MDedge Cardiocast

MDedge Cardiocast

MDedge Cardiocast is the weekly podcast from Cardiology News. The information in this podcast is provided for informational and educational purposes only.

Episodes

December 27, 2019 7 min

ISCHEMIA trial hailed as practice changing
The largest-ever RCT of initial invasive versus conservative management of stable ischemic heart disease makes waves.

DAPA-HF: Dapagliflozin’s HFrEF efficacy confirmed in nondiabetics
Further analyses from the DAPA-HF trial showed dapagliflozin cut death and heart failure events in HFrEF patients with no diabetes.

Colchicine cut post-MI CVD events
Colchicine fulfilled the promise first ...

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Vascepa approved for cardiovascular risk reduction
The FDA’s decision on cutting events in high-risk patients was based primarily on the REDUCE-IT trial.

ENGAGE AF-TIMI: Insulin linked to greater risk for stroke, CV death, bleeding
Novel oral anticoagulants may be preferred over warfarin in patients with diabetes and AFib.

HHS drug importation proposals aim to address high costs
Trump administration drops key health care proposa...

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Women have fewer cardiovascular events after non–ST-segment elevation ACS
But they also remain undertreated with guideline-directed therapies.

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FDA panel rejects vernakalant bid for AFib cardioversion indication
Eleven years after the first attempt of the antiarrhythmic agent, the FDA pan...

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Icosapent ethyl cost effective in REDUCE-IT analysis
Treatment with the fish-derived drug Vascepa for CV event reduction is more effective and less costly than placebo.

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DAPA-HF: Dapagliflozin benefits regardless of age, HF severity
The SGLT2 inhibitor had similar efficacy in the elderly ...

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November 29, 2019 43 min

This week’s Cardiocast is devoted entirely to Card Talk with cardiologist brothers Jim and Jerry Dwyer. They welcome two structural interventionalists at the Structural Heart and Valve Center at Emory Healthcare, Kendra J. Grubb, MD, and Isida Byku, MD. Both followed a unique track, training in both cardiac surgery and interventional cardiology and practicing in the fast-moving field of structural heart disease.

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In this special meeting edition of the Cardiocast, MDedge Cardiology editor Catherine Hackett is joined by MDedge reporters Mitchel L. Zoler, Bruce Jancin, and Richard Mark Kirkner. 

The MDedge cardiology team reviews three big stories from the 2019 annual scientific sessions of the American Heart Association in Philadelphia. 

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ISCHEMIA trial hailed as practice changing

The largest-ever RCT of initial invasive versus conservative management of stable ischemic heart disease makes waves.

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DAPA-HF: Dapagliflozin’s HFrEF efficacy confirmed in nondiabetics

Further analyses from the DAPA-HF trial showed dapagliflozin...

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Getting high heightens stroke, arrhythmia risks

Cannabis use or abuse among the young was associated with adverse cardiovascular consequences in two studies.

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Bempedoic acid cuts LDL by 15% in patients with high levels despite maximal treatment

CLEAR Wisdom may fill a niche for patients who...

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Closing the missing link between childhood risk factors and adult cardiovascular outcomes

Prescient childhood cohort studies launched in the 1970s are paying off. 

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Metabolic signs of adult diabetes apparent in very young children

Disturbed HDL cholesterol metabolism may be one of the earliest fe...

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Patients frequently drive too soon after ICD implantation

Many patients didn’t recall ever receiving instruction about when to drive again.

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One-third of CVD disease in blacks linked to hypertension

A large analysis suggests intervention throughout all ages could have substantial impact.

Cancer ...

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Strong showing for TAVR after 5 years in PARTNER 2A
Transcatheter and surgical aortic valve replacement had similar rates of death or disabling stroke.

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Patiromer allows more CKD patients to continue on spironolactone
After 12 weeks, 86% of the patiromer patients remained on spironolactone...

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MDedge reporters discuss the latest in practice-changing data from the 2019 annual congress of the European Society of Cardiology in Paris.

Join Mitchel L. ZolerBruce JancinKari Oakes, and MDedge Cardiology editor Catherine Hackett as they discuss what they reported from the annual meeting.

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Statin use linked to risk of skin and soft tissue infections

Use of statins was associated with increased risk of SSTIs at an average of 91, 182, and 365 days.

Rivaroxaban trends toward higher thrombotic risk than vitamin K antagonists in APS

Patients who took rivaroxaban experienced almost two times as many thrombotic events as patients who took dose-adjusted vitamin K antagonists.

HHS floats Stark/anti-kickback revisions to su...

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Novel cardiac troponin protocol rapidly rules out MI

Three-quarters of patients who presented with suspected acute coronary syndrome were safely discharged from ED without hospital admission.

Study questions preemptive TEVAR for extended type A dissections

Interim results from a single-center study show that preemptive TEVAR may not be necessary for type A aortic dissections.

TAVR, SAVR share same infective endocarditis risk

Be ...

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Smoking and inactivity are the most powerful lifestyle risk factors after an MI

Insufficient activity beats out obesity or above-target LDL cholesterol.

Ticagrelor monotherapy tops DAPT for high-risk PCI patients

TWILIGHT findings support move to shorter dual-antiplatelet therapy.

Panel releases guidelines for red meat, processed meat consumption

"This assessment may be excessively pessimistic; indeed, we hope that is the ca...

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Cardiology dead last as women’s IM subspecialty choice

Women in internal medicine residencies were more likely than men to report that they had never considered cardiology as a career choice.

Beta-blockers effective, safe for HFrEF with renal dysfunction

Their role is solidified for essentially all such heart failure patients, regardless of their renal function.

Heart failure score derived from machine learning predicts risk in ...

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Prasugrel bests ticagrelor in ACS in surprise findings

ISAR-REACT 5 was the first-ever direct head-to-head look at two potent P2Y12 inhibitors in this setting.

European cholesterol guidelines push LDL targets below 55 mg/dL

PCSK-9 inhibitors are elevated to a top-tier recommendation in very-high-risk patients.

Drug doses for heart failure could possibly be halved for women

Women reached the highest level of drug efficacy at half...

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MDedge reporters discuss the latest in practice-changing data from the 2019 annual congress of the European Society of Cardiology in Paris. 

Join Mitchel L. Zoler, Bruce Jancin, Kari Oakes, and MDedge Cardiology editor Catherine Hackett as they discuss what they reported from the annual meeting. 

 

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We introduce a brand new format with Jerome Dwyer, MD, brother of our host, Jim Dwyer, MD, for a new segment that we're calling 'Card Talk' where Dr. Jim and Dr. Jerry talk about the current clinical state of cardiology and take a peek into the future. 

This week in cardiology news:

  • Survival at ‘overweight’ BMI surpasses ‘normal’
    Data from more than 142,000 middle-aged people worldwide show those with a BMI of 25-29 ou...
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    DAPA-HF results transform dapagliflozin from antidiabetic to heart failure drug

    Proof that dapagliflozin significantly helped heart failure patients without diabetes recategorizes the drug as a major agent for treating heart failure.

     

    New hypertension cases halved with community-wide salt substitution

    Social marketing principles achieved near-universal salt replacement, village by village, in rural Peru.

     

    Ticagrelor: Mod...

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