April 18, 2025 • 30 mins
Dive into the fascinating world of cellular aging with Sebastian Conti, Sales Director at TA Sciences, as we explore the science behind telomeres—those tiny protective caps at the ends of your chromosomes that may hold the key to biological aging.
Sebastian breaks down complex concepts into accessible insights, explaining how telomeres naturally shorten as we age and how this process connects directly to age-related diseases like cardiovascular issues, Alzheimer's, and cancer. What separates TA-65 from other supplements is its impressive scientific backing—twelve published clinical studies, including five double-blind trials—demonstrating its ability to activate telomerase and potentially lengthen telomeres.
The conversation takes us through the practical benefits users experience: improved cognitive function, enhanced recovery after exercise, stronger immune response, and sometimes even improved eyesight in cases of early macular degeneration. Sebastian shares his personal journey with the supplement, noting improved mental clarity and faster physical recovery after about seven months of consistent use.
We also explore who might benefit most from telomerase activation, from high-performance athletes looking for better recovery to adults over 50 experiencing the more noticeable effects of aging. The supplement's ability to reduce senescent cell load—particularly in CMV-positive individuals—and replenish naive T-cell reserves makes it a compelling option for immune health as well.
Whether you're already deep into your wellness journey or just beginning to explore anti-aging interventions, this episode offers valuable insights into addressing aging at its most fundamental level—your DNA. Ready to explore what telomere science could mean for your longevity? Listen now and discover how cellular rejuvenation might change your approach to aging.
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:00):
Hello listeners and thank you for joining us for
another episode of All ThingsSkin, and today I have Sebastian
Conte, who is the salesdirector at TA Sciences, joining
me today.
Sebastian, welcome, Thank youfor being here.
Thanks for having me.
Dr Clifton, Absolutely so.
Tell us a little bit about TASciences and what you guys have
(00:21):
going on over there.
Speaker 2 (00:22):
Yeah, so TA Sciences.
The TA stands for TelomeraseActivation Sciences.
We specialize in products thatyou can take to activate
telomerase and lengthentelomeres.
Really, what we have is aflagship product that's an oral
supplement and you're familiarwith it, obviously, and we're
going to talk about that.
Speaker 1 (00:40):
Yeah, let's start first of all with what's a
telomere, because a lot of ourlisteners may not actually know
what is a telomere.
Speaker 2 (00:48):
Of course.
So if any of you ever can goback to your eighth grade
biology class and you canremember the twisted ladder that
was the double helix, thedouble-stranded DNA at the end,
either end of thatdouble-stranded DNA is two
little tails and those are theend caps of your chromosome.
Those are the telomeres, andthe real, simple role that I can
(01:10):
say that they play in theprocess of your cells is they
help protect the cell throughcellular division and as we age
our cells have to divide and wewant them to divide cleanly.
We don't want to have a lot ofDNA breakage or lack of
recognition of proper DNAstructure.
So the telomeres help protectthat.
(01:31):
Now, as we get older and theylose their length, as they
sacrifice themselves over thecourse of time in cellular
replication, they don't growback.
They don't grow back on theirown.
Typically it's very difficultfor them to do that.
Our product provides the supportthat your cells need to promote
telomere regrowths and it doesit transiently, and transiently
(01:53):
means it's very mild.
It only has a certain amount oftime that it's in your
bloodstream to help promote thatgrowth.
So it's safe and effective.
We've got many years ofpublished clinical data behind
it now and we've got GRAScertification with the FDA as
well.
That does not mean we're an FDAapproved product.
I want to be clear on that.
But yeah, so telomeres, arethey important?
(02:19):
Maybe looking at telomere ageis important as well, and it
gives them a general idea ofwhere they are in regards to
their biological versuschronological age, if you want
to elaborate on that for somefolks, yeah, so you know our
biological age is actually, youknow how old our cells really
really are.
Speaker 1 (02:37):
you know, as opposed to, how old they are by year.
So we can, our biologic age cancan be a little bit different
from our chronological age.
Speaker 2 (02:51):
And so how do you guys measure that, sebastian?
So we don't, we don't actuallyprovide the test and measured it
, but what?
What we do is when we recommendcompanies that do, they take a
simple blood sample and you getit from, and they you get it
from.
Your white blood cells is whatthey look at.
So they're measuring leukocytesand granulocytes.
Anyways, what that does is it'sgoing to help you determine
where you are in compared toyour sex and age amongst other
(03:14):
cohorts that are similar to thatsex and age group, and so
obviously we want to be in thehigher percentile.
You know, if you're in the 80th, 90th percentile of telomere
length for your age.
Let's just say you're a 50 yearold male and you're up there,
you're probably looking verygood, you've been taking care of
yourself or you could havepossibly inherited longer
(03:34):
telomeres.
There's a whole bunch ofdynamics between how health and
telomeres are associated.
We can say that from looking atclinical data and studies that
this is non-product, relevant,that there is a direct
correlation to a high percentageof short telomeres, which is
what we do not want.
Remember, we don't want a lotof short telomeres directly
(03:58):
associated to onset of early agediseases or aging diseases in
general and the big ones that weare familiar with, especially
the biggest killers in societyin the US at least,
cardiovascular Alzheimer's andcancer, and there's quite a bit
of data backing up that.
If you look at, one commonthing between all individuals
that are associated with thosedisease types they all have a
(04:22):
high percentage of short-tailednurse.
Speaker 1 (04:24):
Well, okay, that's fascinating.
I didn't realize that that wasthe case.
That makes perfect sense.
So what can we do as consumers?
Certainly?
Besides, take your product.
What can you do to lengthenyour telomeres or to activate
telomerase, naturally?
Are there ways to do that?
Speaker 2 (04:42):
There's ways to certainly preserve it, there's
still the ways to potentiallyactivate it.
You know there's a, if you'vepeople are familiar with
hyperbarics, hyperbaric oxygenchamber therapy you can
certainly help preserve telomerelength and have some benefits
from that, especially if you'redoing it in a continuous fashion
.
Now, that's mainly.
You can go in a whole rabbithole in regards to acute,
(05:04):
non-acute settings withhyperbarics.
But mild hyperbaric therapiesfor non-acute situations I think
are ideal.
That's one way.
Another way is, if you hearpeople talking about practicing
yoga, really anything that youcan do to reduce stress, you
know in general I will say thatif you can help mitigate onset
(05:25):
or production in higheroxidative stress levels, so if
you can kind of curb oxidativestress, you can really help
reduce the telomere degradationrate in your body, because
oxidative stress plays a hugerole in telomere degradation, as
it is.
One other thing I would say toothat to look at and this is
simple for a lot ofpractitioners our clients do you
(05:46):
don't always have to measuretelomeres per se and say, oh, we
all know that we're aging, weall know that our cells are
dividing and telomeres areshortening over time.
That's just a.
It's sort of unequivocally youknow it's happening right.
Speaker 1 (05:58):
It's a fact, a fact of aging.
Speaker 2 (06:00):
Another thing you can look at is what is our
senescent cell load, and you canactually measure that, and one
of the ways to do that isactually looking at somebody
whether or not they're CMVpositive.
Now, cmv in this case stands forcytomegalovirus.
It's not a well-known thing.
