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October 14, 2025 27 mins
Insulin resistance and dementia are two very different conditions but are they somehow connected? Even more important, how can we use this connection to protect brain function as we age? On this show, leading integrative health authority Jacob Teitelbaum, MD, describes the research connecting these two conditions and then provides practical advice on how to protect and enhance brain function by addressing insulin resistance.


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Speaker 1 (00:00):
Any health related information on the following show provides general
information only. Content presented on any show by any host
or guests should not be substituted for a doctor's advice.
Always consult your physician before beginning any new diet, exercise,
or treatment program.

Speaker 2 (00:41):
Hello everyone, and welcome to Five to Thrive Live. I'm
Carolyn Gazilla and I co host the show with my
good friend doctor Lise Olschuler. Our topic today is such
an important one and it's something that I'm very interested in,
which is protecting an enhancing brain function. And I have
the expert joining me, Doctor Jacob Titelbaum, has been on

(01:03):
the show before because he is truly a wealth of
researched and reputable integrative health information. He is the author
of twelve different books and he is the lead author
of eight studies in three medical textbook chapters so on
effective treatment for fibermiology and chronic fatigue syndrome. But before
we begin, I'd like to thank our sponsors. Beginning with Cetria,

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thank you so much for joining me.

Speaker 3 (02:43):
Carolyn Allohat, to you and to everybody out there, and
we're going to have an exciting data that we're going
to teach you how to keep your brain healthy, thriving,
and optimized.

Speaker 2 (02:52):
I know, I love it. So you know, new research
indicates that there's a significant connection between insulin resistance and
brain function and including dementia and Alzheimer's. But before we
dig into the research regarding this important and interesting connection,
can you just give us a simple explanation of what
insulin resistance is.

Speaker 3 (03:13):
So basically, we have furnaces in our cells called mitochondria.
They burn glucose other things for fuel, and that's what
gives us energy to open the door to the furnace
so the fuel can get in for burning. The insulin
is the key that unlocks the furnace. When you have
too much sugar in your system, the key doesn't work.

(03:36):
The insulin gets stuck. It's just the body is resistant
to it. You can't open the furnace. So the sugar
is building up in your blood, but their cells are starving.

Speaker 2 (03:47):
Yeah, that makes a lot of sense. So how does
someone even know if they have insulin resistance.

Speaker 3 (03:52):
Well, some of the easiest things you know. First of all,
if you have a high sweet tooth and you tend
to high blood pressure, you tend to high cholesterol, you
tend to diabetes. All of these things are weight gain
around the apbudomen. All of these are suggestive of metabolic syndrome,
which is another way of saying insulin resistance. About forty

(04:13):
percent of adults have this and that's growing. This is
an epidemic in the United States. So basically, if you're
overweight from sugar carave and a tendency of high blood
pressure or even being a lot, it's time for you
to suspect it and take simple measures to prevent and
reverse it.

Speaker 2 (04:31):
Yeah, I like what we're going to talk about today.
These are all great things that are going to help
health on many levels. So I like your strategy. You
often get like two furs or three furs for some
of the strategies that you're recommending. They do multiple things
in the body. But let's start with the research. So

(04:52):
the research, new research came out this year, so tell
us about that research regarding this important connection.

Speaker 3 (04:57):
The study is a large study and it looked at
insulin resistance in people with what's called mild cognitive dementia
or impair early dementia basically MCI. And they what they
did is they followed them over time and they took
a measure of insulin resistance. It was basically it's an equation.
It looks that trig destrides and fasting blood sugar. And

(05:20):
they found that people at insulin resistance there are four
hundred percent which is more likely to progress over time
to dementia. So this is again I say this a lot.
The vast majority of dementia is preventable. It's not hard.
It doesn't take a twenty five thousand dollars a year.

(05:40):
Medicine just takes some common sense. And here's one more
approach that has a massive payoff in terms of overall
health and cognitive health.

Speaker 2 (05:49):
Yeah, and I have to be honest that I've been
writing about this since nineteen ninety two, I would have
never connected insulin resistance with brain function and dimension in Alzheimer's.
So I love this new research because, as you mentioned,
this is something preventable. This is something that we can reverse.
So it's become a parent that if we wanted to
protect brain health. We also need to address insulin resistance.

(06:11):
So let's start where you and I like to start
with diet. What should we be doing from a dietary
standpoint to either reduce the risk of insulin resistance or
reverse it.

