September 8, 2025 • 43 mins
A revolution in skincare has arrived, and it's changing the way we think about beauty from the inside out. Meet XOMD – the first true mood-ceutical skincare line that's bridging the gap between emotional wellbeing and physical appearance through the science of oxytocin.
Dr. Sabrina Fabi joins us to share the fascinating journey behind creating this groundbreaking product line with her husband, a fellow aesthetic physician. Their lightbulb moment came during Dr. Fabi's pregnancy when she noticed her skin maintained its radiance despite pausing her usual treatments. The culprit? Oxytocin – the "bonding hormone" that not only helps mothers connect with their babies but also creates that coveted pregnancy glow.
The science is compelling: people with naturally higher oxytocin levels appear approximately three years younger than their peers. XOMD's proprietary jasmine-derived peptide mimics this effect by binding to oxytocin receptors in the skin's epidermis, creating remarkable improvements in radiance, hydration, and inflammation. Clinical trials revealed not just visible skin benefits, but significant emotional impacts – users reported 87% increased confidence and reduced social anxiety after just eight weeks.
What makes this approach truly revolutionary is its dual-action pathway. Unlike most skincare ingredients that work solely on the skin's surface, XOMD's formula creates a positive feedback loop between skin receptors and the brain's hypothalamus. This connection makes it particularly valuable for women experiencing hormonal transitions like menopause, when declining estrogen reduces natural oxytocin receptor binding capacity.
The elegantly designed product line – featuring Detox Cleanser, Intoxicate Serum, and Arouse Moisturizer – delivers professional-grade results while maintaining incredible gentleness. Even post-procedure patients report accelerated healing and reduced redness, sometimes eliminating the need for follow-up treatments.
Ready to experience skincare that transforms both how you look and how you feel? Discover the science of emotional beauty with XOMD – where confidence and radiance begin at the cellular level.
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* Website: https://premierderm.net
Premier Dermatology is located in Bentonville, Fayetteville, & Bella Vista, Arkansas!
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:00):
All right, friends, today is a very exciting day on
our All Things Skin podcast.
One of my really mentors andfriends and just one of the
kindest, most genuine humansI've ever met in the world is
joining me today on the podcastto talk about her XOMD skincare,
(00:22):
which is really kind of areally transformational idea.
She is for the first time, withher adorable husband and
plastic surgeon colleague,bringing us skincare that really
is mood-suitical.
So for the first time, we arebringing not only skin care but
(00:46):
also emotional well-beingtogether in a line and that is
something that is very special.
So, guys, welcome my dear, dearfriend, dr Sabrina Fahby.
Speaker 2 (00:57):
Thank you so much for having me, missy.
The feeling is mutual.
I'm so inspired.
I know you have a beautifulpractice.
Feeling is mutual, I'm soinspired, I know you have a
beautiful practice and I findthat people that have thriving
practices generally the commontheme behind it is that they
love what they do and they'redoing great things for their
patients.
So it's wonderful to be herewith you and share that same
passion.
Speaker 1 (01:17):
Amen, and I will tell you.
I just want to give ourlisteners a little background
into how we met.
And then I want to talk alittle bit about you and your
adorable husband and yourbeautiful baby Mateo he's so
precious and then how the linelaunched and you know just
basically where you got the ideaand what you're doing with the
(01:39):
line.
So first I will say dermatologyis a very small world and,
Sabrina, I think we met probablymaybe 15 years ago at a
conference and I think we wereboth at that point, you know,
kind of just kind of gettingstarted in our career and really
trying to figure out who wewere.
And there was this group ofreally older dermatologists that
(02:00):
were kind of the derm girls,you know, and they were ruling
the roost and they were amazinghumans and some of the best
doctors on the planet.
But I was trying to figure outhow do I get to be a derm girl?
I want to be a derm girl andyou already were a little ahead
of me and you had these contactswith these women and you were
(02:22):
so kind to me.
You brought me under your wing,you introduced me to people,
you treated me as an equal fromthe very beginning and I just
want you to know that that was a.
It was a game changer for mycareer and I love you and I
appreciate you so much forseeing me, and, and, and, and
(02:42):
and just just being so kind andso open to sharing your
knowledge and, you know, helpingme to navigate that world.
So thank you.
Speaker 2 (02:52):
Oh, it's my pleasure, of course.
Speaker 1 (02:55):
You're the best.
Okay, so let's talk.
So tell me about your practice,and tell me about your
relationship with Steve, andthen, and then let, and then
let's talk how this all cameabout.
Speaker 2 (03:10):
Yes, so I've been, as you mentioned, in practice now
for 15 years and I'm here inSouthern California, in San
Diego.
I have been in aesthetics myentire time, so always have been
doing injectables and laserprocedures.
And something that I came torealize very quickly, and
probably where my world collidedwith Steve's, was that I
(03:33):
recognized that much of the timewhen patients came in, it
wasn't necessarily, althoughthey would say that they wanted
to get rid of a line or awrinkle, even if you efface the
line or the wrinkle, it didn'talways equate to a happy patient
.
And so then I started wonderingand questioning why I was doing
what I was doing.
Because I was doing what theytold me to do.
(03:55):
I was doing what you know thephase three clinical trials tell
you you can do with theseproducts.
But I wasn't feeling.
I wasn't feeling fulfilledbecause my patients weren't
happy.
And so I started and I'vepublished a great deal on like
the psychology behind why peopledo what they do, how to not
slip into looking peculiar withperception drift, um, and then
(04:19):
also how to like, not impose ourbias onto our patients are of
beauty standards, like with ouraesthetic bias as practitioners,
and I started realizing thatthere's usually patients don't
know necessarily what they'recoming in for, but they know
that they want to feel betterfrom the things that we're doing
.
Speaker 1 (04:37):
And so.
Speaker 2 (04:39):
I realized the power of what we do and we're in this
unique, I think, very privilegedposition with our patients that
I try to honor and respect, andthat is that we can really help
them feel better aboutthemselves.
And you know, it starts to makeyou wonder is feeling better
about yourself, then?
What makes you look better?
(04:59):
Right, looking betterdefinitely can make you feel
better, but that doesn't alwaysequate to be true, because we
see some of the most beautifully, mathematically perfect women
which is what Steve alwayspublishes on and they're not
necessarily the most attractiveperson in the room, they're not
necessarily the happiest personin the room.
So there's an opportunity,really in the consultation and
(05:22):
in the relationship that weforge with these patients of
ours, to really try tounderstand what's the driving
behavior behind why they want todo what they do, and then meet
them with the right procedure,you know, and that's a blend of,
obviously, psychology and thenhaving an aesthetic eye and then
obviously having like, theskill set with your hands to be
(05:44):
able to like execute that plan.
So there's definitely anintersection between mind and
mood, right With what we do whenit comes to beauty.
So and I think that once Istarted writing about it.
I write generally to almostlearn and it's almost like my
therapy right In learning moreabout it.
I write generally to almostlearn and it's almost like my
(06:05):
therapy right In learning moreabout it.
Speaker 1 (06:08):
Journaling is a big thing, yeah, right, yeah.
And I think you know the thingthat I love about you as a human
is I think you see people Notevery doctor actually sees the
patient in their chair and Ithink you have the unique
capability, like I.
I feel, like my patients tellme I have it that when they come
(06:29):
in I'm not just looking at youknow what they're telling me.
I'm saying, okay, they're likeI hate these lines.
I'm like, okay, but what elseis happening?
Where are you in your hormonaljourney?
Where are you in yourrelationship journey?
What is happening at home?
Because I can fix your line, Ican give you a little lift, I
(06:52):
can tighten up your skin, but atthe end of the day, I can't fix
what's going on at home and Ican't fix you know what else is
happening?
I can't fix.
You know what.
What else is happening.
So I think there is a real pushin all of all of medicine to go
beyond the aesthetic, even togo beyond the, the medical lab
(07:14):
results.
Yes, and look at what ispsychologically happening in
your world and how do we helpyou manage that?
Because you can look like yousaid.
You can look like you said, youcan look mathematically like
the most perfect person on theplanet, and I have women come
into me every day.
I'm like, babe, you are themost beautiful woman I've ever
(07:35):
seen.
You have no body fat.
You are perfect.
But they're miserable.
They don't feel the value thatthey need to feel for themselves
, and so I think what you'redoing with this line is really,
really exciting and it'ssomething so extraordinarily
different.
So you and you and Steve aremarried and you have.
(08:00):
Honestly, I love watching youguys on Instagram.
I love watching your story.
I've known you long before youguys on Instagram.
I love watching your story.
I've known you long before youguys were together and to see
your joy and your happiness andthis beautiful, beautiful young
man, mr Mateo, that you guyshave created, it is such a joy
to see you be a mama.
Thank you, because I knew youbefore you were a mama and you
(08:24):
are a.
You're everything I knew youwould be, because you're a
badass and everything that youdo, but you you're killing it as
a mom and as a wife, and I loveseeing you're happy.
It really makes me so happy tosee you happy.
Speaker 2 (08:37):
Thank you, the feeling is mutual, my friend.
Speaker 1 (08:41):
So tell me about how you and Steve got together, and
then let's talk a little bitabout you.
Know how the concept for theline came about.
