July 31, 2025 • 33 mins
In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Steve Reiter explore various aspects of longevity and health optimization for July Q&A. They discuss the impact of UV light on eye health, nutritional strategies for ocular longevity, and the regenerative potential of cord blood. The conversation also delves into chronic inflammation, particularly in the liver, and its effects on aging. Additionally, they highlight tools and strategies for restoring liver health and introduced a new course and app designed by Gladden Longevity to support individuals on their longevity journey.
For Audience
· Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !
Takeaways
· Bright sunlight can cause oxidative stress and systemic inflammation.
· Preventive measures are crucial for ocular health, especially in high UV environments.
· Cord blood contains youthful stem cells with regenerative capabilities.
· Chronic liver inflammation accelerates aging at the cellular level.
· Lifestyle changes can significantly improve liver health and function.
· Nutritional supplements can aid in ocular longevity and overall health.
· The importance of monitoring inflammatory markers in aging individuals.
· A new course will provide actionable steps for longevity based on individual needs.
· An app is being developed to simplify the journey towards longevity.
Chapters
00:00 Introduction to Age Hacking and Longevity
01:24 The Impact of UV Light on Eye Health
08:35 Nutritional Strategies for Ocular Longevity
09:23 Understanding Cord Blood and Its Regenerative Potential
17:41 Chronic Liver Inflammation and Aging
20:24 Regenerative Tools for Restoring Liver Health
26:41 Developing a Course and App for Longevity
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Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
(00:28):
Welcome to the Gladden Longevity Podcast with Dr.
Jeffrey Gladden, where our passion is helping you become an age hacker.
On this show, we want to help you optimize your life energy, longevity, health and humanperformance with impactful and actionable information by answering four questions.
How good can we be?
How do we make 100 the new 30?
(00:49):
How do we live well beyond 120?
And how do we live young for a lifetime?
I'm Steve Ryder back for another question and answer with you, Dr.
Gladden.
And it is July granted it's late July, but we do have some topics that we're going to betalking about.
How's your July shaped up thus far?
Great.
Yeah, it's been great.
It's been a good summer and it's good to see you again.
(01:10):
I will just add this that we've added a fifth question, which is, yeah, how do we developa 300 year old mine?
that's awesome.
Well, it is July and it is healthy vision and UV safety month.
So how does UV related eye damage contribute to systemic inflammation and aging?
(01:33):
Does it have a factor?
Yeah, so that's an interesting question,
I did a little research on this question.
We've known that, interestingly enough, that it's early morning sunlight, right, before,let's call it 10 a.m., that actually triggers the brain to start making melatonin.
It has a real impact on our circadian rhythm.
(01:54):
And so getting early morning sunlight, like,
first thing in the morning, if you can go outside and get grounded, get some early morningsunlight, it's doing a lot of really good things for you.
However, if you're out in the bright sunshine, let's say between, depending on where youlive, maybe it's 10 a.m.
to 4 p.m., it's another story completely.
And at this point, that really bright sunlight is causing a lot of inflammation, if youwill, in the eyeball.
(02:21):
Really?
because it's a lot of energy coming in that's creating oxidative stress.
And when you have oxidative stress, then you release a lot of inflammatory cytokines,right?
IL-1, IL-6, TNF, alpha.
And it turns out that those are activated not only in the eye, but they're put into thetears, they're reabsorbed into the body and they become systemic.
(02:46):
So now when you're exposing your eyes to bright sunlight, you're actually not onlyincreasing eye inflammation, which we can talk about some of the downsides of that, but
you're also increasing systemic inflammation.
And with that systemic inflammation, what they found is that it alters immune function.
can drive ongoing low grade inflammation in the body, but also it can suppress,
(03:10):
the immune system that makes it more difficult for it to work properly and, uh, impairsour ability to repair.
So it's kind of a big deal.
it can also increase advanced glycation end products, in the body and in the eye itself.
you can almost think of, uh, bright sunlight, almost like causing many, central nervoussystem insults, right?
(03:30):
So it can actually accelerate damage and neuroinflammation.
Uh,
in our brains.
So it's kind of a big deal.
Whereas early morning sunlight is really God's gift to you.
Bright sunlight during the day can be a real problem.
So pretty interesting.
What kinds of nutritional and lifestyle strategies can support ocular longevity,especially in high UV environments like Colorado, where we are at least where I'm at.
(04:00):
I'm at about 7,000 feet above sea level.
Yeah.
You have a double whammy and, it's sunny there pretty much all the time.
I mean, you get the afternoon.
300 plus days of sunshine a year.
Right.
And you do get in the mountains, you do get that afternoon thunderstorm frequently, whichkind of mitigates it a little bit.
But I think the number one thing is to get some sunglasses and you want to get these, youknow, you've seen the guys, the mountaineers, right?
(04:25):
With the kind of the wraparound sunglasses or the sunglasses that have the sort of theflaps on the side to keep extraneous light out.
and those lenses are polarized for one thing, and they're also UV.
400 certified, which means that they're basically block 100 % of the UVA and UVC light.
And that cuts down the dose on your eye about 95 % apparently.
(04:48):
So that's super important.
I think the first thing is, if you're going to be out in the sun is to get some reallygood, expensive, high quality wrap around sunglasses.
That's the first thing.
And then, you know, when it comes to
taking care of your eyes in general.
It's interesting.
You can do a genetics test that will look at genes associated with things like maculardegeneration, right?
(05:14):
Which it turns out all that bright sunlight can accelerate that.
Some of the other things that Intellxx DNA, if I didn't mention that, is a company thathas a really nice pivotal for that.
That's uh I-N-T-E-L-L-X-X.
The other thing that's
Important to note is that smoking, if you have the genes for macular degenerationincreases the risk of macular degeneration like 18 times.
(05:40):
Yeah.
So it's a big, it's a big, add and smoking in general, if you're going to be out in thesun is also adding, to the risk and primarily because it's using up a lot of your body's
antioxidant capacity, right?
alcohol is another problem.
making sure you use blue filters on your phones, even if you're outside.
(06:00):
And then there's certain supplements that you can take, right?
So there's one called AREDS, which is kind of a composite capsule that we use for peoplewith a risk of macular degeneration.
And it contains some vitamin C, vitamin E, a little bit of beta carotene, which is aprecursor to vitamin A, some zinc oxide, and a little bit of copper.
(06:22):
uh And then if you combine that with N acetylcysteine, which of course makes glutathione.
And if you drink molecular hydrogen, which helps you to block oxidative stress, you know,that becomes a pretty good strategy.
Interestingly enough, they have also come up with some eye drops that have exosomes inthem that can mitigate
(06:45):
some of the, some of the issues, right?
So that's pretty interesting.
And now they're also have some platinum nanosyme eye drops that are apparently they'retesting in primates that is showing some ability to decrease the reactive oxygen species.
so yeah, pretty interesting.
