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March 10, 2025 • 60 mins

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Yes, we need stress in our lives! Staying in our comfort zone may be doing us more harm than good. That’s probably surprising to hear from me having spoken about the importance of reducing stress over the years. But, nonetheless, a level of stress that is not overly damaging, and that may actually have positive benefits. 


Today we are going to learn much more about that will be looking at the book, The Stress Paradox with Dr. Sharon Horesh Bergquist. We're going to learn about the"Stress dilemma" that we face, how stress enhances, cellular resilience, how our life compares to the lives of our ancestors in terms of the physical stresses that we endure. We will explore how stressing ourselves in relation to the times that we eat, our physical exercise, and even explore how sleep or lack of sleep, may affect us in negative and even perhaps positive ways. All in all, we"re learning these days how we want to do our best to leverage the value of being out of our comfort zone but also recognizing our

boundaries. 



00:00 Introduction

02:00 Welcoming Sharon and Introducing The Stress Paradox

06:33 Sleep is Critical

07:12 Good Stress (HIIT) vs. Bad Stress (Financial Hardship)

09:50 Hormetic Stress? Current Environment vs. Ancestors' Stress Levels

13:20 Stress Responses Stored in Phytochemicals and our Evolutionary Relationship with Plants

19:01 10,000 DNA Injuries Any Given Day, 7 Per Minute

22:03 The Biggest Factor Related to Longevity

26:01 Relationship with Decreased Risk of Alzheimer’s & The Role of Myokines

30:17 Microglia Cells Can Share Mitochondria (Before & After)

35:13 Heat Exposure Mimics the Benefits of Exercise

38:01 Key Strategies for Longevity and Vitality

45:32 Personalized Health Strategies for Optimal Performance

50:25: The Cortisol Spike and Why It is Necessary 

58:20 Why You Need Non-negotiables In Your Physiology

50:20 Conclusion


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Sharon Horesh Bergquist, MD, is an award-winning physician, innovative healthcare leader, and visionary researcher renowned for spearheading a science-based approach to applying lifestyle as medicine. She has helped lead numerous clinical trials, including the Emory Healthy Aging Study and the NIH funded Emory Healthy Brain Study. Dr. Bergquist is widely published in peer-reviewed journals and has contributed to over 200 news


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