September 9, 2025 • 18 mins
There is a non-infectious epidemic occurring right beneath our noses. The likelihood that you are affected is around 50%. It's the epidemic of small intestinal bacterial overgrowth, or SIBO. In this episode of Defiant Health, I run through the rationale that reveals that, even conservatively estimated, more than 100 million Americans have this condition.
Because of the natural permeability of the small intestine designed for nutrient absorption, invading fecal microbes that have ascended from the colon yield a phenomenon called "endotoxemia," or the entry of bacterial breakdown products into the bloodstream. This is how a disrupted small intestinal microbiome can be experienced as depression, anxiety, neurodegenerative disorders like dementia; heart problems such as coronary disease, atrial fibrillation, and congestive heart failure; skin issues such as as rosacea and psoriasis; muscle and joint issues such as fibromyalgia; gastrointestinal issues such as irritable bowel syndrome and Crohn's disease.
Understand how to recognize this process and manage it and you have been given a huge advantage in regaining control over health.
YouTube channel: https://www.youtube.com/@WilliamDavisMD
Blog: WilliamDavisMD.com
Membership website for two-way Zoom group meetings: InnerCircle.DrDavisInfiniteHealth.com
Books:
Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight
Mark as Played
Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
William Davis, MD (00:06):
There is a non-infectious epidemic
occurring right beneath ournoses.
The likelihood that you areaffected is around 50%.
It's the epidemic of smallintestinal bacterial overgrowth,
or SIBO.
In this episode of DefiantHealth, I run through the
rationale that reveals that,even conservatively estimated,
(00:29):
more than 100 million Americanshave this condition Because the
natural permeability of thesmall intestine designed for
nutrient absorption, invadingfecal microbes that have
ascended from the colon yield aphenomenon called endotoxemia,
or the entry of bacterialbreakdown products into the
(00:51):
bloodstream.
Anxiety, neurodegenerativedisorders like dementia and
Parkinson's disease.
Heart problems such as coronarydisease, atrial fibrillation
and congestive heart failure.
Skin issues such as rosacea andpsoriasis.
(01:14):
Muscle and joint issues such asfibromyalgia.
Metabolic issues such as fattyliver, obesity or type 2
diabetes.
Gastrointestinal issues such asirritable bowel syndrome and
Crohn's disease.
Understand how to recognizethis process and manage it, and
you have been given a hugeadvantage in regaining control
(01:37):
over your health.
I think we have one of thelargest epidemics in the history
of our country right under ournoses and there's a good chance
about a 50% chance.
I believe that it affects youdirectly, that is, you
personally, as well as abouthalf the people around you, and
(01:58):
that's the epidemic of SIBOsmall intestinal bacterial
overgrowth or SIBO, we sayS-I-B-O.
Why do I say it's epidemic?
Well, let's consider all thestudies, about a couple of dozen
studies that have already beenperformed that ask this question
In condition blank whatproportion of people test
(02:19):
positive for SIBO, typicallyusing breath hydrogen gas
testing for SIBO, typicallyusing breath hydrogen gas
testing?
Breath hydrogen gas testing isa way to assess or to map where
microbes are living in yourgastrointestinal tract and it
tells us that the sooner yourbody releases hydrogen gas after
consuming some of that,microbes that metabolize, the
(02:41):
higher up microbes are in yourgastrointestinal tract.
So we want to know if microbesare living at high numbers in
your stomach, duodenum, jejunumand ileum.
So we consume something thatmicrobes metabolize it could be
lactulose, sometimes glucose Ilike to use inulin and then we
test for hydrogen gas and howrapidly you release it.
(03:03):
And if you have microbes livingin the upper 24 feet of your
intestines, that is SIBO.
You'll test positive within 90minutes typically.
And so if we ask that questiononce again in condition blank,
what proportion of people testpositive for SIBO?
Let's insert irritable bowelsyndrome, ibs.
(03:24):
Well, there's 60 to 70 millionAmericans with IBS and while
studies vary, conservatively,31% will test positive.
That's 18 to 20 million peopleright there and, by the way, I
think that's too low.
