February 20, 2024 • 32 mins
The latest disruptors in regenerative skincare are exosomes. But are they effective and more importantly, are they safe?
We sit down with Dr. Sarayna Wyles, M.D., Ph.D., a dermatologist with expertise in regenerative medicine and a keen focus on skin aging. As to her impressive credentials, she provides care at the Mayo Clinic and her research lab studies the role of cellular senescence in age-related skin disease and wound healing.
Key Points:
- Understanding Exosomes: Discover the role of exosomes, the extracellular vesicles acting as messengers that facilitate crucial signals within the body. Think of them as the FedEx or UPS of cellular communication.
- The Source Matters: Dr. Wyles sheds light on the significance of the exosome source, whether derived from platelets, mesenchymal stem cells, or other body fluids. Learn how to ensure the safety and reliability of exosomes to avoid potential risks.
- Skin Regeneration Benefits: Explore the various benefits of exosomes in skin tissue regeneration, from collagen synthesis to inflammation regulation. Dr. Wyles discusses how topical exosomes could potentially revolutionize the aesthetics market.
- Game-Changing Accessibility: Unlike traditional regenerative skin treatments with limited efficacy and high costs, discover how topical exosome products could provide consistent regenerative effects for all patients, including those with diverse skin tones.
- Topical Applications: Dr. Wyles presents a recent study showcasing the effects of (plated) Skin Science’s topical exosomes on collagen. Gain insights into the exciting possibilities for skin rejuvenation.
Tune in to explore the potential game-changers in regenerative skincare. Are exosomes safe, and do they really work? Join us to find out!
Additional Studies:
Shop the Show:
(plated) INTENSE Serum
https://platedskinscience.com/products/intense
(plated) DAILY Serum
https://platedskinscience.com/products/daily
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
(00:00):
This is the Art Beauty podcast,where we are always reaching for truth
in beauty.
Remember,the brands of the people on the show
are not paying to be here,so we get to ask those tough questions.
We know you want answeredbecause you deserve to be informed
so you can make the best choicesfor yourself.
With that said, I'm Amber, Milk and today,My fabulous co-host is Dr.
Saranya Wyles.
(00:21):
She's a board certified dermatologistwith a Ph.D.
in regenerative medicine.
She works at a little placecalled the Mayo Clinic.
So I think we knowthat she's got some credibility here.
She also led the clinical trials
for Plated, which is an exosome productthat we will be discussing.
But before we get into that first.
(00:42):
Welcome to the show, Dr.Wyles. Really appreciate you having.
Really appreciateyou being here with us today.
Thanks, Amber.
It's great to be here with you.
So, you know, we keep it honest here
and I am so excitedabout this episode today because we we did
I did in an episode on Exosome
(01:02):
products,specifically in topical products.
You take it home, not thingsthat are injected or applied after,
you know,you've had some sort of laser treatment
and then,you know, it's the beauty business, right?
So things are always changing.
And then I startedto really dive into Exosomes.
(01:23):
So I was familiarwith the Elevate product. I used it.
I felt like it made my skina little bit more clear.
But then when I startedkind of really digging around
and doing a little more research,I found that
there was a lot of conflicting informationon Exosomes.
With some doctors who were like,yes, this is that the the
the newest, hottest thing to doand other doctors who are like, well,
(01:46):
there's things we need to be concerneda bit a little bit about.
And I'm hoping today, Dr.
Wells, that you can help uskind of clear some of that up.
So to start with,can you give us a very brief explainer
and a reminder of what exosomes are?
Absolutely. Amber.
And I think a lot of the scientific
rhetoric that comes around withthe terminology is new to people.
(02:08):
And when you have a disruptive technologywith new information and new terms,
you have two camps.
Part of the people who understand it,they're onboard
because they see it working.
And then the other part are skepticaland want to learn more.
But there's concerns about it.
So let's break it down, starting fromthe basics, which is what is an exosome.
(02:29):
So and Exosome is just a messagefrom a cell
and we could think about itlike letters or signals.
They have a single signal message thatthey're communicating to another cell.
So it could be anythinglike repair, restore,
it could be multiply or divide for a cell.
It could also be harmful,like metastasized.
(02:50):
So this is where the keyis, the source of the exosome.
Where is it coming from?
What are the cell
or the source that it's coming fromthat really distinguishes the product?
So the first questionwhen somebody is talking about
exosome technology should naturally be,well, what is the source?
And there's great variability.
So if we kind of think about it as
(03:13):
pasta, you
can kind of have different types of pastaand with different sauce
and different types of dressingsand things like that.
So this is really where you just havea blanket terminology
and you really want to ask the next stepsor the next questions
to better understand what it isand how to how to use it.
Now, I'm so glad you brought that upbecause, you know, when you were saying
(03:36):
harmful, like you want to make surethat your exosomes aren't being sourced
from somebody who is either geneticallypredisposed to cancer or had cancer.
Because as you said,those exosomes would be sending cells
to messages to your cellsthat could affect them in negative ways.
So as consumers,how are we supposed to know this?
(03:58):
Because as far as I understand,the FDA is has not approved any exosomes
and they've actually sent warningsto consumers about, you know,
about using them.
Exactly.
So let's talkabout what the FDA can regulate.
And really, it's a gray areawhen it comes to cosmetic applications,
But as long as we're applying iton intact skin,
(04:20):
and that includesreally disrupting the skin barrier.
So this is where we really have to becautious and emphasize
that there are currently no injectableexosome products that are approved
even for cosmetic purposes.
You cannot inject exosomes, and that's FDAhas been very clear about that.
Now when you apply the product topically
(04:41):
on skin for appearanceof skin aging, redness for size, etc.,
that is that lieswithin that cosmetic realm,
which the FDA doesn't necessarily regulatebut does surveil.
So this is where you need to make surethe company has the right strategies,
the right manufacturing,so that the product that they're offering
(05:02):
or sharingis under the guidelines of the FDA.
Now, you know,I want to talk about the injectables,
because that is something
that we sort of heard, you know, k-beautywe know K-beauty a lot of that,
but that is actuallya very popular treatment in Korea
is this idea of injectable skin boostershere.
You know, in the States,
I think what's much more commonis for people to see in-office exosomes
(05:26):
being applied after you've had eithermicroneedling some sort of a laser.
I myselfhave had some microneedling before.
So. So is it just that we need to be,
you know, trusting, I guess, our doctor,that our doctors doing the research
to make sure that these are sourcedfrom reliable companies?
Yes. So let's talkabout sourcing a little bit,
(05:46):
because this is unlike any other productthat we see on the market.
So what do I mean by that?
I mean that when you go into a storeto buy a product, whether it's
glycolic acid or salicylic acid,so those are active ingredients
where you know that those active activesare the same in every single product.
The batch to batch chemistry is the same.
(06:09):
Now when it comes to Exosomes,these are sourced from humans.
So there's great variability in that humansource of what cell is it coming from?
