Weekly updates on new data and best practices in patient care for a variety of infectious diseases including COVID-19, HIV, and viral hepatitis, from Clinical Care Options. Gain practical strategies and earn CME/CE credit for selected episodes.
In this episode, Palak J. Trivedi, BSc, MBBS, PhD, MRCP, ESEGH, discusses the most recent developments in primary biliary cholangitis (PBC) treatment, including cutting-edge data on new and emerging agents and how these updates may be integrated into your practice. Topics include:
Steatotic liver disease and PBC
Vibration-controlled transient elastography (VCTE) and discordant biochemical responses in PBC
In this episode, Dr Gideon Hirschfield meets with patient advocate Jess Schnur to discuss challenges related to the diagnosis and management of primary biliary cholangitis (PBC) to provide actionable strategies for healthcare professionals to incorporate into patient care, including:
Disease concerns and frequently asked questions from a patient perspective
In this podcast, Sonal Kumar, MD, MPH, meets with patient advocate Maria Morais to discuss actionable steps that healthcare providers can incorporate into the care of people with primary biliary cholangitis (PBC). Listen as they discuss:
The chronic nature of PBC
Going beyond biochemical markers to assess and address symptoms such as fatigue and pruritus
The importance of referral to patient support groups
In this podcast, expert faculty, Dr Stuart Gordon and Dr Nancy Reau, use an illustrative patient case to explore the roles of ALP and other biochemical markers in PBC management, and explain what to expect from treatment. Topics covered include:
How baseline ALP can affect ALP normalization after second-line treatment with elafibranor and seladelpar
Potential outcomes if ALP normalization cannot be achieved
In this podcast, expert faculty, Dr Stuart Gordon and Dr Nancy Reau discuss an illustrative patient case to demonstrate how they individualize primary biliary cholangitis (PBC) therapy for patients with cirrhosis. Topics covered include:
AASLD guideline recommendations for second-line therapy for PBC
Considerations when using newer agents for second-line treatment of PBC in patients with cirrhosis: elafibranor and seladelpar
In this podcast, Brett M. Elicker, MD, and David E. Griffith, MD, ATSF, FACCP, FRSM, discuss the pathophysiology of non–cystic fibrosis bronchiectasis (NCFBE), the patient burden, and best practices with diagnosing NCFBE, including:
The vicious vortex of NCFBE (ie, airway dysfunction, inflammation, infection)
Cough as the most significant symptom and burden
Imaging bronchiectasis with classic and inflammatory findings
In this podcast, listen as experts Alan Bonder, MD, AGAF, and Aparna Goel, MD, discuss how they assess the symptoms of primary biliary cholangitis (PBC) and explore how new therapeutic agents may help alleviate symptom burden. Topics include:
Strategies and tools for assessing pruritus
Nonpharmacologic and pharmacologic management of pruritus
How do you decide when to move from first-line to second-line treatment for primary biliary cholangitis (PBC)? In this podcast, listen as experts Alan Bonder, MD, AGAF, and Aparna Goel, MD, discuss this question and more, including:
How and when to measure treatment response
Evidence-based goals of therapy
Considerations for second-line treatment
New agents for second-line treatment: PPAR agonists
Respiratory Syncytial Virus (RSV) significantly impacts adults, especially those over age 60 and those with chronic conditions.
In this podcast, nurse practitioners Drs. Carrico and Stevenson discuss the underestimated burden of RSV. The podcast also explores practical strategies for increasing vaccine uptake that you can apply to your practice starting today so that you can protect your patients against RSV.
Listen in as Carolyn Bridges, MD, FACP, and Laura P. Hurley, MD, MPH, discuss barriers to respiratory syncytial virus (RSV) vaccination for adults, including insurance coverage and vaccine hesitancy, and explore effective, practical strategies for overcoming these barriers. Topics covered include:
Helping patients understand why they need an RSV vaccine
Listen in as Carolyn Bridges, MD, FACP, reviews the estimated burden of respiratory syncytial virus (RSV) disease in older adults and discusses the latest updates on RSV vaccination recommendations and safety data. Topics covered include:
Rates of RSV hospitalizations and emergency department visits
RSV vaccine development
FDA-approved RSV vaccines
Vaccine safety data: rates of atrial fibrillation and Guillain-Barré syndrome
In this episode, Jewel Mullen, MD, MPH, MPA, and Dallas Nelson, MD, CMD, FACP discuss overcoming barriers to RSV vaccine uptake in post-acute and long-term care facilities, including:
How to incorporate the latest RSV vaccination recommendations into clinical practice
Practical strategies for navigating insurance
Effective and empathetic methods of addressing vaccine hesitancy.
In this episode, Chloe Orkin, MBChB, FRCP, MD, and Jean-Michel Molina, MD, PhD, discuss highlights from CCO’s independent conference coverage of CROI 2025, including:
Advances in HIV treatment based on results from CARES
Potential HIV therapies in the pipeline, such as doravirine/islatravir
Effects of broadly neutralizing antibodies on HIV treatment and cure
Key clinical data on HIV and STI prevention obtained from PILLAR, HPTN 08...
Listen in as Cristina Mussini, MD; Martin Witzenrath, MD, FERS; and Michele Bartoletti, MD, PhD, discuss treatment strategies for people who are immunocompromised with COVID-19 in the hospital setting, including:
Antiviral therapy with remdesivir
Dexamethasone for patients with hematologic malignancies
Considerations regarding other immunomodulators such as JAK inhibitors or IL-6 inhibitors
In this episode, Patricia D. Jones, MD, MSCR; Mindie H. Nguyen, MD, MAS, AGAF, FAASLD; and patient advocate, Jennifer Wild, MS, RN, OCN, discuss practical strategies to overcome barriers to hepatitis B virus (HBV) care, including:
Overcoming health insurance navigation
Improving access to HBV care in immigrant communities
In this episode, Stephen Cantrill, MD, FACEP; Rajesh T. Gandhi, MD; and Payal K. Patel, MD, MPH, FIDSA, discuss:
Workup of COVID-19 in the emergency department
Methods of COVID-19 risk stratification
Treatment recommendations for people with severe COVID-19, including how to effectively use antiviral therapy, dexamethasone, and other immunomodulators[CC1] in this population
A detailed patient case to illustrate key takeaways
In this episode, Stephen Cantrill, MD, FACEP; Rajesh T. Gandhi, MD; and Payal K. Patel, MD, MPH, FIDSA, discuss treatment strategies for people who have severe COVID-19, including:
Antiviral therapy with remdesivir
Dexamethasone and other systemic corticosteroids
Immunomodulators, such as JAK inhibitors or IL-6 inhibitors
Overviews of clinical trial data demonstrating how and when to use these therapies
In this episode, Martin Witzenrath, MD, FERS, and Michele Bartoletti, MD, PhD, discuss the management of mild to moderate COVID-19 in patients who are immunocompromised, including:
Initial workup, which may include laboratory tests and/or imaging
Latest data on the use of remdesivir or nirmatrelvir plus ritonavir for mild to moderate COVID-19, including considerations for drug–drug interactions
In this episode, Patricia D. Jones, MD, MSCR; Mindie H. Nguyen, MD, MAS, AGAF, FAASLD; and patient advocate, Jennifer Wild, MS, RN, OCN, discuss best practices in hepatitis B virus (HBV) care, including:
2023 CDC HBV screening recommendations
Summary of guideline recommendations for hepatitis delta virus (HDV) screening
Use of HDV reflex testing to avoid loss to follow-up
2024 WHO HBV treatment recommendations, including recommen...
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