All Episodes

November 8, 2023 22 mins

Ever thought about why you just can't resist that second slice of pie, while your friend can eat an entire pizza and not gain a pound? Or pondered why certain diseases seem to run in families? Join us, your hosts, Dr. Tiffany Montgomery and Trena Weeks, as we pull back the curtain on the fascinating world of genetics and its impact on your everyday life.

Discover how your DNA plays a starring role in everything from your susceptibility to various illnesses to your response to exercise and medication. We’ll take a deep look into inherited diseases, such as cystic fibrosis and sickle cell anemia, and uncover how genes can amplify a woman's risk of developing breast or ovarian cancer. Moreover, we'll guide you on how to leverage your unique genetic makeup to make informed decisions about your lifestyle, maximize your health, and achieve your wellness goals. Be ready to be empowered by success stories from individuals who've navigated their health journey with the guidance of P23 Health. This episode is all about embracing a richer quality of life by understanding and capitalizing on your genetic blueprint.

Support the show

Mark as Played
Transcript

Episode Transcript

Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Dr. Tiffany Montgomery (00:06):
P23.
Hello and welcome to P23telelab talks.
I'm your host, Dr.
Tiffany Montgomery, and joiningme as my esteemed co-host, a

(00:27):
true industry expert and thechief operating officer of P23,
Trena Weeks.
With a wealth of expertise inthe field of molecular testing,
she brings a broad range ofknowledge to our discussions.

Trena Weeks (00:45):
Thank you, Dr T.
You make me sound so important.
I'm happy to be here today.

Dr. Tiffany Montgomery (00:50):
We are happy to have you.
I'm thrilled to have you a partof our telelab talks, Trena.
P23 is amazing because here atP23 Health, we're passionate
about helping you live yourlongest, healthiest and happiest
life possible.
Guess what?

(01:10):
It's all backed by science.
In today's episode of P23Telelab Talks, we are cracking
the code, understanding geneticsand your lifestyle.
In this episode, you can expectto learn critical roles and how

(01:31):
and why DNA impacts your health, a few ways that we're familiar
with and how we can control itand take proactive care of our
health.
Are you excited?

Trena Weeks (01:45):
I'm really excited and I hope I learn how to start
wasting my money on things thatdon't work with my DNA.

Dr. Tiffany Montgomery (01:53):
You are in for a treat, so let's dive in
.
Have you ever wondered why somepeople seem to be able to eat
whatever they want withoutgaining weight, while others
struggle to maintain a healthyweight, no matter how hard they
try?

Trena Weeks (02:10):
Yes, In addition to wondering why it's hard for me
to drop pounds with all thedifferent things that I try,
this is often something that Ithink about and I struggle with.
I read up on it and let's notmention I am definitely a Google
expert on it.

Dr. Tiffany Montgomery (02:27):
I think so many of us can relate to our
Google MD ways, but it's soimportant because we need to
understand why that happens sowe can do something about it.
There's also some people whoare susceptible to certain
diseases and some people whoaren't.
All those answers lie in ourgenes.

(02:51):
I remember the early days ofCOVID-19 and the biggest
question was how some peoplewould get it and some people
would not.
It was the same thing.
If you can remember, in mychildhood there was chickenpox.
Before there was the vaccineand everybody was getting the

(03:15):
vaccine.
We would have little chickenpoxparties.
If one person got chickenpox,everybody would go be in the
room or be around that person sothey could get exposed to
chickenpox, so that they wouldnot get it later.
It was about controlling thespread of the virus by going
ahead and getting it and gettingit out of the way.
I know that sounds like thecraziest thing, but even when I

(03:39):
would go to those chickenpoxparties, I would never get
chickenpox.
Everybody in my house hadchickenpox.
I've never got it.
Then I think when I'm in myteenage years, like while I was
in high school a vaccine wasdeveloped.
Now people all get thechickenpox vaccine, but you have
those situations where yourgenes or your DNA just are going

(04:02):
to determine whether you getsomething or not.
I think that that is aphenomenon that so many people
are trying to understand.
I hope today's discussionprovides you with some insight
and some guidance on how tounderstand the role of DNA.
Dna plays a critical role indetermining your health in

(04:23):
various ways.
It is the blueprint thatdefines your genetic makeup and
provides instructions for yourbody to function correctly.
Any changes or mutations inyour DNA can have a significant
impact on your health.
So, Trinay, we're going to getinto a few ways that DNA can

(04:44):
impact your health.
Can you think of any like themost common that most people
talk about?