Is it coming from one donor, one person,or is it coming from batch donors?
Collective combinationof multiple pooled donors.
And then you have to think abouthow are they manufacturing it
because it can come from human sources.
(06:30):
You have to use good manufacturingpractices or clinical very good
manufacturing practices, cleanlabs, clean rooms, product handling
gowns, loving all of these thingsthat you wouldn't normally think about
in your chemistry of Cosmeceuticals
come into play with the biomanufacturing of Exosomes So this is where
we really have to think about thisas not every product is the same.
(06:54):
And how you makethe exosomes is really important.
And the sterility safety,the reproducibility
meeting batch to batchconsistency is is validated.
So those are some of the things
that you have to ask the manufacturerWhere are these manufactured from?
Who are the donors? Is it one multiple?
And then how are they kind of ensuringthat the product is consistent and
(07:18):
reproducible with each batch?
I mean, for the regular person at home,is there a way for us
to sort of find out that informationor is it just writing to,
you know, either thatthe cosmetic company, the parent company,
but do you have any that you knowor or why I like to do this
podcast is bringing on trustedpeople like yourself, right,
(07:40):
who work at the Mayo Clinic,who specialize in this,
who are here.
Clearly, you are supporting a brand,
but I do think that your credibilitydoes lend to a little bit
more trust than necessarily having,you know, somebody hate to say this from
PR coming onsaying this is the best, greatest thing.
(08:00):
Is there anything that we can do at hometo kind of ensure
that our productsare coming from a safe place?
Yes. And to get that credibility,
the company needs to investin validating its technology.
What does that mean?
That means they need to be doing FDA
clinical trials in the productfor different medical indications.
So even a company like Platedhas the parent company region
(08:24):
and they have different clinical trialsthat's ongoing.
So this is where the consumer can go.
On clinicaltrials.gov,which is an open access public website,
and you just type in the source and seeif the company has FDA INDs ongoing,
meaning do they have medical indicationsthat they're trying this for?
(08:45):
That means they have a good backgroundof manufacturing.
You know, that the FDA has really delvedeep into making sure
that the products are manufacturedconsistently because they're looking
to approve the product for many peopleand safety, which is a big concern
and regulation for FDA.
So you want to make surethat the company is has FDA
(09:06):
studies ongoingthat is separate for medical indications.
And if they have that,then that's good reason to believe
that they've invested inand trusted manufacturing processes.
Here's a little thingto anybody from Plated who's listening.
You guys on your websiteshould have a link
to some of these clinical trialsbecause I think
that it was kind of hard to find out like,well, wait, where are these coming from?
(09:27):
What's going on?
But that's another,that's another conversation altogether.
Maybe I'll write them a little letter.
So okay, So once we, you know,have this idea of that,
we're at least getting trusted source islet's talk
a little bit about the different sourcesthat that exosomes come from.
So I know that plated comes from plateletsversus
(09:48):
elevated VIwhich were taken from the umbilical cord.
What's the difference?
Why does that matter?
Great question. So let's break it down.
So if we were to look at umbilical cord,this is from the cord blood of babies,
and you can understandthat each cord blood source is different.
So you have to understand,is it one or two donors
(10:11):
or is it multiple donorsthat they're combining
the cord blood stem cells the other way,
that the exosomes are manufacturedis that they have to be cultured in a lab.
So if it's coming from stem cells,so look for the buzz word stem cells
so they can be bone
marrow stem cells, adipose stem cells,umbilical cord blood stem cells.
(10:32):
So those stem cell sourcesneed to be taken to a lab
where they're expanded overand over and over again.
And then they take
what's called the culture mediaor the soup that the cells grow in.
They basically take that media outand then they distill
the exosomes down from that.
So think about thatas an intermediate step.
(10:53):
So you have the cord bloodthat's taken from the patient.
You take it to the labwhere this is the biomanufacturing
making sure that there are sterility,good manufacturing processes.
It's all handled under complianceand then it's expanded.
So this takes weeks, two months even.
And then your question is,are you using the same source?
(11:13):
So after several months you have somethingcalled phenotypic deviation.
And the other way to think about itis that it kind of changes when you take
something from its normal environmentand you put it in a different environment.
It tends to adapt to the new environment.
So how do you guarantee that that productis the same as when you harvested it
in the beginning from the fat tissueor bone marrow or umbilical cord?
(11:37):
So that's important to keep in mindfor stem cells.
Okay.
And so what's the differencewith platelets?
Great question.
So the platelets are a blood based source.
So when you get blood, it'sfrom multiple different donors.
They're near expiration platelets.
So we're not depleting from the sourcethat the patients may need for use.
(11:57):
So when you get these platelets,they're pooled.
So first you take away the outliers.
So people that are poor performers
or super performersand you kind of average them in together
when you kind ofget all the platelets pooled together.
So that's how one way to guaranteethat consistency,
that batch to batch consistencythat we talked about.
(12:20):
So pooled plateletsand they're processed immediately.
So there's no step of going toplatelets are actually cell free already.
So platelets in a wayare kind of exosomes themselves.
They come from a parent cellcalled a mega carrier site,
and that's when the bone marrowand then this just kind of spews out.
So platelets don't have that DNA,they don't have that.
(12:40):
The genetic information that we arewe could be concerned about.
It's not a cell in that in that truecell sense.
So when you take the platelets,you actually disrupt them
and you collect the exosomes that is beingreleased from the platelets. So
and the way to do that is proprietary.
They actually take out
(13:01):
all of the other particlesand then what's left is the exosomes.
So it's sort of like a sievethat they kind of sort of distill down
all of the non exosome productsso that you have exosomes leftover.
Okay, So you know what a little light bulbjust went off and tell me if I'm right.
So essentially when you take
(13:22):
brands like Olivia had stem cell basedexosomes, these are platelets
based exosomes and gosh, it's been a whilesince they took a science class.
But platelets are essentially
what your body releasesin response to inflammation, correct?
Exactly. Yes.
Okay. Okay. Got it. Okay. So amazing.
Okay, got it.So it's actually a different type of cell.
And you brought up a good point.
(13:43):
You know, with the stem cell based ones,they have found in Exosomes DNA and RNA.
Right. Like a lot ofwe have heard these buzz words.
So platelets don't have any of thatinformation in them.
No DNA.
You have a microarray dayswhich are again messengers.
So there post there they are a step downso it's not true genetic material.
(14:04):
So it's just a signaland it's actually a mixed bag of signals
because sometimes we get askedthe question,
what's in the nextis what exactly is composed in there?
What's the message?
It's actually pieces of messageof a lot of different signals
that come togetherand that they say repair or regenerate.
And this is where
the source becomes really keybecause the platelets normally do that.
(14:28):
Like you pointed out, they are the firstresponders to wound healing.
So they naturally have that propensityto regenerate.
I'm going to sites of wound,I'm going to repair this site.
So they they release signals of repair.
