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November 15, 2023 • 22 mins

Wondering how your genetics might be shaping your stress response? Join us on this enlightening journey as we uncover the profound role our genes play in managing stress. Our esteemed co-host, Trena Weeks, offers a rich narrative of her personal experiences dealing with stress as a working mom. Together, we unravel the mysteries of how stress can physically manifest itself and how certain genetic variations can influence neurotransmitter release, thereby affecting our mood and anxiety levels.

Brace yourself as we dive deeper, exploring the interconnected world of pharmacogenetics in mental health treatment. You'll learn how genetic testing with P23 can reveal the secrets of how our genes interact with medication, food, and supplements and even influence our exercise regimen. Discover the exciting potential of personalized medicine - how, by understanding an individual's genetic makeup, we can predict their response to certain medications, anticipate potential side effects, and tweak dosages for optimal results. All this and more as we pledge to guide you to live your longest, healthiest, and happiest life possible. Tune in and grab this chance to unlock the secrets of your genes!

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Intro Music (00:00):
P23 Knowledge, access, power.
P23, wellness and Understandingat your Fingertips P23.
And that's no Cap.

Dr. Tiffany Montgomery (00:20):
Hello and welcome to another episode
of P23 Tell-A-Lan Talks, wherewe delve into the fascinating
world of genetics and its impacton our everyday lives.
I'm your host, Dr.
Tiffany Montgomery, and joiningme today as my esteemed co-host

(00:42):
is a true industry expert andthe Chief Operating Officer of
P23, Trena Weeks.
With the wealth of expertise inthe field of molecular testing,
she brings a wide range ofknowledge to our discussions.
She is a mother, a wife, asister, a niece, a cousin, a

(01:08):
friend, a philanthropist.
She is a mother, a wife, adaughter, a sister, a friend, a
niece, a cousin, aphilanthropist, an innovator and
a true trailblazer.

(01:30):
Trena, welcome to ourdiscussions today.

Trena Weeks (01:36):
Thank you, Dr T, for such a warm welcome.
Never really heard all thosehats I wear out now, but you
made them sound so great.
Happy to be here tonight.

Dr. Tiffany Montgome (01:47):
Absolutely .
I couldn't think of anybodybetter to help us understand
stress and how it affects ourreal life and all of the areas.
So thank you for exposingyourself and allowing me to
speak and let others know aboutyou so that we all know that we
can do it.
Because one thing about youyou're very down to earth and

(02:10):
you put your shoes on one at atime, just like everybody else.
So thank you for your time andjoining us today.
I think it's an important topic.
Just to talk about stress.
Stress is an inevitable part oflife and we all experience it
in different ways.
But did you know our geneticsplay a significant role in how

(02:34):
we respond to stress?
Our DNA holds valuable cluesabout our stress response
mechanisms and to shed light onthis fascinating subject, I
could think of no better co-hosttonight to really get into the
subject.
So, as we delve into stressless and how our genetics impact

(02:56):
our stress response, I waswondering if you could tell us a
little bit about stress, Trena.

Trena Weeks (03:02):
Definitely know about stress.
So, being a mother of afive-year-old and a
seven-year-old, I actually dealwith stress on a daily basis.
Currently, my five-year-old isstruggling in school with his
behavior, so I'm having tobalance teaching home techniques
to cope with his behavior aswell as maintaining my

(03:26):
obligations for work in school,which is causing a lot of
pressure and stress and a littlebit of lack of sleep.
So I have experienced stressrecently in that area, as well
as being able to work in somefitness activity and self-care.
I think that self-care is animportant thing for me and not

(03:47):
being able to have thoseself-care activities causes me
stress.
So when you say, am I familiarwith stress, I would say I am an
expert on understanding whatstress is.
Now managing it, that's anotherstory.

Dr. Tiffany Montgomery (04:02):
I can certainly relate to that and I
think so many times we thinkabout stress.
When we look at the physicalsigns and we think about the
physical manifestation of stress, like headaches, back and
shoulder aches, or your gut isjust a mess, right, you could

(04:23):
also break out, so acne oreczema or psoriasis.
These breakouts are oftenstress related.
We sometimes notice it too whenwe start having our weight kind
of creeping up weight gainbecause that nonstop stress can
cause your glucose or your bloodsugar levels to rise, which

(04:44):
could lead to that weight gain,especially in your abdominal
area.
So these are things that we allhave to be mindful of,
especially when we have tobalance work and life right.
Work-life balance is a veryserious thing.
We use that term, but we justheard Trena describe how she has

(05:05):
to balance that all the time.
And with that, we've got totalk about some internal things
that kind of happen when we havestress.
Right, and these internalthings you may or may not be
aware of, but pay attention tothose physical signs, because
those physical signs are goingto share so much light on what

(05:29):
could be happening inside ofyour body.
There are certain genes involvedin regulating the production
and the activity ofstress-related hormones such as
cortisol.
Genetic variations in thesegenes can impact how efficiently
our bodies manage and recoverfrom stressful situations.

