E143 - Bind The Promiscuous CBD Up! The Safeword is NAM - Dr. Robert Laprairie

Don't kink-shame the promiscuous CBD. It's okay that in a world of orthosteric normative binding, CBD is into allosteric binding. In fact, CBD is not just into any allosteric binding. CBD is into negative allosteric binding.

If none of that makes any sense to you, don't worry. We are going to take a deep dive into how the famous cannabinoid, CBD, interacts with the cannabinoid receptor CB1. And it doesn't bind like a key into a lock, which is how pharmacy school told Trevor that all ligands bind to their receptors. Like all things cannabis, things are weirder, more complicated and more nuanced than our co-host, Trevor, thought. Put your science toques on and let's skate into some CB1 receptor research.

Dr. Robert Laprairie Bio

Determination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor A Combined Computational and Site Directed Mutagenesis Study Paper

(Yes we got a SOCAN membership to use this song all legal and proper like)

Music by:

GameChops – Zelda and Chill 2(specifically at the 08:44 mark- Kass’s theme)-YouTube

Additional Music:

Desiree Dorion desireedorion.com

Marc Clement - Facebook

Transcripts, papers and so much more at: reefermed.ca