So that'swhere that exosome source is important.
Now, you know, I hate to dumb this downbecause you are obviously brilliant, but
(14:52):
is the idea
that essentially an exorcismwill be applied
and tell your own skin cells,the ones that aren't acting
in a reparative mode,Hey, wake up and start doing your job.
Is that kind of what's going on here?
Yeah, I love this question, Amber,because basically what this is,
is disruptive technologies.
There's no product that has been this way.
(15:13):
So if you think about growth factors,peptides, anything else
that you're putting on your skin,they work outside of the cell,
so they're kind of creating messagesoutside Exosomes work inside the cell.
They actually have the capacityto go in and deliver a signal.
So this is really newbecause you think about it as a mechanic.
Instead of working on top of the car,the mechanic is now working under the hood
(15:35):
and that's really where Exosomes come into
play of creating a new wayof working with the cells.
Okay, So
thank you so much for getting into this.
I'm so glad we were able to address
some of the concernsthat people are having.
Let's talk a little bit about thistechnology.
So, you know, from personal experience,I had a scar here
(15:56):
that came from a lasertreatment got wrong.
I had Exosome Microneedlingand the scar healed.
I mean, is basically invisible now.
So I've seen that it can work.
But when we talk about topical skin care,how are we making sure
that those messages are getting to areaswhere we where we need them to go?
(16:18):
Right where we we haven't had a treatmentlike a laser or microneedling
where we have these little channels nowhow does that work?
So here's my question for you,which is that
people have the assumptionthat a topical exosome
product cannot penetrate the skin barrier,but that is incorrect
and that's actually what we have foundin our clinical study.
(16:39):
So when we applied twicedaily application of the plated gold
and we followed these patientsfor six weeks and actually
even up to six months, we saw considerableimprovement in their skin.
But beyond that, at 12 weeks,we biopsied the skin
and we looked underneath the hoodand saw what was happening.
This is where we actually found Exosomes
(17:00):
that have been ableto be identified in the collagen fibrils.
So we're actually getting readyto publish this data soon.
And we submitted our datafor the histology studies,
which is really excitingbecause what we're seeing is that
you can have physiological change,new collagen, new elastin
with just topical application,no microneedling, no lasers,
(17:21):
no adjuvant procedures,this is just topical application.
So part of that is two things.
One is has it been manufacturedappropriately the right way
so that the exosomes are intactbecause you can rupture them
and if you rupture themthen they are no longer
going to be able to produce that signalor share that message.
So manufacturing is key there.
(17:43):
But the second thing that's importantis how the exosome size is.
So the size of the exosomes very,very small.
And we know that the skin can allow
anything less than 500 kill adultsand to penetrate into the skin barrier.
So these are very, very small particlesand they're carried right in, and that's
what our study showed.
(18:05):
So now talk a little bit,because your relationship with plated,
like I said, you work
with the Mayo Clinic,you do clinical trials, right?
Correctly through the Mayo Clinic.
So how did how did you sort ofget involved with plated? Yes.
So this was sort of very fortuitous,
(18:26):
right place at the right time, I would say
I actually cameI thought I was going to be a cardiologist
and like Mayo Clinicto do my medical training with Dr.
Andre Chozick and Dr.
Otto,who are the founders of Plated and Rion.
So they are cardiologistsand I did my Ph.D.
work with them.
And when we were doing the work,we were starting to
(18:49):
we actually focusedin a lot on mesenchymal stem cells,
and we later found that actually plateletsare the ideal source.
So we had a switch from mesenchymal stemcells to platelets, but the Ph.D.
work lend itselfto creating some of the research
that went into the product design and
(19:11):
and then I and I delivered the newsthat I'm going to become a dermatologist
and my cardiologist, advisorsand mentors were happy
because they had come up with a productthat would could be topically applied.
And so part of it is rightplace at the right time.
But I've spent about,I would say, 12 years
learning the science,everything starting from Ph.D.
(19:34):
to to being in dermatologyand then running the clinical trials.
So I've really seen that science evolveand really mature,
and it's been very excitingbecause the shift has really gone
from stem cells to exosomes,which is really self free.
That's, that's, that's what we're hearing.
And despite some of the concerns,which I'm glad we were able to address,
(19:54):
you know, I've talked to a lot of doctorswho who, like I said,
are very supportive of thisand do see these types of results.
So let let's talka little bit about plated,
because there's,I think, three different products.
I've got two of them here.
One is the DailySarah, one is the intense serum.
(20:14):
What are these meant for Who
who were these meant for and what are someof the results that you've been seeing?
Absolutely.
So I can start by kind of sharingwith what we found in our clinical study,
which is that the product really workson a very individualized,
personalized level.
So if you start with greater rednessor greater hyperpigmentation,
that's where it's going to target.
(20:35):
And so this is kind of the holy grail ofhow can one product
do all these different facets of skinaging and skin biology?
Well, it'sbecause you're targeting the root
cause of skin agingand the root cause of damage.
So if you kind of help the body,give it the right signals to repair,
it's going to repair what the damageto the damage that's been there already.
So if it's redness, it targets redness.
(20:56):
If it's brown pigmentation or size of finelines, wrinkles, it targets that.
And we're seeing those changesthat as early as six weeks.
So we use the busiest software to evaluatepatients,
everyone from the age 40 to 85.
So we have a whole big group of patients.
Average age was 54.
Now, the two products that you have there.
(21:18):
So let's talk about how we use it.
So product number one is the plated gold,which is the plated intense.
That's the product that we usedin the clinical study.
So the plated, intense,
applied twice daily
helps repairmoderate to severe photo aging.
So this is really meant for you to use
(21:40):
in the summer timeor with significant sun damage.
So this is going to be targeting thatconsiderable damaged skin, actinic damage,
anything that you know, postlaser like you talked about,
if you have more concernsor even three laser.
So I actually primemy patients with plated gold
before they come in for their CO2ablative laser or another type of laser.
(22:03):
And I say use this product twicedaily for six weeks that primes the skin
and then you're going to get better
results from a CO2 or any other laserthat you're kind of looking into.
So I love that gold for that purpose.
Is this also good?
You know,I mean, now we are in the colder months
when a lot of people are goingfor those laser treatments.
Is this is this what you want to use?
If you've had something like you said,you can prime your skin before,
(22:25):
Would you also use this after?
Absolutely.
We have a product called Plated Calm,which is meant specifically
for post procedure,but those are interchangeable.
And to a certain degree.
So you canif you don't have the come with you,
you can certainly use the plated intensefor that purpose.
I have to tell you.
So, you know, I did the labI used L-O-V-E for quite some time.
(22:48):
And what I noticed for me was a lotmore of the clarity, a lot of the
not that I had very, very red skin,but that's where I noticed
the biggest difference.
But one of the things we were honest aboutwas it had a certain smell.
This does not this is not as
Yes. It's not.
As that.And it does have a really nice texture.
I think I just put it on.
