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September 1, 2025 124 mins

On episode 52 of A Chat with Uma, I sit down with my dear friend & role model, Brandon Staglin—co-founder & Chief Advocacy & Engagement Officer of One Mind, the world’s leading brain health nonprofit. For nearly three decades, Brandon has transformed lived experience into leadership: co-creating a global organization, raising hundreds of millions for brain health research, & pushing society toward a future where mental health is prioritized like physical health. But behind the impact is a deeply personal story—one that began with a diagnosis of schizophrenia at 18 & a fight to reclaim his life, voice, & purpose.


Brandon opens up in this honest conversation with rare depth. We walk through his journey from Napa Valley childhood to the terror of psychosis, through recovery & relapse, to the discovery of meaning in advocacy. He shares the cost of stigma, the reality of treatment, the lifeline of family, & the radical belief that worth is inherent—not earned. If you’ve ever wondered what it means to turn survival into legacy, this episode is a testament to courage, connection, & the possibility of healing at scale.


Topics Discussed (+ Timestamps):


(00:00:00) Introduction & welcome to Brandon Staglin, M.S.!


(00:09:28) Who is Brandon behind the titles & roles? His upbringing, childhood, & early influences


(00:17:48) Early cracks in reality: existential questions, “something’s wrong,” & the first shifts in self


(00:29:10) Dartmouth years: When he experienced his first harrowing episode of psychosis


(00:39:16) The team that held him: family, early clinicians, & how early intervention saved him


(00:50:04) 6 years until the word “schizophrenia”: why “thought disorder” landed better at first


(00:51:22) A kitchen table intervention of love: “There’s a lot of love coming from here, Brandon” & choosing to engage in recovery


(01:11:00) Setbacks & recalibration: medication side-effects, suicidality, & rebuilding around values


(01:28:08) How One Mind was cofounded with his parents to accelerate brain-health solutions


(01:37:16) Naming the schizophrenia stigma: what people still say & the cost of silence


(01:41:26) The One Mind ecosystem at a glance: Accelerator (mental-health startups), One Mind at Work (workplace mental health), Rising Star Academy (funding & training scientists), & Lived Experience Initiative (Council & Community Advisory Network)


(01:45:14) How Brandon built the Lived Experience Initiative: giving lived expertise real power alongside scientific & governance bodies


(01:48:26) The Council's profound success thus far: consulting for & advising startup founders, research scientists, & Fortune-level leaders


(01:55:26) The annual One Mind Music Festival for Brain Health: raising hundreds of millions for brain health research & innovation, bringing together leaders & stakeholders across all fields


(02:00:02) Closing reflections, guidance, & inspiration from Brandon


Connect with Brandon!


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