Talk Python To Me

Talk Python To Me

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.

Episodes

June 18, 2025 62 mins
Are you using Polars for your data science work? Maybe you've been sticking with the tried-and-true Pandas? There are many benefits to Polars directly of course. But you might not be aware of all the excellent tools and libraries that make Polars even better. Examples include Patito which combines Pydantic and Polars for data validation and polars_encryption which adds AES encryption to selected columns. We have Ch...
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If you're looking to leverage the insane power of modern GPUs for data science and ML, you might think you'll need to use some low-level programming language such as C++. But the folks over at NVIDIA have been hard at work building Python SDKs which provide nearly native level of performance when doing Pythonic GPU programming. Bryce Adelstein Lelbach is here to tell us about programming your GPU in pure Python.
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If you've heard the phrase "Automate the boring things" for Python, this episode starts with that idea and takes it to another level. We have Glyph back on the podcast to talk about "Programming YOUR computer with Python." We dive into a bunch of tools and frameworks and especially spend some time on integrating with existing platform APIs (e.g. macOS's BrowserKit and Window's COM APIs) to build desktop apps in Py...
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If you want to leverage the power of LLMs in your Python apps, you would be wise to consider an agentic framework. Agentic empowers the LLMs to use tools and take further action based on what it has learned at that point. And frameworks provide all the necessary building blocks to weave these into your apps with features like long-term memory and durable resumability. I'm excited to have Sydney Runkle back on the p...
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The folks over at Astral have made some big-time impacts in the Python space with uv and ruff. They are back with another amazing project named ty. You may have known it as Red-Knot. But it's coming up on release time for the first version and with the release it comes with a new official name: ty. We have Charlie Marsh and Carl Meyer on the show to tell us all about this new project.

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May 13, 2025 71 mins
Python has many string formatting styles which have been added to the language over the years. Early Python used the % operator to injected formatted values into strings. And we have string.format() which offers several powerful styles. Both were verbose and indirect, so f-strings were added in Python 3.6. But these f-strings lacked security features (think little bobby tables) and they manifested as fully-formed s...
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May 5, 2025 69 mins
What trends and technologies should you be paying attention to today? Are there hot new database servers you should check out? Or will that just be a flash in the pan? I love these forward looking episodes and this one is super fun. I've put together an amazing panel: Gina Häußge, Ines Montani, Richard Campbell, and Calvin Hendryx-Parker. We dive into the recent Stack Overflow Developer survey results as a sounding...
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April 28, 2025 68 mins
Pandas is at a the core of virtually all data science done in Python, that is virtually all data science. Since it's beginning, Pandas has been based upon numpy. But changes are afoot to update those internals and you can now optionally use PyArrow. PyArrow comes with a ton of benefits including it's columnar format which makes answering analytical questions faster, support for a range of high performance file form...
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Do you or your company need accounting software? Well, there are plenty of SaaS products out there that you can give your data to. but maybe you also really like Django and would rather have a foundation to build your own accounting system exactly as you need for your company or your product. On this episode, we're diving into Django Ledger, created by Miguel Sanda, which can do just that.

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Have you ever spent an afternoon wrestling with a Jupyter notebook, hoping that you ran the cells in just the right order, only to realize your outputs were completely out of sync? Today's guest has a fresh take on solving that exact problem. Akshay Agrawal is here to introduce Marimo, a reactive Python notebook that ensures your code and outputs always stay in lockstep. And that's just the start! We'll also dig i...
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We're sitting down with Eric Matthes, the educator, author, and developer behind Django Simple Deploy. If you've ever struggled with taking that final step of getting your Django app onto a live server (without spending days wrestling with DevOps complexities), then give Django Simple Deploy a look. Eric shares how Django Simple Deploy automates away the boilerplate parts of deployment, so you can focus on building...
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This episode is all about Beeware, the project that working towards true native apps built on Python, especially for iOS and Android. Russell's been at this for more than a decade, and the progress is now hitting critical mass. We'll talk about the Toga GUI toolkit, building and shipping your apps with Briefcase, the newly official support for iOS and Android in CPython, and so much more. I can't wait to explore ho...
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In this episode, we welcome back Will McGugan, the creator of the wildly popular Rich library and founder of Textualize. We'll dive into Will's latest article on "Algorithms for High Performance Terminal Apps" and explore how he's quietly revolutionizing what's possible in the terminal, from smooth animations and dynamic widgets to full-on TUI (or should we say GUI?) frameworks. Whether you're looking to supercharg...
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March 21, 2025 55 mins
Have you ever wondered why certain data points stand out so dramatically? They might hold the key to everything from fraud detection to groundbreaking discoveries. This week on Talk Python to Me, we dive into the world of outlier detection with Python with Brett Kennedy. You'll learn how outliers can signal errors, highlight novel insights, or even reveal hidden patterns lurking in the data you thought you understo...
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Today we explore the wild world of Python deployment with my friend, Calvin Hendryx-Parker from Six Feet Up. We’ll tackle some of the biggest challenges in taking a Python app from “it works on my machine” to production, covering inconsistent environments, conflicting dependencies, and sneaky security pitfalls. Along the way, Calvin shares how containerization with Docker and Kubernetes can both simplify and compli...
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February 24, 2025 61 mins
On this episode, I'm joined by Dr. Geoff Boeing, an assistant professor at the University of Southern California whose research spans urban planning, spatial analysis, and data science. We explore why OpenStreetMap is such a powerful source of global map data—and how Geoff's Python library, OSMnx, makes that data easier to download, model, and visualize. Along the way, we talk about what shapes city streets around ...
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February 21, 2025 60 mins
As Python developers, we're incredibly lucky to have over half a million packages that we can use to build our applications with over at PyPI. However, when it comes to choosing a UI framework, the options get narrowed down very quickly. Intersect those choices with the ones that work on mobile, and you have a very short list. Flutter is a UI framework for building desktop and mobile applications, and is in fact th...
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In this episode, I'm joined by JJ Allaire, founder and executive chairman at Posit, and Carlos Scheidegger, a software engineer at Posit, to explore Quarto, an open-source tool revolutionizing technical publishing. We discuss how Quarto empowers users to seamlessly transform Jupyter notebooks into polished reports, dashboards, e-books, websites, and more. JJ shares his journey from creating RStudio to developing Qu...
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January 30, 2025 64 mins
Join me as I chat with Rich Iannone and Michael Chow from Posit where we explore the transformative power of data tables with the Great Tables library. We'll cover practical applications of Great Tables, showcasing how thoughtful design and advanced formatting can elevate your data presentations. And you'll learn about innovative features like nano plots and interactive elements and the importance of structure, for...
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Join me for an insightful conversation with Alex Monahan, who works on documentation, tutorials, and training at DuckDB Labs. We explore why DuckDB is gaining momentum among Python and data enthusiasts, from its in-process database design to its blazingly fast, columnar architecture. We also dive into indexing strategies, concurrency considerations, and the fascinating way MotherDuck (the cloud companion to DuckDB)...
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