Speaker 2 (08:50):
Yes, so Steve and I met shortly after I got divorced
.
Now it's going to be 11 yearsago and I met him six weeks
later.
So for all those people goingthrough that, you never know
when you're going to meet themeven when you're not ready for
it.
Speaker 1 (09:06):
Amen baby.
Speaker 2 (09:08):
We've lived across the country from one another.
He still resides in Chicago,and so that always posed a
little bit of a difficultchallenge until in about six
years into the relationship,when we were on and off, we
decided that, okay, well, maybeif we decide that we're not
going to have a baby, then, youknow, being like having this
(09:29):
distance between us wouldn'timpact things as much, and so
decided to move forward with ourrelationship.
We got engaged in 2021 after wehad already decided that we
weren't going to have a childand we were going to continue
working across the country fromone another.
We share very similarviewpoints on the impact that we
(09:52):
have in what we're doing andalso what drives us to do what
we're doing, and that's reallyto make people happy not
(10:16):
necessarily just to efface aline or a wrinkle.
And so in 2022, I spontaneouslygot pregnant.
Two, I spontaneously gotpregnant, so that is possible,
too, when you're 42 years old,even if you have had fertility
(10:38):
issues.
And and it was a most beautifultime in my life- I, I loved
being pregnant.
Speaker 1 (10:40):
You were well, you're already gorgeous, but you had
this incredible glow that I'venever seen.
I mean, you were just a stunnerand you were up on stage
teaching, super pregnant, and Iwas like go moms, and you know
(11:05):
what wives and moms can do andstill be great wives and moms.
We can still make a huge impactand have the career.
We can have it all.
Yes, if we do it well and if we, if we prioritize things and
you are such an example of thatand you've really you've done it
so well, sweetheart.
Thank you, you really haveThank you, yeah.
Speaker 2 (11:28):
So during this time now I had gone now for 13 years
I'd been doing aestheticprocedures and all of a sudden,
in the middle of my 40s, I'm notable to do them because I'm
pregnant and then breastfeeding.
But I felt great and so, justlike any part of my career where
I like to understand whywhether it's my motivations with
(11:50):
patients or how to make themlook better without making them
look unnatural you know we wereresearching why, like I'm, like
gosh, it's like you know, is itbecause I have a boy and I could
have higher testosterone levels?
But like no, I don't seeincreased hair anywhere and my
voice is definitely notdeepening.
And now, when we're pregnant,we definitely have higher levels
(12:14):
of estrogen and they goexponentially up throughout the
trajectory of that pregnancy,which can definitely have an
impact on mood Not always good,though Not always for the mood,
not always for good, not alwaysgood, though Not always for the
good, not always for the good.
You can also be hypervascularwith estrogen, which you know we
(12:35):
lose when we're going intomenopause, and that in that
patient that's wonderful.
But it's not like I was inmenopause because I was pregnant
, so I couldn't attribute it allto estrogen in menopause
because I was pregnant, so Icouldn't attribute it all to
estrogen, and so you know whatwas contributing to like that
dewiness, that radiance and notmaking me look as haggard as I
should look, having been off thetreatments for like nine months
(12:56):
.
And so I looked at a paper in2021 that was published actually
in the JDD.
In 2021 that was publishedactually in the JDD.
And it was funny because, likenothing's by coincidence, I had
already flagged this paper abouttwo years ago, because it was
interesting to me that peoplethat had higher oxytocin levels
(13:16):
just organically looked aboutthree years younger than their
same age counterparts that hadeven more.
Like you could have highoxytocin levels by serum and
have even more history of photodamage, but still have a younger
age or look younger thansomebody who had lower oxytocin
(13:37):
levels, and so that wasinteresting to me.
I'm like so there's somethingthere, and why haven't we
explored that?
Speaker 1 (13:46):
So oxytocin is something that no one's looked
at in really in skincare, or ina lot of ways no one's really
looked at it.
Can you tell our listeners alittle bit about oxytocin?
Speaker 2 (13:58):
Yeah, so oxytocin is a hormone that is biologically
intended to make you bond withyour infant.
It also goes up when you'repregnant, not necessarily
linearly, but it's higher at theend of pregnancy than in the
beginning, as you get ready tobreastfeed and bond with your
(14:18):
baby, and so that's its biologicpurpose.
It's also, I think, interestingbecause it's an
anti-inflammatory hormone, andso that's like its biologic
purpose.
It's also, I think, interestingbecause it's an
anti-inflammatory hormone, andso we know that pregnancy is
likened to one of the most threestressful physiologic
conditions that anybody can evergo through, and it's likened to
trauma or having undergone amassive surgery, because the
(14:43):
physiologic shift that you gothrough when you're pregnant is
extremely intense for the body,and so you are in this kind of
hyper inflammatory statePhysically emotionally all of it
, everything right so oxytocin.
Almost it's smart, like mothernature doesn't make a mistake,
like it's intended to almostalso counteract that
(15:05):
inflammatory state because itprevents reactive oxygen species
from forming free radicals thatultimately break down more
collagen, elastin, but alsooverall for your body, put you
in a worse state and so itcontinues to go up as you
(15:25):
continue to get bigger inpregnancy and then when you meet
your infant.
It's intended to make you bondwith that infant.
It promotes like a feeling offidelity, closeness also true
with your romantic partners.
The effects that it has on menare slightly different than they
have on women, but for women itdoes make you feel more close
(15:50):
to your partner.
For men it promotes a feelingof not wanting to stray from
your partner.
Speaker 1 (15:56):
Well, we might need to put it in the water, Sabrina.
Speaker 2 (16:12):
So it's very interesting for Steve, who is
fascinated with justevolutionary biology.
It's a perfect, you know,neuropeptide for him to study.
But for me it was interestingbecause as a dermatologist I
started wondering okay, so it'ssecreted by your hypothalamus in
your brain, but it's alsosecreted at the level of your
skin.
So it's one of these fewpeptides that can have a
(16:33):
positive feedback loop, in thatwhen you hug and touch, it goes
up when you touch thesemechanical receptors on your
skin.
That's why it's released whenyou hug or you hold someone for
more than 10 seconds.
Everyone has kind of maybeheard about that.
You have to hold and hug formore than 10 seconds.
Speaker 1 (16:53):
Or a baby breastfeed.
Speaker 2 (16:54):
Huh.
Speaker 1 (16:55):
Or a baby breastfeed Right, which is hard.
Speaker 2 (16:57):
Yes, yes, like that skin-on-skin that we talk about,
right, which also that goes toanother topic which is like also
the microbiome that is beinginterchanged with the baby, but
nevertheless so it's intendedfor you.
It makes you feel good, right,that holding, that kissing, that
(17:18):
hugging.
There's a reason why that makesus feel good, why we search for
that.
So when that is released fromholding and touching, it's
because when you touch thesespecific piezoreceptors that are
mechanical receptors that areat the level of your skin, are
(17:38):
bounded to and then they releaseoxytocin.
So you can have a positivesignaling at the level of the
skin, which then triggers apositive signaling release in
your hypothalamus, in your brain.
(17:59):
So usually when you havesomething going up at the skin,
you have a negative feedbackloop later on or more distally,
but here it can be positivelyhappening at your skin and then
it's positively happening inyour brain, making you feel more
relaxed.
So you feel more relaxed afterthe long hug, you feel more
relaxed after the breastfeeding.
Some women even report fallingasleep after breastfeeding and
it's not necessarily becauseyou're sleep deprived, but it's
because it's a hormone thatmakes you feel more relaxed and
(18:22):
less anxious.
Amazing, and so it was reallyinteresting to me that we have
receptors already available tous at the level of the epidermis
, the very top layer of the skin, but no one had thought about
potentially looking at that as areceptor, especially if there's
a possibility that once youbind to it, you can have
(18:45):
downward signaling into thesecond layer of the skin, the
dermis, and there are receptorsfor oxytocin on your fibroblasts
in addition to yourkeratinocytes, which are the top
(19:07):
skin cells.
So we started looking for PhDsthat are doing work in
neuropeptides to try to findsomebody that could help us
formulate or create aneuropeptide that has been found
, in vitro at least, to bind tothe receptor, and we did.
And so, as you know, the invitro work, things that are done
in labs on tissue, don't alwaystranslate to clinical effects,
(19:32):
because many of these productsare sometimes not stable in the
vehicles they're in or sometimesthe molecule itself is too big
to actually be absorbed and havethe effect that it should have.
So we decided to test itclinically and we didn't know.
I mean we just we do things,you know, because we're I mean I
(19:53):
do all kinds of studies all thetime.
Some things pan out, sometimesthings don't, but sometimes you
get some breakthroughs.
And we were curious.
If the receptors are already atthe top layer of the skin, it
doesn't necessarily need topenetrate, so it doesn't matter
what size it is.
Speaker 1 (20:14):
So is.
It is the receptor in thereceptor in the papillary dermis
, epidermis.
It's in the keratinocytes, it'sin the keratinocytes of the
epidermis.
Okay, amazing.
Yes, so it really needs tobarely get in.
Speaker 2 (20:22):
Yes.
Speaker 1 (20:24):
You don't have to get in the dermis, like a lot of
these things where we're tryingto rebuild collagen and elastin.
