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May 30, 2025 143 mins

Psychedelic researchers James Fadiman and Jordan Gruber discuss microdosing protocols, benefits, current research, and safety considerations.

Throughout the interview, you will learn the practical basics of psychedelic microdosing—substances, dosage, frequency and duration, when in the larger arc of our lives, and who would best benefit from microdosing; You will also learn about the benefits of microdosing that Gruber and Faidman discovered in their research, which they describe as A-Z, anorexia to zoster and everything in between—with a particular focus later on in the interview on microdosing for various neurological and mental health conditions like ADHD, TBI, dementia, and depression—as well as for the betterment of well people

You’ll also learn some of the issues facing microdosing as a both a practice and a premise— issues like placebo, research design, and the potential dangers of microdosing.

Enjoy!

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FULL TOPICS BREAKDOWN AND TIMESTAMPS BELOW

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Episode Breakdown

  • (00:00) Opening
  • (03:28) A quick request
  • (05:29) Interview begins
  • (07:13) What microdosing is, and what it is not
  • (08:33) the dose range for microdosing
  • (09:42) Bettering the terminology "Sub-threshold" rather than "sub-perceptual"
  • (15:00) The substances you can microdose (and those that don't qualify and why)
  • (18:00) Fadiman and Gruber got their data from "real world evidence"
  • (20:57) The different microdosing protocols
  • (28:30) Why people tend to stop microdosing after a while
  • (30:54) Once isn't enough with microdosing, and here's why
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