So anyway, the, the, the, the primary thing here is prevention.
(07:07):
The first, you know, if we're just going to consolidate the thoughts here, the
First line of defense is don't go out in the sun in the midday, right?
Early in the morning, later in the afternoon, know, broad brimmed hats, anything thatkeeps you in the shade, excellent sunglasses, and then taking some of the supplements that
we just mentioned becomes very important as well.
(07:28):
So that's it.
And of course, for your skin in general, we recommend the HelioCare, and there's now aHelioCare Ultra.
which comes from polypodium leukotomus, which protects your skin when you're out insunlight like that.
So to your point, Steve, if you're in Colorado uh or Arizona or many places in the Westthat are sunny and dry and hot, depending on whatever, really becomes important.
(07:52):
It's also important for people that are on the water, uh like fishing guides, right?
yeah.
fishing guides, either in rivers or lakes or in the ocean.
Or even in the winter, you can think about it this way.
If you're a snow skier or a snowmobile or a backpack or whatever you are, snowshoeing orwhatever, you're getting cross-country skiing.
(08:14):
Exactly right.
You're going to get a ton of reflected light off that snow and that can be really, reallyintense.
You know, people go quote unquote snow blind.
So
That's really important to keep in mind also.
You really got to protect your, you know, what's coming into the eye, right?
That's probably the most important.
So, yeah.
(08:35):
It's also Core Blood Awareness Month.
We've talked a lot about stem cells over the course of the podcast.
been waiting all year for Cord Blood Awareness Month.
I know you have.
So I guess first, before I ask my question, set it up for the listeners, the evolution ofthis little niche branch within the longevity field.
(09:01):
Yeah.
Well, basically it's, it's, conceptually, it's very simple.
Younger biologic products have more regenerative capacity than older biologic products.
Right.
When you look at cord blood and there's also placental tissue, right.
Which comes out at the same time cord blood does, we're talking about umbilical cord bloodhere.
(09:22):
Just to be clear.
and placental tissue, right?
These are full of very, very youthful factors.
The stem cells that are in here have long telomeres.
There are many regenerative exosomes and forms of messenger RNA and other things that haveincredible regenerative capacity, right?
So if a baby, let's say in utero, suffers an injury, they can heal that injury and thatyou would never know it was injured.
(09:47):
If a young child breaks their arm,
right?
The bone heals and it's like there was never a fracture there.
So very youthful tissues like cord blood, like placental tissue, things like that can beincredibly regenerative.
And so that's why people are really interested in this.
So, yeah.
How is this potentially going to be used in the aging reversal arena?
(10:16):
it's used predominantly as an adjunct to other technologies, right?
So what we've found is that in order to rejuvenate things in an older person, you firsthave to take out the old stuff, which kind of makes sense.
The analogy I always use is that if you've got a youthful Olympic swimmer and you wantthem to go in and do, you know, amazing lap times in the pool,
(10:41):
Well, you got to clean out the pool first, right?
You got to take out all the logs, the twigs, the lawn chairs.
You got to clear out the pool.
Then you got to freshen the water, right?
They can't swim in murky water and dirty water as efficiently, right?
It's more friction, whatever else the analogy is.
But the point is you've got to clear out the trash and you got to clean up the water.
(11:02):
And then you allow them to go and then you've got to feed them.
You've got to give them the right nutrients and you've got to give them enough NAD andyou've got to give them the right peptides and things like this.
Right.
So when you actually get that right, when you get the sequence right, it's not just abouta quote unquote stem cell or a cord blood product or a peptide for that matter.
It's really how you clean up the environment.
(11:24):
Then how you energize the rejuvenation therapies, how you link them together.
And then how you actually support them going forward with more NAD peptides that actuallyare signaling molecules that keep the body kind of in a healing mode, hormone
optimization, thyroid optimization, things like that.
um Once you do this properly, you can get really remarkable results in an older individualwho may have difficulty healing, healing a bone, healing a wound, things like that.
(11:54):
So that's, that's the broad overview of it.
We can get a little more specific if you like as well, but.
Yeah, what kinds of early markers should be monitored to measure success in regenerativeprotocols using core blood derived interventions?
Yeah.
Well, a lot of, a lot of the problem with aging, of course, is that we end up with a lotof inflammatory markers.
(12:15):
And these can be measured in the blood, uh, quite readily, quite readily, right?
IL-6, IL-1, TGF alpha, TGF beta, things like this, can all be measured.
And consequently, when you use products, like cord blood, et cetera, you can actually, seethat there's a,
a diminution of those inflammatory molecules.
(12:37):
There are also ways to show that senescent cell burden is actually being decreased througha new test that we just got a hold of from a company SAPERE, SAPERE that can measure P16.
P16 is a more specific measure of senescent cell burden than beta-galactosidase, which isbetter than nothing, but not as specific.
(13:00):
And so...
You can actually see impacts on P16.
And then based on modifying the cytokinesis, inflammation and the associated oxidativestress, you can also look at measures of DNA methylation H and you can see that those
improve as well.
Right.
So those are ways to kind of track and follow what's happening.
(13:21):
So C-reactive protein can also be measured.
And one of the things that seems to really
augment the impact of cord blood is activating AMPK at the same time.
So AMPK sits on one side of a teeter totter and mTOR sits on the other side, right?
And they go up and down, but they're a teeter totter.
(13:42):
you're low on one, you're high on the other and vice versa.
And mTOR of course is building bone, building muscle, cell division, it's cell growth, etcetera.
And it's a good thing until it's too much of it causes you to have cancer and you diesooner.
Right.
AMPK on the other hand, is what happens when we do fasting, when we do cardio exercise,when we take drugs like metformin or supplements like berberine, and it actually activates
(14:06):
DNA repair and activates sirtuins and it requires NAD to also be present.
so boosting NAD at the same time.
becomes very, very important.
And so we have ways to boost NAD with a couple of different products.
Now, Vitality combined with Ducito Time, throwing some Apigenin as well, jump in an ozonesauna and you can really, really regenerate uh NAD concentrations.
(14:33):
You really feel that.
So anyway, again, it's about putting these pieces together in a way that makes sense.
And then you can get some pretty cool results.
You mentioned the ozone sauna, which you guys have one at the gladden longevity clinic,which I've done on the trip that I did out there last year.
Would an Ibu treatment as well prior to the treatment with the cord blood stem cells help?
(15:00):
Yeah.
So we actually like to energize the system with NAD and many times we will use ozone inone form or another, whether it's ebu, which is filtering the blood and ozonating it,
whether it's the ozone sauna to just, it's cheaper and faster to just jump on an ozonesauna for 20 minutes, or sometimes we'll inject ozone into a joint or an area, skin or
(15:20):
wherever else to help energize the system.
also, ozone itself decreases inflammation.
seems to stimulate regeneration, decreases pain significantly, it works very good forpain.
And then, you you combine these in the right sequence, right?
