Core IM | Internal Medicine Podcast
Core Internal Medicine via following series: 5 Pearls || Clinically relevant pearls Mind the Gap || Why do we do what we do? Gray Matters || Management Reasoning Hoofbeats || Dissecting clinical reasoning At the Bedside || Explore everyday challenges
Episodes
What went wrong? What were the reasoning or contextual missteps that led us astray?
🔹 Sponsor: NEJM Fellowship Program, click here to learn more and/or apply! Due Aug 1, 2025
🔹 Transcript and Show Notes
Timestamps:
(00:02) | Case Presentation and Initial Diagnosis
(02:47) | Tachycardia and Early Impressions
(04:10) | Clinical Deterioration and New Clues
(07:19) | Problem Representation and Reflection
(21:45) | Lessons on Reasoning and Bi...
- Imaging Pearls | (01:12)
- Deciding on Thoracentesis | (04:00)
- Light’s Criteria and Pseudoexudates | (07:00)
- Pleural Fluid Studies: pH and Cell Differential | (16:56)
- Diagnosing and Treating Parapneumonic Effusions | (23:32)
- Malignant Pleural Effusions: Diagnosis and Management | (30:39)
🔹 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion
Use the code "CORE25" for 25% off: https://www.coreimpodcast.com/MKSAP
Listen for some good laughs and relatable stories!
In this episode, we share raw and real stories from July — from rapid responses to unexpected kindness — and reflect on the emotional weight of starting out in medicine.
🔹 Sponsor: NEJM Fellowship Program, click here to learn more and/or apply! Due Aug 1, 2025
Prior July Stories:
July Stories 2.0 (2023)
July Stories (2019)
Timestamps:
(00:32) | Dr. Ali Trainor...
How much do beta blockers help after a heart attack, even when the heart’s pumping well? In this episode, we revisit the origins of beta blockers in post-MI care, examine how evidence evolved, and explore the REDUCE-AMI trial, which questions whether beta blockers are still needed for all.
Listen to this latest episode of Beyond Journal Club, a collaboration between Core IM and NEJM Group, where we put research into context tracing ...
🔹 What is invasive fungal disease, and who is most at risk for developing invasive fungal disease? (~ 02:46)
🔹 What are the main classes of fungi? (~11:35)
🔹 What are the pros and cons of B-D Glucan and Galactomannan (~19:16)
🔹 How to increase the yield of blood cultures? How to interpret yeast growth in sputum/BAL and urine cultures? (~ 30:42)
🔹 How is invasive fu...
🔹What are clinically relevant limitations of an A1c vs. a CGM (1:40)
🔹What do the different parts of the ambulatory glucose profile tell you? (09:59)
🔹What are common pitfalls, medications, lifestyle patterns that are important to ask your patient about when seeing them for a visit to manage blood sugar? (15:19)
🔹 How can you titrate insulin based on when you see the hypoglycemia on the ambulatory glucose profile (20:00)
🔹 When th...
🔹When is an U/S vs. CT vs. MRI helpful before consulting Interventional Radiology?
🔹What factors go into an IR pre-op evaluation?
🔹 When do drains go in, and when do they come out?
🔹 When a patient has trouble with a drain, what are things you can do before calling IR?
🔹 What does outpatient IR follow up entail, and what does a capping trial of PCN tubes entail?
📌 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion
🔹 High-yield reversible causes of constipation? (02:26)
🔹 Which type of fiber is more helpful? And is more hydration really better? And bulk-forming laxatives (9:03)
🔹 Osmotic vs Stimulant Laxatives (15:06)
🔹 Suppositories and enemas? (25:39)
🔹Best practices with opioid induced constipation (34:05)
📌 Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is H...
How good are we at preventing HIV? How do efficacy and effectiveness differ? We journey from oral pre-exposure prophylaxis (PrEP) to long-acting injectables, and then to the PURPOSE trials, which look at the use of long-acting lenacapavir as PrEP — a potential game-changer in the field of HIV.
Listen to this latest episode of Beyond Journal Club, a collaboration between CoreIM and NEJM Group, where we put research into context, tell...
