00:50 How ancient viruses drive modern human development
Research suggests that ancient viral-DNA embedded in the human genome is playing a key role in early embryo development. Around 8% of our genome consists of endogenous retrovirus DNA — the remnants of ancient infections, but knowledge of their activity is limited. Now, a team show that these sequences are required for the correct development of lab-derived embryo analogues, and for the switching on of human-specific genes.
Research Article: Fueyo et al.
News and Views: Ancient viral DNA in the human genome shapes early development
10:39 Research Highlights
Longer whale mothers are more likely to give birth to daughters — plus, how the stink of the corpse flower waxes and wanes to attract pollinators.
Research Highlight: Big mother whales have more daughters than sons
Research Highlight: Corpse flowers waft out stinky compounds as fast as landfills do
13:05 How heat can fuel DNA computers
Researchers have developed a way to use heat to recharge DNA-based computer circuits, which could help overcome one of the stumbling blocks preventing this technology from being scaled up. Although DNA strands have been used to perform computational tasks for some time, current methods can run out of energy or build up waste products, preventing their continued use. Now, using just heat a team have demonstrated a reuseable neural network based on DNA. They hope that ultimately this could be a step in the development of bigger and more powerful DNA computers that could be used to power targeted clinical therapies.
Research Article: Song & Qian
22:20 Briefing Chat
A one-time gene therapy for Huntington’s disease show promise at slowing the brain disorder’s progression — plus, how mitochondria throw out ‘tainted’ DNA.
Nature: Huntington’s disease treated for first time using gene therapy
Nature: Mitochondria expel tainted DNA — spurring age-related inflammation
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