Episode Transcript
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Speaker 1 (00:11):
Hey folks, welcome to
another episode of Broken
Brains with your host, bruceParkman, sponsored by the Mack
Parkman Foundation, where welook at the issue of repetitive
brain trauma in the forms ofrepetitive head impacts from
contact sports and repetitiveblast exposure from our veteran
communities, and how these smallyet continuous hits are
changing brains.
That's resulting in the largestpreventable cause of mental
(00:33):
illness in this country.
And why do we have this podcast?
So we can reach out toresearchers and scientists and
patients and authors and hostsof other shows, so that we can
bring you the most latestinformation on this issue,
because it's not taught in anynursing, medical or
psychological curricula in thiscountry today, and that is why
(00:55):
you need to be informed, so thatyou can protect those that you
love or, if you know those thatare suffering, you can protect
them.
On our show today we haveanother set of amazing guests
from American Cell Technology,both of them dealing in the
far-reaching, exploitative andemerging field of stem cell
(01:17):
research.
First is Sean Berman.
He's a leading expert in stemcell research and regenerative
medicine with over a decade ofexperience Earning his
undergraduate degree fromAmherst College I think that's
Massachusetts University ofAmherst, which is a great place
to grow up and a master ofscience and biology from
Louisiana Tech University,focusing on traumatic brain
(01:39):
injuries and publishing researchon intravenous adult
adipose-derived stem celltherapy and publishing research
on intravenous adultadipose-derived stem cell
therapy.
He's a key member of the CellSurgical Network and
collaborates with internationalphysicians on IRB-approved stem
cell therapy protocols for TBI,ptsd both very important
concepts that we're going todive into on this call with the
United States Air Force anddirects the Cell Surgical
(02:01):
Conference, a CME-accreditedevent in his 12th year, bringing
together more than 45 topexperts in regenerative medicine
.
He's presented at national andinternational medical
conferences and serves as aconsultant for American Cell
Technology, the leading personalstem cell bank in the US.
With him today is Kevin Ferber,the chief operating officer at
(02:21):
American Cell Technology, thelargest personal stem cell bank
in the US.
He leads collaboration with topregenerative medicine
practitioners, driving clinicalgrowth and innovation in stem
cell therapy.
Most recently, he's launchedVital Cells, the only US newborn
stem cell bank, offering accessto billions of live stem cells.
He has over a decade in thefield and his passion began
(02:42):
while shattering top global stemcell doctors.
He's a two-time All-Americanfootball player at Amherst
College and he's witnessedfirsthand the power of personal
stem cells in recovery andperformance, fueling his mission
to advance regenerativemedicine.
Gentlemen, welcome to our showtoday and we look forward to
having an amazing conversationwith both of you on this
emerging and really cool topic.
(03:04):
I mean, we're going to learnall about this stuff, gentlemen,
so looking forward to the chattoday.
So let's just start off with,you know, stem cell medicine.
So what's this all about?
A lot of our listeners are,like me, you know, very
uninformed in the concept.
We know it's emerging.
We know that it's beingutilized in a lot of areas to
treat, you know, to treatdegenerative diseases, to treat
(03:26):
joint conditions.
You know how does it affectbrains?
Speaker 2 (03:29):
Yeah, so it is an
emerging field, but it's really
based off, you know, ancientdogma, ancient techniques.
We wouldn't be here today ifstem cells weren't around.
Stem cells are the way that ourbodies have recovered from
injury for millennia.
That's how evolution made us.
The only problem is that as weget older, we run out of stem
cells and we need more to healnaturally.
(03:51):
And when we don't have enoughstem cells around, we end up
healing with white blood cellswhich form scar tissue, whereas
stem cells will actually formthe natural, normal tissue that
should be there.
So we're just looking at waysto repurpose stem cells and take
them from one part of the bodyand put them in other parts of
the body so that we can getbetter healing.
(04:11):
So your brain has stem cells init and when you were first you
know people were in medicalschool 10, 20, 30, 40 years ago
they thought you were born withthe total number of cells that
you're ever going to have inyour brain and never get any
more, and it's only going towhittle away from there.
But the more that we've learned, you find out the brain's
actually very plastic and it canrecover from injury.
(04:32):
I mean, it's very, veryresilient.
But if we're able to add aboatload more stem cells after
injury, then maybe we can havesome kind of expedited and
enhanced recovery injury, thenmaybe we can have some kind of
expedited and enhanced recovery,get back to normal faster,
better, and get people back onthe playing field, back to work,
(04:53):
back to school, as opposed tojust sitting around and waiting
in a dark room to hope forrecovery.
Does that give you a littleidea of what stem cells are
capable of doing?
Speaker 1 (05:06):
yeah, just a little
bit, I'd say.
The issue is how do we get theminto the brain?
So the brain is a you know aclosed system.
It's, uh, surrounded by, youknow cerebral fluid.
It has a number of you knowprotective barriers to getting,
you know, you know anything intothe actual brain itself.