In Dr Mark Pimentel's study,for instance, a number of years
ago, he showed that 84% ofpeople with IBS test positive,
(03:47):
which is consistent with theidea now that the primary
treatment for irritable bowelsyndrome is an antibiotic,
rifaximin and it has pretty goodefficacy, suggesting that IBS
is a bacterial disease.
All right, let's go on.
So how about obesity?
There's 110 million Americanswith obesity and the studies
(04:07):
tell us about 50% of people testpositive for SIBO.
That's another 55 millionpeople right there.
How about type 2 diabetes?
Well, 37 million Americans havetype 2 diabetes and likewise,
about 50% will test positive.
How about skin rashes likerosacea or psoriasis or eczema?
About 40% of those people testpositive.
(04:29):
That adds about another 6million people.
Now, there's some overlap inthese conditions, right?
An obese type 2 diabetic, forinstance.
But you can see the numbers addup quickly.
And we haven't even factored inrestless leg syndrome, sleep
apnea, type 1 diabetes, diabetes, inflammatory bowel diseases
like ulcerative colitis andCrohn's disease, celiac disease,
(04:51):
neurodegenerative disorderslike Parkinson's disease,
cognitive decline andAlzheimer's, lou Gehrig's
disease.
How about psychiatric oremotional conditions like
anxiety, depression, suicidalideation?
In other words, if we add upall the numbers, you can see we
easily exceed easily exceed 100million people.
I think, more like 150 or moremillion people, or roughly half
(05:15):
the US population, and it'sconsistent with what I'm seeing.
So many of us will test forSIBO.
And there's a home device, bythe way, in case you want to
know.
It's called the AIRE deviceA-I-R-E.
This is the original that testsfor hydrogen gas.
This is a more recent version.
Tests for hydrogen gas.
This is a more recent version.
Tests for hydrogen gas andmethane.
And what you do is you consumeone of those fibers.
(05:37):
A fiber such as lactulose Ilike to use inulin because it's
more broadly metabolized bymicrobes you blow into.
It, talks to your smartphone.
Zero to ten for hydrogen gasand any rise of four units after
consumption of the fiber tellsyou have microbes living in the
upper GI tract where they don'tbelong.
(05:58):
Now think about this the 1918flu epidemic affected about 25
million people.
The flu this year is expectedto involve about 40 million
people.
So we're talking about one ofthe worst epidemics ever in the
history of our species on thisplanet.
But it's not, of course, aninfectious epidemic.
It involves bacteria, but it'snot really infectious.
(06:20):
You can't pass it on to anotherperson, for instance.
It is one of the epidemics oflifestyle that is, a man-made
epidemic, like type 2 diabetesand obesity, and so we have this
man-made epidemic that isaffecting about one in two,
roughly, people.
Now, no one has done this, taken, say, 10,000 people and tested
(06:41):
them all for hydrogen gas to seereally what proportion tests
positive.
We don't really need to knowthat, right, the evidence is
already pretty solid that in allthose conditions, a good
proportion, a significantproportion, tests positive.
Now why is that important?
Well, there's gastrointestinalconsequences of this SIBO.
If you're unfamiliar with thisconversation, all that means is
(07:03):
that because we've been exposedto numerous factors like
antibiotics, often repeatedly,glyphosate and other herbicides,
food additives likepreservatives and emulsifying
agents and all kinds of otherthings that have caused a
decline in beneficial species.
In fact, there's a recent studyfive days of an antibiotic
(07:24):
killed off more than a thousandspecies of the gastrointestinal
microbiome, and you can't getthem back.
At least you can't regrow themspontaneously.
Right, once you kill somethingit's gone.
So just that's one course ofantibiotics.
So we have lost numerousspecies in our colons because of
all those factors.
Well, those species, thosebeneficial species served to
(07:45):
suppress and keep at bay fecalmicrobial species that are
generally resistant toantibiotics.
These are species in the groupof proteobacteria, species such
as E coli, klebsiella,campylobacter, pseudomonas, many
others.
You might recognize those names, by the way, because they're
also very important pathogenscausing sepsis and urinary tract
(08:07):
infections and other infections.
Well, those same fecalmicrobial species, when they're
not suppressed anymore bybeneficial microbes because of
all those exposures, will ascend, will over-proliferate in the
colon, where they belong, butthen ascend into the small
intestine where they don'tbelong.
