Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Dr RR Baliga's 'Got Knowledge Doc?' Podkasts for Physicians and Physician Extenders. Not medical advice or medical opinion www.MasterMedFacts.com
Episodes
🚨🧠 BREAKING: Tenecteplase before thrombectomy boosts chances of stroke recovery!
💉 Faster reperfusion
📈 Higher functional independence (mRS 0–2 at 90d: 52.9% vs 44.1%)
⚠️ Slight ↑ in sICH, but no major safety red flags
🧪 #BRIDGE_TNK trial rewrites the stroke playbook!
#Stroke #Tenecteplase #NeuroTwitter
Nāgārjuna (c. 150 – c. 250 CE) was an Indian Buddhist monk and philosopher, regarded as the founder of the Madhyamaka (Middle Way) school of Mahāyāna Buddhism.
His most famous work, Mūlamadhyamakakārikā (Root Verses on the Middle Way), presents the concept of śūnyatā (emptiness) and the two truths doctrine, emphasizing dependent origination and rejecting inherent existence.
Nāgārjuna’s phil...
📢 New RCT in Nature Medicine 🎯
Can zapping low-voltage areas (LVAs) reduce AF recurrence after PVI?
🔬 SUPPRESS-AF Trial
👥 342 pts with persistent AF
📉 1-yr AF/AT-free: 61% (PVI+LVA) vs 50% (PVI)
❌ Not statistically significant
🧠 Subgroup benefit in high-risk pts
#EPeeps #AFib #CardioT...
🧠💪 Can blood biomarkers of Alzheimer’s predict who’ll lose muscle strength with age?
In a 12-year study, higher p-tau, NfL & GFAP levels forecasted faster decline in grip & leg power — even before dementia onset.
🧬🪑✊ #Aging #Alzheimers #Sarcopenia #Biomarkers #Longevity
📉 New JAMA study tracks U.S. #SedentaryBehavior from 2013–2023:
🪑 Sitting time fell from 7.1 to 5.9 hrs/day pre-COVID
🦠 But plateaued post-pandemic at 6.0 hrs/day
🚶♀️ Progress stalled—time to get moving again!
#PublicHealth #NHANES #PhysicalActivity 🏃♂️📊🛋️
🐒 New study finds no disorganized attachment in wild chimpanzees!
🧠 Only secure & avoidant types observed—just like humans, but without the trauma.
🌿 Evolution favors calm, connected bonds.
📍Taï National Park, Côte d’Ivoire
🔗 Nature knows best. #PrimateScience #AttachmentTheory #Chimpanzees
💡World’s tiniest pacemaker—smaller than a grain of rice!
🫀Leadless, wireless & bioresorbable
🔦 Powered by NIR light
🧬 Perfect for post-op pacing & TAVR
🌱 No wires, no scars, no removal!
#MedTech #Cardiology #Bioengineering #Innovation @Nature
Cutting cysteine = 🔥 30% weight loss in 7 days!
🧬 Triggers stress pathways (ISR/OSR)
❌ CoA & glutathione drop
🔥 Browning fat, futile cycling, energy drain
💡 Reversible & promising for obesity research!
#Metabolism #Obesity #AminoAcids #Science 🧪⚖️🧠
🚨 TAVI Trials Update!
🆚 COMPARE-TAVI 1: 🇮🇳Myval = 💪SAPIEN 3 in safety & efficacy
🆚 ACURATE IDE: ACURATE neo2 ❌not non-inferior to 💥SAPIEN/EVOLUT
📊 Valve wars intensify! #TAVI #HeartValve #Cardiology 🫀
🌶️ Not all chili heat is created equal!
Scientists found hidden compounds—like capsianoside I & roseoside—that cool the burn without changing flavor 🔬❄️
Your next spicy dish might be hot… but not hurt.
#FlavorScience #Capsaicin #TRPV1 #FoodTech 🍽️🧠🔥
📊 New study shows Topological Flow Data Analysis (TFDA) 🌀 detects early cardiac dysfunction in childhood cancer survivors—before LVEF or strain drop!
🔍 A game-changer in cardio-onc surveillance. #CardioOncology #TFDA #EchoRevolution
📉 Mucus plugs matter! In COPD, persistent or new plugs accelerate FEV₁ decline 🫁💨
🖥️ CT imaging tracks their impact
🚬 Smoking worsens the hit
👉 Clear the plugs, preserve the lungs!
#COPD #LungHealth #NEJM #FEV1 #Pulmonology
🩺 New hope for #ResistantHypertension!
A 12-week RCT 🇰🇷 shows 💊 amiloride is noninferior to spironolactone in lowering SBP 📉
Fewer side effects, similar BP drop!
But spironolactone may still reign 👑 for organ protection 🫀🧠
🧪 #Hypertension #Cardiology #JAMA2025
🧬✨ A baby with deadly CPS1 deficiency (which results in elevated ammonia levels) gets a custom-made gene edit—delivered by lipid nanoparticles—in just 6 months! 🚀
Ammonia levels down, no hospitalizations, and hope up.
N-of-1? More like Future-of-Many. 💡👶🔬 #GeneTherapy #PrecisionMedicine #RareDisease
🚨 New framework alert!
Systemic Metabolic Disorder (SMD) gets a clinical staging makeover 🧬
From reversible risks 🌱 to systemic damage 🔥—this EAS consensus guides timely, targeted care 🎯
#MetabolicHealth #Cardiology #PrecisionMedicine #SMD 🩺📊
Pyrrho of Elis (c. 360–270 BCE) was an ancient Greek philosopher and founder of Pyrrhonism, a school of philosophical skepticism.
He advocated for epoché (suspension of judgment) as a path to ataraxia (peace of mind).
Influenced by his travels to India with Alexander the Great, Pyrrho believed that nothing could be definitively known and that by refraining from beliefs, one could achieve tr...
🧬 New hope for lipid warriors!
Solbinsiran (siRNA) slashed apoB 🩸, TGs 🍟, LDL-C 💔 & liver fat 🫀 in just 205 pts with mixed dyslipidaemia.
Safe ✅ Durable ✅ Quarterly dosing? Maybe ✅
Let’s talk outcomes! 🎯
#PROLONGANG3 #RNAtherapy #CardioTwitter #LipidLowering
🧔♂️ Prostate cancer is the most common cancer in US men.
🧪 PSA testing? 🔍 It’s all about shared decision-making.
🧬 From Gleason scores to PSMA-PET, precision reigns.
💉 ARPIs & ADT = survival gains in advanced disease.
⚖️ Screen smart. Treat right. Save lives.
#ProstateCancer #MensHealth #Oncology 🧠💪
🚨 New frontier in lipid-lowering!
🧬 Blocking ANGPTL4 with MAR001 slashed triglycerides & remnant cholesterol by >50%
🛡️ Safe, well-tolerated, no lymph node issues
💡 Promising for residual ASCVD risk
Next step? Big trials, big answers! 📊🫀
#LipidScience #CardioTwitter #PrecisionMedicine
Why do some people sleep just 4 hours and feel great? 😴💪
A new study links the 🧬 SIK3-N783Y mutation to natural short sleep!
Less sleep, more delta power 🧠⚡
🚀🛌
#SleepScience #Genetics #SIK3 #ShortSleepers
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