(23:09):
It's kind of like a gel jelly.
But, you know, he talked aboutone of the things that he talked about
when we did this with Dr.
Blues was how hard it is
to keep that shelf stablebecause Exosomes are are fragile.
How have you managed to do thatwith Plated? Yes.
And this is again, goes back to sourcing.
If you are able to isolate the productand are sourced
(23:31):
in a way that the exosomes are stable,you can keep them shelf stable
and and it should last year.
So when the time the productis manufactured, we have up to two years
that it can remain shelf stable for.
But the studiesand if you're using it consistently,
even from the study that we did twice
daily application at six weeks,that takes you through one bottle.
(23:53):
So technically you don't want to have thisin your drawer for too long
because you want to be applying itto get the effect.
But if you if you do have it,it also is okay because of the source,
because of the manufacturingand the way that it is kept intact.
So I kind of do sometimesuse the example of of an egg.
(24:14):
So if you think about an egg and it's
kind of kept at room temperatureand is kept on your counter,
it can it can remain stablebecause the outer shell is intact.
But if you crack that egg,then that egg is immediately not viable.
You have to get rid of itor less than you know.
So that's that goes intothe consideration of
is the exosome outer shell damagedor is it intact?
(24:38):
Okay.
And then we've got the daily serum,so “Calm” is for which I don't have here
is specifically for post-treatment.
But really you could use any of these,but you do have one that's targeted
specifically for post treatment.
What about the daily?
So the DailyI love the daily for two types of users.
One is for our younger patients who areconsidering this prejuvenation concept.
(25:01):
They want to have somethingwhere they're getting ahead of it.
You know, it's a little bitless of two X compared to the four X,
so that the concentration is a little bitless,
it's a little bitmore hydrating in the sense too.
And so you can you can see how that isso beautifully applied.
And it goes on very nicely glides on.
(25:21):
I love this product.
In fact, I recently had a baby and I.
Congratulations.
Thank you.
So plaited
daily has been my go to for my stretchmarks which has worked beautifully.
So that's another area that you knowbecause you can get more spread with it.
So it's it's great for the younger patientand I would even say
(25:42):
the postpartum patient.
That's amazing to hear. And you know what?
I love that you brought that up
because so many things are marketedfor our our face and we think face only.
But yeah, of course,if you've got stretch marks, I'm
sure like post scarring,that wound repair is probably
going to be very beneficial too.
So, you know, we have to mention pricebut I think, you know,
(26:04):
these, these range from what I thinkthis is in the two hundreds. Yes.
And this will be variablebased on your dispenser.
But yes, that's about what we see. Okay.
And then the daily.
It's priced similarly and that's
because you're getting the volumethere is a little bit more.
(26:25):
Yep. Yep.
But both and I was like you said,it should last like six six weeks. Yes.
And if you're consistently applying it.
So the way that I apply,if you start with a goal, so I kind of use
the gold as pulsing because it'sgoing to deliver really good signals.
So you want to pulse
with the gold twice daily for six weeks,then you're going to achieve this
beautiful maximal effect, glowing skin,all the good stuff.
(26:48):
Then you can switch to the dailyand you can go three times a week
or once a day, whatever,to kind of maintain that effect.
And then you can go again with the gold.
And after a month or so.
So just kind of usingthe gold intermittently,
this is for the average user, right?
For for more mature skin, I say just stickwith the gold for younger skin.
(27:09):
I could say stick with the daily,but if you kind of want to,
if you're in the middle and you'rekind of wanting to get a bit of benefits
of both, you can do it that waywhere you kind of pose with the
skin cycle, with the gold or the intense,
and then go back to the dailyfor maintenance.
And you said you're going to be publishingclinical your clinical trials
(27:30):
for the goldwith the Visio before and after.
The we've already publishedthat of the esthetic surgery journal.
So we do have those results out.
We have submitand we also have results for the hand.
So I love that you brought up other areasthat you can treat self
with the back of the hand.
Yeah.
So wewe recently published that study as well
(27:50):
in the Plastic and reconstructive surgeryjournal where you can see
that is has had considerableimprovement in brown spots
especially because it doeshave that antioxidant effect.
So it does both where it kind ofis antioxidant but also builds collagen.
Man, you have to linkto those on the website.
So that's all I'm going to say is
I would say link that out because I thinkthat that is very compelling.
(28:12):
And for people who are looking forthis type of skin care,
the science matters,the research matters, the results matter.
You know, I always tell
people and I'm sure you can say thisas a dermatologist, you have to manage
expectations when it comesto sort of these these miracle creams.
Right. Because I don't know.
(28:34):
Do you agree with me?
I feel like you're never goingto get in a bottle.
What you're going to get from a laser,what you're going to get from a knife.
So manage expectations.
But from what I saw fromsome of the before and after,
they were very compellingin terms of fine lines and wrinkles.
Hyperpigmentationand certainly with redness.
Absolutely.
And I think redness really likeknocked it out of the park,
which is where I have actually replacedmy laser with this product.
(28:59):
The PDF laser, the pulse eye
laser is what I use for my patientswith rosacea or facial redness.
And now what I've done is thatI provide my patients
with the bladed intentsand have them use it after,
and they're just coming inmaybe twice a year for their PDF laser
instead of once every three months.
(29:19):
Amazing.That was going to my next question.
So for people with sensitive skinwith rosacea
is this this is something you'd recommend?
Yes, definitely recommend.
It's not
it wasn't tested for that indication,but we know that redness
considerably improves.
So I love using it for that patientpopulation here.
Great.
And thank you for being specific about,you know, the claims that you can
(29:41):
and cannot make with this.
So what is next now inflated?
Is there are there new exciting thingson the frontier for you?
Yes. So first, I'm very excitedthat the product is the first
and only now of renewableand recyclable products.
So it's a clean brand of the new packagingwhich we'll send to you
(30:04):
is actually uses reusable inserts.
So actually eliminating a lot of the wasteand kind of becoming
the first physician dispense productthat is truly
green initiativeand and hopefully will continue
to inspire other brands to do the same.
So that's very exciting for us.
The second thing is looking at here,so developing a hair scalp serum,
(30:28):
we know that the product is ableto penetrate through the skin.
So you would have the same type of effectsin the hair and we're kind of
getting ready to launch that productthis year.
Very, very exciting.
I want to thank you so much, Doctor Wyles.
If people want to know more about Plated,
if they want to purchase it,where can they go?
They can go to plated skin science
(30:50):
dot com and and get more information.
They can purchase it.
Also, there's several physician officesthat are dispensing the products.
So just ask your local dermatologistand if you can't find it, follow us
on Instagram at plated skin scienceand we'll be able to connect you.
And what about you?
If we want to follow what you're up to,you know,
(31:13):
is there a way that we can do thatmaybe through the Mayo Clinic?
Yes, certainly You can goon the Mayo Clinic and find my profile.
And we definitely do post more informationabout our lab.