24 feet of small intestinalcolonization by fecal microbes.
(08:31):
Feet of small intestinalcolonization by fecal microbes.
And the small intestine is notwell equipped to deal with this.
It has a thinner mucus barrier.
It's very permeable becausethat's where we're supposed to
absorb nutrients like vitaminsand minerals and fatty acids.
And so when the fecal microbestrillions of them, invade the
small intestine, that alone isvery inflammatory and increases
(08:52):
the already permeable smallintestine.
It makes it more permeable.
These microbes only live for afew hours.
When they die, these fecalmicrobes release.
These are called gram-negativemicrobes because they stain a
certain way, because they havesomething called
lipopolysaccharide endotoxin intheir cell walls when they die,
(09:12):
when these trillions of microbesdie because they only live for
a few hours.
They release thatlipopolysaccharide endotoxin
into the bloodstream and that'show SIBO in the small intestine
can be experienced.
In other organs it could beexperienced as anxiety or
depression, or cognitiveimpairment and Alzheimer's.
(09:33):
In the brain it could beexperienced as atrial
fibrillation, coronary disease,myocardial infarction, heart
attack or sudden cardiac death.
When endotoxin involves theheart and the coronary arteries,
it could lead to rosacea,psoriasis in the skin.
It could lead to joint pain andinflammation, such as that in
(09:53):
fibromyalgia and rheumatoidarthritis.
In other words, microbes livingin the small intestine, where
they don't belong, export theireffects body wide and now this
effect, this, this process, nowinvolves, I believe, 50, 50% of
people.
You know I would have beenskeptical at first when I first
started thinking about this anumber of years ago, until this
(10:16):
air device and, by the way, Ihave no relationship with the
air device, the company iscalled Food Marble, if you're
interested, invented by an IrishPhD engineer.
When that device came out and Igot hold of it, this is going
back almost a decade I sawpeople testing positive left and
right.
Now you might say well, is thetest valid?
It has been validated, by theway.
(10:37):
But is the test valid?
Is it accurate?
Well, here's confirmation.
I believe that the test isuseful.
Someone will say haveulcerative colitis or Crohn's
disease or it'll bowel syndromeor have a weight loss plateau or
has a hemoglobin A1C of 11.7percent.
They eradicate the SIBO andthereby the endotoxemia and you
(11:00):
see, these conditions improvedramatically.
Somebody who say lost weight bygoing low carb, say they lost
maybe 48 pounds but they stillhave another 40 to go.
But they plateaued.
They addressed the SIBO andendotoxemia and their weight
plateau finally gives way.
Or a type 2 diabetic goes lowcarb and does other good things,
drops the hemoglobin A1C, say,from 11.7% to 6.4%.
(11:25):
Much better still, not good.
We're aiming for 5.0% or less.
They addressed the SIBO andendotoxemia.
Now their hemoglobin A1C is4.8%.
That's typical, in other words,people who test positive and
then test negative aftereradication of the SIBO.
That process seems to correlatewith clinical improvement in
(11:49):
some, or actually many,conditions.
So the SIBO, I believe, is areal thing.
It's been debated for now aboutover 30 years, but the science
has become clearer and clearer.
That SIBO is a real thingphenomenon that's very important
and, I would argue, is far morecommon than anyone ever thought
(12:09):
.
Now what do you do if you haveit?
Well, there's a number ofchoices, but if you followed my
advice, I would consume what Icall SIBO yogurt and all it is.
It's not yogurt.
It looks and smells like yogurt.
You can't buy it in the store.
It's nothing like the stuff youbuy in the grocery store that
has some kind of boring microbesin it and has sugar and high
(12:29):
fructose, corn syrup and mixingagents.
So you don't want that stuff.
We're going to make it, butwe're going to use some unusual
methods.
First we're going to choosemicrobes with specific
characteristics.
Then we're going to ferment itfor a prolonged period.
To ferment it for a prolongedperiod, microbes don't have sex,
right?
There's no male and femalemicrobes.
(12:50):
They have asexual reproduction.
So one microbe doubles itselfto become two, two becomes four
and so on.
