Mitchell S. Cairo, MD - Attacking the Clinical Problem of VOD/SOS in HCT Recipients: Insights on Pathophysiology, Diagnosis, and Treatment

Go online to PeerView.com/SXH860 to view the entire program with slides. In this activity, based on a live symposium held during the 2019 Transplantation and Cellular Therapy (TCT) Meetings of the American Society of Blood and Marrow Transplantation (ASBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR), experts in hematology-oncology explore new developments related to the changing clinical consensus for managing veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) as a post-transplant complication. In this program, the panelists will share their views on VOD pathophysiology and proposed revisions to diagnostic and severity grading criteria, while providing guidance on practical issues related to the selection and use of novel treatments for VOD. Ultimately, the experts present a picture of modern VOD management in which diagnoses can be accurately and rapidly made and where a diversity of disease presentations (including in adult and pediatric patients) can be effectively treated. Upon completion of this activity, participants should be better able to: Describe new evidence on VOD/SOS pathophysiology, risk factors, diagnostic criteria, and disease severity grading, Cite factors that may signal the development of multi-organ dysfunction in patients with VOD/SOS, Confirm a diagnosis of VOD/SOS throughout the clinical spectrum, including late-onset disease or disease presenting with or without organ dysfunction in adult and pediatric populations, Utilize effective, timely treatment for patients with confirmed VOD/SOS, including those exhibiting multi-organ dysfunction or failure.