Diabetes Treatment Debate: Should Metformin Still Be Used First?

In this episode, TRC Healthcare editor, Rachel Cole, PharmD, delves into the debate about whether newer medications for Type 2 diabetes, including SGLT-2 inhibitors or GLP-1 agonists, should be used first-line instead of metformin. She examines the benefitsand drawbacks of these newer medications, including their cardiovascular and kidney benefits, side effects, and costs.

This is an excerpt from our March 2025 Pharmacy Essential Updates continuing education webinar series.

The clinical resources mentioned during the podcast are part of a subscription to Pharmacist’s Letter, Pharmacy Technician’s Letter, and Prescriber Insights: 

• Article: Stay Current on Med Recommendations for Diabetes
• Algorithm: Stepwise Treatment of Type 2 Diabetes
• Chart: Diabetes Medications: Cardiovascular and Kidney Impact
• Resource Hub: Diabetes

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