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October 10, 2025 17 mins

Today we’re continuing with our Study Spotlight series on the study entitled ‘Dietary Modification and Supplement Use For Endometriosis Pain’. If you’re new to the series and want to understand what this study was about, the strengths and weaknesses and my overall thoughts on the study, go to episode 365, and the link to that is in the show notes.

Today, we’re diving into one of the supplements with the best response rate, and that is serrapeptase.


Show Notes:

Main study

https://www.theendobellycoach.com/podcast/new-endo-survey-study-review

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831953


Serrepeptase overall research

https://pubmed.ncbi.nlm.nih.gov/29618875/

https://pubmed.ncbi.nlm.nih.gov/23380245/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7585045/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8265778/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8624573/#B8-medicines-08-00068

https://www.mdpi.com/2218-273X/12/10/1468


Serrepeptase inflammation research

https://www.sciencedirect.com/science/article/pii/S181808761630160X

https://www.mdpi.com/2218-273X/12/10/1468


PgE2

https://www.sciencedirect.com/science/article/abs/pii/0090698085902084?via=ihub

https://pubmed.ncbi.nlm.nih.gov/20511671/

https://pmc.ncbi.nlm.nih.gov/articles/PMC4512562/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3081099/


Interleukin 6

https://pubmed.ncbi.nlm.nih.gov/38428575/

https://www.ijfs.ir/article_700967_82be9d71bf5a0f57430b545d9df3ec27.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC5556658

https://pmc.ncbi.nlm.nih.gov/articles/PMC9265783

https://pmc.ncbi.nlm.nih.gov/articles/PMC7943546

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0607-6


Endo and serrepeptase/proteolytic enzyme research

https://journals.sagepub.com/doi/abs/10.5301/je.5000215

https://www.sciencedirect.com/science/article/abs/pii/S0378432019305895


VEGF and endo

https://pmc.ncbi.nlm.nih.gov/articles/PMC3850339/

https://pubmed.ncbi.nlm.nih.gov/9688413/

https://www.frontiersin.org/journals/global-womens-health/articles/10.3389/fgwh.2022.856316/full

https://pubmed.ncbi.nlm.nih.gov/8671190/


TGF-α and endo

https://www.sciencedirect.com/science/article/abs/pii/000293789390356N

https://pubmed.ncbi.nlm.nih.gov/1923211/

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1447-0578.2005.00098.x

https://www.sciencedirect.com/science/article/pii/S2666335X22000386


Dosing

https://www.sciencedirect.com/science/article/pii/S1743919113000265

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831953


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