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September 27, 2025 65 mins

The COVID-19 pandemic was a devastating global event, killing more than seven million people, straining the fabric of societies, and shaking the foundations of the world economy. And yet, as horrifying as the experience was, COVID-19 was not “The Big One” — the dreaded pandemic that haunts the nightmares of epidemiologists and public health officials everywhere. That far deadlier outbreak is still ahead of us, and it will reshape life across the planet unless we’re ready for it.

In this episode, Dr. Michael Osterholm, one of the world’s leading infectious disease experts, explains what we got wrong, what we got right, and what it all reveals about our preparedness for the next great pandemic.

Michael Osterholm is Regents Professor and McKnight Presidential Endowed Chair in Public Health at the University of Minnesota, where he founded and directs the Center for Infectious Disease Research and Policy (CIDRAP). An internationally renowned epidemiologist with fifty years of experience, he's led major outbreak investigations worldwide and authored over 350 papers. He served as a U.S. State Department science envoy from 2017-2019. His new book is The Big One: How We Must Prepare for Future Deadly Pandemics.

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