So the microbes we're going touse double every one to three
hours and I'm going to add someprebiotic fiber like the fibers
used in SIBO testing.
We'll use I like to use inulin,so inulin added.
Prolonged fermentation microbeschosen for very specific
(13:12):
characteristics.
So the microbes I chooselactobacillus eryderi,
lactobacillus gasteri andbacillus subtilis.
I chose those microbes becausethey either colonize or
germinate in the small intestine.
It's unusual, most microbesdon't do that.
They germinate or they colonizethe colon.
Well, these microbes colonizeor germinate in the small
(13:37):
intestine.
They take up residence in thesmall intestine where SIBO
occurs, and all three are verypowerful producers of something
called bacteriocins naturalantibiotics effective in killing
this species of SIBO.
So they're really good atkilling E coli and Klebsiella,
for instance, and for thatmatter, some other microbes too,
(13:59):
like Staphylococcus andEnterococcus.
So we ferment these threemicrobes for a prolonged period
36 hours.
So we ferment these threemicrobes for a prolonged period
36 hours and when we count themicrobes we get hundreds of
billions per half cup or 120milliliters serving, and we
consume it.
Now, the best way to do this isto ferment each microbe
individually, because that waywe get the super-duper high
(14:20):
counts.
Like rhodori fermented byitself, for instance, for 36
hours we get about 300 billionper half cup serving.
You can co-ferment all three,but you'll get lesser numbers.
It's less potent, but it doeswork for the majority.
So you still can do that.
But the only thing I ask isthat should you do that, start
over, start from scratch, maybeevery fifth or sixth batch or so
(14:43):
?
We don't know what happens tothe relative counts, the
proportions of microbes as youmake subsequent batches from a
little of the prior batch.
Now, if you want the details onall this, see my blog.
I have thousands of posts on myWilliamDavisMDcom blog.
Of course, my Supergut bookshows you how to make this
Seabull yogurt and other yogurts.
(15:03):
How to ferment other microbesfor other purposes also seabull
yogurt and other yogurts.
How to ferment other microbesfor other purposes also the
recipes.
In those two locations.
Supergut and my blog usedbacillus coagulans rather than
bacillus subtilis.
I replaced the coagulans withsubtilis because the coagulans,
when we perform quantitativecounts, really didn't achieve
the high numbers we wanted whenfermented in dairy.
There's nothing wrong with themicrobe.
(15:24):
It's not the greatest forfermenting in dairy.
There's nothing wrong with themicrobe, it's just it's not the
greatest for fermenting in dairy.
Coagulants is actually veryinteresting for other reasons.
But the subtlest is a reliablefermenter and it's easy to
ferment.
In fact, if you ferment thesubtlest alone, you can ferment
it for 24 hours because itdoubles faster than the other
two species.
So see my blog, see my SuperGut book.
(15:46):
But if you'd like someassistance, some guidance, I
invite you to join myconversations we have frequently
on my inner circle dot.
Dr davis, infinite health dotcom know that you have the
option of this very benign wayto deal with SIBO that you can
make in the comfort of yourkitchen, consume.
We consume it, by by the way,for four weeks or longer.
(16:07):
I also encourage people toconsume it intermittently
afterwards, even after you'veeradicated SIBO, because SIBO
loves to come back.
Even if you took the antibioticrifaximin for it, which is only
about 55, 60, maybe 70%effective, it comes back as a
rule.
So we're going to use the SIBOyogurt formulation
(16:27):
intermittently, maybe threetimes a week, to prevent
recurrence and because thosemicrobes also have spectacular
benefits, especially the rhodoriand to some degree the gasteri,
beyond just eradicating SIBO.
One caution don't test with theair device or other means of
hydrogen gas testing unless youhold off on the Roteri for two
(16:49):
weeks, because the Roteri willcause hydrogen gas positivity
and it'll screw up your abilityto detect whether your SIBO has
been eradicated or not.
I know it's a complexity, ittook us a while to figure that
out, but if you're going to testagain at the end of your SIBO
yogurt adventure, wait two weekswithout the Roteri.
You can take the other ones,you can take the Gaseri and the
Sutilis, but don't take theRoteri.
