The Nocturnists

What does it mean to live well in a world where nothing is certain — not in medicine, not in life? In this episode, we follow a high school teacher who asks his students to examine “the good life” through philosophy, Buddhism, and existential inquiry. We meet two women — a Buddhist monk and a disability rights advocate — who bring spiritual wisdom to the messy realities of illness, caregiving, and embodiment. Their sto...

Today, we explore the paradox of mortality: something both certain and utterly unknowable. Through a haunting parable from Ursula K. Le Guin and stories from doctors and loved ones, we hear what happens when people try to plan for death—or avoid it. A daughter processes her mother’s calm decision to pursue assisted dying. A physician grapples with an ambiguous advance directive. A neurointensivist weighs the line between hope and f...

Today, we step inside the studio of visual artist Leila Simon Hayes, whose bold, shape-driven designs are born from a process rooted in imperfection, intuition, and trust. Through her story, we explore how Leila’s creative practice helped her navigate decades of chronic pain and medical dismissal, eventually leading her to healing not through certainty, but through listening—both to her art and her body. Her journey in...

Today, we explore the hidden layers of communication in medicine—what gets said, what doesn’t, and how uncertainty lives not just in the clinical data, but in the space between people. From a telemedicine encounter with a stubbornly independent patient in the Santa Cruz mountains, to a deeply personal story of navigating breast cancer risk, and finally to the ICU, where one physician is trying to revolutionize how teams talk about ...

Today, we step into the dance studio with improvisational dance artist Chris Aiken, whose work lives at the intersection of uncertainty, movement, and presence. With insights that resonate far beyond the dance studio, Chris explores how attention, poetic instinct, and even failure are essential tools for responding creatively under pressure—much like an ER doctor at a moment of crisis.

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This week, we explore how time and uncertainty are intertwined in the practice of medicine. A toxicologist faces a split-second decision in the ER that could mean life or death for a young patient. A woman with chronic ankle pain spends years searching for answers as dozens of doctors offer snap diagnoses and failed treatments. A rheumatologist navigates the slow, murky waters of autoimmune disease, where diagnosis and...

When a 7.6 magnitude earthquake leveled entire villages in Pakistan, retired U.S. Navy Admiral Mike LeFever was thrust into the heart of the disaster with no playbook and a simple directive: provide humanitarian aid and strengthen U.S.-Pakistan relations. In this episode, LeFever recounts what it was like to lead a massive relief effort in the chaotic aftermath—coordinating aid, rebuilding schools, and navigating diplomacy in a cou...

What happens when doctors have to make life-or-death decisions in an evidence-free zone — and patients are left to navigate the unknown? In episode 5 of “Uncertainty in Medicine", we bring you three gripping, real-life stories: a neurosurgeon weighing impossible risks in the operating room, a palliative care doctor facing a young man’s quiet resolve to die, and a patient whose long-awaited kidney transplant vanishes in a single pho...

What does uncertainty in medicine have to do with Chernobyl? According to patient safety officer Dr. Ron Wyatt, more than we might think. In the fourth episode of our "Uncertainty in Medicine" series, he draws a chilling connection between one of history’s worst nuclear disasters and the quiet, preventable tragedies that unfold in hospitals every day. In both cases, the warning signs were there. People sensed something...

In episode 3 of the "Uncertainty in Medicine" series, patient Dana undergoes a routine knee replacement and expects a straightforward recovery. Instead, she’s plunged into a baffling and relentless illness—one that defies diagnosis and leaves her life in limbo. As her symptoms intensify and specialists write her off, Dana finds an unwavering ally in her primary care doctor, the one person who refuses to let her fall th...

On this episode of Conversations, Emily sits down with the creative team behind The Pitt—a gripping new medical drama on HBO Max that’s making waves in the healthcare world and beyond. Joining her are showrunner R. Scott Gemmill (ER, NCIS: LA), physician-writer Dr. Joe Sachs (ER), and emergency medicine educator and EM:RAP founder Dr. Mel Herbert. Together, they go behind the scenes of the show, discussing characters, medical cases...

Step inside Alexa Miller’s classroom, where paintings become portals and doctors learn to see like patients. In this episode, Alexa leads a powerful exercise called the “image circle,” where clinicians reflect on their own experiences of medical uncertainty and choose artworks that speak to those moments. What follows is anything but abstract—through close looking and deep conversation, participants begin to feel what it’s like to ...

In the premiere of the "Uncertainty in Medicine" series, The Nocturnists explore medicine’s uneasy relationship with not knowing. From the clean resolutions of medical dramas to the structured rituals of case conferences, the culture of medicine often treats uncertainty as something to be avoided, resolved, or explained away. But what happens when uncertainty is not just a temporary gap in knowledge—but a constant, liv...

Our Uncertainty in Medicine series launches next week, and to set the stage, we’re sharing one of our favorite episodes from the archives - a heartfelt conversation with New York Times columnist Ross Douthat about his journey through the healthcare system while living with chronic Lyme disease.

Medi...

Medicine is full of uncertainty—from ambiguous diagnoses to unpredictable outcomes and the complex emotions of not knowing. Uncertainty in Medicine is a new documentary podcast series, created in collaboration with Alexa Miller of ArtsPractica, that examines how both healthcare workers and patients navigate the unknown. Through powerful personal stories and in-depth conversations with professionals whose work depends o...

Dr. Allan Detsky, a Canadian physician, health economist, and Broadway producer, examines the contrasts between Canadian and American healthcare. He then delves into his passion for musical theater, recounting his unexpected journey into Broadway production and how he integrates musical theater into hospital wards as a means of decompression and connection in medical education.

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Kali Dayton, critical care nurse practitioner, ICU outcomes consultant, and host of the Walking Home from the ICU podcast, joins pioneering ICU physical therapist Heidi Engel to discuss long-standing ICU practices rooted in sedation and immobility. Together, they make a powerful case for a transformative model that keeps patients awake, engaged, and walking—even while on ventilators.

Find show notes, transcript, and more at thenoct...

Dr. Marcy Bolster, Dr. Jason Liebowitz, and Dr. Philip Seo join us to discuss their newly published anthology, A Masterclass in Medicine: Lessons from the Experts. They created this compelling essay series to explore what it means to be a master clinician, featuring lessons from their own clinical heroes as well as other renowned physicians. Through these essays, they highlight the essential qualities of exceptional doctoring—empat...

Physician and New Yorker writer Dhruv Khullar argues that modern medicine is in a Gilded Age—one where groundbreaking innovations mask deep systemic issues, including misaligned incentives, escalating costs, and growing dissatisfaction. From the influence of private equity on healthcare to the flaws of Medicare Advantage and the crucial role of data as the ‘oil’ of the healthcare system, this conversation explores the challenges of...