So you wanna kind of get the bad stuff out, then start putting the good stuff in, thenactivating the good stuff with the ozone.
(15:42):
So that's how we think.
You said dialing up AMPK, things like fasting.
Would a five day fast mimicking dial-
We've had that.
We've had that conversation on the podcast here with the prolon people.
And I did one with them also at the longevity summit on the doctor talks uh network.
(16:03):
Yeah.
The prolon is great for activating AMPK, right?
Because when you deprive yourself of calories or minimize calories,
There's not enough calories around to activate mTOR.
mTOR requires calories.
It basically is monitoring amino acid levels.
And then also uh insulin, which is part of the mTOR pathway.
We think of insulin as just being glucose, but it's also part of the mTOR growth pathwayis obviously monitoring glucose.
(16:30):
So you're monitoring amino acids and glucose levels.
And when those are replete, when you've got plenty of those, then you can activate mTOR.
But when you fast and do a five day fast, and this is
more powerful than just intermittent fasting.
You can actually activate AMPK turn off mTOR.
And then if you take spermidine on top of that, and spermidine is a wonderful moleculebecause it activates AMPK and autophagy and other things.
(16:58):
Now you add spermidine into that.
my gosh, you're really kind of like doing spring cleaning, like a very thorough springcleaning.
And so that's a great way to prep.
We have many people prep for rejuvenation procedures, you know, doing a five day fast,mimicking diet, depending on who they are, what they're coming in with and that sort of
thing.
Yeah.
Nice.
(17:18):
It's also World Hepatitis Day on July 28th.
I know you've been looking forward to this day.
You said at the beginning, you've been looking forward to this.
Well, it was Chord Blood I was really excited about, yeah.
Day, how does chronic liver inflammation, viral hepatitis, accelerate aging at thecellular level?
(17:41):
Yeah, so it's a question.
know, chronic hepatitis, hepatitis C being a prime example.
is really chronic inflammation in the liver and chronic inflammation in the liverincreases oxidative stress, which increases damage, which increases the body's reaction to
(18:03):
damage, which is ultimately fibrosis, which leads to cirrhosis, which leads to liverfailure.
Right.
So there's a whole cascade.
There's a reason why people don't live as long when they have chronic hepatitis.
and it has to do with, a fast track to liver failure.
But in addition to that, just having that inflamed liver basically sends out freecirculating oxidized DNA, right?
(18:28):
And that can lead to activation of the immune system systemically.
And it's been found that the white blood cells in the immune system now have shortertelomere lengths than they would have otherwise.
It's also activating systemic cytokines like IL-6 and TNF-alpha, right?
And it turns out that when you activate those cytokines, you're now driving sarcopenia,which is a loss of muscle, right?
(18:52):
And we know that the loss of muscle is not really about destroying the muscle cells.
It's about destroying the neurons that innervate the muscles.
That's why you lose muscle.
And so that's really interesting.
Yeah.
And it also, now you're depleting your NAD pools.
Right.
So you have less energy to actually repair everything.
and so when you put all this together, you end up with aging signals that get broadcastinto the muscles, into the vasculature, into the immune system and also into the brain.
(19:24):
Right.
So it's a, it's a really big deal.
There is no isolated organ in the body.
You know, we just talked about how the eye,
and exposure to bright light has a systemic impact.
Well, if your liver's inflamed, you're aging yourself dramatically faster, right?
And there are ways to follow liver function.
An ultrasound can look for fatty liver, so can an MRI scan.
(19:44):
There are also blood test routines that will look at probability of fatty liver, ohroutine blood markers like ALT, AST, ALP, GGT, bilirubin, albumin, and...
INR, has to do with clotting factors, along with C-reactive protein, all can give youinsight.
Measuring NAD levels can give you insight as to where you are.
(20:06):
DNA methylation ages actually go up dramatically with chronic hepatitis, like eight to 10years, right, with chronic hepatitis.
So you're aging yourself systemically across the board.
So it's pretty dramatic.
Yeah.
What sorts of regenerative tools can restore liver health?
Yeah.
So, you know, the biggest, driver of liver problems is non-alcoholic fatty liver disease,right?
(20:33):
Um, the number of people that have chronic hepatitis is fairly small, but non-alcoholicfatty liver disease is predominantly related to either drinking too much alcohol or having
insulin resistance.
Right.
So I know it's non-alcoholic, but when you're
When you're drinking alcohol, you're actually changing the milieu and you become moresensitive to the other things.
(20:53):
Now, if you drink a lot, you can damage the liver directly and cause problems, right?
But non-alcoholic fatty liver disease sets the body up on this whole cascade of fataccumulation, inflammation, fibrosis, destruction, increased risk of liver uh cancer and
death from liver failure.
(21:13):
So, you know, when you talk about what can you do, well, some of the first things you cando is basically to control the lifestyle issues, right?
So you don't want to be eating a lot of sugar.
You want to monitor your insulin levels.
You want to see what's happening there, right?
You also want to look at liver function tests, et cetera.
So you've got to start there.
Then we've had good success actually.
(21:37):
in non-alcoholic fatty liver disease by boosting AMPK.
And we just talked about boosting AMPK with fast-memaking diets and then the drugmetformin increases AMPK.
So does berberine, resveratrol does, and then boosting NAD alongside that.
And then milk thistle, right?
Many people have heard of milk thistle.
It turns out that it's very, very good at decreasing fibrosis markers in the liver.
(22:02):
And then there's Tudka and...
And UDCA, right?
Tudka, T-U-D-C-A.
Basically, these are metabolites of bile acids and they actually improve many things inthe body.
They're kind of antioxidants in a way, but they also improve liver function.
And taking omega-3s can be good.
And then when you want to get into the actual antivirals, right?
(22:25):
There's a number of antivirals that have been, they're quite expensive.
They're antibodies typically, but
those can be used to actually treat the uh underlying issue.
you can add to that some of the stem cell infusions, mesenchymal stem cells, anything thatwill quiet some of the cord blood things that we talked about, anything that will help to
quiet down the inflammation can be useful.
(22:48):
So, yeah.
on a, it was actually a living beyond 120 podcast way back in your, in your podcastingjourney, you guys were having success at reversing fatty liver disease.
And, and, and I remember the guests at the time said within the regular doctor,traditional medical community, they thought it was irreversible.
(23:16):
in general.
we were told that, in fact, we had a guy that was on a transplant list.
His father had died with cirrhosis and he'd been placed on a transplant list because ofthe status of his liver.
we started him on a protocol.
You know, that's, know more now than we did then, right?
So that was maybe what, six or seven years ago?
um And maybe, maybe, yeah, seven, at least seven years ago.
(23:40):
And we focused primarily on activating AMPK.
Uh, we didn't know about an NAD at that time.
We didn't know how to really boost NAD.
We didn't know about all the inflammatory cytokines that we could remove with plasma,freezes and all this kind of stuff.
Right.