It just has to get through thestratum corneum and into the
epidermis.
Amazing, okay.
Speaker 2 (20:35):
Love this, right and so.
But could you get enough?
Then the question alwaysbecomes can you have enough bind
to then create a cascadingeffect to get the benefit in the
dermis?
Because it's in the dermiswhere you have your blood
vessels that cause redness.
(20:55):
It's in the dermis where youhave your collagen and elastin
and your fibroblasts.
It's in the dermis where you'retrying to.
The reason we get dewy andradiant in pregnancy is because
it's in the dermis whereoxytocin draws in water to the
dermis.
So that's why you kind of likeget plumped up during pregnancy.
So it's not just because youknow we gain weight and so we
(21:19):
did a trial.
Speaker 1 (21:19):
It's responsible for that glow.
It's responsible for the glowthat everybody, the glow of
pregnancy that everybody talksabout, and I've never, ever
heard a scientific reason for it.
This is blowing my mind.
Speaker 2 (21:31):
a scientific reason for it.
This is this is blowing my minda little bit, yes, but if you
read about it it's.
There's actually literature inthe plastic surgery literature
way before this where theyhypothesized that oxytocin
actually binds to the insulingrowth factor one receptor.
So you can have, it promoteswound healing because of its
anti-inflammatory nature and weknow that it makes sense
(21:54):
postpartum right, pardon me, wow, that makes sense.
Speaker 1 (21:58):
Postpartum, yes, because that's when your whole
body's trying to really heal.
Speaker 2 (22:03):
That makes a lot of sense, and you're responsible
for making a bunch of milk inthis super inflammatory state
and so it's.
You know it's a lot on the body, it's a big toll.
You know you're hormonallyhijacked is what I tell my
patients.
Right, it doesn't just happenin perimenopause or menopause.
Women have to go through thesecycles and gosh if you've had
(22:24):
two kids or three kids everysingle time and it takes about
some studies report 12 to 18months after you deliver your
child for you to achievehomeostasis again.
Speaker 1 (22:37):
And I had two at once , sabrina.
Speaker 2 (22:42):
So that explains why I was a little bit psychotic,
maybe I mean you're on a highwith all this hormone and then
it's like overnight at drop.
That's a lot to ask of our bodyRight.
And now that there's moreattention about the hormonal
implications on the skin, whichyou know, we didn't realize that
(23:03):
all of this data about HRT wasgoing to be refuted in this year
Like it just all.
But there's a lot moreinformation coming to light
about the benefit of you know,it's not just collagen and
elastin and it's there'shormones at play that also
affect the health of our skinright Now we know, like
interesting work done by ZoeDrelos, how about like topical
(23:26):
estriol and estradiol?
You have no systemic effectsfrom it, but you can have an
improvement in your lines andwrinkles and an improvement in
doing this.
But of course, not all womenneed that topical estrogen when
they're perimenopausal or havejust gone through a baby.
So what can you do for thosewomen to get that glow and that
(23:48):
radiance?
So we did the study and we dida placebo controlled.
We took 20 women and only putthem on the vehicle of the serum
and the moisturizer, withoutthe active.
The active has been derivedfrom jasmine and it's a peptide,
just like many of the peptides,not synthetically made, but
(24:10):
it's actually derived fromjasmine, and it's a peptide,
just like many of the peptidesnot synthetically made, but it's
actually derived from jasmine.
And that is what in vitro wasfound to bind to this
oxytocin-like receptor.
And so we put it in thisvehicle and we did stability
testing on it first, which isnecessary in the United States.
For those who are listening,it's not just like you can whip
(24:30):
something off in your kitchen.
You actually have to do thesethings.
And so we then used it on ourpatients, and so we looked at
metrics of the skin that we knewcould potentially improve, like
radiance dewiness.
Theoretically, you should seean improvement in dryness if you
have increased dermal watercapacity, a decrease in redness
(24:53):
if we believe in the data fromthe plastic surgery literature
that it's anti-inflammatory.
And then we also looked atlines and wrinkles almost as
like kind of our metric.
We shouldn't have seen animprovement in lines and
wrinkles because we were onlyusing it for four to eight weeks
.
So you know that if you'regoing to bind to the fibroblast,
that should take like 12 weeksto really have an impact, at
(25:17):
least three to four months yeah.
Right.
So it's like a sanity check,Like okay, is this just you know
?
Like, really does it work?
And we found, in as early asfour weeks, every metric
improved except lines andwrinkles.
The most notable ones wereredness and dryness and radiance
(25:39):
, which makes sense becausethat's what you see in pregnancy
, right?
Then we took those images andwe populated them through
SurveyMonkey and we randomizedthem.
We didn't put before and after,but we just put the image
itself.
So people didn't know if theywere looking at someone on
product.
No, product didn't know.
(26:00):
I want to say it was like over500 people that rated random
images, rated random images andthe people that were on XOMD,
after just four weeks, onaverage look three years younger
than the people that were not,which it's not random that it
was three years, because that'sexactly what the trial in 2021
(26:21):
showed, which was people withintrinsically higher levels of
oxytocin look three yearsyounger than other people.
So it's like we can mimic thosetypes of results if you're on
this topically.
So we were very excited and thenSteve, you know, wanted to see
if we could do more, Like I washappy with just the skin metrics
(26:43):
.
But he was like well, is ithaving a positive feedback loop
in the hypothalamus, Like weshould expect it to see.
And so we did like differentmood questionnaires and it
wasn't significant on any ofthem except social anxiety,
which is what we know.
(27:03):
It's an anxiolytic.
It doesn't help with depressionor anything like that, but it
helps with your anxiety so itmakes you more relaxed and
comfortable in your own skin andthat was statistically
significant.
And then when we looked atconfidence, people by eight
weeks on it, so two monthsreported 87% increase in being
(27:23):
more confident.
So it's not like you can say,oh well, I'm just using a
topical product and now I'mdoing something regularly, so I
must just my skin looks betterand I feel better.
The people that were on theplacebo did not show a
significant improvement inconfidence.
Speaker 1 (27:39):
That's definitely the active.
Speaker 2 (27:41):
Right.
So there was something there.
And then, a step further, weasked people on different sexual
satisfaction questionnaires,because oxytocin is intended to
make you bond.
Now, for women it's supposed to.
If you have higher oxytocinlevels, it makes you trust
(28:02):
others a little bit more.
It makes more masculine facesappear more trustworthy, and so
we again asked women, and wefound that women perceived men
more attractive.
So it's actually it's a greatgift to give a woman technically
, because it makes you come offmore attractive if you're the
(28:23):
man.
And so in the bedroom, womenreported like faster onset of
like orgasm and other metricswhen we looked at sexual
satisfaction, and I think it hasto do with feeling more bonded
to their partner.
And partners even noticed thedifference in.
(28:44):
The partners were like tripleblinded, so it was almost too
good to be true.
But how would the partners everknow?
So there was somethingdefinitely there, and we're
hoping now to repeat the trialusing potentially having women
that are going through menopauseor already in menopause.
We know that when you're goingthrough menopause, a drop in
(29:08):
estrogen decreases your oxytocinreceptor binding capacity.
Speaker 1 (29:15):
Wow, I did not know that.
Speaker 2 (29:16):
So even if you're in love, or you're you know you're
holding that baby.
Your ability to feel thatfeeling of oxytocin diminishes
when estrogen diminishes.
Speaker 1 (29:27):
Wow.
So another reason why HRT youknow when appropriate is so
powerful because it helps youalso bond better, right?
Yes, it helps you to feelconfident again, to feel sexy
again to you know all of thethings that are supposed to
happen when you're feelingamorous actually happen, which
(29:49):
is really lovely.
And then you also have thedesire, because I think that is
the thing with so many women,especially in perimenopause.
You know you see relationshipsfall apart all the time and you
know it's not only physiologic,it's also emotional and it's
also that that bonding thatyou're talking about, that kind
(30:12):
of starts to fall apart.
So this is incredible to hear.
Speaker 2 (30:17):
Yes, wow, I know we were, we were, we were
pleasantly surprised.
I mean we don't really need toput anything out there.
I mean we come up with ideas,naturally and, you know, present
them as keynotes and inlectures all the time, but to
really we wanted to createsomething that can have an
(30:37):
impact, a positive impact, onjust the overall wellbeing of
women, especially since theaverage woman that I see is
about 47.
The average woman Steven seesis about 55 for facelifts,
blephs, you know.
And so we recognize that thosewomen are going through hormonal
shifts.
(30:58):
Those women are going throughhormonal shifts and maybe that
sometimes has an impact on theirperception of the benefit from
treatment, happiness fromtreatment and how they feel
about themselves.
Right, absolutely, and so if wecan support that hormonal
health of their skin and mind, Ithink that we can also just see
better impacts from thetreatments that we're doing.
Speaker 1 (31:18):
This is kind of blowing my mind a little bit.
Thank you, I knew this wasgoing.
I knew talking to you would beamazing, so I, you sent me your
products and I have used themand they're lovely.
They're so cosmetically elegant, they feel good.
They're not, they don't havelike an overpowering fragrance.
I mean they're not they.
They don't have like anoverpowering fragrance.
(31:39):
I mean they're just lovely.