(05:50):
Some individuals may havegenetic variations that make
them more resilient to stress,while others may be more
susceptible to its effects.
Our genetic predisposition caninfluence the way we perceive
and react to stressors.
For example, certain geneticvariations can affect the

(06:13):
release of neurotransmitters,which can impact our mood and
anxiety levels.
Additionally, variations ingenes related to stress response
pathway can affect the durationand intensity of our stress
response.

(06:36):
Just like different people havedifferent genetic makeups,
different people are going torespond differently to that
stress.
You may hear one person'ssituation and say, oh my
goodness, I don't even know howI would manage if that happened
to me.
Or you may hear somebody'ssituation and say that's

(06:56):
lightweight compared to what I'mdealing with.
Either way, your body and yourDNA are going to react to those
stressors and it's importantthat we understand how our DNA
can help us personalize ourstress management strategies.
By knowing our genetic makeup,we can identify specific areas

(07:18):
of vulnerability and developtargeted interventions.
What am I talking about?
For instance, individuals withcertain genetic variations may
benefit from stress-producingactivities such as mindfulness
practices exercise or specificdietary modifications.

(07:45):
This personalized approach canoptimize our stress management
efforts and enhance our overallwell-being.
Trena, do you have any stressmanagement techniques or
strategies that you currentlyuse?

Trena Weeks (08:01):
Yes, there are a few of those techniques that
I've tried before, but one thingthat I know really works for me
just resting and relaxation.

Dr. Tiffany Montgomery (08:14):
I think those are key.
So, thank you.
I think that those are pivotaland sometimes we forget, right,
those little things.
There's also a study of how anindividual's genetic makeup
affects their response tomedication.
That's called pharmacogenetics,and pharmacogenetics, also

(08:41):
known as PGX, can be used in thecontext of mental health
treatment.
It involves analyzing specificgenes to influence how our
bodies metabolize and respond topsychiatric medications, among
many others, but it's reallyreally effective for psychiatric

(09:03):
medication management.
And psychiatric medicineincludes things from anxiety and
depression all the way toschizophrenia, bipolar, multiple
personality disorders.
It's a wide range, right?
So you can't say, ooh,psychiatric medications.

(09:23):
I mean, think about it, howmany of us deal with stress,
anxiety, depression on a regularbasis?
By understanding anindividual's genetic profile, we
can predict their likelihood ofresponding to certain
medications, potential sideeffects and optimal dosage
adjustments.

(09:43):
Pharmacogenetic testing hasbeen particularly useful in the
treatment of depression, anxietydisorders, bipolar disorders
and schizophrenia.
These conditions often require acombination of medication and
dosages, making it challenge tofind the right balance, the

(10:07):
right medication or to take itin the right amounts.
These are all things that Ithink we have to be mindful of,
because no two persons are alike.
This is our DNA is different.
We also experience differenceswith how we're going to respond

(10:32):
or what we need to manage thoseparticular conditions, elements,
whether they're temporary orlong term.
Sometimes you can take amedicine just to temporarily
build up your reserves and yourfortitude, and associated with

(10:52):
other practices, so that after aperiod of time determined by
your doctor three months, sixmonths, a year, two years you're
transitioning away from thosemedications and you're
transitioning to what we wouldcall the balance, using other

(11:16):
natural pathways.
So you're transitioning to thebalance of using other natural
mechanisms or more holisticmechanisms, such as you know,
the things Trena talked aboutyoga, mindfulness, exercise, et
cetera.
But we have to remember all ofthese things work together and

(11:39):
nothing happens in a silo or allby itself.
Right, and that's theoverwhelming part, just
understanding that just likethere are many pieces and parts
to you, there are gonna be manyparts and ways that we can
manage stress and use ourgenetics as a tool to do so.

(12:02):
Trena, with that, I wanna openit up to some questions.
Maybe we received in the chat,the email or in the DMs.
Hopefully we have time for twoor three questions.
Could you give me the first one?

Trena Weeks (12:14):
Sure, and also Dr T , I wanted to say I'm glad that
you explained those medicationsbecause I know for myself I've
always wanted to have a betterunderstanding of taking
medications, because it'ssomething that's found upon when
I talk about it to like mysocial circle.
So thank you for doing that.
The first question is how canwe use the genetic data to

(12:40):
develop our personalized stressmanagement strategy specific to
our own individual needs?

Dr. Tiffany Montgomery (12:46):
That's a great question.
There are tests available, likethose at P23, where we're using
the research alreadyestablished in a clinical
setting, looking at particularvariants on different genes,
such as the serotonintransporter gene, known as the

(13:08):
short allele, and we're lookingat the susceptibility to
developing stress-relateddisorders, such as the anxiety
or depression.
We can look at other allelesthat lower serotonin
availability in the brain,increase cortisol response, and
we look at those variations inthe genes that are involved in

(13:34):
stress response, such as thoserelated to the hypothalamic
pituitary adrenal axis, calledHPA axis, and those all
contribute to an individual'sdifferences and stress
susceptibility.
So when we delve in and reallylook at those genes, we're able

(13:54):
to get guidance and while wecan't change our genetic makeup,
we can certainly take steps tomanage stress and improve our
overall well-being With thosehealthy coping mechanisms that
we talked about, like regularexercise, mindfulness practices,
in addition to maintainingstrong support systems, can all

