Addiction Medicine Journal Club
We believe that addiction is a disease that can be treated, and we want to help you stay up to date with the latest research that you can use in your addiction medicine practice.
Episodes
July 28, 2025 • 36 mins
In episode 63 we discuss the association between buprenorphine dose and neonatal opioid withdrawal syndrome.
Marc B, Marion D, François B, Lakshmipriya L. Is buprenorphine maternal dose associated with neonatal opioid withdrawal syndrome severity? Am J Addict. 2025 Jan;34(1):15-20.
We also discuss private equity in health care and nitrous oxide (Galaxy Gas).
AMA Journal of Ethics: Is Pursuing Profit Commensurable With ...
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July 14, 2025 • 36 mins
In episode 62 we discuss the
article “Oral vs Extended-Release Injectable Naltrexone for
Hospitalized Patients with Alcohol Use Disorder.”
Magane KM, et al.Oral
vs Extended-Release Injectable Naltrexone for Hospitalized Patients
With Alcohol Use Disorder: A Randomized Clinical Trial.
JAMA Intern Med. 2025 Jun 1;185(6):635-645.
We also discuss reduced
overdose deaths and changes in buprenorphine labelling to include
higher ...
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June 16, 2025 • 34 mins
In episode 61 we discuss pregnancy outcomes with bup/nlx compared to bup alone.
Straub L, et al. Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone. JAMA. 2024 Sep 10;332(10):805-816. doi: 10.1001/jama.2024.11501.
We also discuss the elimination of SAMHSA and methamphetamine-related deaths.
STAT News: Trump’s mental health and addiction problem
New York Times: As Fen...
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May 26, 2025 • 42 mins
In episode 60 we discuss treating methamphetamine use disorder with lisdexamfetamine (Vyvanse).
Ezard N, et al; The LiMA Investigator Group. Lisdexamfetamine in the treatment of methamphetamine dependence: A randomised, placebo-controlled trial. Addiction. 2024 Dec 19.
We also discuss why some people don’t get hangovers, and tianeptine, otherwise known as gas station heroin.
New York Times:The People Who Never Get Hango...
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May 5, 2025 • 34 mins
In episode 59 we discuss outpatient low-dose initiation of buprenorphine.
Suen LW, et al. Outpatient Low-Dose Initiation of Buprenorphine for People Using Fentanyl. JAMA Netw Open. 2025 Jan 2;8(1):e2456253.
We also discuss impulse control dysregulation from ropinerole, and the new non-opioid painkiller, suzetrigine.
BBC:Prescription medication made me a gambling addict
Grall-Bronnec M, et al.Dopamine agonists and i...
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April 14, 2025 • 40 mins
In episode 58 we discuss a randomized controlled trial of semaglutide for alcohol use disorder.
Hendershot CS, Bremmer MP, Paladino MB, Kostantinis G, Gilmore TA, Sullivan NR, Tow AC, Dermody SS, Prince MA, Jordan R, McKee SA, Fletcher PJ, Claus ED, Klein KR. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Feb 12:e244789.
We also discuss benzodiazepine taper...
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March 24, 2025 • 32 mins
In this episode we discuss 4 more articles that changed our practice. Listen to us talk through real cases, what we used to do, and what we do now.
Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial. JAMA. 2024 May 28; 331(20):1722-1731.
Extended-Release Injection vs Sublingual Buprenorphine for Opioid Use Disorder With Fentanyl Use: A Post Hoc Analysis of a...
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March 16, 2025 • 36 mins
In this episode we discuss 4 articles that changed our practice. Listen to us talk through real cases, what we used to do, and what we do now.
Quantifying a potential protective effect of buprenorphine on fatality risk during acute fentanyl exposures. Journal of Substance Use and Addiction Treatment, Volume 158, 2024. 209252, ISSN 2949-8759.
Outcomes After Initiation of Medications for Alcohol Use Disorder at Hospital Discharge. JA...
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February 24, 2025 • 41 mins
In episode 57 we discuss a new definition of recovery.
Zemore SE, Ziemer KL, Gilbert PA, Karno MP, Kaskutas LA. Understanding the Shared Meaning of Recovery From Substance Use Disorders: New Findings From the What is Recovery? Study. Subst Abuse. 2023 Sep 15;17:11782218231199372.
We also discuss sports betting and why more people aren’t prescribing buprenorphine.
STAT News: The misguided reason why providers aren’t prescribing more...
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February 10, 2025 • 39 mins
In episode 56 we discuss how many attempts it takes to quit using addictive substances.
Fontes RM, Tegge AN, Freitas-Lemos R, Cabral D, Bickel WK. Beyond the first try: How many quit attempts are necessary to achieve substance use cessation? Drug Alcohol Depend. 2024 Dec 8;267:112525. doi: 10.1016/j.drugalcdep.2024.112525. Epub ahead of print. PMID: 39719807.
We also discuss capping nicotine content in cigarettes and how exercise ...