Maybe it is more amongst thepractitioner world, but not
(06:29):
necessarily amongst just thestandard population In the US.
The statistic is that it'sliterally a coin toss after the
age of 40 that you're CMVpositive.
It's asymptomatic, it's a formof herpes, but it's not the
herpes that we all think of whenwe hear herpes.
You're not going to get thesores on your lip and things
like that.
It's something that actually isjust directly correlated to
immune and what that does is itsort of immunocompromises you as
you get older.
Now this causes a much highersenescence cell load buildup.
(06:50):
That's why, one of the thingsyou can do as a practitioner or
even as an individual, you cango into any lab camp or Quest
lab in the US and you can askthem specifically for what's
called an IgG titer, t-i-t-e-r,specifically looking for CMV.
If you're CMV positive, don'tpanic, it's not a big deal.
A lot of people are.
There's a lot of things you cando.
(07:11):
You're mainly just doing healthmaintenance, ta65, our product
directly.
And now, mind you, I want to puta note on this we're not
intended to treat or cureanything.
This doesn't do that.
It's a supplement.
(07:36):
But in our published clinicaldata double-blinded human trial
data actually we are proven tohelp reduce that senescent cell
load significantly in allpatients and, really important,
in the CMV individuals.
So we really make an impactthere and it helps with that
cellular inflammation reductionthat takes place.
A lot of companies talk aboutsenescence and reducing it.
A lot of them do a great job.
What we've done is taken it astep further by actually
measuring specific senescentcell markers and doing
double-blinded human trial datawith our product directly to
(07:58):
show the results, and a lot ofpeople cannot provide that
information for you.
So that's one thing we've justbeen proving.
I know that you and I havetalked about this in the past.
This is why you trust what wehave to offer.
Speaker 1 (08:08):
Right, yeah, so many things in the supplement market.
It feels like the wild wildwest a little bit, you know, and
in the United States theredoesn't, there's not a lot of
regulation around supplements,so I that was one thing that
really attracted me to to yourcompany is that you guys are
really doing the science andit's actually a really reputable
company.
Tell us a little bit more aboutthe company and how long you
(08:31):
guys have been around and kindof the history of how you came
to the space.
Speaker 2 (08:37):
Yeah, sure thing.
So I don't know if you heardthe part about so.
We're a great scientificcompany and probably not the
best at marketing, but we put alot of our focus into that.
But I'll tell you a littlehistory about the molecule.
We didn't create it or discoverit.
Geron Corporation is a largepharmaceutical R&D company and
in the 90s there was a lot ofresearch going into developing
an anti-aging drug.
(08:57):
Believe it or not, they werekind of hedging right and they
discovered TA65.
And they actually named themolecule.
We never changed the name of it, uh, and in research data they
actually this molecule hasalready made it to face three
drug trials.
Okay, it's already had a lot ofproven uh, um, you know that it
(09:18):
works, that all the things thatall the benefits of it are there
, uh, and they abandoned theproject and went to another and
went to another drug applicationthat they pursued because they
realized the FDA wasn't going toapprove aging as a condition or
disease.
Really, for a while Our ownerat the time was investing in
some science and aging therapiesand he heard about this
(09:41):
molecule.
And he heard about thismolecule and they had promoted,
they provided an offer topurchase the rights, the
intellectual property rights, tothe patented extraction process
of TA-65, the molecule.
So in 2002, they created TASciences, which is, you know,
now our company, and they didn'tlaunch the product, the
(10:02):
supplement product, until 2007.
So they didn't just take it andrun with it.
We actually had to prove that itworked in supplement form and
we needed to show data on that.
So it's been around since 2007on the market.
We were only selling directlythrough practitioners then.
Since then, we have published12 clinical studies now to date
and five of those aredouble-blind, super controlled
trials.
Of the 12, we have, eight ofthose are human trials.
(10:26):
We started with some animalmodel studies in the beginning
to make sure that we had theright track going with what we
wanted to pursue on information.
Speaker 1 (10:35):
Very good, and I was really.
That was one thing that totallybrought me to your company was
the science.
You really stand out and youknow, in a lot of the longevity
and anti-aging space you don'treally know how much is really
science and how much is a littlebit snake oil out there, and so
(10:55):
your company has done it.
So so, so, so well.
How long, just in general,would you say, if someone wanted
to take this supplement?
How long would it take for themto actually see some
improvement in their telomerelength after starting the
product?
Speaker 2 (11:11):
Sure, so in some of our study data you'll see that
we started measuring at threemonths.
This was around our mid-dose of250 units.
There's several doses you cantake, but ultimately you know we
talk about dosing as well in asecond here.
But about three months, I saybeing on the product is when
you're going to start seeingsome movement of the needle.
Now this is also the situationA lot of people.
(11:37):
There's no silver bullet outthere and I have to kind of
validate what I'm saying here.
When you go to do something atthe cellular level and you're
making these changes that aren'tgoing to necessarily produce
what I'd say in the beginningexterior or invisible changes on
the outside, you got to give ita little bit of time.
Some people, if they're goingthrough a very high stress point
in life and they're taking thisand they're still mitigating a
(12:00):
lot of the damage that could beoccurring, but they may not
notice the benefits as soon.
And I just want to, you know,make sure that's understood.
Speaker 1 (12:08):
Right.
The more threats their body'sunder or the more you know
issues that they have, thelonger it's going to take before
they see or feel anythingreally.
Speaker 2 (12:17):
Of course.
I mean you probably go throughthis with your patients when you
are about to embark them on anytype of therapy, especially
BHRT.
Lifestyle plays a role in howwell that BHRT is going to
respond to what they're doing.
I'm sure a lot of people canunderstand that the fatigue and
brain fog doesn't go away asquick if you're not going to
clean up things a little bit.
So it's a dual effort betweenthe practitioner and the patient
(12:41):
.
Now, in regards to just in beingon TA65, most of our data when
we show the final results ofwhat we've done is about 9 to 12
months where we show, you know,the significant improvements
overall.
We're talking measurable dataat the cellular level on
telomere length improvements,senescent cell reduction,
cardiovascular markerimprovements, things like that.
So there's a lot of benefitsthat cascade down.
(13:03):
There's also stuff that theyhave on brain now that they're
doing a lot of data where theylook at telomerase activation
and the benefits of it in glialcells.
Now that is not something we'vepursued directly, but there is
just data out there.
Now there's a lot of data ontelomerase and what's called
TERT, t-e-r-t it's a scientificterm, it's telomerase reverse
(13:27):
transcriptase.
This is sort of the mechanismsof action that allow the
benefits of telomerase to affectother things besides telomeres,
like, for example, shuttlingTERT between the nucleus and the
mitochondria.
Now what this does, obviouslyyou know we have NAD and other
(13:48):
products that really help withthat.
So TA65 ends up being extremelycomplimentary to your other
supplement therapies and yourhormone therapies.
You're talking about sort ofrejuvenate, cellular
rejuvenation in a sense.
Uh, is it?
I say that so, um, but yeah, soI mean you got some time.
Three months is a good numberto say people.
You know you got to stick to it.
Cells really don't startresponding to most nutritional
(14:08):
changes until about thattimeline.
It's usually three, four months.
Speaker 1 (14:14):
Well, that's pretty standard in the laser world too.
