BrainStorm by UsAgainstAlzheimer's

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Endocrinologist and longevity expert Dr. Florence Comite joins Meryl Comer to challenge conventional wisdom about aging, hormones, and brain health. Drawing on decades of clinical experience and her new book Invincible, Dr. Comite explains why the fear around hormone therapy is based on outdated, flawed research. She believes testosterone, progesterone, quality sleep, and resistance...

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What if the way we think about aging and dementia is fundamentally wrong? Dr. Florence Comite, precision medicine pioneer and author of Invincible: Defy Your Genetic Destiny to Live Better Longer, joins host Meryl Comer to make the case that cognitive decline is not inevitable. From the difference between biological and chronological age, to the five key biomarkers everyone should k...

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In part two of Meryl Comer’s conversation with Dr. Nathaniel Chin — geriatrician, researcher, and author of When Memory Fades — they explore the practical and emotional realities of life after an Alzheimer's diagnosis. Drawing on both his clinical expertise and personal experience of caring for his father, Dr. Chin addresses the often-overlooked needs of care partn...

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What if knowing sooner could change everything? In this episode of BrainStorm, host Meryl Comer sits down with Dr. Nathaniel Chin — geriatrician, Alzheimer's researcher, and author of When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer's and Dementia, to explore why early diagnosis of Alzheimer's and dementia is more empowering than...

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In this episode of BrainStorm by UsAgainstAlzheimers, host Meryl Comer continues her conversation with Dr. Sandra Bond Chapman, Founder and Chief Director of the Center for Brain Health at UT Dallas, about how to build a more resilient brain in the face of modern life's relentless stressors. Dr. Chapman breaks down the difference between acute and chronic stress, explains why accept...

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What if you could train your brain to outperform the very biomarkers that signal Alzheimer's risk? In this episode of BrainStorm by UsAgainstAlzheimer’s host Meryl Comer sits down with Dr. Sandra Bond Chapman, founder of the Center for Brain Health at UT Dallas, to explore the groundbreaking science behind the Brain Health Project — a landmark study tracking over 40,000 ...

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In part one of a series on UsAgainstAlzheimer’s Brain Health Journey host Meryl Comer is joined by Nancy Meserve, a lived experience advisor and APOE4 double-carrier, and Catherine Patterson, interim COO of UsAgainstAlzheimer's. Their conversation explores the newly launched Brain Health Journey — a suite of resources designed to help people at elevated Alzheimer's risk,...

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Host Meryl Comer continues her conversation with Dr. Jason Karlawish, professor of medicine, medical ethics, and neurology at the University of Pennsylvania, about the evolving landscape of Alzheimer's disease. Drawing on his book The Problem with Alzheimer's, Dr. Karlawish explores the promise of early detection, the ethical complexities of disclosing uncertain diagnoses, and why h...

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What happens when your carefully mapped career path collides with an Alzheimer's diagnosis — and you're only 26? In this deeply personal episode of BrainStorm by UsAgainstAlzheimer’s, host Meryl Comer sits down with Jessica Guthrie, founder of the online platform Career and Caregiving Collide, whose life changed forever when her mother was diagnosed with early-onset Alzh...

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Alzheimer's disease is no longer just a memory problem — it's a biological, cultural, and ethical challenge reshaping how we think about aging, identity, and medicine. In this episode of Brainstorm by UsAgainstAlzheimers, host Meryl Comer sits down with Dr. Jason Karlawish, professor of medicine, medical ethics, health policy, and neurology at the University of Pennsylvania. T...

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In honor of Black History Month, this episode of BrainStorm by UsAgainstAlzheimer’s explores the critical intersection of Alzheimer's disease and health equity in African-American communities. Host Meryl Comer talks with Daphne Delgado, Vice President for Health Equity at UsAgainstAlzheimer's, and Dr. Charlene Whitaker-Brown, a clinical nursing professor and 2022 Brain Health ...

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This episode of BrainStorm, by UsAgainstAlzheimer’s, features host Meryl Comer interviewing Leah Fisher, a psychotherapist and author who took a bold year-long solo travel sabbatical at age 60 to explore different cultures while maintaining her marriage. The conversation takes a poignant turn as Fisher reveals that after the events in her book, she received an MCI (Mild Cognit...

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BrainStorm guest Vradenburg, Chairman and Founder of UsAgainstAlzheimer's, sits down with host Meryl Comer for a comprehensive look at the state of Alzheimer's research, advocacy, and care in 2025.

Vradenburg addresses critical challenges facing the Alzheimer's community, including threats to NIH funding and the impact of funding instability on researchers and clinical trials. The di...

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Ep 99: The Future of Alzheimer's Trials: AI, Biomarkers, and Remote Research – John Dwyer, CEO of The Global Alzheimer’s Platform

In part 2 John Dwyer, CEO of the Global Alzheimer's Platform (GAP), and BrainStorm host Meryl Comer discuss transforming Alzheimer's research and clinical trials. Dwyer shares how the field is shifting toward earlier intervention and leveraging...

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The quest to speed up clinical trials is personal for John Dwyer, CEO of the Global Alzheimer's Platform (GAP). A long-time UsA2 advocate, he’s been motivated by the generations of family members lost to Alzheimer's and Parkinson's disease. Dwyer shares with BrainStorm host Meryl Comer the critical challenges of NIH funding cuts by the Trump Administration, forcing many trial ...

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Diane Rehm, the legendary 89-year-old NPR talk show host, discusses her passionate advocacy for medical aid in dying with BrainStorm host, Meryl Comer. Rehm’s view was shaped by her husband John's difficult death from Parkinson's disease and the experience transformed her into a fierce advocate for end-of-life autonomy. She's adamant that if diagnosed with serious illness or e...

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Dr. Rachel Buckley discusses the critical link between menopause and Alzheimer's risk in women with BrainStorm host Meryl Comer. Dr. Buckley explains that early menopause can be associated with faster cognitive decline and higher tau levels in the brain. She emphasizes the importance of timing for hormone replacement therapy and how estrogen plays a vital role in brain health throug...

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Dr. Rachel Buckley of Mass General Hospital and Harvard Medical School discusses groundbreaking research revealing stark sex differences in Alzheimer's disease with BrainStorm host Meryl Comer. Her studies found that while men and women show similar levels of amyloid protein, women consistently display significantly higher levels of tau. This discovery has sparked a $50 million Welc...

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In this deeply moving episode of BrainStorm by UsAgainstAlzheimer’s, Emma Heming Willis shares her intimate journey as a caregiver to her husband Bruce Willis, who lives with frontotemporal dementia. Their conversation covers the progression from early warning signs to diagnosis and the complex decisions required in caregiving - including the heartbreaking but necessary choice...