before chest pain, shortness of breath, or heart attack symptoms.
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This episode covers:
• Colon Cancer in the Young and Why Risk May Start in Infancy
New reporting highlights a troubling rise in early-onset colon cancer, including cases in highly fit endurance athletes. Researchers identified a distinct DNA damage signature linked to colibactin, a toxin produced by certain strains of E. coli, with evidence suggesting the damage may occur in infancy. Dave expla...
You’re about to learn how government approved food policies, regulatory loopholes, and corporate lobbying have quietly reshaped what’s allowed in the food supply and why these decisions are driving chronic inflammation, immune dysfunction, and neurological breakdown at scale. This episode exposes how biotoxins, ultra processed ingredients, and systemic regulatory failures contribute to long COVID, POTS, mold...
This solo masterclass on oxalates explains why many people who eat clean still struggle with joint pain, kidney stones, fatigue, brain fog, and chronic inflammation. You’ll learn how oxalates behave very differently from other plant compounds like lectins, phytates, and salicylates. Unlike those compounds, oxalates physically bind minerals and form microscopic crystals that can lodge in tissues, damage mitochondr...
This video reveals the hidden mistake most people make when fasting that causes muscle loss instead of fat loss. You’ll learn how to flip the body’s fat-burning switch so your fast protects muscle, boosts energy, and actually melts fat. It’s positioned around one of the many solutions Dave did to lose 100 pounds.
*** Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide...
This episode covers:
• Trump Drug Pricing Deals and Access to Longevity Medications
New drug-pricing agreements announced under President Donald Trump aim to lower the cost of high-priced prescription drugs through negotiated rebates and pricing pressure on major pharmaceutical companies. Early reporting suggests these changes could affect cardiometabolic and longevity-relevant medications, including GLP-1 di...
The holidays are when drinking quietly ramps up for a lot of people. More parties, more stress, more excuses, and habits that feel temporary but often aren’t. This episode is for anyone reflecting on their relationship with alcohol, substances, or compulsive habits and questioning whether those patterns are actually supporting the life and health they want going forward.
This episode features host Dave A...
Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You’ll hear a systems level analysis of how insulin signaling, mTOR, mitochondrial function, inflammation, and nutrient sensing interact to determine biological age, disease risk, and long term human performance. This is not surface level biohacking. It is a deep dive into the mechanisms ...
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In this video, Dave Asprey exposes the hidden reason why people lose muscle tone and mental sharpness as early as their 30s… and reveals the si...
This episode covers:
• FDA Loosening Supplement Warning Labels
The FDA is considering a rule change that would allow supplement companies to include the DSHEA disclaimer only once per package rather than next to every claim. Dave explains why fewer visible warnings could make marketing look more like medical claims, and why biohackers should treat labels as advertising rather than evidence. He share...
This episode explores how intimacy, desire, and erotic states function as powerful tools for healing, nervous system regulation, and personal transformation. You’ll learn why certain forms of conscious erotic play create genuine altered states of consciousness, not through substances or external compounds, but through the body’s own internal chemistry. This conversation reframes sexuality as a core aspe...
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