You know we tell people afterwe do any kind of damage or
trauma to the skin.
You know it takes collagen.
You know the fibroblast isgoing to take a few months to
really rebuild that collagen andelastic tissue.
So my patients are used tohearing that.
So that'll be good, that'scomplimentary, and I you know we
are so, so focused on wellnessat Premier Aesthetics these days
(14:37):
we're really excited to havethe Pinoy test and all of the
metabolic testing and thingsthat we're doing.
And you know telomere testingis something that we're really
fascinated by.
So I think having our patientscome in and maybe have this test
done, performed, just see whatyour telomere health is, and
then get on this medication andthen test again maybe in six
(14:59):
months or a year and kind of see, see where you stand at that
point.
Speaker 2 (15:03):
Yeah, absolutely, you know, and in conjunction with
other therapies, I think youwould have very good results
with your patients.
Speaker 1 (15:10):
Well, I would.
So here's another question.
So say someone is really doingeverything right, they're eating
a healthy diet, you knowthey're exercising, they're
getting a good amount of sleep,they're on their, you know good
supplements and you knowbioidentical hormone.
Maybe when will that personstart to like feel something
(15:31):
from this, from this therapy?
And what do you, what do peoplenotice when they start to feel
this kind of kicking in, so tospeak?
Speaker 2 (15:34):
Sure, so it depends, I mean it's, it is individual,
no matter whether they'refeeling healthy or not.
So I I'll give you the bestexample I can give you is in of
one myself.
Speaker 1 (15:45):
I think, I was.
Speaker 2 (15:47):
I was running along the lines of following all the
rules and and and and takingcare of myself, cause I started
taking the product back in 2014,20 into 2013.
I started with the company atthe beginning of 2013.
So, after I'd been with themand I had kind of seen enough, I
was like all right, I reallywant to take this, I really want
to be on it, and I gotpermission to begin taking TA65.
(16:08):
For myself.
I was extremely healthy, veryactive.
I had a special group that we'dall go do the we'd create on
workouts.
I was eating very clean.
I had no obligations to anyonebut myself, so I had a special
group that we'd all do.
Go do the all we create onworkouts.
I was eating very clean.
I had no obligations to anyonebut myself, so I had a very good
dynamic for a, a baseline onhealth and and then seeing the
results.
The truth is for me I can bequite frank with you I probably
(16:32):
didn't start noticing effectualchanges for about seven months,
six to seven months.
What are some of the thingsthat occurred?
Now, for me personally, I didactually pick up on a few things
.
I noticed cognitive recall wasimproved, even though I didn't
feel like I needed it.
Basically, when I would go in aconversation with people, my
(16:54):
attention span was a little bitbetter.
I was absorbing informationlike names and numbers and I
could recall them a littleeasier, for example, I can you
know whereas I'd be like, oh, Imet that person, I don't
remember their name.
Those things were coming to mea little easier.
These are just nuance ofchanges, though, right.
Another big one is you knowwhen it came down to, because we
were going through such highintensity activity, when I was
working out with a certain groupof individuals, back then I
(17:15):
mean this is 10 years ago I hadsignificant improved recovery.
I noticed that I did notmaintain the soreness levels
that I was able to perform.
So ultimately it was kind of acorrelation between
cardiovascular improvements andthen also muscle recovery
improvement.
So this is just for theperformance side of things.
I noticed an improvement inlibido, which you know you don't
(17:36):
need it, but you don't noticeit.
You don't notice that thosethings could actually probably
be optimized and I felt sort ofan optimization at that level on
that One of the things.
Now I'm going to kind of goaway from my personal deal and
I'm going to talk a little bitmore about a lot of the feedback
we get from people on it justthroughout the course of
(17:56):
feedback into the company.
One of the things that we see alot of, especially in older
individuals, is improvement ineyesight.
Now this is very specific tomacular or early onset macular,
age related macular degenerationdry, not after it's become wet.
We had there is actually adouble-blinded study that was
done independent of us with asmall cohort, various math
(18:18):
cohort, where they showed withinsix months reversal of that.
That was at a little bit higherdose where you were taking two
of the capsules a day instead ofone Um.
But overall we hear a lot offeedback about my reading
glasses I've had.
I didn't need them anymore.
So it is specific.
I don't think it's going tonecessarily affect presbyopia um
the same.
However, because a lot of usare going to experience that
right I think we all do at somepoint.
(18:40):
But with AMD age-relatedmacular degeneration we've seen
reversal there.
The other one is it is alongthe lines of people experience
kind of the brain fog situationgoing away.
They notice a lot of themnoticed that they don't get sick
.
So when you have these majorflu, you know like we got hit
(19:01):
this past season.
I don't know if you guysexperienced it as much, but, man
, we got a lot of it in Houston.
Speaker 1 (19:06):
We had some really bad flu here.
Yeah, the vaccine didn't seemto be very helpful this year.
Speaker 2 (19:11):
Yeah, it was a strain that hit, that was very
difficult and I was, you know, alot of product and and I I have
two young kids and actually anolder daughter and then my wife
and the whole house caught it.
The immune side is more robuston TA65, right, so I I didn't
(19:32):
really feel the impact of thatthe way that I saw our family go
through it.
And I mean, some of these arepersonal, but we do get a lot of
that too, where there'sindividuals who, because it is
an immune remodeler and on thatnote I'll touch on this one
point you know we talked aboutsenescence, cell reduction,
everything else, but there's athing called your naive T cell
(19:53):
reserve which we replenish.
That's kind of unheard of inthe supplement world.
And what are naivety cells?
And the easiest explanation Ithink I did this when I was
talking to some people at youroffice think of them as exactly
what they sound like.
They're naive, they have notbeen assigned, they're like
soldiers that are privates inthe army, training for war and
(20:13):
they're prepared to fight, butthey haven't been assigned to a
platoon.
They don't know.
They know how to, they justdon't know what to identify to
attack.
Speaker 1 (20:22):
What the enemy?
Speaker 2 (20:23):
is Right and when you have, you know, things that hit
the body, this NianticelReserve is important to have
because that is your reserve tofight against infections, things
like that that are going tocome attack you viruses, and we
actually help replenish thatreserve.
So another big point in beingon some of the results and
benefits of TA-65.
Speaker 1 (20:44):
That's fantastic and it's what's so interesting is, a
lot of times, you know, aspeople age, you know sometimes
those infections are just reallyharder to fight for those older
people.
So that's a that's anothergreat reason for people to be on
on these medications orsupplements.
I should say so tell me how,how young should someone start
(21:05):
taking TA 65?
Start taking TA65?
Speaker 2 (21:07):
Yeah, so it's not age specific, I will say this.
So typically cost comes intoplay too when you think about
youth, and it's more the cost tovalue, right?
So I'll start on the youngerside of things.
High performance athletic,young individuals you start
looking at college athletes,things like that.
Since this is not a performanceenhancer per se, it's not going
(21:31):
to show up on any type, it'snot a drug or anything like that
, so it's not going to evercause any problems on you know,
your testing and all that.
But we see a lot of individualsuse it for that in the youth.