They make my skin feel veryhydrated, very plump, and I I
love them.
And maybe it's the oxytocin.
I didn't even know that I wasloving them.
But you know, I'm in a.
I'm in a a post-divorcesituation as well and I will
tell you I I just feel likeanything that you can do at this
(32:01):
point this post-menopause,post-divorce, post-whatever we
are in in this stage of our lifeto just make us feel confident
and happy and safe in our skin.
It's a big deal for women intheir 40s, 50s and beyond.
Speaker 2 (32:21):
Yes.
Speaker 1 (32:22):
And I think you're really on to something and I'm
so impressed and so proud of youand I really want to hear about
the different products.
Talk to me about each one.
And then we've got to figureout how to get them into Premier
, because I need my patients tobe able to purchase these
(32:42):
products easily and come by andget them.
So talk to me about thedifferent SKUs in the products
line.
Speaker 2 (32:49):
Yes, so we start with the cleanser.
Speaker 1 (32:52):
When I created the cleanser because I do a lot of
fully ablative CO2 laserresurfacing and for those I
don't know if you do them, missy, but I do a lot of Erbium, so,
yeah, my patients know about thedeep halo resurfacing and you
know it's it's it's a take yourface off big time procedure.
Exactly, it's a big deal andyou need.
Speaker 2 (33:13):
sometimes.
These gentle cleansers that werecommend over the counter are
gentle, but they also don'tremove some of that
serosanguinous crust that can bea great something that you
bacteria loves to snack on andthen, before you know it, you
have an infection day four, dayfive.
So I wanted something gentleenough that I can put it on a
post-op laser resurfacing andI'm talking fully ablative CO2
(33:36):
layered with fully ablativeerbium, like day three, and it
doesn't burn my patient's face.
So that was like the vision forthe cleanser right.
Speaker 1 (33:46):
That's why you call it a detox.
Get rid of all the badness thatwe've done to you.
Get rid of it.
Get rid of it.
Speaker 2 (33:54):
And also, just we know that not washing your face,
just the daily grime thatbuilds up on your face,
especially San Diego isconsidered like the sixth most
polluted city in the country.
So if you're a runner andyou're out there, I think you're
a runner, aren't you?
Speaker 1 (34:10):
Oh baby, I used to run and now I just don't run
anymore.
Now I'm a Pilates girl and aweightlifting girl.
But back in back, when we firstmet, yeah, I was running, I was
like doing 5Ks, 10Ks, I did aTough Mudder.
I think the first year we meteach other.
Speaker 2 (34:27):
Yeah, you were running.
Speaker 1 (34:29):
Now, if you see me running, I've probably been
snatched up by body snatchersand they've taken my brain out,
because the running just doesn'twork for my body anymore.
I'm with you, it doesn't workfor my body anymore.
I'm with you Doesn't work.
So, yeah, but I get it.
But I, we, we are.
I'm outside all the time.
I love to bike, I love to hike,I love to walk outside.
Speaker 2 (34:49):
So, um, and there's a lot of pollution in the
universe that damages your skinCan definitely age you and
there's some great studies onhow it could increase your
pigment by about 20% and it canincrease, you know, just overall
lines and wrinkles over time.
So getting the grime off yourface is important and so that's
(35:10):
why it's called detox.
Then comes the.
So it's gentle enough to notirritate your skin, cause I, you
, were dermatologists.
You know everyone that comes inhas sensitive skin or
self-report sensitive skin.
We're doing layer lasers forredness, so it has to be with
that, that person, in mind.
Then intoxicate, intoxicate andarouse.
(35:31):
Or intoxicates the serum,arouse and it's a kind of a play
on the effect that they have.
That's the serum and that's themoisturizer.
Speaker 1 (35:41):
And there's I love the packaging.
I designed it.
I love it so different.
Speaker 2 (35:46):
They're X's and O's, so, and I wanted it to look nice
like on a bathroom counter oreven in a retail space, because
we're in aesthetics, theseproducts are so expensive and
they're in like these cheapplastic bottles, you know.
It just always is like.
I'm like is there noconsideration that we're, you
(36:07):
know, in aesthetics, right?
So I'm sensitive to that.
So I wanted what was in it tomatch what was outside.
Speaker 1 (36:15):
So you did a great job.
They're beautiful, thank you.
Speaker 2 (36:18):
And so here these two have the OX factor, which is
the proprietary blend of thephytopeptides, and then there's
also carob, and so that's what'shaving the effect on the
mechanoreceptors, on thesepiezoreceptors.
But in the serum we have alsoan extract from like honey tree
(36:41):
that comes from Korea and China.
That has been found to decreasepigmentation.
So that's unique in the serum.
That's not found in themoisturizer, which acts a little
bit longer than most HAs,because the problem with
hyaluronic acid, depending onthe formulation you get.
(37:01):
There's various formulations.
Some of the over-counter stuffis just like free HA.
We know free HA vaporizeswithin 15 minutes of being on
the skin.
Some of the more cross-linkedHAs just don't get absorbed.
So it was coming up withsomething that can add to
drawing in.
Speaker 1 (37:19):
Penetrate and then pull in the water.
Yes, yeah.
Speaker 2 (37:23):
And then Arouse is the moisturizer and it serves as
a nice humectant to kind ofseal that top layer of skin,
using glycerin as its base.
Speaker 1 (37:36):
That's why it feels so good.
Pardon me, it feels so goodGood, yes, it does.
It's very soothing.
Speaker 2 (37:42):
And that was the goal , because sometimes some of the
other ingredients that are alittle too fatty just sit on the
skin as they can't get absorbedRight, and I wanted to be able
to put something on, especiallyafter some of the aggressive
lasers that we do for mypatients, so that they could
heal faster.
And so that it was likethinking of the vehicle.
(38:06):
It was like, okay, I love theingredient of OX, but I need it
to be in a vehicle that mypatients can tolerate, so I'm
not adding another problem andthen they're coming in for a
different problem.
Speaker 1 (38:18):
Thank you for that.
So I had the ultra clear devicedone on Monday, with some laser
coring under my chin and myforehead.
So I used your cleanser ohgreat, yes, because I didn't
know how safe it would be to usethe serum and the moisturizer.
But I knew that your cleanserbecause I had used your cleanser
(38:42):
right after microneedling andI'm like this just feels so good
and there's no stinging,there's no burning.
So I was already like sold onthe cleanser 1000%.
But post-treatment, how sooncan we use these products?
Speaker 2 (38:57):
So after, like if I do a non-ablative, so if I do, I
usually do a combination of IPLPulse Dye Laser with a Clear
and Brilliant or IPL Pulse DyeLaser with, like a Fraxel Dual
or Fraxel Restore.
I put it on immediately on thetable to draw in water to the
skin.
So I usually put the IntoxicateSerum first to draw in water.
(39:18):
Then I even use on top of thatI like to use the SkinCeuticals
Phytocorrective Mask to cool theskin.
And then I'll put on, beforethey leave, the Arouse
Moisturizer, so that they can goon about their day, especially
after the restore.
They tend to report that theirface feels on fire, and so
(39:42):
that's been great.
I also do it immediately afterphotodynamic therapy, because
that way it's not so so greasyeither that for my acne patients
it's causing another issue.
So for those folks, thoseprocedures that's what I do or
even a microneedling RF we use,like the Potenza For fully
ablative resurfacing.
(40:02):
I won't use this until theyre-epithelialize at day seven or
day 10.
But we historically, as apractice, have always, because
of how aggressive we are withour CO2, they still have post-op
erythema week four.
So we've always offered like apost, a complimentary pulse dye
laser.
(40:22):
But now that I'm using this dayseven, day 10, by day 28, day
30, their redness is pretty muchgone.
So I don't need to offer themthe PDL like I used to.
So it's great because it'sdecreasing the redness and
that's always the hardest thingfor me.
(40:44):
It is the persistent rednessthat drives people crazy, crazy,
drives people crazy, and evenwith melasma right, Like there's
the vascular component ofmelasma that we can't get.
There's such great things formelanin, but that it's that
erythema right, Whether it'sfrom rosacea, PIE or in melasma
(41:05):
or from the procedures that I do.
So it's been great for that.
Speaker 1 (41:09):
Well, I want your protocols.
So I want to visit with youoffline because I want your
protocols and I want you to tellour listeners, first off, how
to how to how to order yourproduct right now, yes.
And then I want us to to chatabout how we bring the product
line into premier, because I amsold and I absolutely I want my
(41:30):
patients here in Arkansas to youknow glean all of the wisdom
and all of the all of thescience behind what you've put
into these products.
I'm really impressed.
Speaker 2 (41:39):
Thank you.
Thank you so much.
Let's see, yes, so for thosewho are, right now.
Speaker 1 (41:44):
Is there a website where they could go?
Okay.
Speaker 2 (41:48):
XOMDSkincom.
Speaker 1 (41:49):
Okay, all right.
Well, you guys have donesomething really special here,
and I think it is so incrediblyinnovative.
And I am not surprised, becauseI know you have this huge brain
and so does the really amazinghusband that you have, and I'm
so happy for you and I just wishyou all the joy that you
(42:10):
deserve, my dear, because you'rean amazing person, you're an
amazing doctor, you're anamazing mom, an amazing wife and
now even a more amazingscientist.