So what are the modalitiesyou're using to get the stem
(05:27):
cells into the brain?
Speaker 2 (05:28):
Absolutely so.
The really cool thing aboutstem cells is that they have an
ability it's called chemotaxis.
Basically, there's a chemicalsignal and the cells will home
to that chemical signal, sothey'll travel naturally to
sites of inflammation.
Now when you get a concussionor a brain injury, the brain is
displaced beyond the cerebralspinal fluid.
(05:49):
It crashes into the bonystructure that's called our
skull and that protectivebarrier known as a blood-brain
barrier is absolutely disrupted.
I mean, that thing is torn toshreds.
Now what's funny is that theblood-brain barrier and the
neurovasculature will actuallyrecover fairly quickly.
But it's the neurons that sitwithin the blood-brain barrier,
(06:10):
within the parenchyma they'recalled astrocytes that basically
block the blood vessels fromseeping into the brain.
Those neurons take a reallyreally long time to recover.
So a problem is created whenyou get a concussion, While the
blood-brain barrier heals reallyquick, the neurons are still
distressed and they can take along time to recover.
While they're distressed andtaking a long time to recover,
(06:34):
they emit signals to theneurovasculature and those
signals are distress calls.
So they're calling for stemcells, they're calling for an
immune response, and when you'reyoung you have a lot of stem
cells flowing throughout yourblood naturally, your
circulatory system naturally, soyou'll get a more natural
(06:55):
recovery.
But as we age, where we get alot of concussions back to back
to back, it creates a cyclicalcascade of ongoing distress
calls where these neurons arecalling for help.
Macrophages and neutrophils arechewing through the blood-brain
barrier that's already healed,reopening it, trying to go help
the neurons.
And it's this ongoing cycle.
(07:16):
So, God forbid, you're exposedto multiple concussions or
multiple subconcussive injuries,whether that be through
something like football, wherepeople are banging heads
repeatedly, over and over andover again, or in our military.
Blast exposure can causeconcussion, and these, you know,
our brave military men andwomen and veterans are training
(07:38):
with explosive devices regularly.
Automatic weapons, launching,jet engines all this stuff can
cause head trauma and more oftenthan not, unfortunately, it
goes undiagnosed.
So we really got to look atthings a whole lot differently.
Speaker 1 (07:53):
So when we talk about
stem cells because this is
amazing, I mean honestly.
I mean we're the biggestproblem that we know of with
healing the brain and withmental illness is that all of
the modalities for mentalillness just numb the brain
right, they're pharmaceuticalinterventions, they're therapies
.
So anything that can help healthe brain is of enormous
(08:15):
interest to the community thatwe serve, absolutely.
So when those calls go out, sois that directing the body to?
You know, one of my questionsis how do the stem cells know
which part of the brain?
Is they just merely floodingthe brain, or are they attracted
through those distress calls tothe particular section of the
head, the other side of the head, and then you've got the
(08:35):
bruising and inflammation onboth sides of those.
So you've got the physicalinjuries, then you've got the
neuroinflammation, injuries thatoccur at the same time.
So how do these stem cells knowwhere to go?
Speaker 2 (08:56):
The easy answer is
that they're a hell of a lot
smarter than we are, and that'sthrough that chemotaxis.
Speaker 1 (09:01):
That's a good one.
Give me the crayon answers.
Speaker 2 (09:08):
It's their ability to
hone the signs of inflammation.
Now, the reason I'm soconfident in this and I know it
is because my graduate researchwas basically we took an animal
model.
We gave it a left frontalcortex injury this was induced
by a blast and then we took stemcells that we had tagged with
fluorescent markers, gave themvia IV infusion and we were able
(09:30):
to directly track them right tothe site of injury in the brain
, which was the left frontalcortex.
So again, they're a lot smarterthan we are.
So if you were to slip and fall, you're able to hit your head
and it got displaced beyond thecerebral spinal fluid that it
sits in.
You're going to have injury allover.
Again, the cells are a lotsmarter than we are.
(09:51):
That's how you recovernaturally, and all we're trying
to do is put more stem cellsinto circulation so that you can
expedite the recovery process,so that you can outnumber the
white blood cells that you havewith stem cells, so you have the
hope of recovering with lighttissue as opposed to scar tissue
.
Scar tissue is fine.
It's like putting duct tape ona uh you know on a hole in your
(10:12):
wall.
It's not drywall and it's notwhat you want, but it'll.
It'll mask the hole, but thatthat wall is not going to have
the structure, structuralfunction that you intend for it,
which is duct tape.
You actually have to repair it,naturally.
Um, and that's what we'retrying to do with stem cells.
Speaker 3 (10:28):
And Bruce, to kind of
go back to your question of why
would the cells?
Where do they go?
Do we flood the brain withcells?
The mesenchymal stem cells thatSean's referring to.
Their number one properties areanti-inflammatory by nature and
hone in on those sites ofinflammation.