And, like we talked about theimproved recovery aspect, you're
basically just when you gothrough a very like hard,
(21:51):
intense process of breaking downmuscle and you're recovering,
you're speeding up the cellularreplication process to build
back the things that you lost.
And I'm not saying that you'renecessarily going to grow older
faster because of that, butultimately you are burning
through your you know yourcellular, your telomere length,
a lot faster too.
So you want to do something tohelp support that, and I think
(22:12):
TA65 is fantastic when it comesdown to performance athletics.
The other thing is this has notbeen studied.
I want to be clear on this, butone of my.
There's one doctor here,particularly in Houston, that I
work with a lot, and thenthere's a few others that have
talked about this.
In younger patients with um,adhd add, and we're talking
(22:33):
probably the teenage years uh,they have been using low doses
and have found some results inregards to their ability to
refocus.
So I'm hearing more about someof that.
Uh, because there's things thatare happening in the brain.
I don't know the data on it orunderstand completely how that's
going.
I'm just giving the feedbackfrom what I'm getting from those
practitioners.
(22:53):
Now I will say that the peoplethat probably experience or feel
the benefits the most or Inoticed people that are in their
50s and older when you actuallynotice your body changes,
everybody talks about oh, you'llfeel it when you're 40.
And then you really hear peoplesaying, no, you're 50 and 60.
You really feel the differentthings going on While we're in
(23:16):
such a unique age and time ofoptimizing the body.
I think we can do so manythings to make our middle-aged
and older years so much moreviable and productive.
I think that's where a lot ofthe individuals notice it.
I get a lot of great feedbackon I love your product.
I can't not be off of it.
(23:37):
And then here's the ironythey're on it and after a
certain amount of time just likeeven if you're supplementing
with really high qualityvitamins and minerals you may
notice you feel more energy andyour brain falls on in the
beginning, and then after awhile you're just used to
feeling great and you don'treally notice that it's doing
anything for you.
But you notice when you stop it.
So with TA65, that's a bigfeedback I get is I didn't
(24:00):
really notice I was feelinganything after being on it a
while.
But when I stomped it afterabout three or four weeks, I did
notice that I was.
I needed to get back on it.
I wanted to because my, I couldfeel the optimization.
So that's kind of the.
The biggest thing is that you,you, you know the supplement
world is a hard, a hard one todo.
So we, we like to utilizetesting, you know.
That's why, as a practitioner,I always encourage measure their
(24:23):
results.
Really nice for them to see thenumbers move on the needle with
one of those numbers, yep.
Speaker 1 (24:27):
So really nice for them to see the numbers move on
the needle move on those numbers.
Yeah, that's pretty exciting.
So I've been on it gosh,probably about five or six
months, and I mean I'm feelingreally great.
So I have not done the actualtesting though.
So maybe I need to do a littletesting and see what's going on.
Speaker 2 (24:44):
You have about up to a year to give yourself.
Like you know, six months to ayear is fine.
I usually try to encouragepeople to give it about eight
months or so or a little longer.
But yeah, absolutely, I mean,it's fun to do so, you know, and
kind of think about your lifealong that time span.
You know, how did you feel?
Was there a major stress?
(25:04):
Were there any big events thattook place?
I'll give you another one.
If someone's on it, they feelgreat but they break their arm A
very unfortunate event andthere's a lot of rebuilding
going on to heal that arm.
Your telomere length is goingto degrade.
That's why telomeres aremalleable.
They can come back, but youprobably don't want to test them
(25:25):
.
Speaker 1 (25:27):
While they're not found.
Speaker 2 (25:29):
Yeah, you're not going to necessarily see the
most, or if they've caught COVIDor the really bad flu.
You know the body's reallyfighting hard.
There's a depletion going on,and then that's why T65 is
important, in the sense thatyour depletion won't be as bad
typically, and then your reboundwill be a lot better on top of
it.
Speaker 1 (25:46):
Perfect.
So here's another question ondosage.
Say you're taking one tablet aday and maybe you have one of
those stressful events or youbreak an arm or you pull a
muscle or something like that.
Is there benefit to taking moreduring those stressful time
periods?
Speaker 2 (26:04):
Yes, it can be.
In all of us we absorb itdifferently.
That's why we have differentdoses.
There are some people who it'svery effective at a low dose for
them.
We actually have been lookingat the data.
We're trying to get a littlebit closer, but we've kind of
come around to the 80-20hypothesis.
80% of the population is goingto do really well on the
(26:24):
standard mid-dose 250 unit.
The standard mid dose 250 unitUm the years, uh more, is
certainly going to still bebeneficial for you.
You cannot overdose on TA 65.
Uh, just um.
Just another thing to note itdoes not contraindicate with any
other supplements or drugs, soyou're not going to have an
issue with any overlap withanything that's going to affect
(26:45):
it negatively.
Okay, and uh, ultimately I meanyou look at the dosing, so
about you know you find about10% of the population has been
responding really well to thelowest dose, the 100 unit.
You'll know as you go over timesomebody sees their test.
If the needle's still moving onthose biomarkers, then that
dose is working for them.
(27:05):
If it's not, then we want totitrate that dosing upward.
And this is actually from acouple of the doctors that have
been using the product inpractice for more than a decade
and they've been monitoringpatient progress and that's how
they've discovered, you know,the absorbability factor.
We've actually donebioavailability testing.
We know it's in the bloodstream10 to 12 hours and we know that
(27:26):
, yes, different people gethigher, higher C, c, max, pk
levels in the blood versusothers in different doses.
So you just kind of have totake each, each individual case.
But this, you know, if you'rethrowing, you know what do I
start?
Mid dose, 250 and then 500 unitis always a fantastic place to
(27:47):
start.
You really can't go wrong.
Speaker 1 (27:48):
Okay, Okay, and as far as you know GI side effects,
anybody have any trouble.
You know, taking thismedication I haven't had any
issues at all.
I was just curious, if you hearit.
Speaker 2 (27:59):
There's very minimal.
There's not a mix of randomingredients.
The only active in here is themolecule TA65.
It is a natural molecule thatwe extract from a specific
species of astragalus.
The patent extraction processmakes it purified enough to
penetrate the cell, turn on thatenzyme, telomerase.
(28:20):
And that's where the sciencecomes into play.
A lot of people have.
There are products out therethat claim it.
No one has been able to makethe molecule bioavailable enough
to actually turn on telomerasenaturally.
And they one has been able tomake the molecule bioavailable
enough to actually turn ontelomerase naturally and they
have not been able to prove itin human trial data or animal
model data so far.
Speaker 1 (28:38):
Well, this is a very cool product and it's so
different in the anti-agingspace.
It stands out, certainly, fromall the other supplements that
we carry, and we are just soexcited to be partnering with
you guys and offering this toour clients and listeners.
If you are interested inlongevity and you want to do
(28:58):
everything you can to sort ofhack your biomarkers and keep
yourself, you know, reallyreally doing well long term,
ta65 may be something that youwant to add to your regimen.
So, if you're interested at all, we carry it at Premier and we
would love to chat with youabout adding it to possibly your
(29:18):
supplement regimen today.
And, sebastian, before wefinish up, anything else you
would like to add?
Speaker 2 (29:26):
I think that covers it.
I really appreciate your timetoday and thanks for having me
on.
