The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Episodes

August 2, 2026 13 mins

There is one molecule your body already makes that helps protect your cells from aging, but your production of it drops as you get older.

In this video, I explain why glutathione is known as the body’s master antioxidant and why it plays a critical role in cellular defense, mitochondrial energy, immune regulation, and liver detoxification.

You’ll discover why aging is not just your body “wearing out,” but the ...

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Viagra's Cancer Signal, TV's Toll on Your Brain, Heat and Accelerated Aging, and a New Way to Flush Your Brain Explained 

Viagra's Active Ingredient May Block Cancer From Spreading 

A study published in Cancer Research from the Weizmann Institute of Science, in collaboration with Clalit and the U.S. National Cancer Institute, found that sildenafil, the active ingredient in Viagra, may interfere with cancer cells' ability to...

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Inside Igniton: The Quantum Supplement Science Boosting Memory, Sleep, and Longevity 

There's a subatomic particle most scientists don't even know exists, and one entrepreneur just spent $18 million building a private lab to prove it can upgrade your longevity, focus, and sleep. This episode goes inside the lasers, vacuum chambers, and cold plasma behind the new science of quantum-charged supplements. 

Get 15% off your next...

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Urologist Dr. Alex Tatum on Girth Enhancement, Testosterone, and Peptide Therapy 

Most men will never ask their doctor the questions this episode answers. From safe, non-surgical girth enhancement to daily testosterone dosing to the peptides fighting for FDA access right now, this conversation covers what actually works, what's dangerous, and what your doctor probably won't bring up first. 

Host Dave Asprey sits down with D...

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You’ve probably tried everything to sleep better. Magnesium. Melatonin. Blackout curtains. Maybe even expensive sleep gadgets. But what if the real reason your sleep feels broken has nothing to do with any of those things?

In this video, Dave Asprey explains a hidden biological process that controls whether your body stays in stress mode at night… or finally switches into deep recovery mode. He breaks down why so many p...

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Artificial Sweeteners & Cognitive Decline, Myosteatosis on Coronary CT, Merck's Oral PCSK9 Inhibitor, Cyclospora Outbreak, Gut-Brain Synchronization, and the Banana Smoothie Mistake Explained 

Artificial Sweeteners Linked To 62% Faster Cognitive Decline In Landmark Brazilian Study 

A study tracking more than 12,700 adults (average age 52) over eight years found that people consuming the most artificial and low-calorie s...

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Fix Leaky Gut, Boost Testosterone & Slash Endotoxins with Spore-Based Probiotics | Kiran Krishnan

Your bad gut bacteria might be the reason your testosterone, your immune system, and even your sperm count are struggling, and most probiotics never survive long enough to fix it. This episode reveals which strains actually make it through your stomach acid alive, and what happens once they do. 

Go To JustThriveHealth.com/asprey...

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Visceral fat, subcutaneous fat, Prenuvo MRI scans, and the truth about belly fat 

Your gut and your face are telling on you. This episode reveals why the fat under your skin might be protecting you while the fat around your organs is quietly wrecking your metabolism, heart, and longevity, and exactly what to do about the difference. 

Get $300 off your next Prenuvo MRI scan: https://prenuvo.com/?discount=Dave 

Host Dave ...

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Most people think biohacking is only for billionaires with access to expensive machines, private clinics, and million-dollar anti-aging protocols. But the truth is, some of the most powerful upgrades in your biology start with the basic signals your body receives every single day.

In this video, Dave Asprey breaks down how to start biohacking with around $200 by focusing on the foundations that control your sleep, energy, focus, and...

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Shawn Stevenson On The Science of Family Meals, Oxytocin, and Longevity

Your dinner table might be the most overlooked biohack in your house. This episode reveals the exact minimum dose of family meals that lowers a child's risk of obesity, the hormone your body releases every time you eat with people you love, and why teaching your kids to cook may protect their metabolism for life.

Host Dave Asprey sits down with Shawn Stevens...

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Why Oral and IV Glutathione Never Actually Reach Your Cells (The Delivery Breakthrough Changing Everything) 

Most of the supplements you're taking aren't failing you, they're failing to ever reach the cells that need them, and almost nobody selling them wants you to know that. This episode hands you the delivery breakthrough that actually gets it there. 

Use code DAVE for a discount at aurowellness.com/dave 

Host Dave A...

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Cardiologist Dr. Peter McCullough on mRNA Persistence, Nattokinase, and the Fight Over COVID-19 Treatment" 

Six years after standing before the US Senate and calling out the pandemic response in real time, Dr. Peter McCullough returns with new evidence on where the spike protein came from, how long it persists in the body after infection or vaccination, and what's being done to break it d...

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A Nobel Prize-winning discovery revealed that your body has a built-in repair system that can help clear out old cellular damage and support healthier aging from the inside out.

In this video, Dave Asprey breaks down the strange Japanese breakfast ritual linked to some of the longest-living people on Earth, why modern life can shut down your body’s natural repair mode, and how one specific food may help wake it back up.

You&rsq...

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Nervous System Hacking, Willpower vs Habit Systems, Calendar Time Blocking, and the Wallet Posture Fix Damaging Your Spine 

Most people think surviving a life-threatening situation comes down to luck. Jordan Harbinger did it twice, and what got him out wasn't luck, it was a nervous system he had trained to override panic. This episode breaks down what actually happens in your body during a real fight-or-flight response, and how...

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Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk 

Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it. 

Get Dr. Perlmutter’s new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ 

...

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Near-Infrared Light Therapy & EMF Shielding with SaunaSpace Founder Brian Richards 

Your mitochondria are starving for a nutrient you've probably never tracked, and it's not a vitamin or a macro. This episode reveals how a forgotten 1910 therapy uses light to physically restructure water inside your cells, unlocking a mechanism for healing, detox, and mitochondria repair that most of biohacking has completely overlooked.&nb...

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Try Danger Creatine: https://dangercoffee.com/products/danger-creatine

Try TrueDark glasses: https://truedark.com

Try Danger Coffee: https://dangercoffee.com/

Try Suppgrade Labs: https://shopsuppgradelabs.com/

I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delive...

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GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained 

Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults 

A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracked with lower triglycerides, higher HDL chole...

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Carnivore Diet, Cholesterol, Gut Bacteria, Microbiome, and Fasting Insulin Results from a 90-Day Self-Experiment 

What if cutting out fiber entirely actually improved your gut bacteria? This episode breaks down a real 90-day carnivore self-experiment, complete with before and after blood work, stool testing, and continuous glucose data, that challenges everything you think you know a...

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Your Hormones Are Killing You: Oxytocin, FSH, and the Anti-Aging Protocol Most Doctors Ignore 

Your hormones are running your love life, your intuition, your longevity, and your brain, and most doctors are getting it completely wrong. Host Dave Asprey sits down with triple board-certified OBGYN Dr. Anna Cabeca to break down the clinical science of oxytocin, female pleasure, hormonal optimization, and why fixing your hormones ca...

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