Ep 14: The Power of Probiotics: Microbiome, GLP-1, & Mental Wellbeing

🎧 Episode Summary:

In this powerful episode of The Vitality Collective Podcast, Dr. Jeremy Bettle is joined by Christina O'Connor, a registered dietitian and gut health expert from Pendulum Therapeutics. Together, they dive deep into the science of the microbiome, exploring how trillions of organisms in our gut impact everything from metabolism and mood to immune function and long-term health. Christina shares fascinating insights into GLP-1, the gut-brain axis, postbiotics like butyrate, and why modern probiotics might be missing a key player—Akkermansia muciniphila. This conversation is a must-listen for anyone looking to optimize their gut health, naturally boost metabolism, and create a foundation for lasting vitality.

 

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👩‍⚕️ Guest Bio:

Christina O'Connor is a Registered Dietitian with extensive experience in gut health and functional nutrition. She is a clinical educator at Pendulum Therapeutics, a company at the forefront of microbiome research, known for developing innovative probiotic solutions—most notably including Akkermansia muciniphila, a strain with promising metabolic and neurological benefits. Christina’s expertise spans nutrition, functional medicine, microbiome science, and patient education, and she’s passionate about helping people heal their bodies through diet, targeted supplementation, and lifestyle interventions.

 

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🔗 Connect with Christina & Pendulum:

• 🌐 Website: www.pendulumlife.com

• 🌐 Instagram: pendulumlifeco

 

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✅ 3 Actionable Items You Can Start Today:

1. Add More Fiber – Start slowly and build up your intake with chia water, prebiotic-rich veggies (onions, green bananas), or prebiotic sodas to feed beneficial gut bacteria.

2. Prioritize Sleep – Quality sleep boosts gut repair and immune resilience. Optimize your sleep hygiene to support overall vitality.

3. Find Daily Joy – Reduce stress and promote mental wellness by doing something that genuinely brings you happiness every day. Joy is good for your microbiome too!

 

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🔑 Key Takeaways:

• The microbiome influences nearly every body system, from metabolism to mental health.

• GLP-1, a powerful hormone made in the gut, impacts satiety, cravings, blood sugar, and even addiction-related brain activity.

• Fiber is essential to feed butyrate-producing bacteria that help trigger GLP-1 production and support gut lining health.

• Akkermansia muciniphila is a keystone strain that protects the gut barrier, supports immune modulation, and promotes metabolic health—but can’t be obtained through food or the environment.

• Polyphenol-rich foods (like green tea, pomegranate, dark chocolate) are crucial for nourishing Akkermansia and other gut-friendly strains.

• Fermented foods like pickled onions and kombucha add beneficial bacteria and aid digestion—but watch the sugar content.

• Probiotic use after antibiotics (or even during, strategically) helps restore and protect the microbiome.

• Stress weakens the gut barrier and disrupts microbial balance—simple breathing exercises can counter this.

• Pendulum’s glucose control formulation has been clinically shown to improve blood sugar regulation, rivaling traditional diabetes meds like metformin.

• Microbiome repair is a gradual process—give new regimens at least 3 months for real change.