Små pusfyldte blærer breder sig på hele kroppen som et tydeligt tegn på, at de livsfarlige kopper har slået til. Sygdommen dræber i flæng – og overlever man, er man vansiret for livet. Kopper er ikke kun en frygtet sygdom – den bruges også som våben i mod stærke fjender. En årvågen engelsk landmand opdager i slutningen af 1700-tallet noget, der skal vise sig at redde utallige og heriblandt tusinder af danske liv
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