So, as you know better than usin the TBI and the concussive
world, you're really gettingthat inflammation response of
(10:51):
the brain.
And so in Sean's study that he'sreferencing, just even giving
cells IV and we see this at theclinical level the cells will
flow to those sites ofinflammation and help repair the
body more naturally.
So the sooner you can get thesecells in treatment could be
better, because you want to getit as soon as it is inflamed.
So, going back to Sean's point,how do you beat scar tissue?
(11:13):
How do you beat recoverymethods that are more like a
Band-Aid or a duct tape versusregenerative therapy, critical
to getting these cells at pointof care for as soon as you can,
so they can do what they're mostcapable of doing of
regenerating and helping healthe body naturally, calming
those sites of inflammation.
Speaker 1 (11:33):
I mean, look, I mean,
neuroinflammation is a huge
problem, you know, in ourcommunity, right, as you both
know, and you've mentioned itseveral times, and addressing
this issue is key.
Now, is it possible that we canidentify people that don't have
an injury?
They've already been exposed tosubcussive trauma for years.
They probably had concussionswhen they were young playing
(11:55):
contact sports.
Now they're struggling withmental illness.
They really don't have.
What they have is a damagedbrain that was damaged over
years and now has progressedthrough just age or whatever.
Is there a method by which youcould introduce stem cells where
they're not really dealing withthe injury per se, but the
actual aspect, issues that youknow that emerge when you have
(12:17):
long-term toxic?
You know all that cytocline,all that imbalance of chemicals
that are known to cause thistoxic environment causing the
neuroinflammation.
Is there a path for stem cellsto address this without having
(12:38):
an injury?
Speaker 2 (12:38):
Yeah, absolutely, and
I think that what you have to
look at is no, I don't thinkanybody wants to treat
inflammation.
Inflammation is secondary to aninjury.
You want to treat the injury,the injury that gives off or
results in inflammation, right?
(12:59):
So it's just like a beacon,it's a light, it's a signal.
It's not the actual problem.
The actual problem is going tobe unique in many of these cases
, right?
So what you want to do is youwant to fix the root cause, the
root injury, and that's exactlywhat stem cells do.
That's how the body isrecovered naturally for
(13:20):
millennia, long before you and Iwere ever even you know,
thoughts or considerations,right?
If there weren't stem cells, wewouldn't have been here in the
first place, yeah, but millennia, millennia ago.
So if we can treat, the rootcause and the root end.
Speaker 1 (13:33):
Okay, but my point is
millennia, millennia ago we
never had football, we never hadhockey, we never had these
long-term exposures to blast orrepetitive head impacts.
So my question is and I thinkyou've answered it, I just want
to clarify that is that in someof the cases that we're coming
(13:53):
across like veterans that wereexposed to blast but they've
been out of the Army for five orsix years, right so the injury,
it could be that there is adamaged brain.
It hasn't been damaged recently, it was damaged in the back, so
you probably have scar tissue.
You definitely got a ton ofneuroinflammation that's
continuing to go.
You know they've gone on, butwe have to heal the brain.
(14:16):
Is there any?
Would stem cells help that?
Like an older injury like that?
You know that's scarred up, orwould stem cells have?
Do they have a regenerativeapproach where they can create
new neurons, new pathways, newaxons that can help stimulate?
You know additional, you knowbrain, you know tissue or
(14:38):
assistant functionality?
Speaker 2 (14:42):
It's a great question
.
The short answer to that is Idon't know, but the other answer
to that is most likely yes.
Now everybody loves uh,everyone loves neurons.
The reason is they photographreally well.
It's like why everyone loveshot skinny models they
photograph really really well itdoesn't.
That doesn't mean we shouldignore all the other cells in
the brain.
Right, there's a lot ofsupportive microglial tissue
(15:05):
that's around there and, like Isaid earlier, when you have a
neuron that's damaged, it'ssending signals to the
circulatory system asking forhelp and those distress calls
cause basically your neutrophilsand macrophages to come in and
bust through everything.
And when I say bust througheverything, those are all those
supporting microglial cells.
If we can make that environmentbetter, which I think we can
(15:27):
with mesenchymal stem cells,then absolutely there's a huge
hope for using these cells toadvance neurologic injury years
after the fact.
Kevin alluded to it earlier.
The best time to take care ofthis stuff is in the acute phase
.
Stem cells cannot reverse scartissue, so they won't do that.
(15:48):
But there's an ongoing problemwith a lot of this
neuroinflammatory,neurodegenerative conditions and
absolutely you're going to wantto get cells in there so that
they can start repairing thosemicroglial cells and
neurovasculature efficiently andeffectively to create a better
environment for your neurons.
Speaker 1 (16:07):
And you brought up a
good point because, you know,
honestly, the neurons are stillcrying for help, right, because
that's what's keeping theinflammation in place.
The body keeps responding tothese continuous calls, but not
with the right resources, right?
It's like, hey, I want tanks,I'm going to send you
infantrymen, right, they needstem cells, right?