(17:10):
Wait two weeks test if you wantto see if you're negative or
not and then resume your Roteri.
Now learn these lessons foryourself and then educate the
people around you, because it'shalf the world now, half the
people around you.
If you know four people in yourfamily, probably two of them,
maybe more, because you're allsharing utensils and food and
(17:30):
other habits, but it's notuncommon for entire families to
test positive.
So educate the people aroundyou because they're dealing with
high blood, glucose, obesity,neurodegenerative disorders or
risk for autoimmune conditions,skin rashes, depression, anxiety
.
So these are ways to startdealing with these conditions by
(17:51):
getting rid of the invadingfecal microbes in the 24 feet of
your small intestine.
There is a non-infectious epidemic
occurring right beneath ournoses.
The likelihood that you areaffected is around 50%.
It's the epidemic of smallintestinal bacterial overgrowth,
or SIBO.
In this episode of DefiantHealth, I run through the
rationale that reveals that,even conservatively estimated,
(00:29):
more than 100 million Americanshave this condition Because the
natural permeability of thesmall intestine designed for
nutrient absorption, invadingfecal microbes that have
ascended from the colon yield aphenomenon called endotoxemia,
or the entry of bacterialbreakdown products into the
(00:51):
bloodstream.
Anxiety, neurodegenerativedisorders like dementia and
Parkinson's disease.
Heart problems such as coronarydisease, atrial fibrillation
and congestive heart failure.
Skin issues such as rosacea andpsoriasis.
(01:14):
Muscle and joint issues such asfibromyalgia.
Metabolic issues such as fattyliver, obesity or type 2
diabetes.
Gastrointestinal issues such asirritable bowel syndrome and
Crohn's disease.
Understand how to recognizethis process and manage it, and
you have been given a hugeadvantage in regaining control
(01:37):
over your health.
I think we have one of thelargest epidemics in the history
of our country right under ournoses and there's a good chance
about a 50% chance.
I believe that it affects youdirectly, that is, you
personally, as well as abouthalf the people around you, and
(01:58):
that's the epidemic of SIBOsmall intestinal bacterial
overgrowth or SIBO, we sayS-I-B-O.
Why do I say it's epidemic?
Well, let's consider all thestudies, about a couple of dozen
studies that have already beenperformed that ask this question
In condition blank whatproportion of people test
(02:19):
positive for SIBO, typicallyusing breath hydrogen gas
testing for SIBO, typicallyusing breath hydrogen gas
testing?
Breath hydrogen gas testing isa way to assess or to map where
microbes are living in yourgastrointestinal tract and it
tells us that the sooner yourbody releases hydrogen gas after
consuming some of that,microbes that metabolize, the
(02:41):
higher up microbes are in yourgastrointestinal tract.
So we want to know if microbesare living at high numbers in
your stomach, duodenum, jejunumand ileum.
So we consume something thatmicrobes metabolize it could be
lactulose, sometimes glucose Ilike to use inulin and then we
test for hydrogen gas and howrapidly you release it.
(03:03):
And if you have microbes livingin the upper 24 feet of your
intestines, that is SIBO.
You'll test positive within 90minutes typically.
And so if we ask that questiononce again in condition blank,
what proportion of people testpositive for SIBO?
Let's insert irritable bowelsyndrome, ibs.
(03:24):
Well, there's 60 to 70 millionAmericans with IBS and while
studies vary, conservatively,31% will test positive.
That's 18 to 20 million peopleright there and, by the way, I
think that's too low.
In Dr Mark Pimentel's study,for instance, a number of years
ago, he showed that 84% ofpeople with IBS test positive,
(03:47):
which is consistent with theidea now that the primary
treatment for irritable bowelsyndrome is an antibiotic,
rifaximin and it has pretty goodefficacy, suggesting that IBS
is a bacterial disease.
All right, let's go on.
So how about obesity?
There's 110 million Americanswith obesity and the studies
(04:07):
tell us about 50% of people testpositive for SIBO.
That's another 55 millionpeople right there.
How about type 2 diabetes?
Well, 37 million Americans havetype 2 diabetes and likewise,
about 50% will test positive.
How about skin rashes likerosacea or psoriasis or eczema?
About 40% of those people testpositive.