So I'm so excited and I can'twait, and I would love it if you
would come to Arkansas sometime.
Oh, I would love that I haven't.
I would love to come out tovisit you as well.
So let's make it happen andlet's talk about how to get XOMD
(42:35):
into premier dermatology.
Speaker 2 (42:37):
I would love that.
Speaker 1 (42:39):
All right.
So, gang, thank you so much fortuning in to another episode of
All Things Skin.
Thank you for listening to mybeautiful colleague, sabrina
Fahby, and I can't wait for youto learn more about XOMD.
So tune in next time foranother round of All Things Skin
.
So, guys, thank you so much fortuning in to an episode of All
(43:02):
Things Skin.
We sure appreciate you beingone of our listeners.
Not only do we thank you forlistening, but please continue
to follow us, give your reviewson any of the podcast platforms
that you're listening on, and wecan't wait to see you on
another episode of All ThingsSkin.
All right, friends, today is a very exciting day on
our All Things Skin podcast.
One of my really mentors andfriends and just one of the
kindest, most genuine humansI've ever met in the world is
joining me today on the podcastto talk about her XOMD skincare,
(00:22):
which is really kind of areally transformational idea.
She is for the first time, withher adorable husband and
plastic surgeon colleague,bringing us skincare that really
is mood-suitical.
So for the first time, we arebringing not only skin care but
(00:46):
also emotional well-beingtogether in a line and that is
something that is very special.
So, guys, welcome my dear, dearfriend, dr Sabrina Fahby.
Speaker 2 (00:57):
Thank you so much for having me, missy.
The feeling is mutual.
I'm so inspired.
I know you have a beautifulpractice.
Feeling is mutual, I'm soinspired, I know you have a
beautiful practice and I findthat people that have thriving
practices generally the commontheme behind it is that they
love what they do and they'redoing great things for their
patients.
So it's wonderful to be herewith you and share that same
passion.
Speaker 1 (01:17):
Amen, and I will tell you.
I just want to give ourlisteners a little background
into how we met.
And then I want to talk alittle bit about you and your
adorable husband and yourbeautiful baby Mateo he's so
precious and then how the linelaunched and you know just
basically where you got the ideaand what you're doing with the
(01:39):
line.
So first I will say dermatologyis a very small world and,
Sabrina, I think we met probablymaybe 15 years ago at a
conference and I think we wereboth at that point, you know,
kind of just kind of gettingstarted in our career and really
trying to figure out who wewere.
And there was this group ofreally older dermatologists that
(02:00):
were kind of the derm girls,you know, and they were ruling
the roost and they were amazinghumans and some of the best
doctors on the planet.
But I was trying to figure outhow do I get to be a derm girl?
I want to be a derm girl andyou already were a little ahead
of me and you had these contactswith these women and you were
(02:22):
so kind to me.
You brought me under your wing,you introduced me to people,
you treated me as an equal fromthe very beginning and I just
want you to know that that was a.
It was a game changer for mycareer and I love you and I
appreciate you so much forseeing me, and, and, and, and
(02:42):
and just just being so kind andso open to sharing your
knowledge and, you know, helpingme to navigate that world.
So thank you.
Speaker 2 (02:52):
Oh, it's my pleasure, of course.
Speaker 1 (02:55):
You're the best.
Okay, so let's talk.
So tell me about your practice,and tell me about your
relationship with Steve, andthen, and then let, and then
let's talk how this all cameabout.
Speaker 2 (03:10):
Yes, so I've been, as you mentioned, in practice now
for 15 years and I'm here inSouthern California, in San
Diego.
I have been in aesthetics myentire time, so always have been
doing injectables and laserprocedures.
And something that I came torealize very quickly, and
probably where my world collidedwith Steve's, was that I
(03:33):
recognized that much of the timewhen patients came in, it
wasn't necessarily, althoughthey would say that they wanted
to get rid of a line or awrinkle, even if you efface the
line or the wrinkle, it didn'talways equate to a happy patient
.
And so then I started wonderingand questioning why I was doing
what I was doing.
Because I was doing what theytold me to do.
(03:55):
I was doing what you know thephase three clinical trials tell
you you can do with theseproducts.
But I wasn't feeling.
I wasn't feeling fulfilledbecause my patients weren't
happy.
And so I started and I'vepublished a great deal on like
the psychology behind why peopledo what they do, how to not
slip into looking peculiar withperception drift, um, and then
(04:19):
also how to like, not impose ourbias onto our patients are of
beauty standards, like with ouraesthetic bias as practitioners,
and I started realizing thatthere's usually patients don't
know necessarily what they'recoming in for, but they know
that they want to feel betterfrom the things that we're doing
.
Speaker 1 (04:37):
And so.
Speaker 2 (04:39):
I realized the power of what we do and we're in this
unique, I think, very privilegedposition with our patients that
I try to honor and respect, andthat is that we can really help
them feel better aboutthemselves.
And you know, it starts to makeyou wonder is feeling better
about yourself, then?
What makes you look better?
(04:59):
Right, looking betterdefinitely can make you feel
better, but that doesn't alwaysequate to be true, because we
see some of the most beautifully, mathematically perfect women
which is what Steve alwayspublishes on and they're not
necessarily the most attractiveperson in the room, they're not
necessarily the happiest personin the room.
So there's an opportunity,really in the consultation and
(05:22):
in the relationship that weforge with these patients of
ours, to really try tounderstand what's the driving
behavior behind why they want todo what they do, and then meet
them with the right procedure,you know, and that's a blend of,
obviously, psychology and thenhaving an aesthetic eye and then
obviously having like, theskill set with your hands to be
(05:44):
able to like execute that plan.
So there's definitely anintersection between mind and
mood, right With what we do whenit comes to beauty.
So and I think that once Istarted writing about it.
I write generally to almostlearn and it's almost like my
therapy right In learning moreabout it.
I write generally to almostlearn and it's almost like my
(06:05):
therapy right In learning moreabout it.
Speaker 1 (06:08):
Journaling is a big thing, yeah, right, yeah.
And I think you know the thingthat I love about you as a human
is I think you see people Notevery doctor actually sees the
patient in their chair and Ithink you have the unique
capability, like I.
I feel, like my patients tellme I have it that when they come
(06:29):
in I'm not just looking at youknow what they're telling me.
I'm saying, okay, they're likeI hate these lines.
I'm like, okay, but what elseis happening?
Where are you in your hormonaljourney?
Where are you in yourrelationship journey?
What is happening at home?
Because I can fix your line, Ican give you a little lift, I
(06:52):
can tighten up your skin, but atthe end of the day, I can't fix
what's going on at home and Ican't fix you know what else is
happening?
I can't fix.
You know what.
What else is happening.
So I think there is a real pushin all of all of medicine to go
beyond the aesthetic, even togo beyond the, the medical lab
(07:14):
results.
Yes, and look at what ispsychologically happening in
your world and how do we helpyou manage that?
Because you can look like yousaid.
You can look like you said, youcan look mathematically like
the most perfect person on theplanet, and I have women come
into me every day.
I'm like, babe, you are themost beautiful woman I've ever
(07:35):
seen.
You have no body fat.
You are perfect.
But they're miserable.
They don't feel the value thatthey need to feel for themselves
, and so I think what you'redoing with this line is really,
really exciting and it'ssomething so extraordinarily
different.
So you and you and Steve aremarried and you have.
(08:00):
Honestly, I love watching youguys on Instagram.
I love watching your story.
I've known you long before youguys on Instagram.
I love watching your story.
I've known you long before youguys were together and to see
your joy and your happiness andthis beautiful, beautiful young
man, mr Mateo, that you guyshave created, it is such a joy
to see you be a mama.
Thank you, because I knew youbefore you were a mama and you
(08:24):
are a.
You're everything I knew youwould be, because you're a
badass and everything that youdo, but you you're killing it as
a mom and as a wife, and I loveseeing you're happy.
It really makes me so happy tosee you happy.
Speaker 2 (08:37):
Thank you, the feeling is mutual, my friend.
Speaker 1 (08:41):
So tell me about how you and Steve got together, and
then let's talk a little bitabout you.
Know how the concept for theline came about.
Speaker 2 (08:50):
Yes, so Steve and I met shortly after I got divorced
.
Now it's going to be 11 yearsago and I met him six weeks
later.
So for all those people goingthrough that, you never know
when you're going to meet themeven when you're not ready for
it.
Speaker 1 (09:06):
Amen baby.
Speaker 2 (09:08):
We've lived across the country from one another.
He still resides in Chicago,and so that always posed a
little bit of a difficultchallenge until in about six
years into the relationship,when we were on and off, we
decided that, okay, well, maybeif we decide that we're not
going to have a baby, then, youknow, being like having this
(09:29):
distance between us wouldn'timpact things as much, and so
decided to move forward with ourrelationship.
We got engaged in 2021 after wehad already decided that we
weren't going to have a childand we were going to continue
working across the country fromone another.
We share very similarviewpoints on the impact that we
(09:52):
have in what we're doing andalso what drives us to do what
we're doing, and that's reallyto make people happy not
(10:16):
necessarily just to efface aline or a wrinkle.
