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September 23, 2025 49 mins

Welcome to "AI or Not," the podcast where we explore the intersection of digital transformation and real-world wisdom, hosted by the accomplished Pamela Isom. With over 25 years of experience guiding leaders in corporate, public, and private sectors, Pamela, the CEO and Founder of IsAdvice & Consulting LLC, is a veteran in successfully navigating the complex realms of artificial intelligence, innovation, cyber issues, governance, data management, and ethical decision-making.

What happens when change is thrust upon us rather than chosen? In this thought-provoking conversation, Renee Wynn, former NASA CIO, EPA executive, and current independent board director, shares hard-won wisdom about navigating unexpected business disruptions with resilience and strategic clarity.

Drawing from her remarkable 30-year federal career, Renee offers a unique framework for approaching enterprise risk and technological transformation. She recounts how transitioning from EPA's environmental mission to NASA's cutting-edge operations taught her to view disruption as an opportunity for growth. The key? Developing the ability to pause, breathe through emotional reactions, and make thoughtful pivots when plans suddenly change.

Renee provides an insider's perspective on boardroom oversight of AI implementation, emphasizing the critical question organizations should ask: "Are we ready?" Rather than rushing into AI adoption, she advocates for identifying appropriate use cases, establishing governance frameworks, and, most importantly, keeping experienced humans in the loop. Her story about NASA's Automatic Ground Collision Avoidance System, which has saved pilots' lives by taking control of fighter jets during emergencies, powerfully illustrates how AI can enhance human capabilities when thoughtfully implemented.

The conversation culminates with wisdom from former Secretary Condoleezza Rice that perfectly captures the balance organizations must strike: "Innovate aggressively, but guard aggressively." For individuals navigating this rapidly changing landscape, Renee offers this compelling call to action: "Be the human they want in the loop" by continuously upskilling and demonstrating your value.


Whether you're leading an organization through digital transformation or wondering how to remain relevant in an AI-powered world, this episode offers practical guidance for turning unexpected change into your greatest advantage. Subscribe now to join the conversation about creating resilient organizations that combine technological innovation with human wisdom.



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