What does Lipoprotein(a) tell us that a standard lipid panel doesn’t? Should we be testing everyone for it? Dive into the genetics, clinical implications, and evolving management strategies for Lp(a). Learn how to interpret results, counsel patients, and navigate topics with limited data like aspirin and PCSK9 inhibitors in treatment.
🔹 Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learn...
A new way to think of clots beyond provoked vs. unprovoked: Learn all about how important it is to think about reversibility! What patient states affect the inherited thrombophilia testing? Learn the nuances and practical approaches!
🔹 Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant!
What is the impact of microplastics on human health? How can we use observational data to support the argument that microplastics may lead to poor health outcomes?
Join us as we tackle these questions and discuss the APAChE study on microplastics and cardiovascular disease on this episode of Beyond Journal Club, a series brought to you by Core IM in collaboration with NEJM Group.
What is the last sense to go? How can music create connection, ease anxiety, and help process emotions at the end of life? Join Dr. Jafar Al-Mondhiry, Dr. Harry Han, and music therapist Bryanna Tobin as they explore the power of music therapy in hospice care, sharing moving stories and clinical insights.
🔹 This episode is also sponsored by Factor! Get fresh, ready-made meals delivered to your door. Use the code factorpodcast for a ...
Incidental fibrosis on CT —what now? What does prone imaging tell you? Is it fibrosis, aspiration, or atelectasis? And once you diagnose ILD, does the “alphabet soup” really matter for treatment? Antifibrotics vs. immunosuppression?
Plus, how do we bridge the gap when social barriers make care unsafe?
🔹 This episode is also sponsored by Factor! Get fresh, ready-made meals delivered to your door. Use the code factorpodcast for a spec...
SPEP vs. UPEP? What does it tell you and not tell you? What is the role for immunofixation and free light chains in diagnosis? Learn about paraneoplastic antibodies with MGCS and its renal, neurologic, and dermatologic manifestations!
Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant!
Use the code CORE50 to get 50% off your first month with F...
How do you differentiate immune checkpoint inhibitor-related adverse events aka IrAEs from other conditions like infection? Join as we go through pneumonitis, colitis, dermatitis and endocrinopathies due to immune checkpoint inhibitor toxicity!
Sponsor:
- Interested in integrating Glass AI into your EMR? Reach out to enterprise@glass.health.
- Use code "C...
YouTube Videos
- Anion Gap Metabolic Acidosis: https://youtu.be/oE0lygmMANM
- Inhaler Delivery Systems: https://youtu.be/yYPdjClm9Bg
- Iron Deficiency in Pregnancy https://youtu.be/xTzYSXUbLsc
Subscribe to Core IM’s YouTube Channel for more behind the scenes, whiteboard animations and more!
Timestamps:
01:27 | Anion Gap Metabolic Acidosis (Dr. Nick Villano)
02:52 | Inhaler Delivery Systems (Dr. Allie Sheridan)
04:44 | IDA in Pregnan...
What’s the evidence been for the use of PPIs in mechanically ventilated patients? What do more recent studies reveal about PPIs and possible harmful side effects of aspiration pneumonia and C. difficile colitis? To find out, tune into the second season of Beyond Journal Club, a series brought to you by Core IM in collaboration with NEJM Group.
Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed...
Why are we missing peripheral arterial disease (PAD)? How is it diagnosed using the Ankle-Brachial Index (ABI)? What treatments improve symptoms and reduce cardiovascular risks? When should revascularization be considered?
Behind The Scenes YouTube Interview
Subscribe to Core IM’s YouTube Channel for more behind the scenes, whiteboard animations and more!
Timestamps:
(02:23) | PEARL 1: When to suspect PAD? Ris...
How is TPN and PPN similar and how is it different? When should each be used? How does bacterial overgrowth lead to complications? Does TPN cause diarrhea?
Behind the Scenes Youtube Interview
Subscribe to Core IM’s YouTube Channel for more behind the scenes, whiteboard animations and more!
Timestamps:
(01:35) | PEARL 1: Basics of PN: What makes up parenteral nutrition?
(06:54) | PEARL 2: Indications and Contrai...
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