And so in 2022, I spontaneouslygot pregnant.
Two, I spontaneously gotpregnant, so that is possible,
too, when you're 42 years old,even if you have had fertility
(10:38):
issues.
And and it was a most beautifultime in my life- I, I loved
being pregnant.
Speaker 1 (10:40):
You were well, you're already gorgeous, but you had
this incredible glow that I'venever seen.
I mean, you were just a stunnerand you were up on stage
teaching, super pregnant, and Iwas like go moms, and you know
(11:05):
what wives and moms can do andstill be great wives and moms.
We can still make a huge impactand have the career.
We can have it all.
Yes, if we do it well and if we, if we prioritize things and
you are such an example of thatand you've really you've done it
so well, sweetheart.
Thank you, you really haveThank you, yeah.
Speaker 2 (11:28):
So during this time now I had gone now for 13 years
I'd been doing aestheticprocedures and all of a sudden,
in the middle of my 40s, I'm notable to do them because I'm
pregnant and then breastfeeding.
But I felt great and so, justlike any part of my career where
I like to understand whywhether it's my motivations with
(11:50):
patients or how to make themlook better without making them
look unnatural you know we wereresearching why, like I'm, like
gosh, it's like you know, is itbecause I have a boy and I could
have higher testosterone levels?
But like no, I don't seeincreased hair anywhere and my
voice is definitely notdeepening.
And now, when we're pregnant,we definitely have higher levels
(12:14):
of estrogen and they goexponentially up throughout the
trajectory of that pregnancy,which can definitely have an
impact on mood Not always good,though Not always for the mood,
not always for good, not alwaysgood, though Not always for the
good, not always for the good.
You can also be hypervascularwith estrogen, which you know we
(12:35):
lose when we're going intomenopause, and that in that
patient that's wonderful.
But it's not like I was inmenopause because I was pregnant
, so I couldn't attribute it allto estrogen in menopause
because I was pregnant, so Icouldn't attribute it all to
estrogen, and so you know whatwas contributing to like that
dewiness, that radiance and notmaking me look as haggard as I
should look, having been off thetreatments for like nine months
(12:56):
.
And so I looked at a paper in2021 that was published actually
in the JDD.
In 2021 that was publishedactually in the JDD.
And it was funny because, likenothing's by coincidence, I had
already flagged this paper abouttwo years ago, because it was
interesting to me that peoplethat had higher oxytocin levels
(13:16):
just organically looked aboutthree years younger than their
same age counterparts that hadeven more.
Like you could have highoxytocin levels by serum and
have even more history of photodamage, but still have a younger
age or look younger thansomebody who had lower oxytocin
(13:37):
levels, and so that wasinteresting to me.
I'm like so there's somethingthere, and why haven't we
explored that?
Speaker 1 (13:46):
So oxytocin is something that no one's looked
at in really in skincare, or ina lot of ways no one's really
looked at it.
Can you tell our listeners alittle bit about oxytocin?
Speaker 2 (13:58):
Yeah, so oxytocin is a hormone that is biologically
intended to make you bond withyour infant.
It also goes up when you'repregnant, not necessarily
linearly, but it's higher at theend of pregnancy than in the
beginning, as you get ready tobreastfeed and bond with your
(14:18):
baby, and so that's its biologicpurpose.
It's also, I think, interestingbecause it's an
anti-inflammatory hormone, andso that's like its biologic
purpose.
It's also, I think, interestingbecause it's an
anti-inflammatory hormone, andso we know that pregnancy is
likened to one of the most threestressful physiologic
conditions that anybody can evergo through, and it's likened to
trauma or having undergone amassive surgery, because the
(14:43):
physiologic shift that you gothrough when you're pregnant is
extremely intense for the body,and so you are in this kind of
hyper inflammatory statePhysically emotionally all of it
, everything right so oxytocin.
Almost it's smart, like mothernature doesn't make a mistake,
like it's intended to almostalso counteract that
(15:05):
inflammatory state because itprevents reactive oxygen species
from forming free radicals thatultimately break down more
collagen, elastin, but alsooverall for your body, put you
in a worse state and so itcontinues to go up as you
(15:25):
continue to get bigger inpregnancy and then when you meet
your infant.
It's intended to make you bondwith that infant.
It promotes like a feeling offidelity, closeness also true
with your romantic partners.
The effects that it has on menare slightly different than they
have on women, but for women itdoes make you feel more close
(15:50):
to your partner.
For men it promotes a feelingof not wanting to stray from
your partner.
Speaker 1 (15:56):
Well, we might need to put it in the water, Sabrina.
Speaker 2 (16:12):
So it's very interesting for Steve, who is
fascinated with justevolutionary biology.
It's a perfect, you know,neuropeptide for him to study.
But for me it was interestingbecause as a dermatologist I
started wondering okay, so it'ssecreted by your hypothalamus in
your brain, but it's alsosecreted at the level of your
skin.
So it's one of these fewpeptides that can have a
(16:33):
positive feedback loop, in thatwhen you hug and touch, it goes
up when you touch thesemechanical receptors on your
skin.
That's why it's released whenyou hug or you hold someone for
more than 10 seconds.
Everyone has kind of maybeheard about that.
You have to hold and hug formore than 10 seconds.
Speaker 1 (16:53):
Or a baby breastfeed.
Speaker 2 (16:54):
Huh.
Speaker 1 (16:55):
Or a baby breastfeed Right, which is hard.
Speaker 2 (16:57):
Yes, yes, like that skin-on-skin that we talk about,
right, which also that goes toanother topic which is like also
the microbiome that is beinginterchanged with the baby, but
nevertheless so it's intendedfor you.
It makes you feel good, right,that holding, that kissing, that
(17:18):
hugging.
There's a reason why that makesus feel good, why we search for
that.
So when that is released fromholding and touching, it's
because when you touch thesespecific piezoreceptors that are
mechanical receptors that areat the level of your skin, are
(17:38):
bounded to and then they releaseoxytocin.
So you can have a positivesignaling at the level of the
skin, which then triggers apositive signaling release in
your hypothalamus, in your brain.
(17:59):
So usually when you havesomething going up at the skin,
you have a negative feedbackloop later on or more distally,
but here it can be positivelyhappening at your skin and then
it's positively happening inyour brain, making you feel more
relaxed.
So you feel more relaxed afterthe long hug, you feel more
relaxed after the breastfeeding.
Some women even report fallingasleep after breastfeeding and
it's not necessarily becauseyou're sleep deprived, but it's
because it's a hormone thatmakes you feel more relaxed and
(18:22):
less anxious.
Amazing, and so it was reallyinteresting to me that we have
receptors already available tous at the level of the epidermis
, the very top layer of the skin, but no one had thought about
potentially looking at that as areceptor, especially if there's
a possibility that once youbind to it, you can have
(18:45):
downward signaling into thesecond layer of the skin, the
dermis, and there are receptorsfor oxytocin on your fibroblasts
in addition to yourkeratinocytes, which are the top
(19:07):
skin cells.
So we started looking for PhDsthat are doing work in
neuropeptides to try to findsomebody that could help us
formulate or create aneuropeptide that has been found
, in vitro at least, to bind tothe receptor, and we did.
And so, as you know, the invitro work, things that are done
in labs on tissue, don't alwaystranslate to clinical effects,
(19:32):
because many of these productsare sometimes not stable in the
vehicles they're in or sometimesthe molecule itself is too big
to actually be absorbed and havethe effect that it should have.
So we decided to test itclinically and we didn't know.
I mean we just we do things,you know, because we're I mean I
(19:53):
do all kinds of studies all thetime.
Some things pan out, sometimesthings don't, but sometimes you
get some breakthroughs.
And we were curious.
If the receptors are already atthe top layer of the skin, it
doesn't necessarily need topenetrate, so it doesn't matter
what size it is.
Speaker 1 (20:14):
So is.
It is the receptor in thereceptor in the papillary dermis
, epidermis.
It's in the keratinocytes, it'sin the keratinocytes of the
epidermis.
Okay, amazing.
Yes, so it really needs tobarely get in.
Speaker 2 (20:22):
Yes.
Speaker 1 (20:24):
You don't have to get in the dermis, like a lot of
these things where we're tryingto rebuild collagen and elastin.
It just has to get through thestratum corneum and into the
epidermis.
Amazing, okay.
Speaker 2 (20:35):
Love this, right and so.
But could you get enough?
Then the question alwaysbecomes can you have enough bind
to then create a cascadingeffect to get the benefit in the
dermis?
Because it's in the dermiswhere you have your blood
vessels that cause redness.
(20:55):
It's in the dermis where youhave your collagen and elastin
and your fibroblasts.
It's in the dermis where you'retrying to.
The reason we get dewy andradiant in pregnancy is because
it's in the dermis whereoxytocin draws in water to the
dermis.
So that's why you kind of likeget plumped up during pregnancy.
So it's not just because youknow we gain weight and so we
(21:19):
did a trial.
Speaker 1 (21:19):
It's responsible for that glow.
It's responsible for the glowthat everybody, the glow of
pregnancy that everybody talksabout, and I've never, ever
heard a scientific reason for it.
This is blowing my mind.
Speaker 2 (21:31):
a scientific reason for it.