Speaker 3 (06:25):
Well, Carolyn, it's interesting because if you look back three
four hundred years ago, the medical anthropologists have shown that
adult diabetes was extremely rare. It's not childhood diabetes like
you do now, but this adult diabetes, which is affecting
a third to forty percent of the population, you didn't
see it. It was really rare. And then as the

(06:46):
Western diet came in all of a sudden, we see
the epidemic and it got traced back to One. Cut
down the sugar. We get one hundred and forty pounds
of sugar per person dumped in a diet each year.
In food processing. Two, increase the fiber, fruits, vegetables, things
like that. So okay, to have fruit, don't have fruit
juice and orange has twospoons of sugar and plenty of fiber.

(07:10):
Enjoy it. Sixteen ounces of orangers. That's like eight orange
is worth the sugar. That's the thing. Just go with
the fruits, vegetables, whole grains, fiber, and then go for
walks in the sunshine. These simple things make a big difference.
Not just where they keep your your diabetes away, they

(07:31):
will keep your weight down.

Speaker 2 (07:33):
So let's go back to the decreasing sugar, because that
is a problem that a lot of people have. What
are the most egregious dietary sugars that people are ingesting
that they can kind of start, like, where should they
begin when they're cutting back sugar?

Speaker 3 (07:48):
Cut off the sweet drinks. So again, it's funny when
I talk to people and say cut out sugar, I
see suddenly they go to the thing that gives them
the most pleasure in their lives, and I say keep that. Yeah,
living gients get rid of the sodas and Zvia has
a nice Stevia sweetened. Again, there's a lot of issues

(08:09):
with the artificial sweeteners, but the stevia so far seems
to be coming out pretty well. So I use teas.
I mean, I'll have a big cup of tea in
the steviou sweeten that I have next to me. Cut
out fruit juices, so those simple things they're going to
get rid of a massive amount of the sugar number two.
If you're going to go ahead, you know, keep chocolate,

(08:32):
but in moderation. Again, go for quality, not quantity, and
savor it. So it's okay to have a sweet tooth,
but not as your main dish.

Speaker 2 (08:41):
Yeah, and the sweet drinks man, that is that is
a great place to start. So you mentioned walks and
sunshine and least doctor el Schuler and I talk about
being out in nature and being physically active in nature.
What are some other lifestyle factors that we can change
to help us prevent a reverse insulin resistance.

Speaker 3 (09:01):
Well, the main thing is keeping weight down an increasing exercise. Next,
you can cut down stress. Now again, when you're kids.
The media mantra, if you wanted to sell something on
TV back when they had TV networks, you had handsome
guys and good looking gals and you had them next

(09:21):
to the beer or the car you are selling. And
that was a big push of sex cells in media mantra. Nowadays,
the media mantra is fear and devisive missules. There's no
longer a middle path in there. Much, if not most,
of what we see on the media, if it is
scaring you to death or making you hate, have the
population turn it off. It is. One is nonsense. I

(09:44):
don't care which side of the aisle you're looking at.
Both sides are now making things up. And Two it's
not healthy. It raises cortisol levels from the stress, which
can trigger insulin resistance.

Speaker 2 (09:56):
Yes, I do media cleanses and I'm in one now.
And yeah, So I also want to talk about sleep
because I've read over the years insulin re I mean
interesting research showing that even just one night of sleep
deprivation six hours or less can increase insulin resistance. So
tell me about sleep. What's going on with sleep and

(10:18):
insulin resistance.

Speaker 3 (10:19):
So what you're saying with sleep is the number of things.
One deep sleep is when you make growth hormone. It's
also when you make loved and which suppresses appetite. All
these things tend to help insolence sensitivity. They help you
stay young and healthy, They help muscle grow and decrease fat,
They decrease appetite healthfully, So sleep is critical. Also, a

(10:43):
recent study is looking at sleep and low sleep is
associated with increased risk of dementia, and they traced it
to poor sleep triggering inflammation, which will then trigger insolence resistance.
All of these things try and tie together and.

Speaker 2 (10:58):
Health absolutely and lack of sleep and encourages and enhances obesity.
You become overweight when you're not sleeping as well.

Speaker 3 (11:07):
Yes, you get an average six and a half way
gain pound weigh gain and thirty percent increased risk of obesity.
And people who are not getting optimal sleep and the
average night sleep in the United States and the light
bulbs invented one hundred years ago, their perspective was nine
hours a night.