So you know, amazing.
So where are we at in researchright now?
(16:29):
So, stem cells, of course, havebeen out for, you know, a while
.
We've heard about them there.
You know, there's a rapidgrowing acceptance, I guess, in
certain situations vice others,in regards to the brain and
healing the brain.
Where are we at with theapplication of stem cells?
Are we actively using themright now in any trials?
(16:50):
Or where is the research onthis issue right now, because it
sounds to me like it'ssomething that we really need to
focus on.
Speaker 2 (16:58):
Absolutely.
There's a lot of ongoing workright now using stem cells, but
I think one of the mostimportant things that we need to
touch on is what kind of stemcells you ultimately use so you
could put stem cells.
But I think one of the mostimportant things that we need to
touch on is what kind of stemcells you ultimately use so you
could put stem cells directlyinto the ventricle of the brain.
I've been involved in researchthat's done that and it was
actually fairly effective.
The problem is, you have todrill a hole in your head in
(17:18):
order to do that, and a lot ofpeople say you know, I want to
take it easy before I actuallylike go all in on this and see
if I can get a result.
I know right.
So one of the most effectiveways to get cells to the brain
or to any injury actually is viaIV infusion.
I mean, it's non-invasivewhatsoever and the cells
naturally home to sites ofinflammation.
(17:38):
Now, one of the biggestproblems is that people have,
you know, been confused aboutwhat source of cells is best to
use, and people are out theresaying, hey, you want to use
these, the youngest cellspossible, so you should pull
from umbilical cord stem cells.
Well, those are cells thatdon't contain your own DNA.
So if I give them IV, my immunesystem is going to get rid of
(18:03):
those cells within a 24 to 72hour period.
What does that mean?
That means there's no chancefor those cells to get to my
brain and actually do anythinggood, and that's a best case
scenario.
So ultimately it's just taxingmy immune system.
If you really want cells tostick around and do something,
when you give them IV, you'regoing to need your own stem
(18:25):
cells with your own DNA.
Why your body will not rejectthose cells.
Great, that means these stemcells.
You used a military exampleearlier.
Let's call them special forces.
They're not just tanks that areblowing things up and coming in
.
They're coming in withprecision.
They can give off theappropriate signal, they can
differentiate into functionaltissue, they can transfer
(18:46):
healthy mitochondria.
They can do a whole lot torepair neurologic damage.
But if they're foreign DNA fromsomebody else I mean you don't
even know if they're male orfemale cells then they're going
to get expelled out of your body.
There's going to be no chancefor them to do anything good.
So you got to use your own cellswith your own DNA and everyone
(19:08):
says well, I'm this age, I'mthat age, you know, how are my
cells any good?
How am I going to know?
And it depends on where youpull these cells from.
All the cells in your body areall different ages and they age
differently based on how you usethem.
Some cells, like the, the oneson your skin, turn over almost
weekly, so they're constantlyworking.
(19:29):
That's why people's skin looksbad as they age right.
There are other cells, like yourbone marrow stem cells, your
platelets and red blood cells,turn over every eight days.
So every eight days the stemcells in your bone marrow are
making new cells we prefer topull from adipose tissue or fat.
A fat cell has a lifespan ofeight to 10 years, so that means
(19:52):
as an 80-year-old, it'spossible that your fat-derived
stem cells have only workedeight times in their life, not
every eight days.
So that's huge.
That means we have access toyour own cells, your own
personal DNA, that are reallyyoung, healthy and robust.
We can take those and thenKevin can tell you about what he
does with them.
In American cell technologythere's a huge potential to use
(20:15):
these cells for good, to makepeople better, and naturally
with your own DNA, I mean thisis absolutely the cutting edge.
This is the future of medicineand it's all based on the
evolutionary process.
Speaker 3 (20:28):
Sorry but if I could
touch on the research side of
things we were saying on stemcell therapy and neurological
conditions, the neurologicalcondition is not going to be
healed overnight by potential ofone treatment and we see this
in clinical trials where peopleare going to need repeat
treatments of their cells.
So let's take Sean's comment onusing autologous your own cells
(20:50):
or your own DNA that will stayin your system to help repair
itself.
How are people able to do thosestudies?
And it's a lot harder to do soif you're using your own cells.
You need to have a bank orconsortium of your own cells.
Sean didn't touch upon it asmuch, but we can get stem cells
in the adipose.
I think.
Irb studies say around 1 millionmesenchymal stem cells per cc
(21:12):
of fat.
Let's say a tablespoon of fatis 20 cc, so you can get 20
million cells per treatment.
But how many times is a TBIpatient or con you're going to
come back for these repeat uhmini lipo polls to get enough
cells?
So a lot of the research isusing an allergenic donor cell
and so it's almost uncomparableif you're going out of the
(21:34):
country and hearing about thesepeople getting foreign cells
with foreign DNA and trying toquantify the results, because we
we see it in research itself isthat you're not getting um your
cells or your own DNA that'sgoing to stay within the body.