Trena Weeks (04:50):
I can think of when people think about DNA.
It's probably like the abilityto pick up weight and lose
weight quickly, like for me.
I pick it up really, reallyquickly and then it's harder for
me to lose it, but then whenyou look at, like my husband,
he'll pick it up and they candrop it with no thought, just
instantly.
It is so frustrating.

Dr. Tiffany Montgomery (05:14):
I think a lot of women feel like, oh, my
husband just loses weight whenhe thinks about losing weight
and we have to like get ourbutts in gear and figure some
things out.
Well, DNA can impact yourhealth in four major ways.
We're going to just talkbroadly in general about those
four ways.
The first one is inheriteddiseases.

(05:36):
So some genetic mutations arepassed down from parents to
children and they can causeinherited diseases such as
cystic fibrosis, sickle cellanemia, Huntington's disease and
many other.
I think that's the mostfamiliar impact to DNA that
people think about, because it'sjust genetics.

(05:57):
I was born with this, or mychromosome dictates that, and
it's very much expected based onhow we process those
instructions that our body sendsto us.
So it's one of the major ways.
And then the next major impactwould be susceptibility to
diseases.

(06:17):
Certain genetic variations canincrease your risk of developing
certain disease, such as cancer, heart disease and Alzheimer's
disease.
Trena, can you think of anexample?

Trena Weeks (06:30):
So when I think of an example I think about maybe
have blood pressure.
I'm not sure if that's right ornot, but I always think about
how, when you go to the doctor,they sit you down and they say,
okay, tell us, you have thislittle checklist, tell us who
had this, this, this, this, andit's always my mom had high

(06:53):
blood pressure, my dad, now Ihave it, now my child has it.
So I kind of think about thatchecklist when I think about
things that are passed throughthe DNA and I'm sure, even
though a lot of times they don'toften explain it to you in
detail, I'm sure that's why theygo through that checklist to
see who had it and the relationto you and how it connects to

(07:15):
what's going on currently withyou.

Dr. Tiffany Montgomery (07:18):
I think that's a great example.
I think the other one, and morecommon recently in the news, is
BRCA1 or BRCA2, which is a genethat increases a woman's risk
of developing breast cancer orovarian cancer.
It also plays a role in theman's risk to developing breast
cancer, but you didn't know that.

Trena Weeks (07:40):
I did hear about BRCA1 and how it increases the
risk for women developing breastcancer.
I also heard that certain agegroups and certain minorities
should get tested more oftenbecause of it.

Dr. Tiffany Montgomery (07:56):
There's a lot of prevention around that
when you do have the mutation.
That's up for debate.
I think that another majorimpact that DNA can have on your
health is response tomedication.
Now, this is something that'sbecoming increasingly more
common and people are becomingmore aware your genetic makeup

(08:21):
can affect how your bodyprocesses medication, and some
people can be more sensitive tocertain drugs and have a higher
risk of adverse reactions due totheir genetic makeup.
So what does that mean?
For example, one of the teststhat we look at for response to

(08:42):
medication is called a PG X test, or pharmacogenomics.
That's included in our P23optimum.
Recently, I found out that highblood pressure.
So I took a P23 optimum test,looking at the medication

(09:03):
response, trying to gauge ordecide of all of the blood
pressure medications out therewhich one would cause me the
lowest risk of adverse reactionlike hair loss or upset stomach
or any of those other thingsthat happen when you start
taking Medication, especially ablood pressure medication.

