humanOS Radio

humanOS Radio

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Episodes

Why do so many people struggle to stick to a healthy lifestyle? Health-related goals are largely the product of long term modifications to how we live. And we generally don’t see an immediate payoff from these individual choices, at least not in the moment. To paraphrase James Clear, it is only after your efforts have compounded over time that you start to see the payoff of these behaviors, for better or for worse. But therein ... Read more

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All of us have heard the aphorism, “Let food be thy medicine, and medicine be thy food.” This maxim, of course, is usually attributed to ancient Greek physician Hippocrates. However, if you’ve ever spent time looking at health-related content on Twitter and Instagram, you’ll realize that conflating diet and medicine is a modern phenomenon. We like to think of certain foods and combinations of foods as exerting drug-like effects. ... Read more

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On this episode of humanOS Radio, we welcome Aly Orady - founder and CEO of Tonal - to the show. Aly’s story is an all too common example of the price of success in the modern world. Aly was excelling professionally, but in the process his health was falling apart. He was overweight, and had developed type 2 diabetes and sleep apnea. And he was only in his mid-thirties. He was moving on a dangerous path, and he knew it. Realiz... Read more

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Light is essential to life as we know it. Plants rely upon sunlight to generate chemical energy, which is stored in their tissues and fuels various life processes. In turn, animals like us convert the energy from the food that we eat into mechanical energy. Given its fundamental role in our biology, perhaps it makes sense that specific types of light are connected to our health in some surprising ways, which research is only just... Read more

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Insomnia is a uniquely vexing medical problem. It is the most common sleep-related issue, thought to affect around 10-40% of the population in the US. So it is a challenge that affects a whole lot of us. Yet despite its prevalence, treatments for the condition are lackluster at best. Why is this the case? Perhaps because it remains poorly understood. Insomnia has been known and documented for thousands of years, but it has proven ... Read more

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On this episode of humanOS Radio, I welcome Nicola Bondonno to the show. Her research has been examining the effects of bioactive compounds occurring naturally in plant-based foods and beverages, and how they are linked to the cardiovascular health benefits associated with a plant-rich diet. It has become axiomatic that fruits and vegetables are protective against disease. Humans have intuitively recognized the link between edible... Read more

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On this episode of humanOS Radio, I welcome Daniel Gartenberg to the show. Dan has dedicated his life to helping people sleep better (a calling that we here at humanOS can certainly relate to). Daniel has a Ph.D in Human Factors and Applied Cognition from George Mason University, and is an adjunct assistant professor at Penn State University. He has conducted grant-funded research from the National Science Foundation and the Nati... Read more

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In this episode of humanOS Radio, Dan speaks with Sander Kooijman. Sander is a post-doctoral researcher at Leiden University Medical Center, where he is investigating brown adipose tissue activation as a therapeutic target to attenuate obesity, type 2 diabetes, and atherosclerosis in humans. He and his colleagues recently published a paper examining how light exposure and environmental temperature affect measures of glucose and li... Read more

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In this episode of humanOS Radio, I speak with Pamela Maher. Dr. Maher has a Ph.D. in biochemistry from the University of British Columbia. She was formerly an associate professor at The Scripps Research Institute in La Jolla. In 2004, she moved to her current position as a research scientist at the Salk Institute for Biological Studies. Her research has centered on understanding responses of nerve cells to oxidative stress, and h... Read more

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In this episode of humanOS Radio, I speak with Javier Gonzalez. Dr. Gonzalez is a professor at the Department for Health at the University of Bath in the UK. He and his colleagues recently published a hypothesis suggesting that carbohydrate availability plays a key role in the regulation of energy balance, and explains both why exercise increases hunger and (paradoxically) why people who are highly active exhibit better appetite re... Read more

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We live in an era of unprecedented access to information. Technology has endowed us with the ability to immediately retrieve whatever we want to see or whatever we want to read, just by tapping on a screen a few times. Perhaps even more importantly, we have never had so much immediate access to one another, even when we are very far away. In turn, other people - as well as our devices - have the ability to reach out to us and seize... Read more

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In this episode of humanOS Radio, I speak with Scott Byrne. Scott is a professor at the University of Sydney School of Medicine. He is a cellular immunologist who is studying how the ultraviolet part of the solar spectrum activates regulatory pathways that result in immune suppression and tolerance. When Scott and his team were investigating skin cancer development in mice, they happened to notice that mice receiving ultraviolet ... Read more

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On this episode of humanOS Radio, we welcome Pankaj Kapahi to the show. Pankaj is a professor at the Buck Institute, an independent biomedical research institute that is devoted solely to research on aging. He and his team have begun to investigate the role of advanced glycation end products (also known as AGEs) in the aging process. Advanced glycation end products are compounds that are formed when proteins or lipids become glyc... Read more

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On this episode of humanOS Radio, I talk with Dan Siegel. Dr. Siegel is a clinical professor of psychiatry at the UCLA School of Medicine, and is the founding co-director of the Mindful Awareness Research Center at UCLA. He is a pioneer in a field known as interpersonal neurobiology (sometimes referred to as relational neuroscience). Interpersonal neurobiology characterizes human development and function as a product of interaction... Read more

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Why do we sleep? This is a question that has bedeviled researchers for decades. But we think one major reason may be to facilitate DNA repair. In this episode of humanOS Radio, I speak with Lior Appelbaum. Dr. Appelbaum and colleagues have performed some elegant studies elucidating the molecular mechanisms that underlie sleep, using zebrafish as a model organism. In a recent study, the team engineered zebrafish larvae to expres... Read more

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On this episode of humanOS Radio, we welcome Ben Miller to the show. Ben is a principal investigator in the aging and metabolism research program at the Oklahoma Medical Research Foundation. In his study, Miller and his team randomly assigned 53 participants to consume either placebo or metformin for 12-weeks, while completing a supervised aerobic exercise program. This exercise regimen elicited measurable improvements in blood s... Read more

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On this episode of humanOS Radio, I speak with Richard Lin. Like all too many of us, Richard became personally invested in his health when he developed a problem that failed to respond to conventional medical interventions. He eventually realized that a disruption in the gut microbiota was the likely cause of his illness. This inspired him to start Thryve Inside. Thryve helps consumers test and learn about their own microbiota by ... Read more

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We associate getting older with a loss of energy. On the molecular level, this is quite literally true, because one of the hallmarks of aging is mitochondrial dysfunction. Mitochondria are often referred to as “the powerhouse of the cell,” because they convert nutrients from the food we eat into usable energy, in the form of ATP. But as we age, mitochondria become less effective at generating the energy we need for various chemical... Read more

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We tend to think of age in terms of the number of years we have been alive - meaning our chronological age. But the year that you were born is not necessarily an accurate measure of your health or your life expectancy. We are coming to realize that a better predictor is your biological age - and that can be quite different from your chronological age. So how do you learn your biological age? And what can you do with this informatio... Read more

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In this episode of humanOS Radio, I speak with John Newman. Dr. Newman is a geriatrician (a physician who specializes in the care of older people) at UCSF, as well as a professor at the Buck Institute for Research on Aging. He is chief investigator at the Newman Lab, where he is exploring ways to harness metabolic signals to promote health and resilience, particularly in older adults. Dr. Newman’s research focuses predominantly on... Read more

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