Speaker 1 (21:49):
Okay, I mean, this is
fascinating.
So, number one, you can use myfat, which I don't need anywhere
anyway, to go ahead and createa cell-syn bank for my body, my
body.
We can make sure that the cellshave DNA, because the source of
these cells, of course, youknow, you hear there's a lot of
consternation about, you know,possibly using, you know,
(22:16):
embryos and stuff like that, andthat was, you know, one of the
concerns that you know, some ofyou know these people might have
.
So it sounds like we'reactually harvesting these cells
from you know, you're notripping into the bone and
pulling out bone marrow, you'reactually using fat and and and
order to create these cells.
And then you, you're get up,you get an account like a like,
a like a like at the stem cellbank, right?
Speaker 3 (22:38):
Yeah, I can, I can
walk you through that a little
bit and I think that's a big, umbig market gap interest.
And, uh know, us citizens do notknow they have access to
personal autologous stem celltherapy within the US.
A lot of people are going out ofthe country for donor
allergenic cells an inferiorservice offering when they can
stay here in their backyard.
(23:00):
To your point, bruce, you cansend in a tablespoon of fat to
our lab at American CellTechnology and from that one
tablespoon of fat we can isolatethe stem cells in the
FDA-registered, inspectenvironment, clean environment,
processed by our highly skilledlab techs, and we can culture,
expand and let these cellsnaturally self-replicate.
And so, going back to needingmultiple treatments, we can then
(23:20):
cryopreserve those cells intime, so if you're 30, 40 year
old cells, we can use them whenyou're 50, 60 years old and then
, through our partneredphysicians, you could get your
cells back to utilize them.
And now you can actuallyquantify the amount of live
cells that you have, that you'regetting per treatment, and you
can get on a program based onwhat your physician recommends
on how often you should begetting your cells, whether it
(23:43):
be focusing more on TBI andconcussions or we have
physicians working on otherinjuries or autoimmune
conditions and some other reallyfascinating conditions that we
don't, that traditional medicinecannot heal potentially.
Speaker 1 (23:59):
Yeah, so that's a
great point.
And so it sounds like, while wemight be focused on brain
injuries, there could be otherancillary conditions that are
(24:20):
treated at the same time.
But we could have you know.
We know that this is also apossible cause of Parkinson's
and multiple sclerosis and otherneurodegenerative diseases that
can come out.
So there's, what about thosetypes of diseases?
Are there any research showingimprovements in those areas as
well?
Because, as we deal with olderpopulations of RBE and RHI
(24:43):
patients, these are conditionsthat do start emerging.
Speaker 2 (24:49):
That was a good
question.
A company I work with, cellSurgical Network, tracks all
patient outcomes and has done sofor a five-year period, and
we've done this since 2012.
So this is unpublished data, sotake it with a grain of salt,
but it's on hundreds of patients.
We follow up with our multiplesclerosis patients with a
29-point questionnaire lookingat their symptom scores and
(25:11):
outcomes.
After getting an IV infusion ofstem cells, we see symptoms of
multiple sclerosis decreased by52% over a two-year period.
That's amazing, so it's prettysignificant.
Again, these cells are a lotsmarter than we are.
If we can reintroduce them to acirculatory system, they're
basically on a highway to gofind inflammation throughout the
(25:33):
body and they'll go where it'sneeded Again, a lot smarter than
we are.
We work with some amazingdoctors and they can drop a
needle with cells directly toany spot in the body with
pinpoint precision.
But if you can't and you canjust access a vein, you have a
pretty remarkable opportunity toengage in some pretty good
(25:54):
healing.
Speaker 3 (25:57):
And Bruce.
To Sean's point, the only waythis industry moves forward in
the United States is throughresearch and documentation, and
so we hope, when talking toyourself, wes, such as wide
network of TBI and we would loveto work with veterans or others
that have suffered to startdocumenting this with the
follow-ups, and collect the realdata so that you can present it
(26:19):
next time on your show, so thatpeople are aware that this is
out there and something they canutilize as a tool in their tool
chest, potentially help them.
Speaker 1 (26:27):
Yeah, I mean, we're
always interested in helping put
together, you know, grants andprograms to help, you know
promising modalities like thisbecome more.
You know, systematicallyavailable Right, and that's you
know it's a huge issue for thispopulation.
Right, and that's you know it'sa huge issue for this
population.
Now it sounds like you canactually get this done in the
(26:47):
States.
This is this is.
You would be on the show if itwasn't legit, right?
So instead of flying overseasand you know, and getting your
(27:08):
stuff done there, you know youdo have you know FDA approvals
or whatever in place to to goahead and conduct these
procedures on patients withinthe United States.
Speaker 2 (27:12):
So this stuff isn't
FDA approved.
It's compliant with FDAregulations.
And what's interesting andunique is that some people like
to say that stem cells are adrug.
The reason that that is isbecause typically, when stem
cell research started, itstarted with embryonic stem
cells.