We are 3D bioprinting skin.
We're understandingskin cells, senescence.
So there's a lot of exciting things.
You can also follow me on, Dr.
Wyles, w yl e s dot derm on Instagram.
(31:37):
Amazing.
I wantto just thank you so much for your time.
Clearly,you have dedicated your life to this
and I think that you were really ableto shed some light
on some of the confusionthat might be surrounding Exosomes.
I look forward to seeing what'sgoing to happen in this sort of new,
I don't know, the future of skincare.
(31:57):
It's always changing.It's always getting more exciting.
If you at home have any questionsyou want me to pass on to Dr.
Wyles, I'm happy to do so.
You can email me at Hello at ArtBeauty podcast dot com.
You can find us on Facebook, Instagramand YouTube @ArtBeautyPodcast,
and as always,we will see you next Tuesday.
Hopefully just feeling a littlebit more educated. Bye!
This is the Art Beauty podcast,where we are always reaching for truth
in beauty.
Remember,the brands of the people on the show
are not paying to be here,so we get to ask those tough questions.
We know you want answeredbecause you deserve to be informed
so you can make the best choicesfor yourself.
With that said, I'm Amber, Milk and today,My fabulous co-host is Dr.
Saranya Wyles.
(00:21):
She's a board certified dermatologistwith a Ph.D.
in regenerative medicine.
She works at a little placecalled the Mayo Clinic.
So I think we knowthat she's got some credibility here.
She also led the clinical trials
for Plated, which is an exosome productthat we will be discussing.
But before we get into that first.
(00:42):
Welcome to the show, Dr.Wyles. Really appreciate you having.
Really appreciateyou being here with us today.
Thanks, Amber.
It's great to be here with you.
So, you know, we keep it honest here
and I am so excitedabout this episode today because we we did
I did in an episode on Exosome
(01:02):
products,specifically in topical products.
You take it home, not thingsthat are injected or applied after,
you know,you've had some sort of laser treatment
and then,you know, it's the beauty business, right?
So things are always changing.
And then I startedto really dive into Exosomes.
(01:23):
So I was familiarwith the Elevate product. I used it.
I felt like it made my skina little bit more clear.
But then when I startedkind of really digging around
and doing a little more research,I found that
there was a lot of conflicting informationon Exosomes.
With some doctors who were like,yes, this is that the the
the newest, hottest thing to doand other doctors who are like, well,
(01:46):
there's things we need to be concerneda bit a little bit about.
And I'm hoping today, Dr.
Wells, that you can help uskind of clear some of that up.
So to start with,can you give us a very brief explainer
and a reminder of what exosomes are?
Absolutely. Amber.
And I think a lot of the scientific
rhetoric that comes around withthe terminology is new to people.
(02:08):
And when you have a disruptive technologywith new information and new terms,
you have two camps.
Part of the people who understand it,they're onboard
because they see it working.
And then the other part are skepticaland want to learn more.
But there's concerns about it.
So let's break it down, starting fromthe basics, which is what is an exosome.
(02:29):
So and Exosome is just a messagefrom a cell
and we could think about itlike letters or signals.
They have a single signal message thatthey're communicating to another cell.
So it could be anythinglike repair, restore,
it could be multiply or divide for a cell.
It could also be harmful,like metastasized.
(02:50):
So this is where the keyis, the source of the exosome.
Where is it coming from?
What are the cell
or the source that it's coming fromthat really distinguishes the product?
So the first questionwhen somebody is talking about
exosome technology should naturally be,well, what is the source?
And there's great variability.
So if we kind of think about it as
(03:13):
pasta, you
can kind of have different types of pastaand with different sauce
and different types of dressingsand things like that.
So this is really where you just havea blanket terminology
and you really want to ask the next stepsor the next questions
to better understand what it isand how to how to use it.
Now, I'm so glad you brought that upbecause, you know, when you were saying
(03:36):
harmful, like you want to make surethat your exosomes aren't being sourced
from somebody who is either geneticallypredisposed to cancer or had cancer.
Because as you said,those exosomes would be sending cells
to messages to your cellsthat could affect them in negative ways.
So as consumers,how are we supposed to know this?
(03:58):
Because as far as I understand,the FDA is has not approved any exosomes
and they've actually sent warningsto consumers about, you know,
about using them.
Exactly.
So let's talkabout what the FDA can regulate.
And really, it's a gray areawhen it comes to cosmetic applications,
But as long as we're applying iton intact skin,
(04:20):
and that includesreally disrupting the skin barrier.
So this is where we really have to becautious and emphasize
that there are currently no injectableexosome products that are approved
even for cosmetic purposes.
You cannot inject exosomes, and that's FDAhas been very clear about that.
Now when you apply the product topically
(04:41):
on skin for appearanceof skin aging, redness for size, etc.,
that is that lieswithin that cosmetic realm,
which the FDA doesn't necessarily regulatebut does surveil.
So this is where you need to make surethe company has the right strategies,
the right manufacturing,so that the product that they're offering
(05:02):
or sharingis under the guidelines of the FDA.
Now, you know,I want to talk about the injectables,
because that is something
that we sort of heard, you know, k-beautywe know K-beauty a lot of that,
but that is actuallya very popular treatment in Korea
is this idea of injectable skin boostershere.
You know, in the States,
I think what's much more commonis for people to see in-office exosomes
(05:26):
being applied after you've had eithermicroneedling some sort of a laser.
I myselfhave had some microneedling before.
So. So is it just that we need to be,
you know, trusting, I guess, our doctor,that our doctors doing the research
to make sure that these are sourcedfrom reliable companies?
Yes. So let's talkabout sourcing a little bit,
(05:46):
because this is unlike any other productthat we see on the market.
So what do I mean by that?
I mean that when you go into a storeto buy a product, whether it's
glycolic acid or salicylic acid,so those are active ingredients
where you know that those active activesare the same in every single product.
The batch to batch chemistry is the same.
(06:09):
Now when it comes to Exosomes,these are sourced from humans.
So there's great variability in that humansource of what cell is it coming from?
Is it coming from one donor, one person,or is it coming from batch donors?
Collective combinationof multiple pooled donors.
And then you have to think abouthow are they manufacturing it
because it can come from human sources.
(06:30):
You have to use good manufacturingpractices or clinical very good
manufacturing practices, cleanlabs, clean rooms, product handling
gowns, loving all of these thingsthat you wouldn't normally think about
in your chemistry of Cosmeceuticals
come into play with the biomanufacturing of Exosomes So this is where
we really have to think about thisas not every product is the same.
(06:54):
And how you makethe exosomes is really important.
And the sterility safety,the reproducibility
meeting batch to batchconsistency is is validated.
So those are some of the things
that you have to ask the manufacturerWhere are these manufactured from?
Who are the donors? Is it one multiple?
And then how are they kind of ensuringthat the product is consistent and
(07:18):
reproducible with each batch?