Speaker 2 (11:25):
Yeah, I want to talk about dietary supplements and I
actually want to start with sleep. What is your view.
I'm not sure that you and I have had this
conversation about your view of dietary supplementedature interventions for sleep,
things like melatonin or valerian or lavender or I mean,
do you use those? Do you recommend those to your patients.

Speaker 3 (11:47):
Day in and day help? So again, most people can
get to sleep. They need one. Cut out the things
you don't enjoy, like turning off media and social media
and turn that off. Use the time for sleep. Melotoninone
and not only help sleep, but it also improves insulin sensitivity.
It will decrease the glycosylated hemoglobe and the main diabetes

(12:10):
dust by zero point four percent. Pich is a lot.
I will use a mix called the Revitalizing Sleep Formula,
which is a mix of six herbs see passion, flower, lemon, bomb,
vlaria and five atp cnine. So that's one of my favorites.
I'll go ahead and use that. I have a cup
of Camo Mile tea, but again, you want the whole tea.

(12:31):
You don't want this tea dust in a tea bag.
You want the loose tea. And a cup of cam
Mouth tea at bedtime makes a nice, big difference. So
there's so many And then put a lavender in your bedroom,
a drop of lavender oil on your upper lip, right
under your nose. So many ways to optimize sleep.

Speaker 2 (12:51):
Yeah, and you know do you just gave an example
of recommending something a dietary settlement that has dual advantages.
MILITI own and will help with sleep, but it also
helps with insulin sensitivity. So let's talk a little bit
about insulin resistance and supplements. Are there supplements that can directly, indirectly,

(13:11):
or however you'd like help with insulin resistance, either reverse
it or prevent it.

Speaker 3 (13:17):
Absolutely, If I have somebody with diabetes or even metabolic syndrome.
I have a nice slimple thresome that I give and
actually four things. It will reverse diabetes in a large
percent of the population. If you look at the usual
test called coolated hemoglobin normally is five point five. Over

(13:39):
six is considered insulin resistance seven or less as well
controlled diabetes. Eight point eight is poorly controlled. So I
can decrease out of the study show you can decrease
it by two point four percent, which is enough to
take you from poorly controlled diabetes to non diabetic by
taking three simple things. Is an herb called Hintonio lataflora.

(14:04):
It's available to sue coontrall D in the United States.

Speaker 2 (14:07):
Can you spell that? Can you spell that for me? Doctor?

Speaker 3 (14:09):
Titleone s U the n t r a L non
capital D. It's available from Europharma or Euromerica. The second
is Burbering. So the study show now it takes a
year to see the full effect. Ofties, you'll see a
point nine percent decrease on average after one year with

(14:30):
the sue ConTroll D, and then the burd Breen has
a similar effect. Either five hundred milligrams three times a day,
or if you use a high absorption one two hundred
and fifty milligrams twice a day. But again you'll see
the effects start at three months, but they increase dramatically
over one year. And then melotonin. I like to use

(14:50):
the sustained release melotonin like ep I like to ten milligram,
but many melotonins, there's many very good ones out there.
Those three together will decrease after one year. Bichoslated team
of glove and two point four percent. Meanwhile, the met
form and is not a bad medication. A lot of
people like the SLAM, but the main problem is it

(15:12):
will cause vitamin B twelve deficiency often with normal blood tests.
You have to be in a good multi vitamin I
like one called the Energy Revitalization Drink Mix. It's a
simple powder, one drink a day. Really protects the body
and the mind and all kinds of things and diabetes

(15:32):
Ornament Show Essentials is a nice tablet for those who
want tablet forms. But the B twelve and we can
do a whole show about B twelve deficiency with normal
blood levels. It's just a major problem, and you need
a multies at least one hundred micrograms so be twelve,
especially if you're taking that form in which will cause

(15:53):
be told deficiency otherwise.

Speaker 2 (15:55):
So let's go back to melatonin. Did I hear you correctly?
Did you say ten milligrams milligrams?