So you'd have to take theembryo and you'd have to work
with those cells.
You'd work them in a lab andthey'd be always foreign DNA
(27:35):
because you took them from anembryo so that human didn't get
born and you'd give them toother people.
And that's the typicalpharmaceutical model, where you
have a uniform product, you makea lot of it and you distribute
it to a lot of people.
Well, this process is entirelydifferent because every single
cell line is unique to whoeversent in their cells your cells
(27:57):
are for you, kevin's cells arefor Kevin, my cells are for me,
et cetera, et cetera.
Right, so it's a much moreindividualized process and when
you look at the, you knowmedicine and whatnot.
There's not a lot of peoplethat want to invest in
personalized medicine unlessthey can own or patent that
process.
There's nothing to own orpatent.
(28:18):
You can't patent a naturallyoccurring product and your cells
and you and you know who youare is naturally occurring.
So, while it's not necessarilythe best business model, I think
it's by far and away the bestmedical model and medical
solution, because it's somethingthat's been worked on for
millennia, like I keep alludingto, as opposed to, you know,
(28:40):
some brand new chemical that'sjust going to intervene and mask
the symptoms or, you know,maybe get some repair.
But this is a natural way thatyou're supposed to heal and all
we're doing is adding asignificant amount more of these
stem cells back intocirculation to help expedite the
healing process.
Speaker 3 (28:59):
Talk about getting it
here in the US versus
internationally.
It's just, it's completelydifferent service offering.
When you're goinginternationally, most likely not
using your own cell.
If you are using a same dayprocedure to get some of your
cells, then often getting a lotof those donor cells which can
be going through IV and can betaxing your immune system and
maybe not sticking around aslong, as Sean mentioned.
(29:21):
So the biggest difference thatyou can do here is you can work
with a practitioner in the USthat can do a mini-lipo
procedure.
They can give you a same-daystem cell treatment where you
could get some cells back thatday and if they were utilizing
our bank and American CellTechnology, it'd take us eight
weeks to grow out those cellsand then you'd have access to
those cells throughout your lifehopefully, and then you could
(29:41):
actually stay in the US and getrepeat treatments of your own
stem cells with yourpractitioner via IV infusion.
And so that is what's criticalwhen tracking these results,
because not often are peoplegoing to go abroad to continue
to get these donor cells overand over again.
So now you can start using yourown cells, your own DNA, in the
US.
You do have access to manypractitioners that are doing
(30:03):
this right here on our home turf.
Speaker 1 (30:07):
I mean this is.
I mean we do know thatpersonalized medicine is the
forefront of the future.
I mean, you know, obviously youknow farmer wants to take your
procedure and put it in a littlepill and give it away for like
$250 a pill or whatever theirissue is.
So I can imagine there's a lotof pushback to it and
personalized medicine, like Isaid, is important.
So I do see there's a lot ofvalue in this in the future.
(30:30):
As you know, obviously, if DNAis an issue and you know gender
is an issue, whatever, I meannothing's going to work better
than you know stuff.
You know that's been cells thathave been harvested from your
body.
So for the typical patient, itsounds like I mean, you can
literally go to a doctor.
They can extract these cellsand then re-inject them in a
(30:53):
part of your body.
What do they have to do to thecells?
I mean, obviously you justcan't pull fat and stick it
somewhere.
Maybe they can.
How do they extract the cellsin order to re-inject them in a
more concentrated dose in theright part of the body that
needs it?
Speaker 2 (31:11):
so good question.
Uh, well, first of all, itturns out that your adipose
tissue is absolutely loaded withstem cells and, um, you don't
need that much fat tissue.
Uh, despite some people wantingto donate lots of fat tissue,
you don't need that much justabout a tablespoon to get a
significant quantity of stemcells.
Uh, the procedure is wildlyeasy.
(31:32):
I joke it's harder to get myhair cut sometimes than it is to
get this mini liposuction.
It's 15 minutes.
You're wide awake, you lay downon your belly and you know I've
got selfies of me getting itdone, but yeah, it's virtually
painless.
You get about that much fat outand the doctors in the clinic
can actually separate the stemcells from the fat tissue.
(31:55):
So they get rid of the fattissue and adipocytes and they
can just isolate a number ofdifferent stem or progenitor
cells.
So in a typical harvest youcould get 50 to 75 million stem
cells and you can give them backright away that same day.
But what's really really cool isyou could take another small
sample and send it to Kevin.
(32:16):
Kevin takes it in his lab atAmerican Cell Technology and
puts them in a condition wherethe stem cells will just
naturally self-replicate.
And the whole point to all thisis it's all a completely
natural process.
They're not being pushed downany pathways.
Nothing's being done to thecells to change your relevant
biological characteristics.
It's all your cells, from yourown body, your own DNA, and in
(32:40):
the replication process typicallabs want to, you know, push
them down a fancy pathway, makethem turn into some kind of
cells, because they can patentthat process and, you know, own
it and block people out of theirlane.
