Episode Transcript
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William Davis, MD (00:06):
We've been
urged to include plenty of
dietary fiber in our dailyroutines, fibers that come from
vegetables, legumes, grains andother plant sources.
But there is an animal-sourcedfiber that has nearly
disappeared from the modernhuman diet Hyaluronic acid.
Hyaluronic acid has nearlydisappeared from the diet
(00:27):
because it is primarily sourcedfrom animal products, especially
organ meats like brain, skinand tongue.
But hyaluronic acid is a fibercrucial for the health of many
human organs skin joints, uterus, cervix, vagina arteries.
It is also a fiber withsignificant benefits on the
(00:50):
gastrointestinal microbiome thatin turn, yields substantial
benefits via microbialmetabolites.
In this episode of the DefineHealth podcast, let's discuss
the role of this important fiberand how to bring it back into
your lifestyle to obtain itsmany benefits.
I'd like to take a few minutesto talk about this important
(01:15):
fiber, hyaluronic acid.
Now many people are surprisedthat we call it a fiber, but it
is a fiber.
Recall that fibers are nothingmore than polymers of different
sugars.
So cellulose fiber,fructooligosaccharide fiber,
xylooligosaccharides,galactooligosaccharides and
hyaluronic acid these are allexamples of fibers that differ
(01:37):
in their sugar construction.
They also share the propertythat they are indigestible by
humans, that is, we don't havethe enzymes to break down the
unique sequence of sugars inthese fibers, but microbes have
those enzymes, and so thesefibers become a very important
microbial or microbiome typeconversation.
Well, hyaluronic acid is afiber, and it's a very unique
(01:59):
fiber in that it's one of therare fibers that are sourced
from animals.
Right, the vast majority offibers come from plant matter
green leafy vegetables, rootvegetables and similar plant
sourced foods but hyaluronicacid is animal sourced,
typically coming from organssuch as brain, skin, tongue and
(02:22):
other organs.
Of course, most modern peoplehave abandoned consumption of
those hyaluronic acid sources,and so modern people have ended
up leading a hyaluronic aciddepleted lifestyle, and this has
consequences.
So let's talk about thoseconsequences Now.
I know that a lot of ladies willsay things like well, don't
tell me about hyaluronic acid, Iknow all about it.
(02:44):
What they mean is they knowabout topical hyaluronic acid
serums.
I know a lot of you ladies paya lot of money.
I've seen ladies paying $100,$180 for an ounce of serum of
hyaluronic acid and they applyit to the fine wrinkles of their
face, such as the crow's feetor smile lines, and it does work
.
It does at least temporarilyreduce the depth of wrinkles.
(03:07):
But here's the thing If youapply it, say, to the crow's
feet around your eyes.
What does it do to the skin onyour neck or abdomen or thighs
or other areas where skin agingcan occur?
Nothing, of course, right.
It's a topical, superficialapplication.
The real power of hyaluronicacid isn't when ingested orally.
(03:29):
But now most modern people haveessentially abandoned
consumption of hyaluronicacid-rich sources.
So if you go back to obtaininghyaluronic acid, what can you
expect?
Well, since most of you areinterested in skin, you can
expect an increase in dermalcollagen.
So hyaluronic acid in thedermal layer of skin, just below
(03:52):
the surface epidermis, triggersthe production of collagen, so
it increases dermal collagen,thereby reduces wrinkles.
It also increases the retentionof water in the dermal layer,
generating that plumpness thatladies like, and so there are
major skin effects.
Hyaluronic acid also increasesthe production of collagen in
(04:13):
joint cartilage.
So it's Joints like knees andhips have cartilage, of course,
and cartilage is mostly collagen.
The hyaluronic acid that youingest increases dermal collagen
production, so it's one of thethings you can do to help
rebuild joint collagen.
Hyaluronic acid also adds tothe synovial fluid, the
(04:35):
lubricating, gel-like substancein your joints that protects
your joint cartilage in yourjoints.
That protects your jointcartilage, and hyaluronic acid
is also very important andcritical fiber to nourish your
gastrointestinal microbiome.
So when you ingest orallyhyaluronic acid, you bloom very
(04:55):
important species that producethe fatty acid butyrate.
And that's important becausewhen your microbiome produces
more butyrate, you obtaineffects like reduced insulin
resistance, reduced bloodglucose, reduced blood pressure,
better mood, deeper sleep, morevivid dreams and other
beneficial effects.
(05:18):
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With regard to skin, thatbutyrate, also called butyric
acid, goes to the skin and helpsacidify the skin.
(08:16):
Healthy skin is acidic.
It's much more acidic thanunhealthy skin.
Healthy skin is acidic.
It's much more acidic thanunhealthy skin.
So people who have skinproblems like psoriasis, rosacea
, acne they have a less acidicskin that allows proliferation
of unhealthy microbes such asStaphylococcus aureus.
When you get hyaluronic acid itblooms bacterial species in
(08:40):
your gastrointestinal microbiomethat produce abundant
quantities of butyric acid.