Speaker 3 (16:01):
It's funny, you know me, Carolyn Black. When it first
came out, I was telling people takes three tens for
a milligram of melotonin, right all the body usually makes
that all it takes to bring it up to the
midrange of normal. We have no idea what higher doses
are going to do. We have no idea if there's
or a self monitoring system when the body suppresses the zone.
But over the last thirty forty years, the research has

(16:24):
shown we're not seeing these issues, and you get in
addition to the sleep benefits, there's antioxidants, there's I think
immune beneficent benefiting that will help with many things. But
also it's been shown to decrease gycosidic coastlated temoglobe one
point four percent with the use. So I'm personally I

(16:48):
take the EP one twenty ten miligram melotonin, but mother
one wants to take the three tens for milligram ten
milligram anywhere in between. Again, I like to sustained release
that also decreases nighttime asset reflux. I mean, there's so
many good things that it does that you will find
that over the last thirty years, my dose and recommendations
to melotone have changed dramatically.

Speaker 2 (17:10):
Well, it's interesting because our sponsor pro thrivers Wellness sleep
that was specifically designed for thrivers and has the high
dose melatonin because as you mentioned, it has anti cancer effects.
So yeah, melatonin is a powerful, powerful substance. Okay, so
I want to switch gears. But before I switch gears,

(17:30):
are there any other supplements that you want to mention
specifically for insulin resistance?

Speaker 3 (17:35):
These are enough. Again, cut on to sugar drinks, get
your sleep. These are things we talked about, and the
rbals we talked about, get take them. Multi vitamin because again,
vitamin D many other nutrients are critical in diabetes and dress.
So the energy re vitalization drink mix. You've got a
simple thing. It's not a lot of pills. To take

(17:56):
it morning and night. You're done, and it will We'll
get this taken care of for most people. And then again,
I know I'm repeating myself, Carolyn, but cut out the
things that give you the least pleasure. First, I have
the high sugar, the things that give you the most

(18:16):
pleasures to make your eyes feel and make it look
like you're having an orgasm at dinner.

Speaker 2 (18:21):
Yeah, good point. Well, I learned something new from you
and I always do, and it's this connection between chronic
pain like diabetic neuropathy and its impact on dementia. And
it's interesting because I just finished an article on neuropathy,
which is a horribly painful condition. It can not only

(18:44):
be diabetes related, but I also included information on chemotherapy
induced neuropathy, which doctor Alschuler just did an entire show
on that topic. So this surprised me again. Doctor Titelbaum,
tell us, what's the what's the connection between chronic pain
such as diabetic neuropathy or chemotherapy induced neuropathy and the

(19:08):
connection between dementia.

Speaker 3 (19:10):
So here's the thing. Multiple studies are showing that this
is a powerful connection that if you have more than
three sites of chronic pain, your risk of dementia goes
up thirty six percent. This is massive, and there's a
lot of different mechanisms that are proposed. I suspect that
number one, it impacts sleep. Poor sleep increases inflammation, increases

(19:35):
dementia risk, increases in slim resistance risk. Also it triggers
microle all activation. And also it just turts. I mean,
you don't pain is so incredibly treatable unless you go
to the doctor. And this country doctors get no training
virtually in pain management. Given talinol mo trend slash for

(19:57):
cash if there's something you can operate on. And you
know what most of my pain management education was in
that school is don't let them fool you into giving
you a narcotic. You know how drug addicts would pick
their finger and put the drop of blood in the
urine from mimic a kidney stone. But I don't talk
more about that than how to get to the pain.
Almost all pain can be effectively treated. They give lipoic acid,

(20:20):
you give a scarnatine so or they look at the
chemo pain or diabetes pain. Both of those help. They
give the pea, and I'll use one called pea Healthy
information response. Over two hundred studies with that, and pea
genuates brain cells as well as get getting good of
pain and my real activation. People who like for those

(20:44):
who would like, because I know I talk quickly. If
it's okay, I'll give up my email address. I'm happy
to send three information sheets. I'm preventing dementia, I'm treating diabetes,
addressing chronic neuropathy, or using pea for pain. And if
those who would like my email addresses fatigue, that's fat

(21:05):
I g uidoc at gmail dot com. Perfect mask for
the pain, neuropathy, diabetes or Alzheimer's Prevention are all of
the above information sheets.

Speaker 2 (21:16):
Yeah, I highly recommend our listeners reach out great information
and it is interesting. So when I was writing this
article on neuropathy, I was actually quite shocked that conventional
medicine has very little to offer. And you you know,
you mentioned and SAIDs and you know they don't work
with with neuropathic pain. So then that there's an escalation

(21:38):
and all of a sudden, they are prescribing like high
dose opioids or anti convulsive meds or antidepressant meds because
there's so much depression with chronic pain. So it is
something really interesting. Now I want to go back to
this this thirty percent increase. When you set pain, did
you say something about three points of pain? So do

(22:00):
you have to have three different types of pain or
what or did I mismiss that even.