We didn't know about monitoring his diet, um, cutting down on the carbs, things like that.
So we did that.
We had him stay away from alcohol and we just basically gave him, something called StemiaSilvestra.
(24:05):
It's called immortality.
it's a T actually.
Doesn't taste great, but it's a T and it's a known potent AMPK activator.
So we didn't even use yeah, Berberine or metformin.
We used immortality and he went back to see his gastroenterologist about, I'm going to saythree or four months later and they did a follow up echo in the office ultrasound because
(24:28):
you can see fibrosis and fat on an ultrasound just in an office.
You don't have to go for an MRI necessarily.
And his liver had improved significantly and they took them off the transplant list.
And the guy said, I have never seen this before.
And I'm like, well, that's cool.
We like that.
So welcome to our world.
Right.
So yeah.
I'm looking up immortality on, the internet and I'm seeing some ideas.
(24:52):
I'm going to have to get me some of this because I do enjoy some tea, even though itdoesn't taste good.
If, if, if, if I would assume, I would assume if, if I'm doing a five day fast, mimickingdiet or in that, you know, when I'm focused on the AMPK, I'm trying to rejuvenate my body,
heal DNA, that kind of stuff.
(25:13):
The adding that.
to what everything else I'm doing would be a good thing.
I would add that and some spermadine and, um, some of the NAD precursors would be a goodthing also.
And we've done a podcast previously on a product called Mimeo, which is basically, um,kind of a fast mimicking diet in a pill.
(25:36):
Um, and guess what is in Mimeo?
Spermadine, high amounts of spermadine, one with a little bit of niacin.
And also some PEA and OEA.
The PEA is good anti-inflammatory, particularly in the brain and the OEA curbs appetite.
So when we're working with people, you uh know, getting them off their GLP-1s, the Memeois one of the things that we go for.
(25:58):
And also the five day fast memaking diet, because you can reset your appetite, your tastebuds.
It's not just your gut.
It's not just that you have fewer calories.
You're actually recalibrating your nervous system in terms of taste.
desire for food, the gut biome, of course, if you've got the wrong bacteria down there,they're screaming for food.
They're sending out signals, feed me, feed me, feed me.
(26:20):
It's like, think of your intestine almost like a nest with baby birds in it, like feed me,feed me, feed me.
So they're driving part of your appetite as well.
And you can reset all of that with a five day fast-moving diet, which is pretty cool.
Well, Mimeo is one of those supplements that I pretty regularly take and I'm low and Ineed to, I need to get it again.
(26:41):
So thanks for that reminder.
Now you and I over the last handful of months, you mentioned you guys are developing acourse and an app.
Let's, let's, let's tease that for the listeners.
the book, 100 is the New 30, which involves four circles, life energy, longevity, health,and performance.
(27:08):
And now we've added a fifth circle, which is the environments, focusing on theenvironments we reside in, right?
Because we feel like true success is a function of making sure that each environment
And we all live in four predominantly, right?
Home, work, business, travel, vacation, architecting each of those four environments tosupport the mission.
(27:29):
So that when you're, when you go to Italy, the wheels don't come off or when you take aweek off and you go spend it with your family someplace, the wheels don't come off, right?
It's like, how am going to exercise?
Where's the food going to come from?
You know, how easy can I make it for me to be able to take my supplements?
You know, things like that.
So intentionally architecting the, at that level.
(27:49):
But then also what's the water quality?
What's the air quality?
Is there mold in the facility?
You know, all these kinds of things.
If you architect that for people, all of a sudden it's so much easier for them to makeprogress because they're being reinforced.
Their progress is being reinforced in every environment they go into.
Right.
So that's a big deal.
So that's kind of the fifth circle.
So we created a course to train people on actually how to implement.
(28:14):
The book is full of tremendous information, right?
But I didn't, I wrote it in such a way that it wasn't, didn't end up being like terriblyactionable in the sense of, okay, now I know what to do.
It's like, now I understand what the problems are and I understand what the solutionscould be, but I don't know exactly what to do for me based on the book, because it's hard
(28:35):
to make a book that's specific to everybody.
In the course, we're going to break it down so that people can actually see.
You know, okay, what tests do I need to do?
And then what do I need to do about those tests when I get them?
Right?
So this is a, this is a course that we're bringing forward to the, to the public.
So we're excited about that.
It's we've been working on it, refining it.
(28:56):
Um, we were going to bring it forward initially just for practitioners.
and then we realized, you know, this would probably have more benefit for more people ifwe brought it out to the general public.
And of course practitioners will, will benefit from it too.
So we're.
we're reducing the cost significantly and trying to make it accessible for people.
(29:18):
And we're still fine tuning it, but we should have it out fairly soon.
So yeah, that's the idea behind the course.
let's learn, but not only that, but let's learn what I need to do and make it actionable.
So.
Well, go to gladdenlongevity.com, sign up for the email list so that way you can be firstto know when this comes out.
And for many of those supplements that we talked about here on the podcast, they'reavailable in the Gladden Longevity Shop.
(29:44):
Just go to gladdenlongevityshop.com, enter promo code podcast10 and get 10 % off of yourorder.
Dr.
Gladden, anything else?
Yeah, we're working on an app that I'll tell you about.
Super excited about this.
It's a multi-agent AI app, meaning there are multiple AI agents that are in the backdrop.
(30:05):
We're going to be bringing it forward for beta testing in September.
It's going to be coaching off the five circles.
And we've trademarked a name that we like a lot.
It's called the Longevity Wingman.
And so...
What the app is there to do is to kind of be your best friend, your best buddy, to helphelp you make everything as easy as possible.
Right.
Like I'm going to New York next weekend.
(30:26):
Where should I stay?
Where's a hotel that has the right workout room, the right sauna?
Where are the restaurants I should have?
Who's going to have the right food?
All of that's done through for you through the app.
I can order tests.
I can keep track of my supplements.
It'll keep scorecards for you around all the circles in terms of where am I?
on the longevity, health, performance, and life energy circles.
(30:48):
Here are resources for me to continue to build.
It's going to be an ability to, on the app, order what you need, whether it's testing orsupplements or equipment, so that everything is right in the palm of your hand.
It's like, how easy can this be?
How easy?
The thing that's driving it for me is realizing that longevity
(31:09):
not only is it a journey, but it takes time and attention.
So how can we make it as easy as possible for people, right?
They can upload their labs.
We're actually creating connections now where if people click on the lab and order it,they can have it done at their home or they can go to a place close to them to have it
done.
We'll automatically scavenge the, or collect the data from that, put it back in the app.
(31:32):
So ultimately we're going to know more about them.
than anybody else and be able to coach them through this multi-agentic AI on things thatare actually appropriate for them.
So it's incredibly personalized and specific to the individual and it'll have all kinds ofreally cool features.
anyway, be on the lookout for the longevity wingman.
That's going to be very cool.
count me among those that wants to beta test once you guys have that beta test version upthere.
