The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like.
Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Jim...
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Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades.
Ho...
This week's stories:
*Bartonella Hides in Cat Scratches — and It Might Be Why You Feel Like Garbage
A stealth bacterial infection transmitted by everyday cat scratches and flea dirt has been quietly linked to chronic fatigue, brain fog, and neurological symptoms for decades. Dave breaks down how Bartonella slips past standard testing, why it's almost never on a conventional doctor's r...
Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage.
Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme disease, addiction, and metabolic ...
I spent over $2 million hacking my own biology to reverse my age, but one of the most powerful discoveries didn’t come from a pharmaceutical lab. It came from NASA.
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Try Energy Bits: https://energybits.com/discount/dave
Astronauts face the harshest environment known to science: space radiation. To keep them alive, NASA had to identify a nutrient ...
Your home could be quietly stealing your IQ, disrupting your hormones, destroying your mitochondria, and triggering chronic disease, and most people never connect the dots. This episode gives you the full picture on toxic mold, and exactly what to do about it
Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave
Host Dave Asprey sits down w...
Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, what actually triggers it, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen.
Host Dave Asprey sits down with Tracy Slepcevic, bestselling author of Warrior Mom: A Mother's Jo...
Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tell you and gives you the tools to stop poisoning yourself every morning.
-Watch this episode on YouTube for the full video experience: https://www.yo...
Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE
I have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one. Most people fail to get deep rest because they are stuck in Beta brainwaves—a state of hypervigilance fueled by stress and blue light. You can take all the melatonin in the world, but if y...
Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation, and mesenchymal stem cells to tar...
What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with optimization is quietly destroying...
Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is.
- Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
- Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticl...
Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE
I transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".
The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial energy needed for this clea...
This week's stories:
*SNL Roasts the MAHA Movement
Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what&...
Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead.
-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with McCall McPherson, a physician associate, ...
What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has ever encountered.
-Watch this episode on YouTube for the full video experien...
Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.
Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and chronic inflammation. Standard 1...
This week’s stories:
Smartphone App Catches What Sleep Trackers Miss
A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal that traditional sleep scales mi...
Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it.
-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fel...
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