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September 10, 2025 80 mins

In this episode of the 1st Optimal Podcast, Michelle Shapiro, RD, dives into the complexities of MCAS, POTS, and histamine responses. She breaks down how functional medicine addresses these conditions and dispels common myths about supplements and biohacking. Tune in for expert insights on balancing immune responses and optimizing health.


00:00:00 - Introduction to the podcast and guest Michelle Shapiro

00:08:00 - Michelle's journey into functional medicine and personal health struggles

00:16:00 - Michelle's experience with mold exposure and its health impact

00:24:00 - Introduction to Mass Cell Activation Syndrome (MCAS) and its symptoms

00:32:00 - Understanding histamines and their connection to MCAS and POTS

00:40:00 - Histamines and their effect on blood flow and symptoms like dizziness

00:48:00 - Exploring Postural Orthostatic Tachycardia Syndrome (POTS) and its neurological link

00:56:00 - Challenges in diagnosing MCAS and the fragmented healthcare system

01:04:00 - Triggers of histamine issues and the role of environmental and dietary factors

01:12:00 - Estrogen and histamine interaction in women’s health and hormonal cycles



#MCAS #POTS #FunctionalMedicine #HistamineIntolerance #HealthOptimization

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🧑‍⚕️ 1st Optimal helps women and men optimize their health through personalized treatment plans that integrate lifestyle, exercise, supplementation, nutrition, and medications. As a cutting-edge telehealth platform specializing in functional medicine, we offer tailored hormone therapy, precision weight management, and performance-driven care—all designed to help you thrive from home.

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