I mean, for the regular person at home,is there a way for us
to sort of find out that informationor is it just writing to,
you know, either thatthe cosmetic company, the parent company,
but do you have any that you knowor or why I like to do this
podcast is bringing on trustedpeople like yourself, right,
(07:40):
who work at the Mayo Clinic,who specialize in this,
who are here.
Clearly, you are supporting a brand,
but I do think that your credibilitydoes lend to a little bit
more trust than necessarily having,you know, somebody hate to say this from
PR coming onsaying this is the best, greatest thing.
(08:00):
Is there anything that we can do at hometo kind of ensure
that our productsare coming from a safe place?
Yes. And to get that credibility,
the company needs to investin validating its technology.
What does that mean?
That means they need to be doing FDA
clinical trials in the productfor different medical indications.
So even a company like Platedhas the parent company region
(08:24):
and they have different clinical trialsthat's ongoing.
So this is where the consumer can go.
On clinicaltrials.gov,which is an open access public website,
and you just type in the source and seeif the company has FDA INDs ongoing,
meaning do they have medical indicationsthat they're trying this for?
(08:45):
That means they have a good backgroundof manufacturing.
You know, that the FDA has really delvedeep into making sure
that the products are manufacturedconsistently because they're looking
to approve the product for many peopleand safety, which is a big concern
and regulation for FDA.
So you want to make surethat the company is has FDA
(09:06):
studies ongoingthat is separate for medical indications.
And if they have that,then that's good reason to believe
that they've invested inand trusted manufacturing processes.
Here's a little thingto anybody from Plated who's listening.
You guys on your websiteshould have a link
to some of these clinical trialsbecause I think
that it was kind of hard to find out like,well, wait, where are these coming from?
(09:27):
What's going on?
But that's another,that's another conversation altogether.
Maybe I'll write them a little letter.
So okay, So once we, you know,have this idea of that,
we're at least getting trusted source islet's talk
a little bit about the different sourcesthat that exosomes come from.
So I know that plated comes from plateletsversus
(09:48):
elevated VIwhich were taken from the umbilical cord.
What's the difference?
Why does that matter?
Great question. So let's break it down.
So if we were to look at umbilical cord,this is from the cord blood of babies,
and you can understandthat each cord blood source is different.
So you have to understand,is it one or two donors
(10:11):
or is it multiple donorsthat they're combining
the cord blood stem cells the other way,
that the exosomes are manufacturedis that they have to be cultured in a lab.
So if it's coming from stem cells,so look for the buzz word stem cells
so they can be bone
marrow stem cells, adipose stem cells,umbilical cord blood stem cells.
(10:32):
So those stem cell sourcesneed to be taken to a lab
where they're expanded overand over and over again.
And then they take
what's called the culture mediaor the soup that the cells grow in.
They basically take that media outand then they distill
the exosomes down from that.
So think about thatas an intermediate step.
(10:53):
So you have the cord bloodthat's taken from the patient.
You take it to the labwhere this is the biomanufacturing
making sure that there are sterility,good manufacturing processes.
It's all handled under complianceand then it's expanded.
So this takes weeks, two months even.
And then your question is,are you using the same source?
(11:13):
So after several months you have somethingcalled phenotypic deviation.
And the other way to think about itis that it kind of changes when you take
something from its normal environmentand you put it in a different environment.
It tends to adapt to the new environment.
So how do you guarantee that that productis the same as when you harvested it
in the beginning from the fat tissueor bone marrow or umbilical cord?
(11:37):
So that's important to keep in mindfor stem cells.
Okay.
And so what's the differencewith platelets?
Great question.
So the platelets are a blood based source.
So when you get blood, it'sfrom multiple different donors.
They're near expiration platelets.
So we're not depleting from the sourcethat the patients may need for use.
(11:57):
So when you get these platelets,they're pooled.
So first you take away the outliers.
So people that are poor performers
or super performersand you kind of average them in together
when you kind ofget all the platelets pooled together.
So that's how one way to guaranteethat consistency,
that batch to batch consistencythat we talked about.
(12:20):
So pooled plateletsand they're processed immediately.
So there's no step of going toplatelets are actually cell free already.
So platelets in a wayare kind of exosomes themselves.
They come from a parent cellcalled a mega carrier site,
and that's when the bone marrowand then this just kind of spews out.
So platelets don't have that DNA,they don't have that.
(12:40):
The genetic information that we arewe could be concerned about.
It's not a cell in that in that truecell sense.
So when you take the platelets,you actually disrupt them
and you collect the exosomes that is beingreleased from the platelets. So
and the way to do that is proprietary.
They actually take out
(13:01):
all of the other particlesand then what's left is the exosomes.
So it's sort of like a sievethat they kind of sort of distill down
all of the non exosome productsso that you have exosomes leftover.
Okay, So you know what a little light bulbjust went off and tell me if I'm right.
So essentially when you take
(13:22):
brands like Olivia had stem cell basedexosomes, these are platelets
based exosomes and gosh, it's been a whilesince they took a science class.
But platelets are essentially
what your body releasesin response to inflammation, correct?
Exactly. Yes.
Okay. Okay. Got it. Okay. So amazing.
Okay, got it.So it's actually a different type of cell.
And you brought up a good point.
(13:43):
You know, with the stem cell based ones,they have found in Exosomes DNA and RNA.
Right. Like a lot ofwe have heard these buzz words.
So platelets don't have any of thatinformation in them.
No DNA.
You have a microarray dayswhich are again messengers.
So there post there they are a step downso it's not true genetic material.
(14:04):
So it's just a signaland it's actually a mixed bag of signals
because sometimes we get askedthe question,
what's in the nextis what exactly is composed in there?
What's the message?
It's actually pieces of messageof a lot of different signals
that come togetherand that they say repair or regenerate.
And this is where
the source becomes really keybecause the platelets normally do that.
(14:28):
Like you pointed out, they are the firstresponders to wound healing.
So they naturally have that propensityto regenerate.
I'm going to sites of wound,I'm going to repair this site.
So they they release signals of repair.
So that'swhere that exosome source is important.
Now, you know, I hate to dumb this downbecause you are obviously brilliant, but
(14:52):
is the idea
that essentially an exorcismwill be applied
and tell your own skin cells,the ones that aren't acting
in a reparative mode,Hey, wake up and start doing your job.
Is that kind of what's going on here?
Yeah, I love this question, Amber,because basically what this is,
is disruptive technologies.
There's no product that has been this way.
(15:13):
So if you think about growth factors,peptides, anything else
that you're putting on your skin,they work outside of the cell,
so they're kind of creating messagesoutside Exosomes work inside the cell.
They actually have the capacityto go in and deliver a signal.
So this is really newbecause you think about it as a mechanic.
Instead of working on top of the car,the mechanic is now working under the hood
(15:35):
and that's really where Exosomes come into
play of creating a new wayof working with the cells.
Okay, So
thank you so much for getting into this.