(31:58):
Because I'd love to give my feedback on here as well once once it's actually live.
Yeah, absolutely.
No, we'll be sure to include you.
Dr.
Gladden, thanks so much for another Q &A, monthly Q &A.
What are the big plans for August?
Hmm.
Big plans for August.
you know, finishing the app right now.
(32:19):
I'm really, really in the middle of that, finishing the app and a little bit of travel.
so trying to stay out of the heat, get my mountain biking in early in the day here inTexas this summer.
So all good, but it's all good.
you come to Colorado, let's set up a 14 or a 13 or together and do another hike together.
(32:41):
Yeah, we'll do it.
I love it.
Wear our sunglasses.
All right.
Later.
Yeah.
Welcome to the Gladden Longevity Podcast with Dr.
Jeffrey Gladden, where our passion is helping you become an age hacker.
On this show, we want to help you optimize your life energy, longevity, health and humanperformance with impactful and actionable information by answering four questions.
How good can we be?
How do we make 100 the new 30?
(00:49):
How do we live well beyond 120?
And how do we live young for a lifetime?
I'm Steve Ryder back for another question and answer with you, Dr.
Gladden.
And it is July granted it's late July, but we do have some topics that we're going to betalking about.
How's your July shaped up thus far?
Great.
Yeah, it's been great.
It's been a good summer and it's good to see you again.
(01:10):
I will just add this that we've added a fifth question, which is, yeah, how do we developa 300 year old mine?
that's awesome.
Well, it is July and it is healthy vision and UV safety month.
So how does UV related eye damage contribute to systemic inflammation and aging?
(01:33):
Does it have a factor?
Yeah, so that's an interesting question,
I did a little research on this question.
We've known that, interestingly enough, that it's early morning sunlight, right, before,let's call it 10 a.m., that actually triggers the brain to start making melatonin.
It has a real impact on our circadian rhythm.
(01:54):
And so getting early morning sunlight, like,
first thing in the morning, if you can go outside and get grounded, get some early morningsunlight, it's doing a lot of really good things for you.
However, if you're out in the bright sunshine, let's say between, depending on where youlive, maybe it's 10 a.m.
to 4 p.m., it's another story completely.
And at this point, that really bright sunlight is causing a lot of inflammation, if youwill, in the eyeball.
(02:21):
Really?
because it's a lot of energy coming in that's creating oxidative stress.
And when you have oxidative stress, then you release a lot of inflammatory cytokines,right?
IL-1, IL-6, TNF, alpha.
And it turns out that those are activated not only in the eye, but they're put into thetears, they're reabsorbed into the body and they become systemic.
(02:46):
So now when you're exposing your eyes to bright sunlight, you're actually not onlyincreasing eye inflammation, which we can talk about some of the downsides of that, but
you're also increasing systemic inflammation.
And with that systemic inflammation, what they found is that it alters immune function.
can drive ongoing low grade inflammation in the body, but also it can suppress,
(03:10):
the immune system that makes it more difficult for it to work properly and, uh, impairsour ability to repair.
So it's kind of a big deal.
it can also increase advanced glycation end products, in the body and in the eye itself.
you can almost think of, uh, bright sunlight, almost like causing many, central nervoussystem insults, right?
(03:30):
So it can actually accelerate damage and neuroinflammation.
Uh,
in our brains.
So it's kind of a big deal.
Whereas early morning sunlight is really God's gift to you.
Bright sunlight during the day can be a real problem.
So pretty interesting.
What kinds of nutritional and lifestyle strategies can support ocular longevity,especially in high UV environments like Colorado, where we are at least where I'm at.
(04:00):
I'm at about 7,000 feet above sea level.
Yeah.
You have a double whammy and, it's sunny there pretty much all the time.
I mean, you get the afternoon.
300 plus days of sunshine a year.
Right.
And you do get in the mountains, you do get that afternoon thunderstorm frequently, whichkind of mitigates it a little bit.
But I think the number one thing is to get some sunglasses and you want to get these, youknow, you've seen the guys, the mountaineers, right?
(04:25):
With the kind of the wraparound sunglasses or the sunglasses that have the sort of theflaps on the side to keep extraneous light out.
and those lenses are polarized for one thing, and they're also UV.
400 certified, which means that they're basically block 100 % of the UVA and UVC light.
And that cuts down the dose on your eye about 95 % apparently.
(04:48):
So that's super important.
I think the first thing is, if you're going to be out in the sun is to get some reallygood, expensive, high quality wrap around sunglasses.
That's the first thing.
And then, you know, when it comes to
taking care of your eyes in general.
It's interesting.
You can do a genetics test that will look at genes associated with things like maculardegeneration, right?
(05:14):
Which it turns out all that bright sunlight can accelerate that.
Some of the other things that Intellxx DNA, if I didn't mention that, is a company thathas a really nice pivotal for that.
That's uh I-N-T-E-L-L-X-X.
The other thing that's
Important to note is that smoking, if you have the genes for macular degenerationincreases the risk of macular degeneration like 18 times.
(05:40):
Yeah.
So it's a big, it's a big, add and smoking in general, if you're going to be out in thesun is also adding, to the risk and primarily because it's using up a lot of your body's
antioxidant capacity, right?
alcohol is another problem.
making sure you use blue filters on your phones, even if you're outside.
(06:00):
And then there's certain supplements that you can take, right?
So there's one called AREDS, which is kind of a composite capsule that we use for peoplewith a risk of macular degeneration.
And it contains some vitamin C, vitamin E, a little bit of beta carotene, which is aprecursor to vitamin A, some zinc oxide, and a little bit of copper.
(06:22):
uh And then if you combine that with N acetylcysteine, which of course makes glutathione.
And if you drink molecular hydrogen, which helps you to block oxidative stress, you know,that becomes a pretty good strategy.
Interestingly enough, they have also come up with some eye drops that have exosomes inthem that can mitigate
(06:45):
some of the, some of the issues, right?
So that's pretty interesting.
And now they're also have some platinum nanosyme eye drops that are apparently they'retesting in primates that is showing some ability to decrease the reactive oxygen species.
so yeah, pretty interesting.
So anyway, the, the, the, the primary thing here is prevention.
(07:07):
The first, you know, if we're just going to consolidate the thoughts here, the
First line of defense is don't go out in the sun in the midday, right?
Early in the morning, later in the afternoon, know, broad brimmed hats, anything thatkeeps you in the shade, excellent sunglasses, and then taking some of the supplements that
we just mentioned becomes very important as well.
(07:28):
So that's it.
And of course, for your skin in general, we recommend the HelioCare, and there's now aHelioCare Ultra.
which comes from polypodium leukotomus, which protects your skin when you're out insunlight like that.
So to your point, Steve, if you're in Colorado uh or Arizona or many places in the Westthat are sunny and dry and hot, depending on whatever, really becomes important.