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January 27, 2025 • 35 mins
In episode 55 we discuss the pharmacokinetics and pharmacodynamics of buprenorphine in pregnancy.
Caritis, Steve N. MD; Venkataramanan, Raman PhD. A Pharmacologic Evaluation of Buprenorphine in Pregnancy and the Postpartum Period. Journal of Addiction Medicine ():10.1097/ADM.0000000000001380, September 2, 2024.
We also discuss fraud in Baltimore recovery houses, and the doubling of alcohol-related deaths.
The New York Time...
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January 14, 2025 • 42 mins
In episode 54 we discuss an article about 24-mg daily of buprenorphine and behavioral health hospitalizations.
Axeen S, Pacula RL, Merlin JS, Gordon AJ, Stein BD. Association of Daily Doses of Buprenorphine With Urgent Health Care Utilization. JAMA Netw Open. 2024 Sep 3;7(9):e2435478.
We also discuss the decline in overdose deaths and RFK’s experience with recovery.
The White House: Biden-Harris Administration Marks Hist...
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December 30, 2024 • 39 mins
In episode 53 we discuss an article comparing treatment retention and mortality in patients who are prescribed methadone vs. buprenorphine/naloxone for treatment of opioid use disorder.
Nosyk B, Et al. Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder. JAMA. 2024 Oct 17.
We also discuss the Modernizing Opioid Treatment Access Act, engaging non-abstinent patients in treatment, and hostility to medica...
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December 16, 2024 • 33 mins
In episode 52 we discuss precipitated withdrawal in the era of fentanyl.
Thakrar AP, Et al. Buprenorphine-Precipitated Withdrawal Among Hospitalized Patients Using Fentanyl. JAMA Netw Open. 2024 Sep 3;7(9):e2435895.
We also discuss kratom, brain injury after overdose, and syringe services.
The Kratom Sobriety Podcast
Making Kratom Safer
The Conversation: Brain injury after overdose is a hidden epidemic
NIDA: Syringe serv...
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December 2, 2024 • 34 mins
In episode 51 we discuss the connection between fun activities and success in recovery from substance use disorder.
Acuff, S. F., Ellis, J. D., Rabinowitz, J. A., Hochheimer, M., Hobelmann, J. G., Huhn, A. S., & Strickland, J. C. (2024). A brief measure of non-drug reinforcement: Association with treatment outcomes during initial substance use recovery. Drug and Alcohol Dependence, 256, 111092.
We also discuss whether people...
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November 18, 2024 • 62 mins
41-50. Round-Up
Quick summaries of our last 10 (actually 11) articles.
41. Electronic Nicotine-Delivery Systems for Smoking Cessation
42. Quantifying a potential protective effect of buprenorphine on fatality risk during acute fentanyl exposures
43. Outcomes After Initiation of Medications for Alcohol Use Disorder at Hospital Discharge
44 Association of Cannabis Use With Cardiovascular Outcomes Among US Adults
45. Association ...
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November 4, 2024 • 53 mins
In episode 50 we discuss 3 articles about kratom.
We are again joined by our friend Dr. Casey Grover from the Addiction Medicine Made Easy Podcast.
Smith KE, Dunn KE, Rogers JM, Grundmann O, McCurdy CR, Garcia-Romeu A, Schriefer D, Swogger MT, Epstein DH. Kratom use as more than a "self-treatment". Am J Drug Alcohol Abuse. 2022 Nov 2;48(6):684-694.
Hill K, Grundmann O, Smith KE, Stanciu CN. Prevalence of Kratom Use Disorder...
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October 21, 2024 • 37 mins
In episode 49 we discuss the 12-week follow-up data from the ADAPT-2 trial about using ER injectable naltrexone and bupropion for methamphetamine use disorder.
Li MJ, Chau B, Belin T, Carmody T, Jha MK, Marino EN, Trivedi M, Shoptaw SJ. Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT-2 trial. Addiction. 2024 Jun 10. doi: 10.1111/add.16529. Epub ahead of print. PMID: 38856...
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October 14, 2024 • 40 mins
In this episode we discuss kratom with our friend Dr. Casey Grover of the Addiction Medicine Made Easy podcast. Stay tuned for part 2 coming next, Kratom Journal Club.
Tampa Bay Times: Deadly Dose
Annals of Internal Medicine Kratom: An Emerging Issue for Research and Physician Education
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This episode is not eligible for CME, but other episodes offer category 1 and MATE-ACT CME credits through MI CARES and Michigan State...
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October 7, 2024 • 35 mins
In episode 48 we discuss the association between semaglutide and alcohol use disorder.
Wang, W., Volkow, N.D., Berger, N.A. et al. Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population. Nat Commun 15, 4548 (2024).
The Journal of Addiction Medicine: The Efficacy of GLP-1 Agonists in Treating Substance Use Disorder in Patients
We also discuss THC products that look like ca...
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