If you have any other questions, of course I'm happy to answer
them, and then any links youwant me to send you, or whatever
you name it, I'll send it yourway.
Speaker 1 (29:37):
That would be great.
I would love a link to you guysso that people can read a
little bit more about what youhave going on, and, of course,
we will have the link topurchase TA-65.
You can buy that at our store,shoppremieredermcom, anytime.
And also come by.
We would love to chat with youmore about TA-65 and All Things
(29:59):
Skin at Premier.
Thanks for listening.
So, guys, thank you so much fortuning in to an episode of All
Things Skin.
We sure appreciate you beingone of our listeners.
Not only do we thank you forlistening, but please continue
to follow us, give your reviewson any of the podcast platforms
that you're listening on, and wecan't wait to see you on
another episode of All ThingsSkin.
Hello listeners and thank you for joining us for
another episode of All ThingsSkin, and today I have Sebastian
Conte, who is the salesdirector at TA Sciences, joining
me today.
Sebastian, welcome, Thank youfor being here.
Thanks for having me.
Dr Clifton, Absolutely so.
Tell us a little bit about TASciences and what you guys have
(00:21):
going on over there.
Speaker 2 (00:22):
Yeah, so TA Sciences.
The TA stands for TelomeraseActivation Sciences.
We specialize in products thatyou can take to activate
telomerase and lengthentelomeres.
Really, what we have is aflagship product that's an oral
supplement and you're familiarwith it, obviously, and we're
going to talk about that.
Speaker 1 (00:40):
Yeah, let's start first of all with what's a
telomere, because a lot of ourlisteners may not actually know
what is a telomere.
Speaker 2 (00:48):
Of course.
So if any of you ever can goback to your eighth grade
biology class and you canremember the twisted ladder that
was the double helix, thedouble-stranded DNA at the end,
either end of thatdouble-stranded DNA is two
little tails and those are theend caps of your chromosome.
Those are the telomeres, andthe real, simple role that I can
(01:10):
say that they play in theprocess of your cells is they
help protect the cell throughcellular division and as we age
our cells have to divide and wewant them to divide cleanly.
We don't want to have a lot ofDNA breakage or lack of
recognition of proper DNAstructure.
So the telomeres help protectthat.
(01:31):
Now, as we get older and theylose their length, as they
sacrifice themselves over thecourse of time in cellular
replication, they don't growback.
They don't grow back on theirown.
Typically it's very difficultfor them to do that.
Our product provides the supportthat your cells need to promote
telomere regrowths and it doesit transiently, and transiently
(01:53):
means it's very mild.
It only has a certain amount oftime that it's in your
bloodstream to help promote thatgrowth.
So it's safe and effective.
We've got many years ofpublished clinical data behind
it now and we've got GRAScertification with the FDA as
well.
That does not mean we're an FDAapproved product.
I want to be clear on that.
But yeah, so telomeres, arethey important?
(02:19):
Maybe looking at telomere ageis important as well, and it
gives them a general idea ofwhere they are in regards to
their biological versuschronological age, if you want
to elaborate on that for somefolks, yeah, so you know our
biological age is actually, youknow how old our cells really
really are.
Speaker 1 (02:37):
you know, as opposed to, how old they are by year.
So we can, our biologic age cancan be a little bit different
from our chronological age.
Speaker 2 (02:51):
And so how do you guys measure that, sebastian?
So we don't, we don't actuallyprovide the test and measured it
, but what?
What we do is when we recommendcompanies that do, they take a
simple blood sample and you getit from, and they you get it
from.
Your white blood cells is whatthey look at.
So they're measuring leukocytesand granulocytes.
Anyways, what that does is it'sgoing to help you determine
where you are in compared toyour sex and age amongst other
(03:14):
cohorts that are similar to thatsex and age group, and so
obviously we want to be in thehigher percentile.
You know, if you're in the 80th, 90th percentile of telomere
length for your age.
Let's just say you're a 50 yearold male and you're up there,
you're probably looking verygood, you've been taking care of
yourself or you could havepossibly inherited longer
(03:34):
telomeres.
There's a whole bunch ofdynamics between how health and
telomeres are associated.
We can say that from looking atclinical data and studies that
this is non-product, relevant,that there is a direct
correlation to a high percentageof short telomeres, which is
what we do not want.
Remember, we don't want a lotof short telomeres directly
(03:58):
associated to onset of early agediseases or aging diseases in
general and the big ones that weare familiar with, especially
the biggest killers in societyin the US at least,
cardiovascular Alzheimer's andcancer, and there's quite a bit
of data backing up that.
If you look at, one commonthing between all individuals
that are associated with thosedisease types they all have a
(04:22):
high percentage of short-tailednurse.
Speaker 1 (04:24):
Well, okay, that's fascinating.
I didn't realize that that wasthe case.
That makes perfect sense.
So what can we do as consumers?
Certainly?
Besides, take your product.
What can you do to lengthenyour telomeres or to activate
telomerase, naturally?
Are there ways to do that?
Speaker 2 (04:42):
There's ways to certainly preserve it, there's
still the ways to potentiallyactivate it.
You know there's a, if you'vepeople are familiar with
hyperbarics, hyperbaric oxygenchamber therapy you can
certainly help preserve telomerelength and have some benefits
from that, especially if you'redoing it in a continuous fashion
.
Now, that's mainly.
You can go in a whole rabbithole in regards to acute,
(05:04):
non-acute settings withhyperbarics.
But mild hyperbaric therapiesfor non-acute situations I think
are ideal.
That's one way.
Another way is, if you hearpeople talking about practicing
yoga, really anything that youcan do to reduce stress, you
know in general I will say thatif you can help mitigate onset
(05:25):
or production in higheroxidative stress levels, so if
you can kind of curb oxidativestress, you can really help
reduce the telomere degradationrate in your body, because
oxidative stress plays a hugerole in telomere degradation, as
it is.
One other thing I would say toothat to look at and this is
simple for a lot ofpractitioners our clients do you
(05:46):
don't always have to measuretelomeres per se and say, oh, we
all know that we're aging, weall know that our cells are
dividing and telomeres areshortening over time.
That's just a.
It's sort of unequivocally youknow it's happening right.
Speaker 1 (05:58):
It's a fact, a fact of aging.
Speaker 2 (06:00):
Another thing you can look at is what is our
senescent cell load, and you canactually measure that, and one
of the ways to do that isactually looking at somebody
whether or not they're CMVpositive.
Now, cmv in this case stands forcytomegalovirus.
It's not a well-known thing.
Maybe it is more amongst thepractitioner world, but not
(06:29):
necessarily amongst just thestandard population In the US.
The statistic is that it'sliterally a coin toss after the
age of 40 that you're CMVpositive.
It's asymptomatic, it's a formof herpes, but it's not the
herpes that we all think of whenwe hear herpes.
You're not going to get thesores on your lip and things
like that.
It's something that actually isjust directly correlated to
immune and what that does is itsort of immunocompromises you as
you get older.
Now this causes a much highersenescence cell load buildup.
(06:50):
That's why, one of the thingsyou can do as a practitioner or
even as an individual, you cango into any lab camp or Quest
lab in the US and you can askthem specifically for what's
called an IgG titer, t-i-t-e-r,specifically looking for CMV.