(07:52):
It's also important for people that are on the water, uh like fishing guides, right?
yeah.
fishing guides, either in rivers or lakes or in the ocean.
Or even in the winter, you can think about it this way.
If you're a snow skier or a snowmobile or a backpack or whatever you are, snowshoeing orwhatever, you're getting cross-country skiing.
(08:14):
Exactly right.
You're going to get a ton of reflected light off that snow and that can be really, reallyintense.
You know, people go quote unquote snow blind.
So
That's really important to keep in mind also.
You really got to protect your, you know, what's coming into the eye, right?
That's probably the most important.
So, yeah.
(08:35):
It's also Core Blood Awareness Month.
We've talked a lot about stem cells over the course of the podcast.
been waiting all year for Cord Blood Awareness Month.
I know you have.
So I guess first, before I ask my question, set it up for the listeners, the evolution ofthis little niche branch within the longevity field.
(09:01):
Yeah.
Well, basically it's, it's, conceptually, it's very simple.
Younger biologic products have more regenerative capacity than older biologic products.
Right.
When you look at cord blood and there's also placental tissue, right.
Which comes out at the same time cord blood does, we're talking about umbilical cord bloodhere.
(09:22):
Just to be clear.
and placental tissue, right?
These are full of very, very youthful factors.
The stem cells that are in here have long telomeres.
There are many regenerative exosomes and forms of messenger RNA and other things that haveincredible regenerative capacity, right?
So if a baby, let's say in utero, suffers an injury, they can heal that injury and thatyou would never know it was injured.
(09:47):
If a young child breaks their arm,
right?
The bone heals and it's like there was never a fracture there.
So very youthful tissues like cord blood, like placental tissue, things like that can beincredibly regenerative.
And so that's why people are really interested in this.
So, yeah.
How is this potentially going to be used in the aging reversal arena?
(10:16):
it's used predominantly as an adjunct to other technologies, right?
So what we've found is that in order to rejuvenate things in an older person, you firsthave to take out the old stuff, which kind of makes sense.
The analogy I always use is that if you've got a youthful Olympic swimmer and you wantthem to go in and do, you know, amazing lap times in the pool,
(10:41):
Well, you got to clean out the pool first, right?
You got to take out all the logs, the twigs, the lawn chairs.
You got to clear out the pool.
Then you got to freshen the water, right?
They can't swim in murky water and dirty water as efficiently, right?
It's more friction, whatever else the analogy is.
But the point is you've got to clear out the trash and you got to clean up the water.
(11:02):
And then you allow them to go and then you've got to feed them.
You've got to give them the right nutrients and you've got to give them enough NAD andyou've got to give them the right peptides and things like this.
Right.
So when you actually get that right, when you get the sequence right, it's not just abouta quote unquote stem cell or a cord blood product or a peptide for that matter.
It's really how you clean up the environment.
(11:24):
Then how you energize the rejuvenation therapies, how you link them together.
And then how you actually support them going forward with more NAD peptides that actuallyare signaling molecules that keep the body kind of in a healing mode, hormone
optimization, thyroid optimization, things like that.
um Once you do this properly, you can get really remarkable results in an older individualwho may have difficulty healing, healing a bone, healing a wound, things like that.
(11:54):
So that's, that's the broad overview of it.
We can get a little more specific if you like as well, but.
Yeah, what kinds of early markers should be monitored to measure success in regenerativeprotocols using core blood derived interventions?
Yeah.
Well, a lot of, a lot of the problem with aging, of course, is that we end up with a lotof inflammatory markers.
(12:15):
And these can be measured in the blood, uh, quite readily, quite readily, right?
IL-6, IL-1, TGF alpha, TGF beta, things like this, can all be measured.
And consequently, when you use products, like cord blood, et cetera, you can actually, seethat there's a,
a diminution of those inflammatory molecules.
(12:37):
There are also ways to show that senescent cell burden is actually being decreased througha new test that we just got a hold of from a company SAPERE, SAPERE that can measure P16.
P16 is a more specific measure of senescent cell burden than beta-galactosidase, which isbetter than nothing, but not as specific.
(13:00):
And so...
You can actually see impacts on P16.
And then based on modifying the cytokinesis, inflammation and the associated oxidativestress, you can also look at measures of DNA methylation H and you can see that those
improve as well.
Right.
So those are ways to kind of track and follow what's happening.
(13:21):
So C-reactive protein can also be measured.
And one of the things that seems to really
augment the impact of cord blood is activating AMPK at the same time.
So AMPK sits on one side of a teeter totter and mTOR sits on the other side, right?
And they go up and down, but they're a teeter totter.
(13:42):
you're low on one, you're high on the other and vice versa.
And mTOR of course is building bone, building muscle, cell division, it's cell growth, etcetera.
And it's a good thing until it's too much of it causes you to have cancer and you diesooner.
Right.
AMPK on the other hand, is what happens when we do fasting, when we do cardio exercise,when we take drugs like metformin or supplements like berberine, and it actually activates
(14:06):
DNA repair and activates sirtuins and it requires NAD to also be present.
so boosting NAD at the same time.
becomes very, very important.
And so we have ways to boost NAD with a couple of different products.
Now, Vitality combined with Ducito Time, throwing some Apigenin as well, jump in an ozonesauna and you can really, really regenerate uh NAD concentrations.
(14:33):
You really feel that.
So anyway, again, it's about putting these pieces together in a way that makes sense.
And then you can get some pretty cool results.
You mentioned the ozone sauna, which you guys have one at the gladden longevity clinic,which I've done on the trip that I did out there last year.
Would an Ibu treatment as well prior to the treatment with the cord blood stem cells help?
(15:00):
Yeah.
So we actually like to energize the system with NAD and many times we will use ozone inone form or another, whether it's ebu, which is filtering the blood and ozonating it,
whether it's the ozone sauna to just, it's cheaper and faster to just jump on an ozonesauna for 20 minutes, or sometimes we'll inject ozone into a joint or an area, skin or
(15:20):
wherever else to help energize the system.
also, ozone itself decreases inflammation.
seems to stimulate regeneration, decreases pain significantly, it works very good forpain.
And then, you you combine these in the right sequence, right?
So you wanna kind of get the bad stuff out, then start putting the good stuff in, thenactivating the good stuff with the ozone.
(15:42):
So that's how we think.
You said dialing up AMPK, things like fasting.
Would a five day fast mimicking dial-
We've had that.
We've had that conversation on the podcast here with the prolon people.
And I did one with them also at the longevity summit on the doctor talks uh network.
(16:03):
Yeah.
The prolon is great for activating AMPK, right?
Because when you deprive yourself of calories or minimize calories,
There's not enough calories around to activate mTOR.
mTOR requires calories.
It basically is monitoring amino acid levels.
And then also uh insulin, which is part of the mTOR pathway.
We think of insulin as just being glucose, but it's also part of the mTOR growth pathwayis obviously monitoring glucose.