(04:29):
That adds about another 6million people.
Now, there's some overlap inthese conditions, right?
An obese type 2 diabetic, forinstance.
But you can see the numbers addup quickly.
And we haven't even factored inrestless leg syndrome, sleep
apnea, type 1 diabetes, diabetes, inflammatory bowel diseases
like ulcerative colitis andCrohn's disease, celiac disease,
(04:51):
neurodegenerative disorderslike Parkinson's disease,
cognitive decline andAlzheimer's, lou Gehrig's
disease.
How about psychiatric oremotional conditions like
anxiety, depression, suicidalideation?
In other words, if we add upall the numbers, you can see we
easily exceed easily exceed 100million people.
I think, more like 150 or moremillion people, or roughly half
(05:15):
the US population, and it'sconsistent with what I'm seeing.
So many of us will test forSIBO.
And there's a home device, bythe way, in case you want to
know.
It's called the AIRE deviceA-I-R-E.
This is the original that testsfor hydrogen gas.
This is a more recent version.
Tests for hydrogen gas.
This is a more recent version.
Tests for hydrogen gas andmethane.
And what you do is you consumeone of those fibers.
(05:37):
A fiber such as lactulose Ilike to use inulin because it's
more broadly metabolized bymicrobes you blow into.
It, talks to your smartphone.
Zero to ten for hydrogen gasand any rise of four units after
consumption of the fiber tellsyou have microbes living in the
upper GI tract where they don'tbelong.
(05:58):
Now think about this the 1918flu epidemic affected about 25
million people.
The flu this year is expectedto involve about 40 million
people.
So we're talking about one ofthe worst epidemics ever in the
history of our species on thisplanet.
But it's not, of course, aninfectious epidemic.
It involves bacteria, but it'snot really infectious.
(06:20):
You can't pass it on to anotherperson, for instance.
It is one of the epidemics oflifestyle that is, a man-made
epidemic, like type 2 diabetesand obesity, and so we have this
man-made epidemic that isaffecting about one in two,
roughly, people.
Now, no one has done this, taken, say, 10,000 people and tested
(06:41):
them all for hydrogen gas to seereally what proportion tests
positive.
We don't really need to knowthat, right, the evidence is
already pretty solid that in allthose conditions, a good
proportion, a significantproportion, tests positive.
Now why is that important?
Well, there's gastrointestinalconsequences of this SIBO.
If you're unfamiliar with thisconversation, all that means is
(07:03):
that because we've been exposedto numerous factors like
antibiotics, often repeatedly,glyphosate and other herbicides,
food additives likepreservatives and emulsifying
agents and all kinds of otherthings that have caused a
decline in beneficial species.
In fact, there's a recent studyfive days of an antibiotic
(07:24):
killed off more than a thousandspecies of the gastrointestinal
microbiome, and you can't getthem back.
At least you can't regrow themspontaneously.
Right, once you kill somethingit's gone.
So just that's one course ofantibiotics.
So we have lost numerousspecies in our colons because of
all those factors.
Well, those species, thosebeneficial species served to
(07:45):
suppress and keep at bay fecalmicrobial species that are
generally resistant toantibiotics.
These are species in the groupof proteobacteria, species such
as E coli, klebsiella,campylobacter, pseudomonas, many
others.
You might recognize those names, by the way, because they're
also very important pathogenscausing sepsis and urinary tract
(08:07):
infections and other infections.
Well, those same fecalmicrobial species, when they're
not suppressed anymore bybeneficial microbes because of
all those exposures, will ascend, will over-proliferate in the
colon, where they belong, butthen ascend into the small
intestine where they don'tbelong.
24 feet of small intestinalcolonization by fecal microbes.
(08:31):
Feet of small intestinalcolonization by fecal microbes.
And the small intestine is notwell equipped to deal with this.
It has a thinner mucus barrier.
It's very permeable becausethat's where we're supposed to
absorb nutrients like vitaminsand minerals and fatty acids.
And so when the fecal microbestrillions of them, invade the
small intestine, that alone isvery inflammatory and increases
(08:52):
the already permeable smallintestine.
It makes it more permeable.
These microbes only live for afew hours.
When they die, these fecalmicrobes release.