(14:18):
help an individual regulatetheir stress response.
Additionally, seekingprofessional help, such as
therapy or counseling, can bebeneficial in managing
stress-related disorders.
So I'm glad you bring that upbecause sometimes, depending on

(14:39):
where people are coming from,they might say move on or you
need to get over that, andsometimes we all need a little
help.
I was talking to my sister lastweek and we were processing just
stress and I think our mom saidsomething like come on, you're

(14:59):
stronger than that, get going.
And I was trying to explain toher that you have moments now
where everything is so rapid,emails are so right away, bills
are emailing you now to pay them.
Problems, coworkers, clientservices All of these work

(15:20):
relationships are coming at you24 hours a day and there's no
off button, there's no do notdisturb.
In my mom's day you were ableto or she was able to, put a
letter in the mail, deal withthat stress.
Later Somebody mail her a bill.
You say I didn't get the mailyet.
17, 20 days sometimes it takesfor the mail.

(15:42):
You get the mail and then yourespond and your response takes
10, 20 days and there was acooling off period that allowed
people time to separate from aproblem, to think it through, to
get help, to get guidance.
There is something to be saidabout the technology age that we

(16:02):
live in.
With so many factors makinginstantaneous gratification,
fulfillment, everyday part oflife, it doesn't allow you those
moments to separate.
So, whereas they were able tohave coping mechanisms and time

(16:23):
to balance those stressors.
We miss a lot of that in thetechnology age.
So my sister and I have to forma support group for each other
to say, hey, stop breathe.
Let's think about this.
Do we want to talk to atherapist?
Are we gonna provide therapyfor each other or whatever that

(16:43):
looks like, just to get throughthose moments.
So I wanna encourage you andall of our listeners to develop
that support system and don't beafraid to do whatever it is
that you need to do to tacklethose health issues.
But let's not worry about whatpeople have to say about our
stress or our mental health.
It's gonna be up to us tounderstand our genetics and to

(17:06):
proactively deal with thosethings.
And do you have one morequestion?

Trena Weeks (17:12):
I do, I do.
Could you explain how or ifknowing your genetic makeup in
DNA can help with creating thatexercise routine?

Dr. Tiffany Montgome (17:24):
Absolutely At P23, we have a test called
P23 Optimum, where we actuallylook at genetic markers that
will help you decide the mosteffective fitness mechanism or
routine for you.
Are you better at strengthexercises?
Are you better suited for, anddo you see the most result out

(17:47):
of, cardiovascular exercises?
Is your genetic makeup onewhere you need to be equally
balanced, where, instead ofalternating days, you probably
need to focus every day on 30minutes cardio, 30 minutes
strength training?
We're able to look geneticallyand help you come up with the

(18:10):
best type of workouts that willwork for you, so that you could
work with your fitness trainersor our health coaches and really
define a workout routine withthe correct physiology,
exercises and guidance that workfor you.
So our testing will give youthe class and then you will work

(18:32):
with the trainer to tell thetype of exercises within that
class that would be mosteffective for you, and
biomarkers is a phenomenal wayto do that, which is based
strictly on your geneticcomposition.
So thank you for those greatquestions and I will turn it

(18:55):
over to you for any wrap up orfinal points that you'd like to
throw in.

Trena Weeks (19:00):
After our discussion, our final advice
would be to have open and honestconversations with your health
care provider aboutpharmacogenomic testing.
Ask questions there's alwaysways to find solutions and talk
about the limitations and makeinformed decisions that are best

(19:21):
for you to gather with yourhealth care provider.
Remember that everyone'sjourney is different.
It's unique, and what works forone person may not work for
another.

Dr. Tiffany Montgomery (19:32):
Thank you, Trena.
That is a phenomenal piece ofadvice and I think you summed
that up perfectly for both of us.
In this episode of P23 TeleLabsTalks, we were able to really
get into the topic of stress andhow it holds valuable
information within our DNA onhow to manage and respond to

(19:56):
stress.
We were able to shed light onthis fascinating topic and
really get into the genes,understand our DNA to
personalize stress managementstrategies, and then we were
also able to talk about howthose genetics not only help

(20:18):
with stress management but alsoaffect medications and
pharmacogenetics.
More importantly, we were ableto give you the solution, and
one of the strongest solutionswe can offer is testing with P23
, whether you choose to test forpharmacogenomics or

(20:40):
nutrigenomics or the combinationof what we call P23 optimum,
where we look at your medicationmetabolism, your food
metabolism, your supplementmetabolism the best exercises
for you and really hone in onthose stress management genes.

(21:00):
I think it is definitely wellworth joining our membership
program and talking to ourhealthcare providers and
specialists today.
I would also like to take amoment just to thank our
phenomenal co-hosts and ourlisteners.

(21:22):
Thank you so much for tuninginto this episode of Tell a Lab
Talks here at P23 Health, we'repassionate about helping you
live your longest, healthiestand happiest life possible.
It is all backed by science.

Intro Music (21:55):
Thank you.
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