MDS Podcast

MDS Podcast

Stay up to date on novel, clinically-relevant research findings in Parkinson's disease and other movement disorders. Each episode of the International Parkinson and Movement Disorder Society podcast discusses a relevant development in the field, including highlighted journal articles and interviews with the authors.

Episodes

What you missed: MDS Congress Day 4

October 9, 2025
The last full day of the #mdscongress was full of exciting sessions and events. Dr. Laura Silveira-Moriyama shares her excitement about the keynote speaker, updates on disease modifying clinical trials, and of course, the crowd pleasing MDS Video Challenge.
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What you missed: MDS Congress Day 3

October 8, 2025
Dr. Huw Morris discusses the session highlights from #mdscongress day three, which included a plenary session on protein aggregation clearance, movement disorder grand rounds, and several exciting oral platforms.
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What you missed: MDS Congress Day 2

October 7, 2025
Prof. Francesca Morgante breaks down the second day of the #mdscongress which included the presidential lectures, junior awardees, and several enlightening teaching sessions.
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What you missed: MDS Congress Day 1

October 6, 2025
An eventful first day of the 2025 #mdscongress has come to a close. Listen here as Dr. Davide Martino reviews the events and interesting scientific sessions for those near and far. Don’t miss out!
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Junior Awardee: Mitochondrial and oligodendrocytic processes in MSA | Congress 2025

September 29, 2025
Dr. Eduardo de Pablo-Fernández interviews one of the 2025 Junior Awardees, Dr. Lydia Chougar about her work combining neuroimaging with transcriptomics and PET maps to elucidate the biological underpinnings of structural abnormalities in multiple system atrophy.
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Junior Awardee: Identifying a subthalamic nucleus cell subtype responsible for motor benefit in a Parkinsonian mouse model | Congress 2025

September 29, 2025
Dr. Mitra Afshari chats with Dr. Jung Hawn Shin, one of this year’s MDS Congress Junior Awardees. Together they discuss his career path and what lead him to studying, and ultimately deciphering specific neuronal cell-types within the subthalamic nucleus (STN) that could be responsible for anti-parkinsonian motor benefits, and potentially non-motor side effects, of stimulation using optogenetic technology in Parkinsonian mice.
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MDCP Research Article of the Year: Are hyposmia and REM sleep behavior disorder reliable indicators of Lewy body pathology?

September 22, 2025
There is an important role for cost-effective clinical biomarkers in the diagnosis of Parkinson's disease. Dr. Eduardo de Pablo-Fernández and Dr. Cecilia Tremblay discuss how accurate hyposmia and REM sleep behavior disorder can predict Lewy pathology in a non-selected population using data from the Arizona clinicopathological study on Aging and Neurodegeneration. Read the article.
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MDCP Review of the Year: Why should subacute sclerosing panencephalitis be on our radar?

September 22, 2025
This year’s MDCP Review Article of the Year covers the spectrum of movement disorders associated with subacute sclerosing panencephalitis (SSPE). Dr. Sarah Camargos interviews Dr. Charulata Sankhla on her team’s findings and why she believes movement disorder specialists should be aware of this measle-associated complication. Read the article.
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Presidential Lecture Awardee: Holistic conceptualization of patients with chronic illness | Congress 2025

September 15, 2025
Prof. Mark Edwards, the awardee for the 2025 Stanley Fahn Lecture Award, discusses his work and interest in the neurology-psychiatry continuum as it relates to the care of patients with chronic neurological diseases, including functional neurological disorders.
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Presidential Lecture Awardee: A career observing the brain in action | Congress 2025

September 15, 2025
Dr. Jon Stoessl looks back on his distinguished career in neuroimaging, highlighting the discoveries that have advanced our understanding of Parkinson’s disease and related conditions. In this conversation, he reflects on the evolution of imaging technologies, the challenges of interpreting complex data, and the lessons learned throughout his journey. His recognition with the David Marsden Lecture Award underscores the lasting impa...
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Decoding epilepsy dyskinesia syndrome: Clinical clues and genotypic spectrum

