Dr RR Baliga's 'Got Knowledge Doc?' Podkasts for Physicians and Physician Extenders. Not medical advice or medical opinion www.MasterMedFacts.com
๐จ New Guidance Alert!
The ๐ 2025 ACC Expert Consensus on Pericarditis is out โ and itโs a game-changer.
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๐ Clearer diagnostic criteria
๐ฅ๏ธ Emphasis on multimodality imaging
๐ Refined therapeutic pathways (NSAIDs, colchicine, IL-1 blockers)
๐ฅ...
๐ New in Nature: Groundbreaking study reveals how the origin of your genes โ from mom ๐ฉโ๐ผ or dad ๐จโ๐ผ โ can push human growth ๐ and metabolism ๐ฅ in opposite directions!
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๐งฌ Using data from 236,781 people across UK Biobank, Estonian Biobank, and MoBa, researchers uncovered 30+ parent-of-origin effects (POEs), many showing bipolar impact...
๐จ New AHA Scientific Statement ๐จ
โFood Is Medicineโ isnโt just a sloganโitโs a growing clinical movement. ๐๐ This systematic review of 14 U.S.-based RCTs explores how Produce Prescriptions (PRx), Medically Tailored Groceries (MTG), and Meals (MTM) impact diet, food insecurity, and health outcomes.
๐ Results show improvements in diet quality and food security, wi...
๐ฌ New study in Nature Medicine reveals that not all healthy diets are created equal โ even when nutrient content is matched, ๐ ultra-processed foods (UPFs) hinder weight loss compared to ๐ฅ minimally processed foods (MPFs).
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๐ Participants lost twice as much weight on MPF diets, with greater ...
๐จ New Insights in Heart Failure Management! ๐ก๐ซ
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Just explored the latest 2025 European Journal of Heart Failure review by Hulot et al. redefining how we view HF recovery. No longer just โimprovementโ โ we now distinguish HFimpEF, remission, and recovery as stages along a phenotypic spectrum.
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๐ New JAMA Review: Ovarian Cancer โ From Symptoms to Survival ๐ธ
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Approximately 21,000 women are diagnosed with ovarian cancer annually in the U.S.โand 80% present with advanced-stage disease.
The latest JAMA review by Caruso, Weroha, and Cliby (2025) offers a comprehensive update on:
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๐งฌ Evolving ...
๐จ New Insights in Heart Failure Care! ๐ซ๐
A landmark meta-analysis in Nature Medicine shows that intravenous iron therapy significantly reduces heart failure hospitalizations and cardiovascular deaths โ especially in the first year of treatment. ๐๐ช
With over 7,000 pat...
๐จ Spotlight on Medieval Thought! ๐ง ๐
Explore the legacy of Anselm of Canterburyโfather of Scholasticism and originator of the Ontological Argument for Godโs existence. His fusion of faith ๐ and reason ๐งฉ shaped Western theology.
๐ #Philosophy #MedievalStudies #Anselm #Theology
Tropical cyclones donโt just shake buildings โ they shake hearts too.
A powerful multicountry study in Science Advances links ๐ storm exposure to a 13% rise in cardiovascular hospitalizations, especially ischemic heart disease and stroke.
Vulnerable groups? Men, adults aged 20โ59, and socioeconomically deprived communities.
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<...๐ 42,939 lives lost in 2021 โ the U.S. motor vehicle fatality rate remains far higher than other high-income nations.
The NEJM review on Motor Vehicle Crash Prevention highlights the Safe System Approach:
๐ฃ๏ธ Safer roads
๐ Safer vehicles
๐ฅ Safer people
๐๏ธ New Podcast Episode!
โHole in the Heart, Stroke on the Brain, Science at the Coreโ ๐ง โค๏ธ๐ฌ
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Discover how a tiny openingโpresent in 1 in 4 adultsโcan lead to devastating strokes ๐ฉบโ ๏ธ. We unpack the latest JAMA review on PFO, cryptogenic stroke, and how RoPE and PASCAL scores guide who benefits from clos...
๐งฌ Just explored the largest GWAS on stutteringโover 1 million participants!
๐ต Fascinating link uncovered between impaired rhythm and speech disfluency, supporting the Atypical Rhythm Risk Hypothesis.
๐ง Genes like VRK2 and FANCL connect beat synchronization and stuttering risk.
๐ A big step toward precision care in developme...
๐๏ธ From MRAs to ASIs: Rewriting Heart Failureโs Aldosterone Story
๐จ New Episode Alert! ๐ง
Title: From MRAs to ASIs: Rewriting Heart Failureโs Aldosterone Story
๐๐งฌ๐
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In this episode of Got Knowledge Doc, we unpack the double-edged role of aldosterone in
๐ซ๐โก๏ธโ๏ธ The GLP-1 Comeback: Weight Regain After the Stopโ
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๐ Based on the 2025 BMC Medicine meta-analysis, we explore what happens after stopping anti-obesity meds like GLP-1 receptor agonists.
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๐ Key takeaways:
โ Weight regain begins as early as 8 weeks after stopping
โ GLP-1 drugs show the highest rebound ๐
โ Life...
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๐จ Podcast Alert: โMove. Breathe. Beat AF ๐โโ๏ธ๐ซ๐ฅโ
The latest Cochrane systematic review + meta-analysis shows that exercise-based cardiac rehabilitation (ExCR) meaningfully reduces:
โ AF recurrence
โ Symptom severity
โ AF burden and frequency
โ And improves VOโ peak & mental healthโa...
Titrate, Train, Triumph ๐งฌ๐๏ธโโ๏ธ๐ฏโ
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Obesity medications like semaglutide and tirzepatide are game-changersโbut managing GI side effects, sarcopenia risk, and long-term adherence requires nuance, nutrition, and teamwork. ๐ก
From nausea to nutrition, and from missed doses to muscle massโthis episode offers practical, evidence-based strategies to optimize incretin therapy. ๐๐ฅฆ...
๐ฌ New Insights in Lipidology! ๐ซ A landmark study in European Heart Journal (2025) shows that Apolipoprotein B (ApoB) particle count is a more powerful predictor of coronary artery disease than traditional LDL cholesterol. While VLDL particles are more atherogenic per unit, LDL dominates by count โ making total ApoB count + Lipo...
๐ง โจ Just read a thought-provoking article in JAMA on the US POINTER trial!
Structured lifestyle changes (think ๐โโ๏ธ๐ฅ๐งฉ) showed modest but real gains in cognition for older adults at risk of dementia. But hereโs the twist: even light-touch self-guided changes yielded nearly similar benefits. ๐คฏ
Soโฆ ๐ฌ Is intensity always worth the investment? Or can simplicity scale smarter?
๐ Worth pondering as we shape the future of brain healt...
๐ฌ New Review Alert! ๐ซ
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South Asians face one of the highest global burdens of premature heart disease โ and Lp(a) may be the silent culprit. ๐ In a comprehensive JAHA 2025 review, researchers reveal how 25% of South Asians have dangerously elevated Lp(a) levels, doubling their risk of myocar...
๐ข New insights on education & brain aging! ๐ง ๐
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A mega-analysis across 33 countries (170K+ participants, 15K+ MRIs) shows ๐ higher education boosts baseline memoryโbut doesnโt slow brain aging or cognitive decline over time. โ๐ง
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โ Early-life traits (like childhood cognition & environment) drive the advantage.
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๐ Education matte...
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