Addiction Medicine Journal Club
We believe that addiction is a disease that can be treated, and we want to help you stay up to date with the latest research that you can use in your addiction medicine practice.
Episodes
December 1, 2025 • 27 mins
In episode 69 we discuss cytisinicline for smoking cessation.
Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655.
We also discuss treating opioid use disorder in nursing homes and compulsive TikTok scrolling.
Carolina Public Press: NC nursing home lawsuit settlement could expand access for people with drug issues
Me...
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November 17, 2025 • 40 mins
In episode 68 we discuss an article about adding behavioral treatments to buprenorphine for opioid use disorder.
McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529.
We also discuss online gambling addiction, and neuroanatomy that predisposes adolescents to addiction.
Stat...
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November 10, 2025 • 26 mins
In episode 67 we discuss an article about starting buprenorphine injectables without stopping fentanyl or going into opioid withdrawal.
Waters RC, et al. Injectable-Only Overlapping Buprenorphine Starting Protocol in a Low-Threshold Setting. JAMA Netw Open. 2025;8(8):e2527016.
We also discuss over-the-counter magic mushrooms and banning cigarette filters.
JAMA Network Open: Active Constituents of Psilocybin Mushro...
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November 3, 2025 • 31 mins
In episode 66 we discuss an article about smoking during substance use disorder recovery.
Parks MJ, Blanco C, Creamer MR, et al. Cigarette Smoking During Recovery From Substance Use Disorders. JAMA Psychiatry. Published online August 13, 2025.
We also discuss how the White House is pressuring the FDA to fast-track nicotine products and shenanigans regarding alcohol in the upcoming FDA dietary guidelines.
Reuters: US...
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October 27, 2025 • 30 mins
In episode 65 we discuss varenicline and bupropion for alcohol use disorder.
Söderpalm B, Lidö H, Franck J, Håkansson A, Lindqvist D, Heilig M, Guterstam J, Samuelson M, Askerup B, Wallmark-Nilsson C, de Bejczy A. Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial. Lancet Reg Health Eur. 2025 May 13;54:101310.
...
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September 8, 2025 • 38 mins
In episode 64 we discuss an article about addictive screen use and suicide.
Xiao Y, Meng Y, Brown TT, Keyes KM, Mann JJ. Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths. JAMA. 2025;334(3):219–228.
We also discuss the impact of the first 100 days of the Trump administration on addiction treatment, and the DEA scheduling of 7-OH (hydroxymitrigynine).
Journal of Addict...
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August 25, 2025 • 58 mins
Quick summaries of articles 51-60. Enjoy!
51. Fun Activities and Recovery Acuff, S. F., et al. A brief measure of non-drug reinforcement: Association with treatment outcomes during initial substance use recovery. Drug and Alcohol Dependence, 256, 111092.
52. Buprenorphine-precipitated Fentanyl Withdrawal
Thakrar AP, et al. Buprenorphine-Precipitated Withdrawal Among Hospitalized Patients Using Fentanyl. JAMA Netw Open. 2024 ...
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August 12, 2025 • 47 mins
Four addiction specialists talk about what it takes to keep your
knowledge current. The Addiction Medicine Journal Club is joined by
Dr. Casey Grover (Addiction
Medicine Made Easy Podcast) and
Thomas Bannard (VCU Health) to discuss how to further
your knowledge as a busy professional.
PSAM Review (Page 6):
Staying Current: How to Keep up with the Addiction Medicine Literature
---
Some of Our Favorite Addiction Medicine Resour...
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July 28, 2025 • 36 mins
In episode 63 we discuss the association between buprenorphine dose and neonatal opioid withdrawal syndrome.
Marc B, Marion D, François B, Lakshmipriya L. Is buprenorphine maternal dose associated with neonatal opioid withdrawal syndrome severity? Am J Addict. 2025 Jan;34(1):15-20.
We also discuss private equity in health care and nitrous oxide (Galaxy Gas).
AMA Journal of Ethics: Is Pursuing Profit Commensurable With ...
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July 14, 2025 • 36 mins
In episode 62 we discuss the article “Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients with Alcohol Use Disorder.”
Magane KM, et al. Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):635-645.
We also discuss reduced overdose deaths and changes in buprenorphine labelling to include high...
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June 16, 2025 • 34 mins
In episode 61 we discuss pregnancy outcomes with bup/nlx compared to bup alone.
Straub L, et al. Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone. JAMA. 2024 Sep 10;332(10):805-816. doi: 10.1001/jama.2024.11501.