I'm so glad we were able to address
some of the concernsthat people are having.
Let's talk a little bit about thistechnology.
So, you know, from personal experience,I had a scar here
(15:56):
that came from a lasertreatment got wrong.
I had Exosome Microneedlingand the scar healed.
I mean, is basically invisible now.
So I've seen that it can work.
But when we talk about topical skin care,how are we making sure
that those messages are getting to areaswhere we where we need them to go?
(16:18):
Right where we we haven't had a treatmentlike a laser or microneedling
where we have these little channels nowhow does that work?
So here's my question for you,which is that
people have the assumptionthat a topical exosome
product cannot penetrate the skin barrier,but that is incorrect
and that's actually what we have foundin our clinical study.
(16:39):
So when we applied twicedaily application of the plated gold
and we followed these patientsfor six weeks and actually
even up to six months, we saw considerableimprovement in their skin.
But beyond that, at 12 weeks,we biopsied the skin
and we looked underneath the hoodand saw what was happening.
This is where we actually found Exosomes
(17:00):
that have been ableto be identified in the collagen fibrils.
So we're actually getting readyto publish this data soon.
And we submitted our datafor the histology studies,
which is really excitingbecause what we're seeing is that
you can have physiological change,new collagen, new elastin
with just topical application,no microneedling, no lasers,
(17:21):
no adjuvant procedures,this is just topical application.
So part of that is two things.
One is has it been manufacturedappropriately the right way
so that the exosomes are intactbecause you can rupture them
and if you rupture themthen they are no longer
going to be able to produce that signalor share that message.
So manufacturing is key there.
(17:43):
But the second thing that's importantis how the exosome size is.
So the size of the exosomes very,very small.
And we know that the skin can allow
anything less than 500 kill adultsand to penetrate into the skin barrier.
So these are very, very small particlesand they're carried right in, and that's
what our study showed.
(18:05):
So now talk a little bit,because your relationship with plated,
like I said, you work
with the Mayo Clinic,you do clinical trials, right?
Correctly through the Mayo Clinic.
So how did how did you sort ofget involved with plated? Yes.
So this was sort of very fortuitous,
(18:26):
right place at the right time, I would say
I actually cameI thought I was going to be a cardiologist
and like Mayo Clinicto do my medical training with Dr.
Andre Chozick and Dr.
Otto,who are the founders of Plated and Rion.
So they are cardiologistsand I did my Ph.D.
work with them.
And when we were doing the work,we were starting to
(18:49):
we actually focusedin a lot on mesenchymal stem cells,
and we later found that actually plateletsare the ideal source.
So we had a switch from mesenchymal stemcells to platelets, but the Ph.D.
work lend itselfto creating some of the research
that went into the product design and
(19:11):
and then I and I delivered the newsthat I'm going to become a dermatologist
and my cardiologist, advisorsand mentors were happy
because they had come up with a productthat would could be topically applied.
And so part of it is rightplace at the right time.
But I've spent about,I would say, 12 years
learning the science,everything starting from Ph.D.
(19:34):
to to being in dermatologyand then running the clinical trials.
So I've really seen that science evolveand really mature,
and it's been very excitingbecause the shift has really gone
from stem cells to exosomes,which is really self free.
That's, that's, that's what we're hearing.
And despite some of the concerns,which I'm glad we were able to address,
(19:54):
you know, I've talked to a lot of doctorswho who, like I said,
are very supportive of thisand do see these types of results.
So let let's talka little bit about plated,
because there's,I think, three different products.
I've got two of them here.
One is the DailySarah, one is the intense serum.
(20:14):
What are these meant for Who
who were these meant for and what are someof the results that you've been seeing?
Absolutely.
So I can start by kind of sharingwith what we found in our clinical study,
which is that the product really workson a very individualized,
personalized level.
So if you start with greater rednessor greater hyperpigmentation,
that's where it's going to target.
(20:35):
And so this is kind of the holy grail ofhow can one product
do all these different facets of skinaging and skin biology?
Well, it'sbecause you're targeting the root
cause of skin agingand the root cause of damage.
So if you kind of help the body,give it the right signals to repair,
it's going to repair what the damageto the damage that's been there already.
So if it's redness, it targets redness.
(20:56):
If it's brown pigmentation or size of finelines, wrinkles, it targets that.
And we're seeing those changesthat as early as six weeks.
So we use the busiest software to evaluatepatients,
everyone from the age 40 to 85.
So we have a whole big group of patients.
Average age was 54.
Now, the two products that you have there.
(21:18):
So let's talk about how we use it.
So product number one is the plated gold,which is the plated intense.
That's the product that we usedin the clinical study.
So the plated, intense,
applied twice daily
helps repairmoderate to severe photo aging.
So this is really meant for you to use
(21:40):
in the summer timeor with significant sun damage.
So this is going to be targeting thatconsiderable damaged skin, actinic damage,
anything that you know, postlaser like you talked about,
if you have more concernsor even three laser.
So I actually primemy patients with plated gold
before they come in for their CO2ablative laser or another type of laser.
(22:03):
And I say use this product twicedaily for six weeks that primes the skin
and then you're going to get better
results from a CO2 or any other laserthat you're kind of looking into.
So I love that gold for that purpose.
Is this also good?
You know,I mean, now we are in the colder months
when a lot of people are goingfor those laser treatments.
Is this is this what you want to use?
If you've had something like you said,you can prime your skin before,
(22:25):
Would you also use this after?
Absolutely.
We have a product called Plated Calm,which is meant specifically
for post procedure,but those are interchangeable.
And to a certain degree.
So you canif you don't have the come with you,
you can certainly use the plated intensefor that purpose.
I have to tell you.
So, you know, I did the labI used L-O-V-E for quite some time.
(22:48):
And what I noticed for me was a lotmore of the clarity, a lot of the
not that I had very, very red skin,but that's where I noticed
the biggest difference.
But one of the things we were honest aboutwas it had a certain smell.
This does not this is not as
Yes. It's not.
As that.And it does have a really nice texture.
I think I just put it on.
(23:09):
It's kind of like a gel jelly.
But, you know, he talked aboutone of the things that he talked about
when we did this with Dr.
Blues was how hard it is
to keep that shelf stablebecause Exosomes are are fragile.
How have you managed to do thatwith Plated? Yes.
And this is again, goes back to sourcing.
If you are able to isolate the productand are sourced
(23:31):
in a way that the exosomes are stable,you can keep them shelf stable
and and it should last year.
So when the time the productis manufactured, we have up to two years
that it can remain shelf stable for.
But the studiesand if you're using it consistently,
even from the study that we did twice
daily application at six weeks,that takes you through one bottle.
(23:53):
So technically you don't want to have thisin your drawer for too long
because you want to be applying itto get the effect.
But if you if you do have it,it also is okay because of the source,
because of the manufacturingand the way that it is kept intact.
So I kind of do sometimesuse the example of of an egg.
