Making sense of Unexplained infertility with James Nicopoullos

Welcome to this episode of The Fertility Podcast, the official podcast of Fertility Action. In this conversation, Natalie is joined by long-time friend of the show and Fertility Action trustee Dr. James Nicopoullos, consultant gynaecologist and medical director at The Lister. They dive into the often frustrating diagnosis of unexplained infertility - what it actually means, how it impacts your treatment options, and what you can do when you feel like you're hitting a wall.

This episode also covers highlights from Fertility Action’s recent campaign in Parliament, new shifts in male fertility awareness, and why conversations around fertility at work still have a long way to go.

What we discuss:

• Parliament updates and raising awareness about cuts to NHS fertility funding
• The Fertility Show and how to handle the overwhelm as a new patient
• James' role as a Fertility Action trustee and why he believes in Katie’s mission
• What unexplained infertility really means (and why it's so common)
• The emotional toll of having no clear answers, especially for people used to being in control
• Questions to ask your doctor when faced with unexplained or subfertility
• What to rule out: hormones, anatomy, sperm DNA, and more
• The reality of add-ons and how to weigh evidence-based versus emerging options
• When it makes sense to seek a second opinion and how clinics typically respond
• The evolving conversation around male infertility and the importance of male involvement
• Fertility in the workplace, what patients are still dealing with, and how employers can do better
• Why infertility still isn’t fully recognized as a legitimate health condition in some policies
• How education, advocacy, and testing are slowly shifting public perception

Quote to remember:

“You should be using your annual leave for a holiday, not to do fertility treatment.”

Listen if you’re:

Dealing with a diagnosis of unexplained infertility, feeling stuck after multiple cycles, or needing a reminder that there are still questions worth asking and answers worth pursuing.

Links & Resources

• Follow Fertility Action: @fertility.action
• DM Natalie: @fertilitypoddy
• Email: [e-mail]
• Subscribe to the podcast on your app of choice
• Learn more about Dr. James Nicopoullos: Lister Fertility Clinic
• Explore Fertility Action’s support groups and advocacy work: fertilityaction.org