These are called gram-negativemicrobes because they stain a
certain way, because they havesomething called
lipopolysaccharide endotoxin intheir cell walls when they die,
(09:12):
when these trillions of microbesdie because they only live for
a few hours.
They release thatlipopolysaccharide endotoxin
into the bloodstream and that'show SIBO in the small intestine
can be experienced.
In other organs it could beexperienced as anxiety or
depression, or cognitiveimpairment and Alzheimer's.
(09:33):
In the brain it could beexperienced as atrial
fibrillation, coronary disease,myocardial infarction, heart
attack or sudden cardiac death.
When endotoxin involves theheart and the coronary arteries,
it could lead to rosacea,psoriasis in the skin.
It could lead to joint pain andinflammation, such as that in
(09:53):
fibromyalgia and rheumatoidarthritis.
In other words, microbes livingin the small intestine, where
they don't belong, export theireffects body wide and now this
effect, this, this process, nowinvolves, I believe, 50, 50% of
people.
You know I would have beenskeptical at first when I first
started thinking about this anumber of years ago, until this
(10:16):
air device and, by the way, Ihave no relationship with the
air device, the company iscalled Food Marble, if you're
interested, invented by an IrishPhD engineer.
When that device came out and Igot hold of it, this is going
back almost a decade I sawpeople testing positive left and
right.
Now you might say well, is thetest valid?
It has been validated, by theway.
(10:37):
But is the test valid?
Is it accurate?
Well, here's confirmation.
I believe that the test isuseful.
Someone will say haveulcerative colitis or Crohn's
disease or it'll bowel syndromeor have a weight loss plateau or
has a hemoglobin A1C of 11.7percent.
They eradicate the SIBO andthereby the endotoxemia and you
(11:00):
see, these conditions improvedramatically.
Somebody who say lost weight bygoing low carb, say they lost
maybe 48 pounds but they stillhave another 40 to go.
But they plateaued.
They addressed the SIBO andendotoxemia and their weight
plateau finally gives way.
Or a type 2 diabetic goes lowcarb and does other good things,
drops the hemoglobin A1C, say,from 11.7% to 6.4%.
(11:25):
Much better still, not good.
We're aiming for 5.0% or less.
They addressed the SIBO andendotoxemia.
Now their hemoglobin A1C is4.8%.
That's typical, in other words,people who test positive and
then test negative aftereradication of the SIBO.
That process seems to correlatewith clinical improvement in
(11:49):
some, or actually many,conditions.
So the SIBO, I believe, is areal thing.
It's been debated for now aboutover 30 years, but the science
has become clearer and clearer.
That SIBO is a real thingphenomenon that's very important
and, I would argue, is far morecommon than anyone ever thought
(12:09):
.
Now what do you do if you haveit?
Well, there's a number ofchoices, but if you followed my
advice, I would consume what Icall SIBO yogurt and all it is.
It's not yogurt.
It looks and smells like yogurt.
You can't buy it in the store.
It's nothing like the stuff youbuy in the grocery store that
has some kind of boring microbesin it and has sugar and high
(12:29):
fructose, corn syrup and mixingagents.
So you don't want that stuff.
We're going to make it, butwe're going to use some unusual
methods.
First we're going to choosemicrobes with specific
characteristics.
Then we're going to ferment itfor a prolonged period.
To ferment it for a prolongedperiod, microbes don't have sex,
right?
There's no male and femalemicrobes.
(12:50):
They have asexual reproduction.
So one microbe doubles itselfto become two, two becomes four
and so on.
So the microbes we're going touse double every one to three
hours and I'm going to add someprebiotic fiber like the fibers
used in SIBO testing.
We'll use I like to use inulin,so inulin added.
Prolonged fermentation microbeschosen for very specific
(13:12):
characteristics.
So the microbes I chooselactobacillus eryderi,
lactobacillus gasteri andbacillus subtilis.
I chose those microbes becausethey either colonize or
germinate in the small intestine.
It's unusual, most microbesdon't do that.
They germinate or they colonizethe colon.
Well, these microbes colonizeor germinate in the small
(13:37):
intestine.