This is this is blowing my minda little bit, yes, but if you
read about it it's.
There's actually literature inthe plastic surgery literature
way before this where theyhypothesized that oxytocin
actually binds to the insulingrowth factor one receptor.
So you can have, it promoteswound healing because of its
anti-inflammatory nature and weknow that it makes sense
(21:54):
postpartum right, pardon me, wow, that makes sense.
Speaker 1 (21:58):
Postpartum, yes, because that's when your whole
body's trying to really heal.
Speaker 2 (22:03):
That makes a lot of sense, and you're responsible
for making a bunch of milk inthis super inflammatory state
and so it's.
You know it's a lot on the body, it's a big toll.
You know you're hormonallyhijacked is what I tell my
patients.
Right, it doesn't just happenin perimenopause or menopause.
Women have to go through thesecycles and gosh if you've had
(22:24):
two kids or three kids everysingle time and it takes about
some studies report 12 to 18months after you deliver your
child for you to achievehomeostasis again.
Speaker 1 (22:37):
And I had two at once , sabrina.
Speaker 2 (22:42):
So that explains why I was a little bit psychotic,
maybe I mean you're on a highwith all this hormone and then
it's like overnight at drop.
That's a lot to ask of our bodyRight.
And now that there's moreattention about the hormonal
implications on the skin, whichyou know, we didn't realize that
(23:03):
all of this data about HRT wasgoing to be refuted in this year
Like it just all.
But there's a lot moreinformation coming to light
about the benefit of you know,it's not just collagen and
elastin and it's there'shormones at play that also
affect the health of our skinright Now we know, like
interesting work done by ZoeDrelos, how about like topical
(23:26):
estriol and estradiol?
You have no systemic effectsfrom it, but you can have an
improvement in your lines andwrinkles and an improvement in
doing this.
But of course, not all womenneed that topical estrogen when
they're perimenopausal or havejust gone through a baby.
So what can you do for thosewomen to get that glow and that
(23:48):
radiance?
So we did the study and we dida placebo controlled.
We took 20 women and only putthem on the vehicle of the serum
and the moisturizer, withoutthe active.
The active has been derivedfrom jasmine and it's a peptide,
just like many of the peptides,not synthetically made, but
(24:10):
it's actually derived fromjasmine, and it's a peptide,
just like many of the peptidesnot synthetically made, but it's
actually derived from jasmine.
And that is what in vitro wasfound to bind to this
oxytocin-like receptor.
And so we put it in thisvehicle and we did stability
testing on it first, which isnecessary in the United States.
For those who are listening,it's not just like you can whip
(24:30):
something off in your kitchen.
You actually have to do thesethings.
And so we then used it on ourpatients, and so we looked at
metrics of the skin that we knewcould potentially improve, like
radiance dewiness.
Theoretically, you should seean improvement in dryness if you
have increased dermal watercapacity, a decrease in redness
(24:53):
if we believe in the data fromthe plastic surgery literature
that it's anti-inflammatory.
And then we also looked atlines and wrinkles almost as
like kind of our metric.
We shouldn't have seen animprovement in lines and
wrinkles because we were onlyusing it for four to eight weeks
.
So you know that if you'regoing to bind to the fibroblast,
that should take like 12 weeksto really have an impact, at
(25:17):
least three to four months yeah.
Right.
So it's like a sanity check,Like okay, is this just you know
?
Like, really does it work?
And we found, in as early asfour weeks, every metric
improved except lines andwrinkles.
The most notable ones wereredness and dryness and radiance
(25:39):
, which makes sense becausethat's what you see in pregnancy
, right?
Then we took those images andwe populated them through
SurveyMonkey and we randomizedthem.
We didn't put before and after,but we just put the image
itself.
So people didn't know if theywere looking at someone on
product.
No, product didn't know.
(26:00):
I want to say it was like over500 people that rated random
images, rated random images andthe people that were on XOMD,
after just four weeks, onaverage look three years younger
than the people that were not,which it's not random that it
was three years, because that'sexactly what the trial in 2021
(26:21):
showed, which was people withintrinsically higher levels of
oxytocin look three yearsyounger than other people.
So it's like we can mimic thosetypes of results if you're on
this topically.
So we were very excited and thenSteve, you know, wanted to see
if we could do more, Like I washappy with just the skin metrics
(26:43):
.
But he was like well, is ithaving a positive feedback loop
in the hypothalamus, Like weshould expect it to see.
And so we did like differentmood questionnaires and it
wasn't significant on any ofthem except social anxiety,
which is what we know.
(27:03):
It's an anxiolytic.
It doesn't help with depressionor anything like that, but it
helps with your anxiety so itmakes you more relaxed and
comfortable in your own skin andthat was statistically
significant.
And then when we looked atconfidence, people by eight
weeks on it, so two monthsreported 87% increase in being
(27:23):
more confident.
So it's not like you can say,oh well, I'm just using a
topical product and now I'mdoing something regularly, so I
must just my skin looks betterand I feel better.
The people that were on theplacebo did not show a
significant improvement inconfidence.
Speaker 1 (27:39):
That's definitely the active.
Speaker 2 (27:41):
Right.
So there was something there.
And then, a step further, weasked people on different sexual
satisfaction questionnaires,because oxytocin is intended to
make you bond.
Now, for women it's supposed to.
If you have higher oxytocinlevels, it makes you trust
(28:02):
others a little bit more.
It makes more masculine facesappear more trustworthy, and so
we again asked women, and wefound that women perceived men
more attractive.
So it's actually it's a greatgift to give a woman technically
, because it makes you come offmore attractive if you're the
(28:23):
man.
And so in the bedroom, womenreported like faster onset of
like orgasm and other metricswhen we looked at sexual
satisfaction, and I think it hasto do with feeling more bonded
to their partner.
And partners even noticed thedifference in.
(28:44):
The partners were like tripleblinded, so it was almost too
good to be true.
But how would the partners everknow?
So there was somethingdefinitely there, and we're
hoping now to repeat the trialusing potentially having women
that are going through menopauseor already in menopause.
We know that when you're goingthrough menopause, a drop in
(29:08):
estrogen decreases your oxytocinreceptor binding capacity.
Speaker 1 (29:15):
Wow, I did not know that.
Speaker 2 (29:16):
So even if you're in love, or you're you know you're
holding that baby.
Your ability to feel thatfeeling of oxytocin diminishes
when estrogen diminishes.
Speaker 1 (29:27):
Wow.
So another reason why HRT youknow when appropriate is so
powerful because it helps youalso bond better, right?
Yes, it helps you to feelconfident again, to feel sexy
again to you know all of thethings that are supposed to
happen when you're feelingamorous actually happen, which
(29:49):
is really lovely.
And then you also have thedesire, because I think that is
the thing with so many women,especially in perimenopause.
You know you see relationshipsfall apart all the time and you
know it's not only physiologic,it's also emotional and it's
also that that bonding thatyou're talking about, that kind
(30:12):
of starts to fall apart.
So this is incredible to hear.
Speaker 2 (30:17):
Yes, wow, I know we were, we were, we were
pleasantly surprised.
I mean we don't really need toput anything out there.
I mean we come up with ideas,naturally and, you know, present
them as keynotes and inlectures all the time, but to
really we wanted to createsomething that can have an
(30:37):
impact, a positive impact, onjust the overall wellbeing of
women, especially since theaverage woman that I see is
about 47.
The average woman Steven seesis about 55 for facelifts,
blephs, you know.
And so we recognize that thosewomen are going through hormonal
shifts.
(30:58):
Those women are going throughhormonal shifts and maybe that
sometimes has an impact on theirperception of the benefit from
treatment, happiness fromtreatment and how they feel
about themselves.
Right, absolutely, and so if wecan support that hormonal
health of their skin and mind, Ithink that we can also just see
better impacts from thetreatments that we're doing.
Speaker 1 (31:18):
This is kind of blowing my mind a little bit.
Thank you, I knew this wasgoing.
I knew talking to you would beamazing, so I, you sent me your
products and I have used themand they're lovely.
They're so cosmetically elegant, they feel good.
They're not, they don't havelike an overpowering fragrance.
I mean they're not they.
They don't have like anoverpowering fragrance.
(31:39):
I mean they're just lovely.
They make my skin feel veryhydrated, very plump, and I I
love them.
And maybe it's the oxytocin.
I didn't even know that I wasloving them.
But you know, I'm in a.
I'm in a a post-divorcesituation as well and I will
tell you I I just feel likeanything that you can do at this
(32:01):
point this post-menopause,post-divorce, post-whatever we
are in in this stage of our lifeto just make us feel confident
and happy and safe in our skin.
It's a big deal for women intheir 40s, 50s and beyond.
Speaker 2 (32:21):
Yes.
Speaker 1 (32:22):
And I think you're really on to something and I'm
so impressed and so proud of youand I really want to hear about
the different products.
Talk to me about each one.
And then we've got to figureout how to get them into Premier
, because I need my patients tobe able to purchase these
(32:42):
products easily and come by andget them.
So talk to me about thedifferent SKUs in the products
line.
Speaker 2 (32:49):
Yes, so we start with the cleanser.