But maybe that's not the bestsolution medically.
So again, let themself-replicate naturally.
(33:01):
You can get a huge number ofcells and then clinically
they're very easy to deploy andgive back repeatedly over time.
Speaker 1 (33:08):
What's the primary
pushback to this?
You know, procedure, I mean itsounds amazing.
Go to a doctor's office.
They can pull some fat, youknow, spin it, you know,
separate it in a centrifuge orwhatever it is, and then
re-inject it.
I mean, it sounds like it's notsurgery, right, you're not
going under, you're not.
You know, whatever it could bean IV injection it could be, you
know it could be a.
(33:29):
It sounds like you've got well,number one, the procedure,
dialed in.
And then, you know, it soundslike from Kevin's perspective.
Now, you know, I can harvest mycells in my 20s and keep
getting those young cells forthe rest of my life.
I become an old, damaged oldman.
So what is the pushback from theindustry right now, you know,
is it the business model?
I mean, it sounds like this issomething that could be very
(33:52):
affordable to, you know, anybodyin the country that might have
some resource.
I mean, right now, forpsychedelics, you pay 500 bucks
to get a ketamine treat, right,you, you know, you, you know
you're going to pay a thousanddollars to go on an ayahuasca
ceremony.
You know all these things havecosts that people are already
paying.
Hbot therapy, whatever it is.
So what?
What is the pushback to theyour to this?
(34:13):
Why is this not available now?
What is the pushback to this?
Why is this not available now?
Speaker 3 (34:22):
And then what are the
costs associated with it, so
our audience can understand that, I think.
Speaker 2 (34:25):
Sean and I will have
two different views on pushbacks
.
Let me go find my tinfoil hat.
Speaker 3 (34:29):
first, the initial
pushback I would say is lack of
education in Bruce and reallythat is.
Folks hear the word stem cellsand think all of it's the same.
So if you're not educated inunderstanding the benefits of
autologous your own stem cellsand knowing that you want to
have a certain amount of live ormesenchymal stem cells that
(34:50):
come from your own DNA, youmight equivalent that to an
amniotic fluid that has no livecells and they'll call it stem
cell therapy.
And so if patients aren'teducated on their different
options and the benefits ofthose options, they may see
their own stem cells as worsefrom an amniotic fluid donor.
I'll call it growth factortissue and they're completely
(35:13):
different service offerings andwhat they can do and the
benefits.
So I think the biggest thing iseducation, understanding and
having these conversations ofknowing the benefits of using
your own cells with your own DNAand how that can be beneficial
for repeat treatments and thesafety of it.
Shocking of his background onmaybe more of his pushback
differentially and then we cango into cost too associated.
Speaker 2 (35:36):
Bruce, I'm going to
absolutely agree with Kevin.
You know, when I first got intostem cell research, everyone
thought that stem cells werefrom embryonic sources, and
embryonic sources actually are.
There's a moral and ethicalissue with them, but they're
actually not safe.
They can form teratomas andtumors.
So that's, you know, nothingthat we want to do.
We want to make situationsbetter, not worse.
(35:57):
Ultimately, people found thatyour own body had stem cells in
it, and these stem cells arecalled adult stem cells.
So even if they're fromumbilical cord tissue, which is
from a baby, those are stilladult stem cells.
And umbilical cord, till youknow, the day you die, there are
stem cells floating around inthe body.
And these stem cells areactually a lot safer.
One, they have the potential tohave your own DNA and two, they
(36:21):
don't form cancer, which isfantastic.
So they give us the ability tomake things better.
But then, going back toeducation, is people think, hey,
I have a problem.
That's why I'm coming to see mydoctor.
How could it be that my ownbody could help me solve this
issue?
And that's why I'm coming tosee my doctor.
How could it be that my ownbody could help me solve this
issue?
And that's where the educationgame begins.
And people will try and go pullan allergenic or somebody's
(36:43):
donor tissue to use to supporttheir recovery, and that's just
not the safest way to go aboutthings.
Despite whatever your age is,despite whatever your ailment is
, you have essentially the powerwithin.
That sounds pretty corny, butit's true, and your stem cells
and your fat are one greatsource.
They're easily accessible andthey're generally fairly young
(37:07):
and robust.
So, again, it's just aneducation game, and the more
that we're able to communicatewith people and get this out
there, the more the amazingdoctors that we work with are
able to, you know, perform andadvance the research that we're
doing.
You always want to do somethingthat's incredibly safe, and
when it's as effective as it is,that's when it gets wildly
exciting.
I mean, I feel like with ourjob, we're showing up to job
(37:30):
sites with power tools andeveryone else has a screwdriver
and a hammer, and I love solvingproblems, and these stem cells
give us an ability to solvemedical problems that have gone
on for way too long with nodecent solution and why, in the
educational space, are we notseeing in who we're working with
?