(16:30):
So you're monitoring amino acids and glucose levels.
And when those are replete, when you've got plenty of those, then you can activate mTOR.
But when you fast and do a five day fast, and this is
more powerful than just intermittent fasting.
You can actually activate AMPK turn off mTOR.
And then if you take spermidine on top of that, and spermidine is a wonderful moleculebecause it activates AMPK and autophagy and other things.
(16:58):
Now you add spermidine into that.
my gosh, you're really kind of like doing spring cleaning, like a very thorough springcleaning.
And so that's a great way to prep.
We have many people prep for rejuvenation procedures, you know, doing a five day fast,mimicking diet, depending on who they are, what they're coming in with and that sort of
thing.
Yeah.
Nice.
(17:18):
It's also World Hepatitis Day on July 28th.
I know you've been looking forward to this day.
You said at the beginning, you've been looking forward to this.
Well, it was Chord Blood I was really excited about, yeah.
Day, how does chronic liver inflammation, viral hepatitis, accelerate aging at thecellular level?
(17:41):
Yeah, so it's a question.
know, chronic hepatitis, hepatitis C being a prime example.
is really chronic inflammation in the liver and chronic inflammation in the liverincreases oxidative stress, which increases damage, which increases the body's reaction to
(18:03):
damage, which is ultimately fibrosis, which leads to cirrhosis, which leads to liverfailure.
Right.
So there's a whole cascade.
There's a reason why people don't live as long when they have chronic hepatitis.
and it has to do with, a fast track to liver failure.
But in addition to that, just having that inflamed liver basically sends out freecirculating oxidized DNA, right?
(18:28):
And that can lead to activation of the immune system systemically.
And it's been found that the white blood cells in the immune system now have shortertelomere lengths than they would have otherwise.
It's also activating systemic cytokines like IL-6 and TNF-alpha, right?
And it turns out that when you activate those cytokines, you're now driving sarcopenia,which is a loss of muscle, right?
(18:52):
And we know that the loss of muscle is not really about destroying the muscle cells.
It's about destroying the neurons that innervate the muscles.
That's why you lose muscle.
And so that's really interesting.
Yeah.
And it also, now you're depleting your NAD pools.
Right.
So you have less energy to actually repair everything.
and so when you put all this together, you end up with aging signals that get broadcastinto the muscles, into the vasculature, into the immune system and also into the brain.
(19:24):
Right.
So it's a, it's a really big deal.
There is no isolated organ in the body.
You know, we just talked about how the eye,
and exposure to bright light has a systemic impact.
Well, if your liver's inflamed, you're aging yourself dramatically faster, right?
And there are ways to follow liver function.
An ultrasound can look for fatty liver, so can an MRI scan.
(19:44):
There are also blood test routines that will look at probability of fatty liver, ohroutine blood markers like ALT, AST, ALP, GGT, bilirubin, albumin, and...
INR, has to do with clotting factors, along with C-reactive protein, all can give youinsight.
Measuring NAD levels can give you insight as to where you are.
(20:06):
DNA methylation ages actually go up dramatically with chronic hepatitis, like eight to 10years, right, with chronic hepatitis.
So you're aging yourself systemically across the board.
So it's pretty dramatic.
Yeah.
What sorts of regenerative tools can restore liver health?
Yeah.
So, you know, the biggest, driver of liver problems is non-alcoholic fatty liver disease,right?
(20:33):
Um, the number of people that have chronic hepatitis is fairly small, but non-alcoholicfatty liver disease is predominantly related to either drinking too much alcohol or having
insulin resistance.
Right.
So I know it's non-alcoholic, but when you're
When you're drinking alcohol, you're actually changing the milieu and you become moresensitive to the other things.
(20:53):
Now, if you drink a lot, you can damage the liver directly and cause problems, right?
But non-alcoholic fatty liver disease sets the body up on this whole cascade of fataccumulation, inflammation, fibrosis, destruction, increased risk of liver uh cancer and
death from liver failure.
(21:13):
So, you know, when you talk about what can you do, well, some of the first things you cando is basically to control the lifestyle issues, right?
So you don't want to be eating a lot of sugar.
You want to monitor your insulin levels.
You want to see what's happening there, right?
You also want to look at liver function tests, et cetera.
So you've got to start there.
Then we've had good success actually.
(21:37):
in non-alcoholic fatty liver disease by boosting AMPK.
And we just talked about boosting AMPK with fast-memaking diets and then the drugmetformin increases AMPK.
So does berberine, resveratrol does, and then boosting NAD alongside that.
And then milk thistle, right?
Many people have heard of milk thistle.
It turns out that it's very, very good at decreasing fibrosis markers in the liver.
(22:02):
And then there's Tudka and...
And UDCA, right?
Tudka, T-U-D-C-A.
Basically, these are metabolites of bile acids and they actually improve many things inthe body.
They're kind of antioxidants in a way, but they also improve liver function.
And taking omega-3s can be good.
And then when you want to get into the actual antivirals, right?
(22:25):
There's a number of antivirals that have been, they're quite expensive.
They're antibodies typically, but
those can be used to actually treat the uh underlying issue.
you can add to that some of the stem cell infusions, mesenchymal stem cells, anything thatwill quiet some of the cord blood things that we talked about, anything that will help to
quiet down the inflammation can be useful.
(22:48):
So, yeah.
on a, it was actually a living beyond 120 podcast way back in your, in your podcastingjourney, you guys were having success at reversing fatty liver disease.
And, and, and I remember the guests at the time said within the regular doctor,traditional medical community, they thought it was irreversible.
(23:16):
in general.
we were told that, in fact, we had a guy that was on a transplant list.
His father had died with cirrhosis and he'd been placed on a transplant list because ofthe status of his liver.
we started him on a protocol.
You know, that's, know more now than we did then, right?
So that was maybe what, six or seven years ago?
um And maybe, maybe, yeah, seven, at least seven years ago.
(23:40):
And we focused primarily on activating AMPK.
Uh, we didn't know about an NAD at that time.
We didn't know how to really boost NAD.
We didn't know about all the inflammatory cytokines that we could remove with plasma,freezes and all this kind of stuff.
Right.
We didn't know about monitoring his diet, um, cutting down on the carbs, things like that.
So we did that.
We had him stay away from alcohol and we just basically gave him, something called StemiaSilvestra.
(24:05):
It's called immortality.
it's a T actually.
Doesn't taste great, but it's a T and it's a known potent AMPK activator.
So we didn't even use yeah, Berberine or metformin.
We used immortality and he went back to see his gastroenterologist about, I'm going to saythree or four months later and they did a follow up echo in the office ultrasound because
(24:28):
you can see fibrosis and fat on an ultrasound just in an office.
You don't have to go for an MRI necessarily.
And his liver had improved significantly and they took them off the transplant list.
And the guy said, I have never seen this before.
And I'm like, well, that's cool.
We like that.