Speaker 3 (22:06):
One area of pain is associated with increased risk. But
the more different areas of pain that you get, the
higher the dementia risk. So using three as one level,
that was associated with the thirty six percent increase risk
of dementia. Now you notice we throw out little numbers here,
like thirty six percent increase risk with this very preventable thing,

(22:26):
four hundred percent increased risk with this common preventable thing.
Most dementia is preventable, but the doctors I still boggled
my mind. I remember a recent presidential debate and they're
talking about should Medicare cover this new like twenty five
thousand dollars a year drug for dementia that probably does

(22:47):
like five percent effect and ignores that folic acid B twelve.
All these natural things and the things we talked about
today are way way way way way way way way
more effective with side benefits instead of side effects. Yeah
about it?

Speaker 2 (23:07):
Yeah? I mean even I learned that saffron not only
with chemotherapy induced neuropathy, but also diabetic neuropathy. The studies
are phenomenal. It's it's a great natural product. And I
also do want to give doctor Al Schuler's show a
little plug. So if you go to ithriveplan dot com

(23:28):
and you just scroll down, you'll see that show. So
if you have somebody that's struggling with neuropathy, because it
is a very hard to treat painful condition, go to
I thriveplan dot com and look for doctor Al Schuler's show.
So when it comes to chronic pain, what is your
final advice? Because that is a tough one. What's your

(23:48):
final advice? If somebody is listening and they're struggling with
chronic pain.

Speaker 3 (23:53):
Pain can be effectively treated. Your doctor just is not
taught how There's four key domains of pain management, and
most people have several of these activity ones they're not
hard to treat. Number one is low energies causes your
muscles to get lockedness, shortened position. Take a good volume
powder like the Energy Revitalization drink mix that will give

(24:14):
your body a lot of energy. The muscles will relax.
To treat inflammation, kurkcumin, bozwoalia, all kinds of things like that.
I use something called Cureman, very simple thing. Give it
three months, rush six weeks for the Kureman. It's a
pain relief miracle. It will balance inflammation. Get your sleep

(24:35):
and stuff that's in there too. Number three, if your
pain is chronic, you do have brain information called micro
clear activation. The PEA we talked about the PEA information
sheet pomped all us and all my blah blah blah
over two hundred studies, especially including neuropathy, dramatic decrease in
pain after three months of use. And number four if

(25:00):
apathy is present. Again, there's a chapter from my old
book Paint three one two three. Email me at fatigue
doc at gmail dot com. I'll send you the chapter.
We'll go through dozens of nutrients and standard medications, but
these are usually low costs. Somebody talks about them and
give you a protocol going start here in this wourk,
going down till the pain has gone. Because neuropathy pain

(25:24):
is more challenging, but it's really really really really really treatable.
And again I'm we use the best of natural prescription.
I'm not against prescription medications. I'm just against the insane
way they use based on profit, drous and science. Right.

Speaker 2 (25:37):
Yeah, So that's fatigue doc doc at gmail dot com.
What is your website? I'd like to have people know
where they can find out more information about you.

Speaker 3 (25:47):
So the supplements I carry I talk about our available
most everywhere, any helpful through Amazon, you can find them.
My website is and as e and like Nancy D
like David Fatigue dot com. My website for information is
Vitality one zero one dot com. What I'd recommend is
my book From Fatigued to Fantastic Shamless Plug. It will

(26:10):
go through each kind of pain and how to make
the go away.

Speaker 2 (26:13):
Yeah, it's a bestseller. I highly recommend it as well well,
Doctor Titlebaum. This has been very informative. Thank you so
much again for joining me.

Speaker 3 (26:22):
Always a pleasure.

Speaker 2 (26:24):
All right, well, that wraps up this episode of five
to Thrive Live. Once again, I'd like to thank our
sponsors pro Thriver's Wellness sleep formula, Cetria Glutathione the superior
glutathione and support liver at Immune Health Cognizance Ticoline to
help enhance memory, focus and attention. Doctor oher is award
winning shelf Stable Probatic And once again thanks for listening.

(26:46):
And remember you can find past shows, including that one
that I mentioned from doctor al Schuler and her guest
at I thriveplan dot com. That's I thriveplan dot com.
Thanks for listening. May you experience joy, laughter and love.
It's time to strive everyone, have a great night.
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