We also discuss the elimination of SAMHSA and methamphetamine-related deaths.
STAT News: Trump’s mental health and addiction problem
New York Times: As Fen...
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May 26, 2025 • 42 mins
In episode 60 we discuss treating methamphetamine use disorder with lisdexamfetamine (Vyvanse).
Ezard N, et al; The LiMA Investigator Group. Lisdexamfetamine in the treatment of methamphetamine dependence: A randomised, placebo-controlled trial. Addiction. 2024 Dec 19.
We also discuss why some people don’t get hangovers, and tianeptine, otherwise known as gas station heroin.
New York Times:The People Who Never Get Hango...
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May 5, 2025 • 34 mins
In episode 59 we discuss outpatient low-dose initiation of buprenorphine.
Suen LW, et al. Outpatient Low-Dose Initiation of Buprenorphine for People Using Fentanyl. JAMA Netw Open. 2025 Jan 2;8(1):e2456253.
We also discuss impulse control dysregulation from ropinerole, and the new non-opioid painkiller, suzetrigine.
BBC:Prescription medication made me a gambling addict
Grall-Bronnec M, et al.Dopamine agonists and i...
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April 14, 2025 • 40 mins
In episode 58 we discuss a randomized controlled trial of semaglutide for alcohol use disorder.
Hendershot CS, Bremmer MP, Paladino MB, Kostantinis G, Gilmore TA, Sullivan NR, Tow AC, Dermody SS, Prince MA, Jordan R, McKee SA, Fletcher PJ, Claus ED, Klein KR. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Feb 12:e244789.
We also discuss benzodiazepine taper...
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March 24, 2025 • 32 mins
In this episode we discuss 4 more articles that changed our practice. Listen to us talk through real cases, what we used to do, and what we do now.
Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial. JAMA. 2024 May 28; 331(20):1722-1731.
Extended-Release Injection vs Sublingual Buprenorphine for Opioid Use Disorder With Fentanyl Use: A Post Hoc Analysis of a...
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March 16, 2025 • 36 mins
In this episode we discuss 4 articles that changed our practice. Listen to us talk through real cases, what we used to do, and what we do now.
Quantifying a potential protective effect of buprenorphine on fatality risk during acute fentanyl exposures. Journal of Substance Use and Addiction Treatment, Volume 158, 2024. 209252, ISSN 2949-8759.
Outcomes After Initiation of Medications for Alcohol Use Disorder at Hospital Discharge. JA...
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February 24, 2025 • 41 mins
In episode 57 we discuss a new definition of recovery.
Zemore SE, Ziemer KL, Gilbert PA, Karno MP, Kaskutas LA. Understanding the Shared Meaning of Recovery From Substance Use Disorders: New Findings From the What is Recovery? Study. Subst Abuse. 2023 Sep 15;17:11782218231199372.
We also discuss sports betting and why more people aren’t prescribing buprenorphine.
STAT News: The misguided reason why providers aren’t prescribing more...
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February 10, 2025 • 39 mins
In episode 56 we discuss how many attempts it takes to quit using addictive substances.
Fontes RM, Tegge AN, Freitas-Lemos R, Cabral D, Bickel WK. Beyond the first try: How many quit attempts are necessary to achieve substance use cessation? Drug Alcohol Depend. 2024 Dec 8;267:112525. doi: 10.1016/j.drugalcdep.2024.112525. Epub ahead of print. PMID: 39719807.
We also discuss capping nicotine content in cigarettes and how exercise ...
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January 27, 2025 • 35 mins
In episode 55 we discuss the pharmacokinetics and pharmacodynamics of buprenorphine in pregnancy.
Caritis, Steve N. MD; Venkataramanan, Raman PhD. A Pharmacologic Evaluation of Buprenorphine in Pregnancy and the Postpartum Period. Journal of Addiction Medicine ():10.1097/ADM.0000000000001380, September 2, 2024.
We also discuss fraud in Baltimore recovery houses, and the doubling of alcohol-related deaths.
The New Yor...
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January 14, 2025 • 42 mins
In episode 54 we discuss an article about 24-mg daily of buprenorphine and behavioral health hospitalizations.
Axeen S, Pacula RL, Merlin JS, Gordon AJ, Stein BD. Association of Daily Doses of Buprenorphine With Urgent Health Care Utilization. JAMA Netw Open. 2024 Sep 3;7(9):e2435478.
We also discuss the decline in overdose deaths and RFK’s experience with recovery.
The White House: Biden-Harris Administration Marks Hist...
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