In this episode of the SuperCreativity Podcast, James Taylor speaks with Professor Masud Husain, neurologist, neuroscientist, essayist, and author of Our Brains, Ourselves: What a Neurologist's Patients Tell Him About the Brain. A leading researcher at the University of Oxford, Husain explores how the brain constructs our sense of self—and what happens when that system breaks down.
Through remarkable patient stories—from a man who loses his motivation after a stroke to a woman whose hand acts with a mind of its own—Husain shows how identity, motivation, and consciousness emerge from the fragile architecture of the brain. Together, they discuss the neuroscience of apathy and addiction, the role of dopamine in behavior, the intersection of AI and neurobiology, and what it truly means to be human.
If you've ever wondered how much of "you" is shaped by your brain—and how much you can change—this conversation offers profound insights into the science of the self.
The brain builds identity — Selfhood arises from multiple interacting functions: memory, motivation, attention, and perception.
Apathy and addiction share the same circuitry — Dopamine links motivational cues to action; too little or too much disrupts balance.
Motivation can be restored — Dopaminergic treatments show promise for patients whose "will to act" has vanished after brain injury.
Attention is selective and limited — The brain filters vast sensory input, sustaining focus through the right hemisphere's networks.
We remain flexible — Even in adulthood, the brain's plasticity allows for self-directed change in habits, motivation, and mindset.
"Our brains create our identities—ourselves. And when a part of that function fails, so does a piece of who we are." – Prof. Masud Husain
"Motivation is not just psychological—it's biological. It lives in deep circuits that connect desire to action." – Prof. Masud Husain
"Apathy and addiction are two sides of the same coin—they both involve the brain's motivation system gone wrong." – Prof. Masud Husain
"We can still learn and reshape who we are. Even in adulthood, the brain remains astonishingly flexible." – Prof. Masud Husain
00:00 – Introduction to Professor Masud Husain and Our Brains, Ourselves
01:24 – How neurological patients reveal the building blocks of identity
03:18 – Why the self is a neuro function, not a philosophical abstraction
05:24 – The brain as a "controlled hallucination" machine
06:57 – Case study: David, apathy, and the basal ganglia
09:54 – Dopamine, motivation, and recovery through treatment
14:35 – Oxford study on apathy and brain activation differences
16:23 – Apathy vs. addiction: the same motivation circuitry at work
19:02 – Dopamine as the "wanting" transmitter, not the pleasure chemical
21:52 – Attention, distraction, and why focus is so difficult to sustain
24:50 – How Marvin Minsky's "society of mind" shaped modern neuroscience
27:55 – The illusion of self: from Descartes to Buddhist philosophy
30:12 – Case study:
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My Favorite Murder with Karen Kilgariff and Georgia Hardstark
My Favorite Murder is a true crime comedy podcast hosted by Karen Kilgariff and Georgia Hardstark. Each week, Karen and Georgia share compelling true crimes and hometown stories from friends and listeners. Since MFM launched in January of 2016, Karen and Georgia have shared their lifelong interest in true crime and have covered stories of infamous serial killers like the Night Stalker, mysterious cold cases, captivating cults, incredible survivor stories and important events from history like the Tulsa race massacre of 1921. My Favorite Murder is part of the Exactly Right podcast network that provides a platform for bold, creative voices to bring to life provocative, entertaining and relatable stories for audiences everywhere. The Exactly Right roster of podcasts covers a variety of topics including historic true crime, comedic interviews and news, science, pop culture and more. Podcasts on the network include Buried Bones with Kate Winkler Dawson and Paul Holes, That's Messed Up: An SVU Podcast, This Podcast Will Kill You, Bananas and more.