Speaker 3 (37:49):
I guess Bruce is
private practitioners that are
experienced physicians that arelooking for alternative
treatments where traditionalmedicine has failed them.
If you think about any kid whocomes out of med school.
You have to go through ahospital system to get your
training and most medical schoolis funded by big pharma or
you're shown how to treat viamedication.
(38:10):
And what happens when you comeout of a US medical school?
You're burdened with a ton ofdebt and you take on a
high-paying job at a hospitaland traditionally accepting
insurance money.
The US healthcare system is setup for you to want to use your
insurance.
You're paying a premium for it.
You should want to use it Rightnow.
Stem cell therapy is not coveredby insurance.
It's cash pay to using your owncells.
(38:32):
So you have to have this greatcombination of one being willing
to pay cash in a pocket to seethese practitioners that have
sought out stem cell therapythat they were not taught in
medical school and you're notforced to go learn about stem
cell therapy.
It's really these curiousphysicians that are ultimately
looking for the best results fortheir patients, and not all
(38:54):
physicians are looking for thatand just like any job industry.
If I've been doing total kneereplacements for 25 years and
I'm able to bill insurance andI'm getting decent outcomes and
I have a great reputation, whyam I looking to push the needle
and say status quo?
There has to be a drive, and sowe're dealing with some of the
best physicians across alldifferent specialties that are
(39:15):
looking for alternativemodalities and are really trying
to heal the patient from withina more natural way.
And I think we have a ton ofgreat tailwinds as an industry
because I think people arestarting to wake up and starting
to challenge big pharma orstatus quo and whatever's
happened in the past handful ofyears, and people are really
looking for natural alternativesas they start to learn more.
Speaker 1 (39:36):
So I think, as we
close this out with RFK in
office, I think now is the time,just like we're seeing interest
in legislation for RHI and RBE.
Time for these types ofmodalities are actually there
Anytime you can take use yourown body's resources to improve
your natural health is actuallya very, very compelling argument
, and I want to learn more.
I'd like to have you guys backon the show so as we, as we get
(39:59):
ready to close out.
Kevin, sean, you know, tell,tell our audience.
How do they find you?
How do they get ahold of you?
What are the research orwebsites they should be looking
at, because I think there'sgoing to be a lot of interest in
this in this modality, so youknow.
Speaker 3 (40:20):
So tell our folks how
to get ahold of you.
Yeah, hopefully.
I'm not sure how the show noteswork, but our bank is called
American Cell Technology.
We're located in South Florida.
That's for the adults lookingto harvest their stem cells, and
we can help partner withpractitioners in their area.
We have fantastic physiciansall over the US from different
modalities, depending on whatyou're looking for, and then
separately, what we do have wedidn't get into is we have a
(40:42):
newborn stem cell banking calledVital Cells, where you can
store your baby's day one stemcells at birth from their cobalt
cord tissue, where we can dothe same process where we
isolate the day one mesenchymalstem cells and culture
expandexpanding, cryopreservethose baby cells to use
throughout their life.
So either way, you can reachout to us.
Our staff is here on normalwork hours and they're happy to
answer questions and can alwaysput you directly in contact with
(41:05):
me.
Speaker 1 (41:06):
Amazing Sean.
It would be like what Kevinsaid yeah, you can find me
through.
Speaker 2 (41:13):
Kevin, my one parting
message to the people listening
is if you're interested in stemcell therapy and you go see
your doctor, uh, just make sureyou ask them about data.
I mean, if anybody's doinganything legit, they should be
working with the database.
They should have data that theyshould be able to report to you
and make sure you're using yourown cells.
It's just the safest,healthiest way to go about
(41:35):
things.
So that would be my partingmessage.
But there's a lot ofopportunity here.
It's a wildly exciting field,and brain health I mean.
We know more about the moonthan we do about the brain and
it's time for that to change.
Speaker 1 (41:47):
Great closing
statement and I'm all in.
I'll be doing a little bit moreresearch in this.
Alex has been in touch with meand we're big proponents of
anything that can help ourveterans.
That needs to be studied moreFolks.
Thank you so much for joiningthe call today.
Another great episode, a lot tolearn.
Very, very exciting emergingfield of science and research I
think is going to help and behelpful for a large number of
(42:11):
patients suffering from RHI andRBE To our audience.
Another great podcast.
Really appreciate the folks atAmerican Cell Technologies and
you stay informed.
Remember, go to the website.
We have the free book forparents, get on there.
We've got an app, smartsafe orSmartHead, on the Apple Store
and Google Store.
We've got the second annualconference, the only one in the
(42:31):
world, on repetitive braintrauma coming up in Tampa
September 3rd and 4th.
And don't forget our VeteransTown Halls March 28th here in
Tampa there's going to be livestream talking about repetitive
blast exposure and a whole bunchof other questions we didn't
even get into on this call.
So anyways, folks, take care ofyour brains, take care of your
kids, stay safe, be informed andGod bless.
Bruce Parkman, broken Brain,signing out.
(42:52):
Thank you.