(09:25):
You hear a lot of people talkabout thinning hair and that
kind of thing, so I was happy tobe able to have a test like
that where we can look at,before we even put that drug in
our body, what's our likelihoodof having those adverse
reactions and which one wouldgive us the best genetic outcome

(09:48):
, because it would be absorbedbest in our body and help treat
the condition that we'rediagnosed with.
So it's important as we moveinto the future of medicine that
we understand adverse reactionsare how to manage and mitigate
those risks.
And then the last way that DNAcan impact your health Is one of

(10:11):
those ways that we don't alwayslike to talk about.
It's the way I think you talkedabout initially tonight
lifestyle choices.
Your DNA can also impact yourresponse to lifestyle choices
such as diet and exercise.
For instance, some people mayhave a genetic predisposition to

(10:34):
obesity or diabetes, making itharder for them to maintain a
healthy weight or regulate theirblood shippers.
I think when you get into thoselifestyle choices, that is
where we all beat ourselves upor we're the hardest of

(10:57):
ourselves.
I think we're most forgiving ofinherited diseases because you
can't control the genes that yougot.
But when it comes to lifestylechoices, I think there's a
burden there to show hey, I'vedone what I can do to reduce
those risks.
Sometimes, if we don't have theright diet or we consume a lot

(11:20):
of alcohol or we don't exerciseas much as we do, we seem to
blame ourselves.
Do you feel that way, or do youthink that lifestyle choices
are what they are?

Trena Weeks (11:37):
I definitely blame myself.
Listening to you talk, I'mstarting to blame myself more,
because I didn't understand thatDNA could help us understand
what medications we should betaking.
Does it also help us understandwhat vitamins we should be
taking?
Because if that's the case, Ican save a lot of money.

Dr. Tiffany Montgomery (11:57):
It actually does.
The way it helps is not thetraditional way.
You can't take the test andit'll just say this will help
you and this won't.
But what it will tell you ishow much calcium or how much
selenium or how much CoQt orwhatever the vitamin is that you

(12:19):
need to take for your body toabsorb it and process it.
Do you need three vitamin Dpills a day?
Should you be taking 300, 500,1000 milligrams of vitamin B1,
for example?
The guidance is based on howyour body processes those

(12:41):
vitamins and that guides howmuch you should take.
If you're processing it slowlyand not efficiently, you might
have to take more in thebeginning and taper off as you
go down.
If you are taking, let's say, anominal amount and your body is

(13:10):
processing that and to speed itup, you're just running through
it, then you will need to takeless.
Looking at this as a blueprintand working with your health
care team nutritionists,physicians because I'm just a
research doctor but if you areworking with treating physicians
, then you're able to manage andmake and create blueprints for

(13:39):
your diet, supplement andmedication routine based on your
body's absorbance.
And, yes, you can save money.
However, on the flip side, itcould also cost you money,
because you might realize, gee,I wasn't taking nearly as much

(14:00):
XYZ as I should have been takingand that's why I've been tired,
I've been sluggish.
It all makes sense now, and soyou'll hit that while I, or that
eureka moment and you'll beginto optimize or begin that
journey of living your best life.
I think, overall, understandinghow DNA impacts your health can

(14:25):
help you make informeddecisions about your health care
, including Genetic testing anddisease prevention strategies.
I want to open it up forquestions Trena.
I don't know if you have any orif we have some questions from
viewers that were previouslysent in, but I love to take some
questions.

Trena Weeks (14:46):
Sure, let me ask you this If you understand your
DNA, would that help you toselect better exercises and
fitness routines for your body,or is that not related?

Dr. Tiffany Montgomery (14:59):
That is a huge part of what we look at
and what other tests on themarket look at.
I would welcome the listenerwith that question, or other
listeners with that question, toreach out to us and connect
with one of our nutritionists orphysicians today to help you

(15:22):
understand if this test is rightfor you.
We do look at the geneticmarkers that contribute to your
exercise and your body'sresponse to that, telling us
whether your DNA is bettersuited and reactive to
cardiovascular exercises or ifit will be more for you to do

(15:45):
strength training, weightlifting and muscle building type
exercises.
Some people are perfect splitdown the middle and their DNA
tells them they should be doing50% of both every day.
So I know a lot of exerciseroutines call for 30 minutes of

(16:07):
cardio and then the next day youdo 30 minutes of weight lifting
, next day 30 minutes of cardio.
But you might need to besplitting up 15 minutes and 15
minutes just based on your DNAso that you can really see those
results that you want to see.
So I think that's an excellentquestion and we have time for
one more.

Trena Weeks (16:27):
So this came in from a listener and this
listener wants to know is itreasonable to consider breast
implants for women who doesn'tplan on having children after
being diagnosed with Brca 1mutation?

