We discuss a new class of medications, Immune Checkpoint Inhibitors, and their side effects.
Hosts:
Avir Mitra, MD
Brian Gilberti, MD
September 2, 2024
Show Notes
Overview of Immune Checkpoint Inhibitors (ICIs)
- ICIs are a relatively new class of oncologic drugs that have revolutionized cancer treatment.
- Unlike chemotherapy, ICIs help the immune system develop memory against cancer cells and adapt as the cancer mutates.
- Since their release in 2011, ICIs have expanded to 83 indications for 17 different cancers, with approximately 230,000 patients using them.
Mechanism of Action
- Cancer cells can evade the immune system by binding to T cell receptors that downregulate the immune response.
- ICIs work by blocking these receptors or ligands, preventing the downregulation and allowing T cells to proliferate and attack cancer cells.
- Common ICIs
Risks and Toxicities of ICIs
- ICIs can lead to autoimmune attacks on healthy cells due to immune system upregulation.
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