Speaker 1 (32:52):
When I created the cleanser because I do a lot of
fully ablative CO2 laserresurfacing and for those I
don't know if you do them, missy, but I do a lot of Erbium, so,
yeah, my patients know about thedeep halo resurfacing and you
know it's it's it's a take yourface off big time procedure.
Exactly, it's a big deal andyou need.
Speaker 2 (33:13):
sometimes.
These gentle cleansers that werecommend over the counter are
gentle, but they also don'tremove some of that
serosanguinous crust that can bea great something that you
bacteria loves to snack on andthen, before you know it, you
have an infection day four, dayfive.
So I wanted something gentleenough that I can put it on a
post-op laser resurfacing andI'm talking fully ablative CO2
(33:36):
layered with fully ablativeerbium, like day three, and it
doesn't burn my patient's face.
So that was like the vision forthe cleanser right.
Speaker 1 (33:46):
That's why you call it a detox.
Get rid of all the badness thatwe've done to you.
Get rid of it.
Get rid of it.
Speaker 2 (33:54):
And also, just we know that not washing your face,
just the daily grime thatbuilds up on your face,
especially San Diego isconsidered like the sixth most
polluted city in the country.
So if you're a runner andyou're out there, I think you're
a runner, aren't you?
Speaker 1 (34:10):
Oh baby, I used to run and now I just don't run
anymore.
Now I'm a Pilates girl and aweightlifting girl.
But back in back, when we firstmet, yeah, I was running, I was
like doing 5Ks, 10Ks, I did aTough Mudder.
I think the first year we meteach other.
Speaker 2 (34:27):
Yeah, you were running.
Speaker 1 (34:29):
Now, if you see me running, I've probably been
snatched up by body snatchersand they've taken my brain out,
because the running just doesn'twork for my body anymore.
I'm with you, it doesn't workfor my body anymore.
I'm with you Doesn't work.
So, yeah, but I get it.
But I, we, we are.
I'm outside all the time.
I love to bike, I love to hike,I love to walk outside.
Speaker 2 (34:49):
So, um, and there's a lot of pollution in the
universe that damages your skinCan definitely age you and
there's some great studies onhow it could increase your
pigment by about 20% and it canincrease, you know, just overall
lines and wrinkles over time.
So getting the grime off yourface is important and so that's
(35:10):
why it's called detox.
Then comes the.
So it's gentle enough to notirritate your skin, cause I, you
, were dermatologists.
You know everyone that comes inhas sensitive skin or
self-report sensitive skin.
We're doing layer lasers forredness, so it has to be with
that, that person, in mind.
Then intoxicate, intoxicate andarouse.
(35:31):
Or intoxicates the serum,arouse and it's a kind of a play
on the effect that they have.
That's the serum and that's themoisturizer.
Speaker 1 (35:41):
And there's I love the packaging.
I designed it.
I love it so different.
Speaker 2 (35:46):
They're X's and O's, so, and I wanted it to look nice
like on a bathroom counter oreven in a retail space, because
we're in aesthetics, theseproducts are so expensive and
they're in like these cheapplastic bottles, you know.
It just always is like.
I'm like is there noconsideration that we're, you
(36:07):
know, in aesthetics, right?
So I'm sensitive to that.
So I wanted what was in it tomatch what was outside.
Speaker 1 (36:15):
So you did a great job.
They're beautiful, thank you.
Speaker 2 (36:18):
And so here these two have the OX factor, which is
the proprietary blend of thephytopeptides, and then there's
also carob, and so that's what'shaving the effect on the
mechanoreceptors, on thesepiezoreceptors.
But in the serum we have alsoan extract from like honey tree
(36:41):
that comes from Korea and China.
That has been found to decreasepigmentation.
So that's unique in the serum.
That's not found in themoisturizer, which acts a little
bit longer than most HAs,because the problem with
hyaluronic acid, depending onthe formulation you get.
(37:01):
There's various formulations.
Some of the over-counter stuffis just like free HA.
We know free HA vaporizeswithin 15 minutes of being on
the skin.
Some of the more cross-linkedHAs just don't get absorbed.
So it was coming up withsomething that can add to
drawing in.
Speaker 1 (37:19):
Penetrate and then pull in the water.
Yes, yeah.
Speaker 2 (37:23):
And then Arouse is the moisturizer and it serves as
a nice humectant to kind ofseal that top layer of skin,
using glycerin as its base.
Speaker 1 (37:36):
That's why it feels so good.
Pardon me, it feels so goodGood, yes, it does.
It's very soothing.
Speaker 2 (37:42):
And that was the goal , because sometimes some of the
other ingredients that are alittle too fatty just sit on the
skin as they can't get absorbedRight, and I wanted to be able
to put something on, especiallyafter some of the aggressive
lasers that we do for mypatients, so that they could
heal faster.
And so that it was likethinking of the vehicle.
(38:06):
It was like, okay, I love theingredient of OX, but I need it
to be in a vehicle that mypatients can tolerate, so I'm
not adding another problem andthen they're coming in for a
different problem.
Speaker 1 (38:18):
Thank you for that.
So I had the ultra clear devicedone on Monday, with some laser
coring under my chin and myforehead.
So I used your cleanser ohgreat, yes, because I didn't
know how safe it would be to usethe serum and the moisturizer.
But I knew that your cleanserbecause I had used your cleanser
(38:42):
right after microneedling andI'm like this just feels so good
and there's no stinging,there's no burning.
So I was already like sold onthe cleanser 1000%.
But post-treatment, how sooncan we use these products?
Speaker 2 (38:57):
So after, like if I do a non-ablative, so if I do, I
usually do a combination of IPLPulse Dye Laser with a Clear
and Brilliant or IPL Pulse DyeLaser with, like a Fraxel Dual
or Fraxel Restore.
I put it on immediately on thetable to draw in water to the
skin.
So I usually put the IntoxicateSerum first to draw in water.
(39:18):
Then I even use on top of thatI like to use the SkinCeuticals
Phytocorrective Mask to cool theskin.
And then I'll put on, beforethey leave, the Arouse
Moisturizer, so that they can goon about their day, especially
after the restore.
They tend to report that theirface feels on fire, and so
(39:42):
that's been great.
I also do it immediately afterphotodynamic therapy, because
that way it's not so so greasyeither that for my acne patients
it's causing another issue.
So for those folks, thoseprocedures that's what I do or
even a microneedling RF we use,like the Potenza For fully
ablative resurfacing.
(40:02):
I won't use this until theyre-epithelialize at day seven or
day 10.
But we historically, as apractice, have always, because
of how aggressive we are withour CO2, they still have post-op
erythema week four.
So we've always offered like apost, a complimentary pulse dye
laser.
(40:22):
But now that I'm using this dayseven, day 10, by day 28, day
30, their redness is pretty muchgone.
So I don't need to offer themthe PDL like I used to.
So it's great because it'sdecreasing the redness and
that's always the hardest thingfor me.
(40:44):
It is the persistent rednessthat drives people crazy, crazy,
drives people crazy, and evenwith melasma right, Like there's
the vascular component ofmelasma that we can't get.
There's such great things formelanin, but that it's that
erythema right, Whether it'sfrom rosacea, PIE or in melasma
(41:05):
or from the procedures that I do.
So it's been great for that.
Speaker 1 (41:09):
Well, I want your protocols.
So I want to visit with youoffline because I want your
protocols and I want you to tellour listeners, first off, how
to how to how to order yourproduct right now, yes.
And then I want us to to chatabout how we bring the product
line into premier, because I amsold and I absolutely I want my
(41:30):
patients here in Arkansas to youknow glean all of the wisdom
and all of the all of thescience behind what you've put
into these products.
I'm really impressed.
Speaker 2 (41:39):
Thank you.
Thank you so much.
Let's see, yes, so for thosewho are, right now.
Speaker 1 (41:44):
Is there a website where they could go?
Okay.
Speaker 2 (41:48):
XOMDSkincom.
Speaker 1 (41:49):
Okay, all right.
Well, you guys have donesomething really special here,
and I think it is so incrediblyinnovative.
And I am not surprised, becauseI know you have this huge brain
and so does the really amazinghusband that you have, and I'm
so happy for you and I just wishyou all the joy that you
(42:10):
deserve, my dear, because you'rean amazing person, you're an
amazing doctor, you're anamazing mom, an amazing wife and
now even a more amazingscientist.
So I'm so excited and I can'twait, and I would love it if you
would come to Arkansas sometime.
Oh, I would love that I haven't.
I would love to come out tovisit you as well.
So let's make it happen andlet's talk about how to get XOMD
(42:35):
into premier dermatology.
Speaker 2 (42:37):
I would love that.
Speaker 1 (42:39):
All right.
So, gang, thank you so much fortuning in to another episode of
All Things Skin.
Thank you for listening to mybeautiful colleague, sabrina
Fahby, and I can't wait for youto learn more about XOMD.
So tune in next time foranother round of All Things Skin
.
So, guys, thank you so much fortuning in to an episode of All
(43:02):
Things Skin.
We sure appreciate you beingone of our listeners.
Not only do we thank you forlistening, but please continue
to follow us, give your reviewson any of the podcast platforms
that you're listening on, and wecan't wait to see you on
another episode of All ThingsSkin.
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