MDS Podcast

MDS Podcast

Stay up to date on novel, clinically-relevant research findings in Parkinson's disease and other movement disorders. Each episode of the International Parkinson and Movement Disorder Society podcast discusses a relevant development in the field, including highlighted journal articles and interviews with the authors.

Episodes

Myoclonus Series: Myoclonus dystonia: Motor & non-motor symptoms and the effect of DBS

June 16, 2025
Prof. Marina de Koning-Tijssen interviews Prof. Kathryn Peall about her expertise on a topic that lies at the heart of her work: Myoclonus dystonia. We’ll hear her insights on both the motor and non-motor challenges faced by patients, and how deep brain stimulation is reshaping treatment possibilities.
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Genetic testing in deep brain stimulation for Parkinson's disease

June 6, 2025
In this episode, we explore the role of genetics and genetic testing in the decision-making and outcome of deep brain stimulation in Parkinson's disease with two experts in the field: Dr. David Arkadir and Dr. Saar Anis. This interview is also available in the text format within the MDS Scientific Issues: Read the issue
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Special Series: Is propriospinal myoclonus a functional movement disorder?

June 2, 2025
In this episode, Prof. Marina de Koning-Tijssen interviews Prof. Mark Edwards. Together they delve into both the clinical and electrophysiological aspects of propriospinal myoclonus, and explore the distinguishing features and current treatment options for functional movement disorders.
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SCA3 & life in the countryside: Exploring the interplay between genetics and environment

May 27, 2025
Dr. Sarah Camargos talks with Prof. Laura Bannach Jardim about how rural living might influence the age at onset of Machado-Joseph disease. Read the article.
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Special Series: Differential diagnosis of myoclonus

May 19, 2025
Prof. Marina de Koning-Tijssen interviews Dr. Christos Ganos on the differential diagnosis of myoclonus. Dr. Ganos explains how he distinguishes between jerky movements based on clinical history and examination, and discusses the differential diagnosis across various parts of the body.
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Special Issue: Intraventricular infusion of anaerobic dopamine

May 12, 2025
Dr. Hugo Morales Briceno interviews Prof. David Devos from the University of Lille, France, about the results of the phase 1/2 clinical trial using intracerebroventricular anaerobic dopamine in Parkinson’s disease with L-dopa-related complications. Read the article.
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Special Series: Electrophysiology with a focus on cortical myoclonus

May 5, 2025
Prof. Marina de Koning-Tijssen interviews Professors Anna Latorre and Shabbir Merchant on the topic of electrophysiology, with a focus on cortical myoclonus. Together they discuss the potential applications of electrophysiology for myoclonus in clinical practice. They also explore the complex interface between cortical myoclonus and epilepsy.
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What can the locus coeruleus tell us about cognition in Lewy body disorders?

April 28, 2025
Dr. Michele Matarazzo interviews Prof. Irena Rektorová about her recent study on early changes in the locus coeruleus in mild cognitive impairment with Lewy bodies. Using neuromelanin-sensitive MRI, the study reveals selective vulnerability of the caudal locus coeruleus and its association with specific cognitive and other nonmotor features. The conversation explores the implications for early diagnosis, the “body-first” hypothesis...
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Special Series: Myoclonus new classification & treatment

April 21, 2025
Prof. Marina de Koning-Tijssen interviews Prof. John Caviness on the topic of myoclonus, focusing on its new classification and treatment. They discuss the long-awaited recently published classification of myoclonus and explore the latest treatment options.
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Celebrating the Parkinson's community

April 11, 2025
On this special World Parkinson’s Day episode, Dr. Michele Matarazzo is joined by John Dean—speech-language pathologist and Chair of the MDS Allied Health Professionals Group—to explore the essential roles of care partners, allied health professionals, and the broader Parkinson’s community. From physiotherapists to family members, we shine a light on the many people who support those living with Parkinson’s disease every day. Worl...
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Gender differences in DBS decision making

April 7, 2025
Dr. Sara Schaefer discusses with Dr. Michelle Fullard the similarities and differences in how men and women with Parkinson's disease approach the decision of whether or not to undergo deep brain stimulation. Read the article.
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Special Issue: GLP-1 agonists in Parkinson’s disease: New evidence, new questions?

March 31, 2025
In this episode, Dr. Michele Matarazzo interviews Prof. Tom Foltynie about the recently published phase 3 clinical trial of exenatide as a disease-modifying therapy for Parkinson’s disease in The Lancet. While the findings were disappointing, ongoing post-hoc analyses aim to understand the discrepancy with previous phase 2 results and explore how they might shape the future of exenatide and other GLP-1 agonists in neurodegenerative...
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Mitochondrial DNA copy number: A potential biomarker for Parkinson's disease progression

March 24, 2025
Prof. Sarah Camargos interviews Prof. Sun Ju Chung about his recent paper in the Movement Disorders Journal investigating diagnostic and prognostic capabilities of measuring blood mitochondrial DNA copy number (mtDNA-CN) for Parkinson’s disease.
Journal CME is available until March 3, 2026 Read the article.
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tDCS for Tourette syndrome

March 17, 2025
Dr. Sara Schaefer and Dr. Davide Martino discuss his recent paper exploring the use of transcranial direct current stimulation over the supplementary motor area for the suppression of tics in patients with Tourette Syndrome. Read the article.
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Are hyposmia and REM sleep behavior disorder reliable indicators of Lewy body pathology?

March 10, 2025
There is an important role for cost-effective clinical biomarkers in the diagnosis of Parkinson's disease. Dr. Eduardo de Pablo-Fernández and Dr. Cecilia Tremblay discuss how accurate hyposmia and REM sleep behavior disorder can predict Lewy pathology in a non-selected population using data from the Arizona clinicopathological study on Aging and Neurodegeneration. Read the article.
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Combined habit reversal and acceptance and commitment therapies for tics

March 3, 2025
Dr. Jennifer Eisenhauer joins Dr. Sara Schaefer to discuss her recent article describing a combined therapy approach for adult patient with tics: habit reversal therapy (HRT) + acceptance and commitment therapy (ACT). They further discuss what these therapies are, their effect in tics, what is gratifying about working with patients with tics, and next steps to determine efficacy of this approach. Read the article.
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Immune, metabolic and tau markers in blood cells in progressive supranuclear palsy

February 24, 2025
Dr. Eduardo de Pablo-Fernández and Dr Tommaso Schirinzi discuss the results of his study evaluating markers of immune response, metabolism, inflammatory regulation and tau levels in blood cells in patients with progressive supranuclear palsy (PSP). They also discuss how these results contribute to the growing evidence of neuroinflammation contributing to the pathogenesis of PSP.
Journal CME is available until October 21, 2025...
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Focused ultrasound for cervical dystonia

February 17, 2025
Dr. Shiro Horisawa discusses the latest clinical trial results on MR-guided focused ultrasound pallidothalamic tractotomy for cervical dystonia. He explores the technique's limitations, future prospects, and how it compares to existing therapeutic options. Read the article.
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Hot Topic: Subcutaneous levodopa infusion

February 10, 2025
Dr. Hugo Morales Briceno interviews Prof. Ray Chaudhuri to discuss the real world-use of levodopa subcutaneous infusion in patients with Parkinson's disease.
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Vibrotactile foot stimulation for freezing of gait

February 3, 2025
Dr. Chan joins the podcast to discuss the results of their pilot study with Dr. Eduardo De Pablo-Fernández. The study uses a foot vibrotactile stimulation as an external cue for the treatment of freezing of gait in Parkinson's disease. Together they discuss how vibrotactile devices can be implemented in clinical practice. Read the article.
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