Origins - Inside Venture Capital, Hosted by a GP and an LP

Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, unpack their conversation with Zach Weinberg, Co-Founder and CEO of Curie.Bio. They discuss the “innovation energy” that drives new breakthroughs and take a closer look at Sapphire’s approach to biotech investing.

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Zach Weinberg, co-founder and CEO of Curie.Bio, is redefining early-stage biotech investing with an operator’s mindset and a founder-first philosophy. His approach combines funding with operational support and direct access to world-class drug hunters to dramatically increase odds of success. Today, Zach sits down with Nick Chirls, GP at Asylum Ventures and Beezer Clarkson,  LP at Sapphire Partners to discuss the massive risk assoc...

Origins hosts Nick Chirls, GP at Asylum Ventures and Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, unpack their conversation with Theory Ventures’ Tomasz Tunguz,  discussing  how strategies that once set firms apart – like pre-seed or founder-centric  investing  – become industry standards over time. They dive deep on counter-positioning, adaptability, and the power of differentiation in today’s venture world....

Tomasz Tunguz, Founder of Theory Ventures, is widely recognized for his analytical approach to venture investing. Now, he’s building Theory with a philosophy rooted in research and data-driven decision-making.  Tomasz sits down with Nick Chirls, General Partner at Asylum Ventures and Beezer Clarkson,  LP at Sapphire Partners and co-founder of OpenLP, to discuss spinouts and succession in established firms and the value of running h...

Origins host Beezer Clarkson sits down with her colleague Nate Leung, fellow LP and Partner at Sapphire Partners, to riff on  her recent conversation with Nina Achadjian, Partner at Index Ventures. Together, Beezer and Nate walk through the steps Index took to become a franchise - the decisions they made and the mistakes they avoided, plus the firm’s ability to pick excellent companies early. They discuss the edge GPs gain by inves...

Nina Achadjian is a Partner at Index Ventures, where she invests across seed, venture, and growth stages in AI, enterprise software, and vertical SaaS. She sits down with Beezer Clarkson, LP at Sapphire Partners, and the two discuss Nina’s predictions for M&A in 2025, the importance of product market fit and what Nina looks for in a new hire. Plus, the two dig into Index’s recent IPO with ServiceTitan, and how they managed a hi...

Origins host Beezer Clarkson sits down with her colleague Laura Thompson, fellow LP and Partner at Sapphire Partners, to riff on her recent conversation with Thomas Kristensen, Partner at LGT Capital Partners. Together they discuss 2025’s sluggish exit market, and whether or not that’s a sign that venture is broken. They also discuss the importance of reinventing yourself to stay current with the market - even though LPs don’t love...

Thomas Kristensen, Partner at LGT Capital Partners, has decades of experience backing the top players in venture, but as an LP, doesn’t love the term "franchise fund.” He sits down with Bezer Clarkson,  Partner at Sapphire Partners, to discuss why GPs can’t rest on their laurels, that being a franchise shouldn’t be every VC’s ultimate goal, and how LPs can dig deep to find firms with a great founder product– and avoid ones tha...

Beezer Clarkson, LP at Sapphire Partners, revisits her conversation from 2023 with David Clark, Investment Director at VenCap International plc. In this episode, she and co-host Nick Chirls, Partner at Asylum Ventures, dive into David’s nearly four decades of experience in investing in some of the most established VC funds across the US, Europe, China and India. David shares historical figures on where to find performance in ventur...

Origins host Beezer Clarkson sits down with her colleague Laura Thompson, fellow LP and Partner at Sapphire Partners, to unpack her recent conversation with Jessica Archibald, a GP at Top Tier Capital. They discuss Jessica’s engineering-based analytical approach to answering the question “what makes a franchise?” and discuss some surprising things they learned - Jessica’s view that there’s only one real way to do succession, the im...

Jessica Archibald is a GP and member of the Investment Committee at Top Tier Capital Partners, where she is co lead of the funds team and participates extensively in the capital formation efforts of the firm. She and Beezer Clarkson, LP at Sapphire Partners, sit down for the next episode in this miniseries on franchise funds - what it takes to build one, and how some firms lose their franchise status. Jessica digs into Top Tier’s n...

Origins host Beezer Clarkson sits down with her colleague Laura Thompson, fellow LP and Partner at Sapphire Partners, to discuss her recent conversation with Stephen Bluestein, Partner of Primary Investments at Adams Street and formerly Packard Foundation, about what it takes to make (and potentially later break) a franchise fund in venture. Together, Beezer and Laura debrief their top takeaways, including: do the hallmarks of a fr...

Stephen Bluestein has had an impressive career in Venture, beginning at Bessemer Venture Partners before moving to TCV, Light Street Capital, and the David and Lucille Packard Foundation, before landing in his current role as a partner in the primary investment team at Adams Street Partners. He sits down with Beezer Clarkson, LP at Sapphire Partners, to discuss what makes a fund a franchise. They discuss the importance of building ...

Nick Chirls, GP at Asylum Ventures,  and Beezer Clarkson, LP at Sapphire Partners go deep into their recent conversation with Wesley Chan, the Co-Founder and Managing Partner of FPV Ventures. They unpack Wesley’s direct learnings from Sergey Brin coming up at Google, how it is the job of the investor to spot greatness, his views on company pivots (and how they oppose another recent guest, Mike Maples’ views on pivots), the difficul...

Wesley Chan is a true legend in Silicon Valley. He spent time at Microsoft and HP, and in 2002 he jumped to Google. There, he worked as Sergey Brin’s Chief of Staff and founded Google Analytics and Google Voice - all before then founding and leading the seed investing program at Google Ventures as GP. Under his tenure, GV was the first institutional check into companies like Plaid, Gusto, Lucid, and Robinhood. Wesley sits down with...

Nick Chirls, GP at Asylum Ventures,  and Beezer Clarkson, LP at Sapphire Partners, unpack their recent conversation with Jai Das, President + Partner at Sapphire Ventures and Mike Maples, Co-Founder + Partner at Floodgate,  to answer their burning question: What changes in the way seed and growth investors think, and what stays the same? They discuss the crushing importance of team no matter the stage; the parallels in LP land (at ...

With a few dozen software exits under his belt (including Box, Square, Mulesoft & JFrog), nobody knows enterprise investing like Sapphire Ventures’ President + PartnerJai Das. Likewise, Floodgate co-founder + Partner Mike Maples Jr. is often credited with pioneering seed investing as we know it, with names like Twitter, Twitch and Lyft in his portfolio. Together, they join Nick Chirls, GP at Asylum Ventures,  and Beezer Clarkso...

Nick Chirls, GP at Asylum Ventures,  and Beezer Clarkson, LP at Sapphire Partners, go inside their recent conversation with Alt Capital’s Jack Altman to answer their burning question: What  does the journey look like from VC-backed founder to angel investor to institutional VC? How does one successfully jump from investing their own capital to taking on LP dollars? Where is Jack comfortable taking bigger bets? Plus, the two of them...