If you're CMV positive, don'tpanic, it's not a big deal.
A lot of people are.
There's a lot of things you cando.
(07:11):
You're mainly just doing healthmaintenance, ta65, our product
directly.
And now, mind you, I want to puta note on this we're not
intended to treat or cureanything.
This doesn't do that.
It's a supplement.
(07:36):
But in our published clinicaldata double-blinded human trial
data actually we are proven tohelp reduce that senescent cell
load significantly in allpatients and, really important,
in the CMV individuals.
So we really make an impactthere and it helps with that
cellular inflammation reductionthat takes place.
A lot of companies talk aboutsenescence and reducing it.
A lot of them do a great job.
What we've done is taken it astep further by actually
measuring specific senescentcell markers and doing
double-blinded human trial datawith our product directly to
(07:58):
show the results, and a lot ofpeople cannot provide that
information for you.
So that's one thing we've justbeen proving.
I know that you and I havetalked about this in the past.
This is why you trust what wehave to offer.
Speaker 1 (08:08):
Right, yeah, so many things in the supplement market.
It feels like the wild wildwest a little bit, you know, and
in the United States theredoesn't, there's not a lot of
regulation around supplements,so I that was one thing that
really attracted me to to yourcompany is that you guys are
really doing the science andit's actually a really reputable
company.
Tell us a little bit more aboutthe company and how long you
(08:31):
guys have been around and kindof the history of how you came
to the space.
Speaker 2 (08:37):
Yeah, sure thing.
So I don't know if you heardthe part about so.
We're a great scientificcompany and probably not the
best at marketing, but we put alot of our focus into that.
But I'll tell you a littlehistory about the molecule.
We didn't create it or discoverit.
Geron Corporation is a largepharmaceutical R&D company and
in the 90s there was a lot ofresearch going into developing
an anti-aging drug.
(08:57):
Believe it or not, they werekind of hedging right and they
discovered TA65.
And they actually named themolecule.
We never changed the name of it, uh, and in research data they
actually this molecule hasalready made it to face three
drug trials.
Okay, it's already had a lot ofproven uh, um, you know that it
(09:18):
works, that all the things thatall the benefits of it are there
, uh, and they abandoned theproject and went to another and
went to another drug applicationthat they pursued because they
realized the FDA wasn't going toapprove aging as a condition or
disease.
Really, for a while Our ownerat the time was investing in
some science and aging therapiesand he heard about this
(09:41):
molecule.
And he heard about thismolecule and they had promoted,
they provided an offer topurchase the rights, the
intellectual property rights, tothe patented extraction process
of TA-65, the molecule.
So in 2002, they created TASciences, which is, you know,
now our company, and they didn'tlaunch the product, the
(10:02):
supplement product, until 2007.
So they didn't just take it andrun with it.
We actually had to prove that itworked in supplement form and
we needed to show data on that.
So it's been around since 2007on the market.
We were only selling directlythrough practitioners then.
Since then, we have published12 clinical studies now to date
and five of those aredouble-blind, super controlled
trials.
Of the 12, we have, eight ofthose are human trials.
(10:26):
We started with some animalmodel studies in the beginning
to make sure that we had theright track going with what we
wanted to pursue on information.
Speaker 1 (10:35):
Very good, and I was really.
That was one thing that totallybrought me to your company was
the science.
You really stand out and youknow, in a lot of the longevity
and anti-aging space you don'treally know how much is really
science and how much is a littlebit snake oil out there, and so
(10:55):
your company has done it.
So so, so, so well.
How long, just in general,would you say, if someone wanted
to take this supplement?
How long would it take for themto actually see some
improvement in their telomerelength after starting the
product?
Speaker 2 (11:11):
Sure, so in some of our study data you'll see that
we started measuring at threemonths.
This was around our mid-dose of250 units.
There's several doses you cantake, but ultimately you know we
talk about dosing as well in asecond here.
But about three months, I saybeing on the product is when
you're going to start seeingsome movement of the needle.
Now this is also the situationA lot of people.
(11:37):
There's no silver bullet outthere and I have to kind of
validate what I'm saying here.
When you go to do something atthe cellular level and you're
making these changes that aren'tgoing to necessarily produce
what I'd say in the beginningexterior or invisible changes on
the outside, you got to give ita little bit of time.
Some people, if they're goingthrough a very high stress point
in life and they're taking thisand they're still mitigating a
(12:00):
lot of the damage that could beoccurring, but they may not
notice the benefits as soon.
And I just want to, you know,make sure that's understood.
Speaker 1 (12:08):
Right.
The more threats their body'sunder or the more you know
issues that they have, thelonger it's going to take before
they see or feel anythingreally.
Speaker 2 (12:17):
Of course.
I mean you probably go throughthis with your patients when you
are about to embark them on anytype of therapy, especially
BHRT.
Lifestyle plays a role in howwell that BHRT is going to
respond to what they're doing.
I'm sure a lot of people canunderstand that the fatigue and
brain fog doesn't go away asquick if you're not going to
clean up things a little bit.
So it's a dual effort betweenthe practitioner and the patient
(12:41):
.
Now, in regards to just in beingon TA65, most of our data when
we show the final results ofwhat we've done is about 9 to 12
months where we show, you know,the significant improvements
overall.
We're talking measurable dataat the cellular level on
telomere length improvements,senescent cell reduction,
cardiovascular markerimprovements, things like that.
So there's a lot of benefitsthat cascade down.
(13:03):
There's also stuff that theyhave on brain now that they're
doing a lot of data where theylook at telomerase activation
and the benefits of it in glialcells.
Now that is not something we'vepursued directly, but there is
just data out there.
Now there's a lot of data ontelomerase and what's called
TERT, t-e-r-t it's a scientificterm, it's telomerase reverse
(13:27):
transcriptase.
This is sort of the mechanismsof action that allow the
benefits of telomerase to affectother things besides telomeres,
like, for example, shuttlingTERT between the nucleus and the
mitochondria.
Now what this does, obviouslyyou know we have NAD and other
(13:48):
products that really help withthat.
So TA65 ends up being extremelycomplimentary to your other
supplement therapies and yourhormone therapies.
You're talking about sort ofrejuvenate, cellular
rejuvenation in a sense.
Uh, is it?
I say that so, um, but yeah, soI mean you got some time.
Three months is a good numberto say people.
You know you got to stick to it.
Cells really don't startresponding to most nutritional
(14:08):
changes until about thattimeline.
It's usually three, four months.
Speaker 1 (14:14):
Well, that's pretty standard in the laser world too.
You know we tell people afterwe do any kind of damage or
trauma to the skin.
You know it takes collagen.
You know the fibroblast isgoing to take a few months to
really rebuild that collagen andelastic tissue.
So my patients are used tohearing that.
So that'll be good, that'scomplimentary, and I you know we
are so, so focused on wellnessat Premier Aesthetics these days
(14:37):
we're really excited to havethe Pinoy test and all of the
metabolic testing and thingsthat we're doing.
And you know telomere testingis something that we're really
fascinated by.
So I think having our patientscome in and maybe have this test
done, performed, just see whatyour telomere health is, and
then get on this medication andthen test again maybe in six
(14:59):
months or a year and kind of see, see where you stand at that
point.