(24:14):
So if you think about an egg and it's
kind of kept at room temperatureand is kept on your counter,
it can it can remain stablebecause the outer shell is intact.
But if you crack that egg,then that egg is immediately not viable.
You have to get rid of itor less than you know.
So that's that goes intothe consideration of
is the exosome outer shell damagedor is it intact?
(24:38):
Okay.
And then we've got the daily serum,so “Calm” is for which I don't have here
is specifically for post-treatment.
But really you could use any of these,but you do have one that's targeted
specifically for post treatment.
What about the daily?
So the DailyI love the daily for two types of users.
One is for our younger patients who areconsidering this prejuvenation concept.
(25:01):
They want to have somethingwhere they're getting ahead of it.
You know, it's a little bitless of two X compared to the four X,
so that the concentration is a little bitless,
it's a little bitmore hydrating in the sense too.
And so you can you can see how that isso beautifully applied.
And it goes on very nicely glides on.
(25:21):
I love this product.
In fact, I recently had a baby and I.
Congratulations.
Thank you.
So plaited
daily has been my go to for my stretchmarks which has worked beautifully.
So that's another area that you knowbecause you can get more spread with it.
So it's it's great for the younger patientand I would even say
(25:42):
the postpartum patient.
That's amazing to hear. And you know what?
I love that you brought that up
because so many things are marketedfor our our face and we think face only.
But yeah, of course,if you've got stretch marks, I'm
sure like post scarring,that wound repair is probably
going to be very beneficial too.
So, you know, we have to mention pricebut I think, you know,
(26:04):
these, these range from what I thinkthis is in the two hundreds. Yes.
And this will be variablebased on your dispenser.
But yes, that's about what we see. Okay.
And then the daily.
It's priced similarly and that's
because you're getting the volumethere is a little bit more.
(26:25):
Yep. Yep.
But both and I was like you said,it should last like six six weeks. Yes.
And if you're consistently applying it.
So the way that I apply,if you start with a goal, so I kind of use
the gold as pulsing because it'sgoing to deliver really good signals.
So you want to pulse
with the gold twice daily for six weeks,then you're going to achieve this
beautiful maximal effect, glowing skin,all the good stuff.
(26:48):
Then you can switch to the dailyand you can go three times a week
or once a day, whatever,to kind of maintain that effect.
And then you can go again with the gold.
And after a month or so.
So just kind of usingthe gold intermittently,
this is for the average user, right?
For for more mature skin, I say just stickwith the gold for younger skin.
(27:09):
I could say stick with the daily,but if you kind of want to,
if you're in the middle and you'rekind of wanting to get a bit of benefits
of both, you can do it that waywhere you kind of pose with the
skin cycle, with the gold or the intense,
and then go back to the dailyfor maintenance.
And you said you're going to be publishingclinical your clinical trials
(27:30):
for the goldwith the Visio before and after.
The we've already publishedthat of the esthetic surgery journal.
So we do have those results out.
We have submitand we also have results for the hand.
So I love that you brought up other areasthat you can treat self
with the back of the hand.
Yeah.
So wewe recently published that study as well
(27:50):
in the Plastic and reconstructive surgeryjournal where you can see
that is has had considerableimprovement in brown spots
especially because it doeshave that antioxidant effect.
So it does both where it kind ofis antioxidant but also builds collagen.
Man, you have to linkto those on the website.
So that's all I'm going to say is
I would say link that out because I thinkthat that is very compelling.
(28:12):
And for people who are looking forthis type of skin care,
the science matters,the research matters, the results matter.
You know, I always tell
people and I'm sure you can say thisas a dermatologist, you have to manage
expectations when it comesto sort of these these miracle creams.
Right. Because I don't know.
(28:34):
Do you agree with me?
I feel like you're never goingto get in a bottle.
What you're going to get from a laser,what you're going to get from a knife.
So manage expectations.
But from what I saw fromsome of the before and after,
they were very compellingin terms of fine lines and wrinkles.
Hyperpigmentationand certainly with redness.
Absolutely.
And I think redness really likeknocked it out of the park,
which is where I have actually replacedmy laser with this product.
(28:59):
The PDF laser, the pulse eye
laser is what I use for my patientswith rosacea or facial redness.
And now what I've done is thatI provide my patients
with the bladed intentsand have them use it after,
and they're just coming inmaybe twice a year for their PDF laser
instead of once every three months.
(29:19):
Amazing.That was going to my next question.
So for people with sensitive skinwith rosacea
is this this is something you'd recommend?
Yes, definitely recommend.
It's not
it wasn't tested for that indication,but we know that redness
considerably improves.
So I love using it for that patientpopulation here.
Great.
And thank you for being specific about,you know, the claims that you can
(29:41):
and cannot make with this.
So what is next now inflated?
Is there are there new exciting thingson the frontier for you?
Yes. So first, I'm very excitedthat the product is the first
and only now of renewableand recyclable products.
So it's a clean brand of the new packagingwhich we'll send to you
(30:04):
is actually uses reusable inserts.
So actually eliminating a lot of the wasteand kind of becoming
the first physician dispense productthat is truly
green initiativeand and hopefully will continue
to inspire other brands to do the same.
So that's very exciting for us.
The second thing is looking at here,so developing a hair scalp serum,
(30:28):
we know that the product is ableto penetrate through the skin.
So you would have the same type of effectsin the hair and we're kind of
getting ready to launch that productthis year.
Very, very exciting.
I want to thank you so much, Doctor Wyles.
If people want to know more about Plated,
if they want to purchase it,where can they go?
They can go to plated skin science
(30:50):
dot com and and get more information.
They can purchase it.
Also, there's several physician officesthat are dispensing the products.
So just ask your local dermatologistand if you can't find it, follow us
on Instagram at plated skin scienceand we'll be able to connect you.
And what about you?
If we want to follow what you're up to,you know,
(31:13):
is there a way that we can do thatmaybe through the Mayo Clinic?
Yes, certainly You can goon the Mayo Clinic and find my profile.
And we definitely do post more informationabout our lab.
We are 3D bioprinting skin.
We're understandingskin cells, senescence.
So there's a lot of exciting things.
You can also follow me on, Dr.
Wyles, w yl e s dot derm on Instagram.
(31:37):
Amazing.
I wantto just thank you so much for your time.
Clearly,you have dedicated your life to this
and I think that you were really ableto shed some light
on some of the confusionthat might be surrounding Exosomes.
I look forward to seeing what'sgoing to happen in this sort of new,
I don't know, the future of skincare.
(31:57):
It's always changing.It's always getting more exciting.
If you at home have any questionsyou want me to pass on to Dr.
Wyles, I'm happy to do so.
You can email me at Hello at ArtBeauty podcast dot com.
You can find us on Facebook, Instagramand YouTube @ArtBeautyPodcast,
and as always,we will see you next Tuesday.
Hopefully just feeling a littlebit more educated. Bye!
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