A review of the science between the metabolic syndrome, including discussion of obesity, diabetes, hypertension, and hyperlipidemia. We discuss the pathophysiology of how enlargement of adipocytes disrupts metabolic signalling pathways and leads to buildup of lipid intermediates. We then consider how these effects impair health, examining the causes of insulin resistance, atherosclerosis, and dysregulation of blood pressure. We conclude by looking at how such symptoms lead to pathology and increased mortality in overweight and obese individuals. Recommended prelistening is Episode 151: Diet and Nutrition, and Episode 18: Biochemistry Basics.
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Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by audiochuck Media Company.
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If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.