Speaker 2 (15:03):
Yeah, absolutely, you know, and in conjunction with
other therapies, I think youwould have very good results
with your patients.
Speaker 1 (15:10):
Well, I would.
So here's another question.
So say someone is really doingeverything right, they're eating
a healthy diet, you knowthey're exercising, they're
getting a good amount of sleep,they're on their, you know good
supplements and you knowbioidentical hormone.
Maybe when will that personstart to like feel something
(15:31):
from this, from this therapy?
And what do you, what do peoplenotice when they start to feel
this kind of kicking in, so tospeak?
Speaker 2 (15:34):
Sure, so it depends, I mean it's, it is individual,
no matter whether they'refeeling healthy or not.
So I I'll give you the bestexample I can give you is in of
one myself.
Speaker 1 (15:45):
I think, I was.
Speaker 2 (15:47):
I was running along the lines of following all the
rules and and and and takingcare of myself, cause I started
taking the product back in 2014,20 into 2013.
I started with the company atthe beginning of 2013.
So, after I'd been with themand I had kind of seen enough, I
was like all right, I reallywant to take this, I really want
to be on it, and I gotpermission to begin taking TA65.
(16:08):
For myself.
I was extremely healthy, veryactive.
I had a special group that we'dall go do the we'd create on
workouts.
I was eating very clean.
I had no obligations to anyonebut myself, so I had a special
group that we'd all do.
Go do the all we create onworkouts.
I was eating very clean.
I had no obligations to anyonebut myself, so I had a very good
dynamic for a, a baseline onhealth and and then seeing the
results.
The truth is for me I can bequite frank with you I probably
(16:32):
didn't start noticing effectualchanges for about seven months,
six to seven months.
What are some of the thingsthat occurred?
Now, for me personally, I didactually pick up on a few things
.
I noticed cognitive recall wasimproved, even though I didn't
feel like I needed it.
Basically, when I would go in aconversation with people, my
(16:54):
attention span was a little bitbetter.
I was absorbing informationlike names and numbers and I
could recall them a littleeasier, for example, I can you
know whereas I'd be like, oh, Imet that person, I don't
remember their name.
Those things were coming to mea little easier.
These are just nuance ofchanges, though, right.
Another big one is you knowwhen it came down to, because we
were going through such highintensity activity, when I was
working out with a certain groupof individuals, back then I
(17:15):
mean this is 10 years ago I hadsignificant improved recovery.
I noticed that I did notmaintain the soreness levels
that I was able to perform.
So ultimately it was kind of acorrelation between
cardiovascular improvements andthen also muscle recovery
improvement.
So this is just for theperformance side of things.
I noticed an improvement inlibido, which you know you don't
(17:36):
need it, but you don't noticeit.
You don't notice that thosethings could actually probably
be optimized and I felt sort ofan optimization at that level on
that One of the things.
Now I'm going to kind of goaway from my personal deal and
I'm going to talk a little bitmore about a lot of the feedback
we get from people on it justthroughout the course of
(17:56):
feedback into the company.
One of the things that we see alot of, especially in older
individuals, is improvement ineyesight.
Now this is very specific tomacular or early onset macular,
age related macular degenerationdry, not after it's become wet.
We had there is actually adouble-blinded study that was
done independent of us with asmall cohort, various math
(18:18):
cohort, where they showed withinsix months reversal of that.
That was at a little bit higherdose where you were taking two
of the capsules a day instead ofone Um.
But overall we hear a lot offeedback about my reading
glasses I've had.
I didn't need them anymore.
So it is specific.
I don't think it's going tonecessarily affect presbyopia um
the same.
However, because a lot of usare going to experience that
right I think we all do at somepoint.
(18:40):
But with AMD age-relatedmacular degeneration we've seen
reversal there.
The other one is it is alongthe lines of people experience
kind of the brain fog situationgoing away.
They notice a lot of themnoticed that they don't get sick
.
So when you have these majorflu, you know like we got hit
(19:01):
this past season.
I don't know if you guysexperienced it as much, but, man
, we got a lot of it in Houston.
Speaker 1 (19:06):
We had some really bad flu here.
Yeah, the vaccine didn't seemto be very helpful this year.
Speaker 2 (19:11):
Yeah, it was a strain that hit, that was very
difficult and I was, you know, alot of product and and I I have
two young kids and actually anolder daughter and then my wife
and the whole house caught it.
The immune side is more robuston TA65, right, so I I didn't
(19:32):
really feel the impact of thatthe way that I saw our family go
through it.
And I mean, some of these arepersonal, but we do get a lot of
that too, where there'sindividuals who, because it is
an immune remodeler and on thatnote I'll touch on this one
point you know we talked aboutsenescence, cell reduction,
everything else, but there's athing called your naive T cell
(19:53):
reserve which we replenish.
That's kind of unheard of inthe supplement world.
And what are naivety cells?
And the easiest explanation Ithink I did this when I was
talking to some people at youroffice think of them as exactly
what they sound like.
They're naive, they have notbeen assigned, they're like
soldiers that are privates inthe army, training for war and
(20:13):
they're prepared to fight, butthey haven't been assigned to a
platoon.
They don't know.
They know how to, they justdon't know what to identify to
attack.
Speaker 1 (20:22):
What the enemy?
Speaker 2 (20:23):
is Right and when you have, you know, things that hit
the body, this NianticelReserve is important to have
because that is your reserve tofight against infections, things
like that that are going tocome attack you viruses, and we
actually help replenish thatreserve.
So another big point in beingon some of the results and
benefits of TA-65.
Speaker 1 (20:44):
That's fantastic and it's what's so interesting is, a
lot of times, you know, aspeople age, you know sometimes
those infections are just reallyharder to fight for those older
people.
So that's a that's anothergreat reason for people to be on
on these medications orsupplements.
I should say so tell me how,how young should someone start
(21:05):
taking TA 65?
Start taking TA65?
Speaker 2 (21:07):
Yeah, so it's not age specific, I will say this.
So typically cost comes intoplay too when you think about
youth, and it's more the cost tovalue, right?
So I'll start on the youngerside of things.
High performance athletic,young individuals you start
looking at college athletes,things like that.
Since this is not a performanceenhancer per se, it's not going
(21:31):
to show up on any type, it'snot a drug or anything like that
, so it's not going to evercause any problems on you know,
your testing and all that.
But we see a lot of individualsuse it for that in the youth.
And, like we talked about theimproved recovery aspect, you're
basically just when you gothrough a very like hard,
(21:51):
intense process of breaking downmuscle and you're recovering,
you're speeding up the cellularreplication process to build
back the things that you lost.
And I'm not saying that you'renecessarily going to grow older
faster because of that, butultimately you are burning
through your you know yourcellular, your telomere length,
a lot faster too.
So you want to do something tohelp support that, and I think
(22:12):
TA65 is fantastic when it comesdown to performance athletics.
The other thing is this has notbeen studied.
I want to be clear on this, butone of my.
There's one doctor here,particularly in Houston, that I
work with a lot, and thenthere's a few others that have
talked about this.
In younger patients with um,adhd add, and we're talking
(22:33):
probably the teenage years uh,they have been using low doses
and have found some results inregards to their ability to
refocus.
So I'm hearing more about someof that.