They take up residence in thesmall intestine where SIBO
occurs, and all three are verypowerful producers of something
called bacteriocins naturalantibiotics effective in killing
this species of SIBO.
So they're really good atkilling E coli and Klebsiella,
for instance, and for thatmatter, some other microbes too,
(13:59):
like Staphylococcus andEnterococcus.
So we ferment these threemicrobes for a prolonged period
36 hours.
So we ferment these threemicrobes for a prolonged period
36 hours and when we count themicrobes we get hundreds of
billions per half cup or 120milliliters serving, and we
consume it.
Now, the best way to do this isto ferment each microbe
individually, because that waywe get the super-duper high
(14:20):
counts.
Like rhodori fermented byitself, for instance, for 36
hours we get about 300 billionper half cup serving.
You can co-ferment all three,but you'll get lesser numbers.
It's less potent, but it doeswork for the majority.
So you still can do that.
But the only thing I ask isthat should you do that, start
over, start from scratch, maybeevery fifth or sixth batch or so
(14:43):
?
We don't know what happens tothe relative counts, the
proportions of microbes as youmake subsequent batches from a
little of the prior batch.
Now, if you want the details onall this, see my blog.
I have thousands of posts on myWilliamDavisMDcom blog.
Of course, my Supergut bookshows you how to make this
Seabull yogurt and other yogurts.
(15:03):
How to ferment other microbesfor other purposes also seabull
yogurt and other yogurts.
How to ferment other microbesfor other purposes also the
recipes.
In those two locations.
Supergut and my blog usedbacillus coagulans rather than
bacillus subtilis.
I replaced the coagulans withsubtilis because the coagulans,
when we perform quantitativecounts, really didn't achieve
the high numbers we wanted whenfermented in dairy.
There's nothing wrong with themicrobe.
(15:24):
It's not the greatest forfermenting in dairy.
There's nothing wrong with themicrobe, it's just it's not the
greatest for fermenting in dairy.
Coagulants is actually veryinteresting for other reasons.
But the subtlest is a reliablefermenter and it's easy to
ferment.
In fact, if you ferment thesubtlest alone, you can ferment
it for 24 hours because itdoubles faster than the other
two species.
So see my blog, see my SuperGut book.
(15:46):
But if you'd like someassistance, some guidance, I
invite you to join myconversations we have frequently
on my inner circle dot.
Dr davis, infinite health dotcom know that you have the
option of this very benign wayto deal with SIBO that you can
make in the comfort of yourkitchen, consume.
We consume it, by by the way,for four weeks or longer.
(16:07):
I also encourage people toconsume it intermittently
afterwards, even after you'veeradicated SIBO, because SIBO
loves to come back.
Even if you took the antibioticrifaximin for it, which is only
about 55, 60, maybe 70%effective, it comes back as a
rule.
So we're going to use the SIBOyogurt formulation
(16:27):
intermittently, maybe threetimes a week, to prevent
recurrence and because thosemicrobes also have spectacular
benefits, especially the rhodoriand to some degree the gasteri,
beyond just eradicating SIBO.
One caution don't test with theair device or other means of
hydrogen gas testing unless youhold off on the Roteri for two
(16:49):
weeks, because the Roteri willcause hydrogen gas positivity
and it'll screw up your abilityto detect whether your SIBO has
been eradicated or not.
I know it's a complexity, ittook us a while to figure that
out, but if you're going to testagain at the end of your SIBO
yogurt adventure, wait two weekswithout the Roteri.
You can take the other ones,you can take the Gaseri and the
Sutilis, but don't take theRoteri.
(17:10):
Wait two weeks test if you wantto see if you're negative or
not and then resume your Roteri.
Now learn these lessons foryourself and then educate the
people around you, because it'shalf the world now, half the
people around you.
If you know four people in yourfamily, probably two of them,
maybe more, because you're allsharing utensils and food and
(17:30):
other habits, but it's notuncommon for entire families to
test positive.
So educate the people aroundyou because they're dealing with
high blood, glucose, obesity,neurodegenerative disorders or
risk for autoimmune conditions,skin rashes, depression, anxiety
.
So these are ways to startdealing with these conditions by
(17:51):
getting rid of the invadingfecal microbes in the 24 feet of
your small intestine.
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