Recent discoveries show that some neurodegenerative disorders occur because of abnormalities in the processing of RNA in the cell nucleus and/or its export from the nucleus. Johns Hopkins University Associate Professor Shuying Sun is at the forefront of research that is establishing the molecular mechanisms responsible for RNA dysregulation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Her research is contributing to a rapid acceleration of understanding of the causes of ALS and FTD and to the development of new pharmacological and gene therapy-based treatments for these disorders.
LINKS
Dr. Sun's laboratory webpage:
https://sunlab.jhmi.edu/
Review article
https://pmc.ncbi.nlm.nih.gov/articles/PMC11790913/pdf/44318_2024_Article_352.pdf
Original research articles
https://pmc.ncbi.nlm.nih.gov/articles/PMC5754368/pdf/41467_2017_Article_2495.pdf
https://pmc.ncbi.nlm.nih.gov/articles/PMC6895427/pdf/nihms-1539444.pdf
https://www.biorxiv.org/content/10.1101/2025.09.30.679260v1
https://www.biorxiv.org/content/10.1101/2025.09.30.679260v1
https://www.biorxiv.org/content/10.1101/2025.06.13.659508v1
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