Dr. Tiffany Montgomery (16:44):
So I think that that is a great
question for a physician andit's a personal question.
Like I told you, I'm a researchscientist, so from a research
perspective it's always going tobe reasonable for consideration

(17:05):
.
We kind of consider all of theodds and then we take all of
those considerations and we putthem in research papers or
online and then your physicianlooks at the vast multitude of
possibilities and, based on yourage, your DNA, your life stance

(17:27):
, your circumstances, yourlifestyle, your life goals, they
can help you decide if breastimplants are right for you.
Is it in the realm ofconsideration Absolutely?
Is it reasonable to considertotally?
Is it recommended?
I have to pause there andencourage you to go back to your

(17:50):
provider.
Take your blueprint, take yournotes, take what you know about
your DNA, take your lifestyle,take your goals, take your
journey, Make it your own, giveit a voice and communicate that
to your healthcare provider sothat you can make the best

(18:11):
decision that you can make tolive your healthiest, longest
and happiest life.
And with that I am going toclose the questions Trena.

Trena Weeks (18:25):
no problem, Dr.
T, thank you for inviting metoday.
It sounds like, if we areinterested in creating a
healthier lifestyle, or ifthere's listeners like me
interested in getting rid ofthis full-on and living a more
sound and exercising more, thatwe should listen in.

(18:46):
So, in conclusion,understanding our genetic
footprint is an important partof this and maintaining good
health.
By learning more about genesand how to interact with our
lifestyle, we can take thosesteps to reduce the risk of
disease and just be happier andlive a happier life.

Dr. Tiffany Montgomery (19:07):
All right, thank you.
This has been an excitingepisode of P23 Tele Labs Talk In
this episode, cracking the CodeUnderstanding Genetics and your
Lifestyle.
We want to highlight and talkabout the genetic blueprint on

(19:29):
your health and how genes caninfluence everything from your
risk for certain diseases to howyou respond to different
treatments.
We've covered the four majorways that DNA can impact your
health, talking about inheriteddisease, susceptibility to
disease, response to medicationand lifestyle choices.

(19:54):
The problem is notunderstanding how these
influences work and how each ofthese factors contribute to our
overall health.
At P23 Health, we want to be apart of the solution.
We encourage you to look at ourP23 optimum testing, read our

(20:17):
white papers, join ourmembership program and
understand how you can use thesetools to empower you every day.
I would like to take a momentand invite you all to like us,
share us, interact with us,message us, email us, go to the
DM on the different socialchallenges and social media

(20:41):
outlets.
We're looking, we're monitoring.
We want to engage with you.
Send us an email to support.
At p23health.
com, we would like to have otherindustry leaders as future
guests and co-hosts or sponsors.
Let's use this as anopportunity to empower and build

(21:01):
our community and have thoseconversations with each other
that we normally have behindclosed doors, with the people
trying to take control of theirhealth.
Thank you for tuning in to P23Health.
We exist to help you capitalizeon your health and wellness,
empowering you to embrace aricher quality of life.

(21:24):
With a treasure trove ofsuccess stories from individuals
just like you, we're here toguide you toward your goals.
At P23 Health, we're with youevery step of the way, and
that's no cap Until next time.
Be well.
Advertise With Us

Popular Podcasts

Stuff You Should Know
Dateline NBC

Dateline NBC

Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Follow now to get the latest episodes of Dateline NBC completely free, or subscribe to Dateline Premium for ad-free listening and exclusive bonus content: DatelinePremium.com

On Purpose with Jay Shetty

On Purpose with Jay Shetty

I’m Jay Shetty host of On Purpose the worlds #1 Mental Health podcast and I’m so grateful you found us. I started this podcast 5 years ago to invite you into conversations and workshops that are designed to help make you happier, healthier and more healed. I believe that when you (yes you) feel seen, heard and understood you’re able to deal with relationship struggles, work challenges and life’s ups and downs with more ease and grace. I interview experts, celebrities, thought leaders and athletes so that we can grow our mindset, build better habits and uncover a side of them we’ve never seen before. New episodes every Monday and Friday. Your support means the world to me and I don’t take it for granted — click the follow button and leave a review to help us spread the love with On Purpose. I can’t wait for you to listen to your first or 500th episode!

Music, radio and podcasts, all free. Listen online or download the iHeart App.

Connect

© 2025 iHeartMedia, Inc.