So welcome to our world.
Right.
So yeah.
I'm looking up immortality on, the internet and I'm seeing some ideas.
(24:52):
I'm going to have to get me some of this because I do enjoy some tea, even though itdoesn't taste good.
If, if, if, if I would assume, I would assume if, if I'm doing a five day fast, mimickingdiet or in that, you know, when I'm focused on the AMPK, I'm trying to rejuvenate my body,
heal DNA, that kind of stuff.
(25:13):
The adding that.
to what everything else I'm doing would be a good thing.
I would add that and some spermadine and, um, some of the NAD precursors would be a goodthing also.
And we've done a podcast previously on a product called Mimeo, which is basically, um,kind of a fast mimicking diet in a pill.
(25:36):
Um, and guess what is in Mimeo?
Spermadine, high amounts of spermadine, one with a little bit of niacin.
And also some PEA and OEA.
The PEA is good anti-inflammatory, particularly in the brain and the OEA curbs appetite.
So when we're working with people, you uh know, getting them off their GLP-1s, the Memeois one of the things that we go for.
(25:58):
And also the five day fast memaking diet, because you can reset your appetite, your tastebuds.
It's not just your gut.
It's not just that you have fewer calories.
You're actually recalibrating your nervous system in terms of taste.
desire for food, the gut biome, of course, if you've got the wrong bacteria down there,they're screaming for food.
They're sending out signals, feed me, feed me, feed me.
(26:20):
It's like, think of your intestine almost like a nest with baby birds in it, like feed me,feed me, feed me.
So they're driving part of your appetite as well.
And you can reset all of that with a five day fast-moving diet, which is pretty cool.
Well, Mimeo is one of those supplements that I pretty regularly take and I'm low and Ineed to, I need to get it again.
(26:41):
So thanks for that reminder.
Now you and I over the last handful of months, you mentioned you guys are developing acourse and an app.
Let's, let's, let's tease that for the listeners.
the book, 100 is the New 30, which involves four circles, life energy, longevity, health,and performance.
(27:08):
And now we've added a fifth circle, which is the environments, focusing on theenvironments we reside in, right?
Because we feel like true success is a function of making sure that each environment
And we all live in four predominantly, right?
Home, work, business, travel, vacation, architecting each of those four environments tosupport the mission.
(27:29):
So that when you're, when you go to Italy, the wheels don't come off or when you take aweek off and you go spend it with your family someplace, the wheels don't come off, right?
It's like, how am going to exercise?
Where's the food going to come from?
You know, how easy can I make it for me to be able to take my supplements?
You know, things like that.
So intentionally architecting the, at that level.
(27:49):
But then also what's the water quality?
What's the air quality?
Is there mold in the facility?
You know, all these kinds of things.
If you architect that for people, all of a sudden it's so much easier for them to makeprogress because they're being reinforced.
Their progress is being reinforced in every environment they go into.
Right.
So that's a big deal.
So that's kind of the fifth circle.
So we created a course to train people on actually how to implement.
(28:14):
The book is full of tremendous information, right?
But I didn't, I wrote it in such a way that it wasn't, didn't end up being like terriblyactionable in the sense of, okay, now I know what to do.
It's like, now I understand what the problems are and I understand what the solutionscould be, but I don't know exactly what to do for me based on the book, because it's hard
(28:35):
to make a book that's specific to everybody.
In the course, we're going to break it down so that people can actually see.
You know, okay, what tests do I need to do?
And then what do I need to do about those tests when I get them?
Right?
So this is a, this is a course that we're bringing forward to the, to the public.
So we're excited about that.
It's we've been working on it, refining it.
(28:56):
Um, we were going to bring it forward initially just for practitioners.
and then we realized, you know, this would probably have more benefit for more people ifwe brought it out to the general public.
And of course practitioners will, will benefit from it too.
So we're.
we're reducing the cost significantly and trying to make it accessible for people.
(29:18):
And we're still fine tuning it, but we should have it out fairly soon.
So yeah, that's the idea behind the course.
let's learn, but not only that, but let's learn what I need to do and make it actionable.
So.
Well, go to gladdenlongevity.com, sign up for the email list so that way you can be firstto know when this comes out.
And for many of those supplements that we talked about here on the podcast, they'reavailable in the Gladden Longevity Shop.
(29:44):
Just go to gladdenlongevityshop.com, enter promo code podcast10 and get 10 % off of yourorder.
Dr.
Gladden, anything else?
Yeah, we're working on an app that I'll tell you about.
Super excited about this.
It's a multi-agent AI app, meaning there are multiple AI agents that are in the backdrop.
(30:05):
We're going to be bringing it forward for beta testing in September.
It's going to be coaching off the five circles.
And we've trademarked a name that we like a lot.
It's called the Longevity Wingman.
And so...
What the app is there to do is to kind of be your best friend, your best buddy, to helphelp you make everything as easy as possible.
Right.
Like I'm going to New York next weekend.
(30:26):
Where should I stay?
Where's a hotel that has the right workout room, the right sauna?
Where are the restaurants I should have?
Who's going to have the right food?
All of that's done through for you through the app.
I can order tests.
I can keep track of my supplements.
It'll keep scorecards for you around all the circles in terms of where am I?
on the longevity, health, performance, and life energy circles.
(30:48):
Here are resources for me to continue to build.
It's going to be an ability to, on the app, order what you need, whether it's testing orsupplements or equipment, so that everything is right in the palm of your hand.
It's like, how easy can this be?
How easy?
The thing that's driving it for me is realizing that longevity
(31:09):
not only is it a journey, but it takes time and attention.
So how can we make it as easy as possible for people, right?
They can upload their labs.
We're actually creating connections now where if people click on the lab and order it,they can have it done at their home or they can go to a place close to them to have it
done.
We'll automatically scavenge the, or collect the data from that, put it back in the app.
(31:32):
So ultimately we're going to know more about them.
than anybody else and be able to coach them through this multi-agentic AI on things thatare actually appropriate for them.
So it's incredibly personalized and specific to the individual and it'll have all kinds ofreally cool features.
anyway, be on the lookout for the longevity wingman.
That's going to be very cool.
count me among those that wants to beta test once you guys have that beta test version upthere.
(31:58):
Because I'd love to give my feedback on here as well once once it's actually live.
Yeah, absolutely.
No, we'll be sure to include you.
Dr.
Gladden, thanks so much for another Q &A, monthly Q &A.
What are the big plans for August?
Hmm.
Big plans for August.
you know, finishing the app right now.
(32:19):
I'm really, really in the middle of that, finishing the app and a little bit of travel.
so trying to stay out of the heat, get my mountain biking in early in the day here inTexas this summer.
So all good, but it's all good.
you come to Colorado, let's set up a 14 or a 13 or together and do another hike together.
(32:41):
Yeah, we'll do it.
I love it.
Wear our sunglasses.
All right.
Later.
Yeah.
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