Dr. James Lloyd, Research Fellow at the University of Western Australia and the ARC Centre of Excellence in Plants for Space discusses his journey from rural England to the forefront of synthetic biology. He explains his innovative work on "gene circuits," a technology that offers more flexible and precise control over plant genetics than traditional methods like CRISPR. Instead of making a single, permanent change, these circuits can turn genes on or off in response to specific conditions like heat or chemical triggers.
Dr. Lloyd connects this research to his role in the "Plants for Space" initiative, a multidisciplinary project aiming to grow plants in space to support human exploration. He details the immense challenges, such as microgravity and radiation, and explains how solving these extreme problems will lead to breakthroughs for agriculture on Earth, improving food security and enabling sustainable manufacturing of medicines and bioplastics. The conversation explores the complexities of genetic engineering, the balance between scientific hype and reality, and the importance of interdisciplinary collaboration to solve humanity's biggest challenges.
Dr. Lloyd's publications: Google Scholar, LinkedIn
Read what Dr. Lloyd is reading: The MaddAddam Trilogy Series by
Watch Dr. Lloyd's lecture SynBio4ALL on YouTube
Support the pod: https://3reate.com, https://ko-fi.com/3reate or https://patreon.com/3reate
(0:00) Start
(0:41) Introduction: Dr. James Lloyd joins from Perth, Australia
(5:22) Rewriting the Genome: Introduction to synthetic biology and creating artificial gene controls
(7:02) Comparing gene circuits to the more widely known CRISPR technology for gene editing
(8:43) The Power of Gene Circuits
(15:04) Beyond "One-and-Done" Edits: Discussing the flexibility of gene circuits compared to older methods like Roundup Ready corn
(19:25) The challenges of engineering biological systems and the "context is king" principle.
(38:30) Plants for Space: Introducing the ambitious project to grow plants in space to support human exploration
(45:12) Space Research for Earthly Problems: How solving for space agriculture can improve food security and vertical farming on Earth
(51:30) Plants as Replicators: Exploring the futuristic idea of using plants to manufacture drugs, bioplastics, and other materials
(1:09:56) Hype vs. Reality in Biotech
(1:32:28) Starting a Research Lab: Dr. Lloyd shares the challenges and rewards of transitioning from a postdoc to running his own lab
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