That in turn acidifies the skinand discourages the
proliferation of those unhealthymicrobes like staphylococcus
aureus and it makes it moredifficult, makes it less likely
to have those skin rashes and itimproves complexion, reduces
blemishes and redness.
(09:00):
So hyaluronic acid taken orallyis a wonderful factor in
generating better appearing skinand skin health.
Now those butyrogenic speciesthat are bloomed by hyaluronic
acid, such as acromantiamuciniphila, fecalobacterium
prosnitzii, lachnosporacea,ruminic, acacia.
(09:21):
Those are very beneficialspecies for gastrointestinal and
overall health as well.
And hyaluronic acid even goesso far as to discourage the
proliferation, the overproliferation, of fecal microbes
like E coli and Klebsiella.
Those are the species ofcolonic dysbiosis or SIBO small
intestinal bacterial overgrowth.
(09:41):
If you've been following myconversations, you know that
SIBO is epidemic now.
About half the US populationhas it.
Now, hyaluronic acid is veryimportant, it's helpful.
It's insufficient by itself.
So please don't hear thattaking hyaluronic acid gets rid
of SIBO.
It can be part of the program.
You can do more like see myvideos, see my Define Health
(10:01):
podcast, see my many blog postsabout SIBO and the use of SIBO
yogurt.
But hyaluronic acid, because ofits wonderful effect on blooming
butyrogenic species, is part ofthe solution.
Now there's some uncertainbenefits, further benefits to
hyaluronic acid.
But think about this the uterus, cervix and vagina is largely
(10:23):
made of hyaluronic acid.
Now many ladies lose moistureand sensation in their vagina as
they age, especially over age65, it becomes universal.
Well, restoration of hyaluronicacid can be part of the
solution.
There's more that a woman cando, but part of the solution is
to ingest hyaluronic acid.
You know the eyes and brain arelargely hyaluronic acid also.
(10:47):
So what does a diet depleted inhyaluronic acid do?
So we can only speculate, butit's likely that restoration of
depleted in hyaluronic acid do.
So we can only speculate, butit's likely that restoration of
orally consumed hyaluronic acidis also important for those
organs.
Then, lastly, arteries Arterialdisease, like coronary disease,
heart attack, sudden cardiacdeath, need for stents and
bypass surgery, all that stuff?
(11:08):
Well, arteries.
Healthy arteries are lined bysomething called a glycocalyx.
These are hair-like projectionsthat are microscopic, that line
all arteries and they are thepressure sensors and they
control the tone of arteries.
Healthy arteries are relaxed.
Unhealthy arteries areconstriction prone.
They constrict and that'sgoverned by the glycocalyx.
(11:32):
What do you think?
The glycocalyx is made ofHyaluronic acid.
So I believe that emergingscience in coming months and
years is going to tell us thathyaluronic acid is one of the
most important things you can dofor heart and arterial health.
So how do you get hyaluronicacid?
Well, you could go back toconsuming organ meats,
(11:53):
especially brain and skin.
Most Americans don't want to dothat, of course, because we've
been told I think given absurdadvice to cut your saturated fat
and cholesterol.
It costs most modern people toabandon consumption of organ
meats.
So you could do that.
One thing I would not urge youto do is consume something
called bone broth, becausepeople think it mobilizes the
(12:13):
collagen and hyaluronic acid aswell as minerals, but it's also
concentrated in lead, the heavymetal lead.
So I would not do that.
If you want to use soups andbroths, make what I call the
unhabitizing sounding carcassbroth.
Let's say you bake a chicken,eat meat whatever, save the skin
, bones, tendons, ligaments,whatever organs you might have,
(12:36):
and don't boil it like you wouldfor bone broth.
Don't do it 36 hours.
Don't add vinegar, becausethose things mobilize lead
stored in the bones.
Instead, boil for a briefperiod, maybe no more than three
or four hours.
Do not add vinegar, and youmobilize the collagen and the
hyaluronic acid from theligaments, tendons and other
body parts from that carcass.
(12:58):
Now you can also take asupplement.
That's probably the easiest wayfor most modern people who are
averse to eating organ meats.
It's become kind of a commoditysupplement.
The quality differences are notthat great.
If you want to be reallyspecific, you want what's called
high molecular weighthyaluronic acid, because that
seems to have somewhat betterbenefits.
But what you're doing really isfeeding microbes that in turn
(13:21):
convert the pieces aftermicrobial digestion into all the
things that benefit skin,joints, brain, arteries, etc.
So the dose typical dose is 120milligrams per day.
We don't know if more would bebetter.
There's very little information, only one clinical study I'm
aware.
I've used 240 milligrams in askin study and there was no
(13:44):
additional improvement.
So that has resulted in thefact that most manufacturers,
most retailers, use 120milligrams.
It's up to future research tosee if that's true.
I suspect that more could bebetter, but no one has yet, to
my knowledge, tested that.
So 120 milligrams of hyaluronicacid fiber per day in powder
form, added to coffee, added toyour smoothie, added to yogurt,
(14:06):
whatever doesn't matter.
And that's how you get, that'show you restore hyaluronic acid
to obtain all those variedbenefits from this thing lacking
in modern life.