Can the Gut Microbiome Predict your Response to Psychedelics? with Giorgia Caspani, PhD

In this episode of the Psychedelic Medicine Podcast, Giorgia Caspani, PhD joins to discuss the intersection of psychedelics and the gut microbiome and ramifications for future personalized medicine. Dr. Caspani is a neuroscientist and computational biologist working at the intersection of gut microbiome, psychedelics and personalized medicine.

In this conversation, Dr. Caspani discusses her research published in the article “Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis.” She shares what we know about how psychedelics impact the gut microbiome from initial studies and what questions remain unanswered. She draws connections between the way the gut microbiome metabolizes SSRI drugs and how serotonin impacts the gut microbiota to hypothesize the potential ways psychedelics interact with this complex living system. In closing, Dr. Caspani discusses the possibility of predicting responses to psychedelic treatments using data from the microbiota, and the research currently happening to make this possible. 

 

In this episode you'll hear:

• How human beings and our gut microbiome co-evolved and the benefits achieved through this symbiotic relationship
• The correlation between the gut microbiome and stress levels 
• The effects of psychedelics on immune responses
• Why personalized medicine may be a more effective approach for treating depression
• How personalized medicine could help make psychedelic therapies more accessible and effective

 

Quotes:

“Without our gut microbes… We wouldn't be able to really perform a lot of the metabolic functions that we rely on as humans.” [4:26]

“The gut microbiome is different in every person—it’s very unique. And so every person carries this unique microbial signature that can potentially map out to all of the treatment options that we already have available; it’s just a matter of understanding and identifying markers that can predict which patient will benefit from a specific drug.” [18:22]

“[We hypothesize that] the gut microbiome shapes individual responses to psychedelic treatment. And so if that [hypothesis] is correct, if that is true, we could potentially target the microbiome, change the composition of the gut microbiome like we wanted to, to be able to maximize the effectiveness of these [psychedelic] drugs.” [25:14]

Links:

Dr. Caspani’s article, “Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis”

Dr. Caspani on LinkedIn

Dr. Caspani on X

Onaya Science website

Psychedelic Medicine Association

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