September 8, 2025
In this episode, we dive into the world of epilepsy dyskinesia syndrome (EDS) with our guest, Dr. Darius Ebrahimi-Fakhari. Listen as he unpacks the findings from one of the largest multinational studies to date, involving over 600 patients across 25 countries. Read the article.
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Hot Topic: Normal pressure hydrocephalus - Assessments for intervention, outcomes, and future directions

September 2, 2025
In the third and final episode of the normal pressure hydrocephalus (NPH) Hot Topic series, Dr. Sara Schaefer speaks with Dr. Joachim Krauss about the assessment of patients with NPH for neurosurgical intervention, outcomes data, and his vision for the future of NPH research and clinical care.
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Hot Topic: Normal pressure hydrocephalus - Pathophysiology and controversies

August 25, 2025
In this second episode of the Hot Topic series on normal pressure hydrocephalus, Dr. Sara Schaefer discusses with Dr. Alfonso Fasano the pathophysiological theories behind NPH, co-pathology in this population, and controversies surrounding the disease.
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Hot Topic: Normal pressure hydrocephalus - Clinical aspects and differential diagnosis

August 18, 2025
In this first episode of the Hot Topic series on normal pressure hydrocephalus, Dr. Sara Schaefer discusses with Dr. Mats Tullberg the symptoms of NPH, examination techniques and pearls, imaging findings, and the differential diagnosis.
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The cholinergic contribution to freezing of gait in Parkinson’s disease

August 11, 2025
In this episode, host Dr. Michele Matarazzo interviews Dr. Nicolaas Bohnen about his team’s recent study using FEOBV PET to investigate cholinergic deficits in Parkinson’s disease patients with dopa-unresponsive freezing of gait (FOG). The results reveal a distinct pattern of cortical cholinergic denervation that may underlie this challenging and poorly treatable symptom. Dr. Bohnen discusses the implications for subtyping FOG, the...
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The longest prospective study of pallidal DBS for isolated dystonia

August 4, 2025
Dr. Mitra Afshari interviews Drs. Patricia Krause and Andrea Kühn on the results of a 10-year prospective follow-up study of a multicenter trial of GPI-DBS in isolated generalized and segmental dystonia. Together they discuss motor, non-motor, and safety outcomes, as well as the strong and stable long-term improvements in dystonia from pallidal DBS. Further, they provide their expert insights on the common themes with respect to tr...
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Neurotrophic factors to restore dopaminergic terminals in Parkinson's disease: A viral vector-delivered genetic therapy

July 28, 2025
Could gene therapy with neurotrophic factors help restore dopaminergic terminals in Parkinson’s disease? Dr. Michele Matarazzo speaks with Dr. Amber Van Laar about her team’s Phase 1b trial of AAV2–GDNF gene therapy delivered directly to the putamen. They discuss the preclinical evidence for GDNF, how advanced delivery techniques and higher putamen coverage may overcome past challenges, and the encouraging early results in moderate...
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Do social workers play a role in preoperative evaluation for DBS?

July 21, 2025
Nicole Duff and Dr. Amanda Currie discuss the potential role of the social worker in deep brain stimulation (DBS) and the work of Dr. Currie’s team in creating a simple pneumonic that could be used to determine whether a social worker's involvement would be beneficial to DBS patients. They also discuss the clinical implications of this study as well as possible future directions to further outline the role of the social worker in D...
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Surprise neuropathological findings in LRRK2 mutation carriers

July 14, 2025
Mutations in LRRK2 are a common cause of familial and sporadic Parkinson’s. Though clinical features resemble typical PD, about half of cases lack Lewy pathology. Doctors Hiroaki Sekiya and Nanna Møller Jensen discuss their recent studies on the neuropathology of LRRK2-PD patients. They dive into their methods and how proximity ligation assays may compare to alpha-synuclein seeding assays in identification of alpha-synuclein oligom...
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Artificial intelligence in the diagnostic approach of chronic ataxias

July 7, 2025
Dr. Hugo Morales interviews Drs. Malco Rossi and Lucas Alessandro about their work on an AI-powered virtual assistant designed to aid in the diagnosis of chronic ataxias. They discuss how the assistant performed when put to the test, evaluating its diagnostic accuracy head-to-head against movement disorder experts.
Journal CME is available until May 21, 2026
Read the article.
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