#48 - The Hidden Heart Benefits of GLP-1s (with Dr. Ralph DeFronzo)

In this breakthrough episode, Dr. Ralph DeFronzo—one of the most respected names in metabolic health—joins Elizabeth to discuss the real story behind GLP-1 medications.

If you’ve ever wondered:

Do I have to stay on GLP-1s forever?

Are lower doses (or “microdoses”) actually effective?

Can I activate GLP-1 naturally—without prescriptions?

Is it really safe for long-term use?

…this episode gives you honest answers, straight from an expert who helped define modern diabetes treatment.

Dr. D explains how GLP-1s not only facilitate weight loss by reducing one’s appetite, but also protect your heart, liver, brain and kidneys—and why most people overlook this crucial benefit. You’ll learn what makes someone a “super responder,” the link between cortisol and weight loss resistance, and how to finally quiet “Food Noise” for good. ✨

 

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CLICK HERE TO GET ==>  FREE "Freedom From Food Noise" Masterclass:

https://go.elizabethmcgann.com/start

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SHOW NOTES:

[ 00:00 ] Introduction

[ 01:45 ] GLP-1s: Not just for weight loss—they also protect your heart, liver, kidneys & brain

[ 03:40 ] People often forget: GLP-1s were originally created to treat diabetes

[ 07:35 ]  Are low doses (aka “microdosing”) effective? DeFronzo’s take on trending wellness practices

[ 10:55 ] Significant benefits of GLP-1s for non-diabetics

[ 13:25 ] How much weight do you really need to lose to help your heart? The 10% threshold explained

[ 15:55 ] “Weighted” Question: Once on them, do you need to be on GLP-1s forever? The real answer from an expert who knows

[ 19:30 ] Why diet and exercise alone don’t work long-term for most people—and what actually does work

[ 22:30 ] Can you “reverse” diabetes or insulin resistance naturally? The symptoms, YES... but it’s complicated!

[ 25:00 ] How GLP-1s reduce inflammation and rewire your metabolism at the cellular level

[ 28:00 ] The truth about “natural” GLP-1 boosters like berberine, fiber and protein

[ 31:00 ] Dr. DeFronzo’s surprising eating habit—and what it reveals about fasting myths

[ 35:00 ] How GLP-1s may help food addiction by rewiring brain circuitry

[ 39:45 ] Insights from four-year safety data: What we do and don’t know about long-term use

[ 42:00 ] Black box warnings and thyroid cancer risk—what’s real and what’s hype?

[ 44:50 ] Can someone taper off of GLP-1s successfully? Who are the 10–15% that do—and how?

[ 49:00 ] Will future GLP-1s render current meds obsolete? Why retatrutide may change the game

[ 56:00 ] Super-responders vs. non-responders—and the cortisol connection you’ve never heard

[ 59:00 ] Why Dr. DeFronzo thinks the next big breakthrough will be insulin-sensitizers

[ 01:02:00 ] Final thoughts: a hopeful but cautionary note about access, cost and a new generation of GLP-1s on the way

 

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🔗 Mentioned in This Episode:
Learn how to activate GLP-1 naturally and silence cravings!
CLICK HERE TO GET ⇒ Free Masterclass: Freedom From Food Noise: https://go.elizabethmcgann.com/start

 

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Learn more about Dr. Ralph DeFronzo:

University of Texas Health San Antonio Bio : https://directory.uthscsa.edu/academics/profile/defronzo

Appearance on Dr. Peter Attia’s THE DRIVE Podcast: https://www.youtube.com/watch?v=vYQaLV3Fm00

Dr. DeFronzo’s Work: Just Google him—you’ll find over 900 scientific publications!