Uh, because there's things thatare happening in the brain.
I don't know the data on it orunderstand completely how that's
going.
I'm just giving the feedbackfrom what I'm getting from those
practitioners.
(22:53):
Now I will say that the peoplethat probably experience or feel
the benefits the most or Inoticed people that are in their
50s and older when you actuallynotice your body changes,
everybody talks about oh, you'llfeel it when you're 40.
And then you really hear peoplesaying, no, you're 50 and 60.
You really feel the differentthings going on While we're in
(23:16):
such a unique age and time ofoptimizing the body.
I think we can do so manythings to make our middle-aged
and older years so much moreviable and productive.
I think that's where a lot ofthe individuals notice it.
I get a lot of great feedbackon I love your product.
I can't not be off of it.
(23:37):
And then here's the ironythey're on it and after a
certain amount of time just likeeven if you're supplementing
with really high qualityvitamins and minerals you may
notice you feel more energy andyour brain falls on in the
beginning, and then after awhile you're just used to
feeling great and you don'treally notice that it's doing
anything for you.
But you notice when you stop it.
So with TA65, that's a bigfeedback I get is I didn't
(24:00):
really notice I was feelinganything after being on it a
while.
But when I stomped it afterabout three or four weeks, I did
notice that I was.
I needed to get back on it.
I wanted to because my, I couldfeel the optimization.
So that's kind of the.
The biggest thing is that you,you, you know the supplement
world is a hard, a hard one todo.
So we, we like to utilizetesting, you know.
That's why, as a practitioner,I always encourage measure their
(24:23):
results.
Really nice for them to see thenumbers move on the needle with
one of those numbers, yep.
Speaker 1 (24:27):
So really nice for them to see the numbers move on
the needle move on those numbers.
Yeah, that's pretty exciting.
So I've been on it gosh,probably about five or six
months, and I mean I'm feelingreally great.
So I have not done the actualtesting though.
So maybe I need to do a littletesting and see what's going on.
Speaker 2 (24:44):
You have about up to a year to give yourself.
Like you know, six months to ayear is fine.
I usually try to encouragepeople to give it about eight
months or so or a little longer.
But yeah, absolutely, I mean,it's fun to do so, you know, and
kind of think about your lifealong that time span.
You know, how did you feel?
Was there a major stress?
(25:04):
Were there any big events thattook place?
I'll give you another one.
If someone's on it, they feelgreat but they break their arm A
very unfortunate event andthere's a lot of rebuilding
going on to heal that arm.
Your telomere length is goingto degrade.
That's why telomeres aremalleable.
They can come back, but youprobably don't want to test them
(25:25):
.
Speaker 1 (25:27):
While they're not found.
Speaker 2 (25:29):
Yeah, you're not going to necessarily see the
most, or if they've caught COVIDor the really bad flu.
You know the body's reallyfighting hard.
There's a depletion going on,and then that's why T65 is
important, in the sense thatyour depletion won't be as bad
typically, and then your reboundwill be a lot better on top of
it.
Speaker 1 (25:46):
Perfect.
So here's another question ondosage.
Say you're taking one tablet aday and maybe you have one of
those stressful events or youbreak an arm or you pull a
muscle or something like that.
Is there benefit to taking moreduring those stressful time
periods?
Speaker 2 (26:04):
Yes, it can be.
In all of us we absorb itdifferently.
That's why we have differentdoses.
There are some people who it'svery effective at a low dose for
them.
We actually have been lookingat the data.
We're trying to get a littlebit closer, but we've kind of
come around to the 80-20hypothesis.
80% of the population is goingto do really well on the
(26:24):
standard mid-dose 250 unit.
The standard mid dose 250 unitUm the years, uh more, is
certainly going to still bebeneficial for you.
You cannot overdose on TA 65.
Uh, just um.
Just another thing to note itdoes not contraindicate with any
other supplements or drugs, soyou're not going to have an
issue with any overlap withanything that's going to affect
(26:45):
it negatively.
Okay, and uh, ultimately I meanyou look at the dosing, so
about you know you find about10% of the population has been
responding really well to thelowest dose, the 100 unit.
You'll know as you go over timesomebody sees their test.
If the needle's still moving onthose biomarkers, then that
dose is working for them.
(27:05):
If it's not, then we want totitrate that dosing upward.
And this is actually from acouple of the doctors that have
been using the product inpractice for more than a decade
and they've been monitoringpatient progress and that's how
they've discovered, you know,the absorbability factor.
We've actually donebioavailability testing.
We know it's in the bloodstream10 to 12 hours and we know that
(27:26):
, yes, different people gethigher, higher C, c, max, pk
levels in the blood versusothers in different doses.
So you just kind of have totake each, each individual case.
But this, you know, if you'rethrowing, you know what do I
start?
Mid dose, 250 and then 500 unitis always a fantastic place to
(27:47):
start.
You really can't go wrong.
Speaker 1 (27:48):
Okay, Okay, and as far as you know GI side effects,
anybody have any trouble.
You know, taking thismedication I haven't had any
issues at all.
I was just curious, if you hearit.
Speaker 2 (27:59):
There's very minimal.
There's not a mix of randomingredients.
The only active in here is themolecule TA65.
It is a natural molecule thatwe extract from a specific
species of astragalus.
The patent extraction processmakes it purified enough to
penetrate the cell, turn on thatenzyme, telomerase.
(28:20):
And that's where the sciencecomes into play.
A lot of people have.
There are products out therethat claim it.
No one has been able to makethe molecule bioavailable enough
to actually turn on telomerasenaturally.
And they one has been able tomake the molecule bioavailable
enough to actually turn ontelomerase naturally and they
have not been able to prove itin human trial data or animal
model data so far.
Speaker 1 (28:38):
Well, this is a very cool product and it's so
different in the anti-agingspace.
It stands out, certainly, fromall the other supplements that
we carry, and we are just soexcited to be partnering with
you guys and offering this toour clients and listeners.
If you are interested inlongevity and you want to do
(28:58):
everything you can to sort ofhack your biomarkers and keep
yourself, you know, reallyreally doing well long term,
ta65 may be something that youwant to add to your regimen.
So, if you're interested at all, we carry it at Premier and we
would love to chat with youabout adding it to possibly your
(29:18):
supplement regimen today.
And, sebastian, before wefinish up, anything else you
would like to add?
Speaker 2 (29:26):
I think that covers it.
I really appreciate your timetoday and thanks for having me
on.
If you have any other questions, of course I'm happy to answer
them, and then any links youwant me to send you, or whatever
you name it, I'll send it yourway.
Speaker 1 (29:37):
That would be great.
I would love a link to you guysso that people can read a
little bit more about what youhave going on, and, of course,
we will have the link topurchase TA-65.
You can buy that at our store,shoppremieredermcom, anytime.
And also come by.
We would love to chat with youmore about TA-65 and All Things
(29:59):
Skin at Premier.
Thanks for listening.
So, guys, thank you so much fortuning in to an episode of All
Things Skin.
We sure appreciate you beingone of our listeners.
Not only do we thank you forlistening, but please continue
to follow us, give your reviewson any of the podcast platforms
that you're listening on, and wecan't wait to see you on
another episode of All ThingsSkin.
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